Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression.

abstract：:Immunoaffinity adsorption techniques, utilizing specific antisera for hCG and its subunits bound to Sepharose 4B, have been employed to separate hCG alpha beta dimer and free subunits of hCG. As previously reported by this and a number of other laboratories, trophoblast cells (in vivo and in vitro) produce free alpha ...

journal_title：Endocrinology

authors： Cole LA,Hartle RJ,Laferla JJ,Ruddon RW

更新日期：1983-09-01 00:00:00

abstract：:We report here 1) that GnRH and a potent GnRH agonist inhibit basal and LH stimulated ovarian androgen biosynthesis in vitro, 2) that the inhibitory effects of GnRH are dose-dependent and completely inhibited by concomitant treatment with a GnRH antagonist and 3) that the GnRH action is very rapid (t1/2 = 10 min) and ...

journal_title：Endocrinology

authors： Magoffin DA,Reynolds DS,Erickson GF

更新日期：1981-08-01 00:00:00

abstract：:Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular...

journal_title：Endocrinology

authors： Viennois E,Esposito T,Dufour J,Pommier A,Fabre S,Kemeny JL,Guy L,Morel L,Lobaccaro JM,Baron S

更新日期：2012-07-01 00:00:00

abstract：:Adult female transgenic mice expressing the human GH (hGH) gene with mouse metallothionein-I promoter are sterile. To evaluate the hypothalamic-pituitary function in these animals, adult female transgenic mice and nontransgenic normal littermates were ovariectomized. On days 7 and 8 after ovariectomy, mice were inject...

journal_title：Endocrinology

authors： Chandrashekar V,Bartke A,Wagner TE

更新日期：1992-04-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:T3 stimulates in vitro GH secretion, whereas somatomedins have been shown to suppress GH. We, therefore, tested the effects of a recombinant human insulin-like growth factor analog (IGF-I; Thr 59) on T3-induced GH secretion. Pituitary monolayer cultures were derived from 4- to 7-week surgically thyroidectomized male r...

journal_title：Endocrinology

authors： Melmed S,Yamashita S

更新日期：1986-04-01 00:00:00

abstract：:Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

journal_title：Endocrinology

authors： Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

更新日期：2019-12-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity and impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced by hyperglycemia, leads to myocardial fibrosis and impaired contractile function in the left...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Alloatti G,Vercellinatto I,Bardini P,Geuna S,Catalano MG,Danni O,Boccuzzi G

更新日期：2008-01-01 00:00:00

abstract：:The atrial natriuretic peptide (ANP) gene is expressed in several extraatrial tissues in which ANP may be involved in the regulation of autocrine or paracrine functions. In the ovary, the synthesis of ANP, its binding sites, and a physiological role were found. The ANP system in the oviduct, however, is yet to be defi...

journal_title：Endocrinology

authors： Kim SH,Cho KW,Kim SZ,Koh GY

更新日期：1997-06-01 00:00:00

abstract：:To examine the mechanism of estrogen's direct stimulation of steroidogenesis in the rabbit corpus luteum, we tested the hypothesis that the effect of estrogen on progestin production occurs at the site of processing of the precursor for pregnenolone (i.e. cholesterol) in the mitochondrion. For this purpose, we manipul...

journal_title：Endocrinology

authors： Holt JA,Wittmaack FM,Schreiber JR,Ghosh DK,Menon KM

更新日期：1988-05-01 00:00:00

abstract：:Molecular and cellular mechanisms involved in artificially induced ovarian differentiation were analyzed by exposing embryos of medaka (Oryzias latipes) to a potent nonsteroidal estrogen, diethylstilbestrol (DES). Embryos were exposed for short-exposure (SE) [from 0 to 8 d postfertilization (dpf)] and long-exposure (L...

journal_title：Endocrinology

authors： Paul-Prasanth B,Shibata Y,Horiguchi R,Nagahama Y

更新日期：2011-02-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:We tested the hypothesis that chronic maternal GH administration would increase fetal substrate supply, increase maternal and fetal insulin-like growth factor I (IGF-I) concentrations, and therefore enhance growth in the late gestation fetal sheep. Eleven ewes received bovine GH 0.1 mg/kg twice daily for 10 days, wher...

journal_title：Endocrinology

authors： Harding JE,Evans PC,Gluckman PD

更新日期：1997-12-01 00:00:00

abstract：:Mineralocorticoid receptor (MR), highly expressed in the hippocampus, binds corticosteroid hormones and coordinately participates, with the glucocorticoid receptor, to the control of stress responses, memorization, and behavior. To investigate the impact of MR in neuronal survival, we generated murine embryonic stem (...

journal_title：Endocrinology

authors： Munier M,Law F,Meduri G,Le Menuet D,Lombès M

更新日期：2012-03-01 00:00:00

abstract：:Activin A is a dimeric protein hormone that regulates numerous cellular functions. A clear physiological role for this molecule in pregnancy is suggested by previous studies in the human, wherein activin A rises dramatically as women approach parturition. To determine whether the rodent is a suitable animal model for ...

journal_title：Endocrinology

authors： Draper LB,Chong H,Wang E,Woodruff TK

更新日期：1997-07-01 00:00:00

abstract：:We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. VDR messenger RNA (mRNA) was assayed by Northern blot, and VDR protein was determined immunocytochemically....

journal_title：Endocrinology

authors： Zineb R,Zhor B,Odile W,Marthe RR

更新日期：1998-04-01 00:00:00

abstract：:Growth hormone-releasing factor-like immunoreactivity (GRF-LI) was detected in partially purified extracts of rat hypothalamus and duodenum with a highly specific RIA for rat GRF (rGRF). The concentration of rGRF-LI in the rat hypothalamus was 32.5 fmol/mg dry weight (455 fmol or 3.18 ng/region), while the rat duodenu...

journal_title：Endocrinology

authors： Bruhn TO,Mason RT,Vale WW

更新日期：1985-10-01 00:00:00

abstract：:Modulation of activin and other TGF beta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). However, most studies of these ligands use activin A due to its wide availability. We have now tested the ability of FS288 and FSTL-3 to bind and neutralize activin B rela...

journal_title：Endocrinology

authors： Schneyer A,Schoen A,Quigg A,Sidis Y

更新日期：2003-05-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

journal_title：Endocrinology

authors： Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

更新日期：2008-11-01 00:00:00

abstract：:Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...

journal_title：Endocrinology

authors： Yang CR,Lowther KM,Lalioti MD,Seli E

更新日期：2016-01-01 00:00:00

abstract：:Light and electron microscopic triple immunostaining was performed on coronal vibratome sections prepared from the hypothalamus of ovariectomized (OVX) and OVX plus estrogen-treated African green monkeys (Cercopithecus aethiops). Immunoreactivity for progesterone receptors (PRs) and neuropeptide-Y (NPY) was visualized...

journal_title：Endocrinology

authors： Horvath TL,Shanabrough M,Naftolin F,Leranth C

更新日期：1993-07-01 00:00:00

abstract：:Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunor...

journal_title：Endocrinology

authors： Chihara K,Arimura A,Kubli-Garfias C,Schally AV

更新日期：1979-12-01 00:00:00

abstract：:A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...

journal_title：Endocrinology

authors： Xiao J,Sun B,Cai GP

更新日期：2010-07-01 00:00:00

abstract：:The calcium-dependent class of cell adhesion molecules known as cadherins mediate homotypic cell interactions in most epithelia. We have now investigated the expression and distribution of cadherins and cadherin-associated molecules in the developing and maturing rat testis. E-Cadherin was not detected in the seminife...

journal_title：Endocrinology

authors： Byers SW,Sujarit S,Jegou B,Butz S,Hoschutzky H,Herrenknecht K,MacCalman C,Blaschuk OW

更新日期：1994-02-01 00:00:00

abstract：:The possibility of direct pituitary effects of sex steroids on gonadotropin gene expression and synthesis was studied in male rats. The animals were treated with a potent GnRH antagonist, Ac-D-pClPhe-D-pClPhe-D-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-D-Ala-+ ++NH2CH3COOH (Org 30276; 0.5 mg/kg BW, sc, twice daily) for 10 days. G...

journal_title：Endocrinology

authors： Perheentupa A,Huhtaniemi I

更新日期：1990-06-01 00:00:00

abstract：:Aprotinin caused a dose-dependent inhibition of [125I]hCG binding to its receptor in plasma membranes prepared from luteinized rat ovaries. Displacement of [125I]hCG from its receptor by aprotinin was temperature dependent, with an ID50 of 300 microM at 4 C and an ID50 of 3700 microM at 22 C. Equilibrium binding data ...

journal_title：Endocrinology

authors： Wilks JW,Hui OJ

更新日期：1987-03-01 00:00:00

abstract：:Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic syndrome, a cluster of diseases that includes obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. It has been proposed that sustained endoplasmic reticulum stress, which appears to occur in obesity and ...

journal_title：Endocrinology

authors： Wang D,Wei Y,Schmoll D,Maclean KN,Pagliassotti MJ

更新日期：2006-01-01 00:00:00

abstract：:A serially transplantable, chemically induced pancreatic islet cell tumor was developed in Lewis rats. The original tumor was induced by the administration of streptozotocin and nicotinamide. It was subsequently maintained by ip or sc transplantation of tissue fragments into recipient animals. Tumors generally grew to...

journal_title：Endocrinology

authors： Chick WL,Appel MC,Weir GC,Like AA,Lauris V,Porter JG,Chute RN

更新日期：1980-10-01 00:00:00

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00