Release of oxytocin and vasopressin by intracerebroventricular vasoactive intestinal polypeptide.

abstract：:Genetically obese Zucker rats, like obese humans, have normal or elevated circulating insulin-like growth factor-I (IGF-I) levels in the presence of low GH secretion. Hyperinsulinemia, increased energy status, or other nutritional factors associated with obesity could be responsible for these findings directly by incr...

journal_title：Endocrinology

authors： Melián E,Velasco B,Barrios R,Sanchez-Franco F

更新日期：1997-03-01 00:00:00

abstract：:Throughout spermatogenesis, germ cells migrate from the basal to the adluminal compartment while remaining attached to Sertoli cells via actin-based adherens and intermediate filament-based anchoring junctions. However, the events that trigger deadhesion and adhesion remain largely unknown. As part of our continued ef...

journal_title：Endocrinology

authors： Lau AS,Mruk DD

更新日期：2003-04-01 00:00:00

abstract：:Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membr...

journal_title：Endocrinology

authors： Ku CY,Qian A,Wen Y,Anwer K,Sanborn BM

更新日期：1995-04-01 00:00:00

abstract：:During luteinization of bovine granulosa cells in vitro in the presence of insulin, or insulin plus forskolin, there is a massive upregulation not only of progesterone production, but also of the gene for the peptide hormone oxytocin, with secretion of the peptide into the medium. By using the progesterone receptor an...

journal_title：Endocrinology

authors： Lioutas C,Einspanier A,Kascheike B,Walther N,Ivell R

更新日期：1997-11-01 00:00:00

abstract：:The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...

journal_title：Endocrinology

authors： Son YL,Ubuka T,Narihiro M,Fukuda Y,Hasunuma I,Yamamoto K,Belsham DD,Tsutsui K

更新日期：2014-05-01 00:00:00

abstract：:Specific binding of human chorionic gonadotropin (hCG), and the hCG-sensitive adenyl cyclase of granulosa cells from small (1-2 mm), medium (3-5 mm), and large (6-12 mm) porcine ovarian follicles have been studied. The number of hCG-binding sites per cell (n) increases during follicle maturation without a change in th...

journal_title：Endocrinology

authors： Lee CY

更新日期：1976-07-01 00:00:00

abstract：:Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activati...

journal_title：Endocrinology

authors： Ernst MC,Haidl ID,Zúñiga LA,Dranse HJ,Rourke JL,Zabel BA,Butcher EC,Sinal CJ

更新日期：2012-02-01 00:00:00

abstract：:We have investigated the characteristics and properties of cholesterol esterase (CEase) in the rat adrenal to clarify the mechanism of synthesis of free cholesterol from esterified cholesterol. CEase activity was estimated using substrate vesicles which were sonicated mixtures of cholesteryl oleate and phosphatidylcho...

journal_title：Endocrinology

authors： Nishikawa T,Mikami K,Saito Y,Tamura Y,Kumagai A

更新日期：1981-03-01 00:00:00

abstract：:The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

journal_title：Endocrinology

authors： Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

更新日期：2020-03-01 00:00:00

abstract：:We previously found that the sustained rise in active sodium transport by the toad urinary bladder after exposure to insulin is associated with the synthesis of a membrane protein with a molecular weight of 25,000. Studying the effects of insulin on the incorporation of uridine into RNA of epithelial cells of the blad...

journal_title：Endocrinology

authors： Cobb MH,Yang CP,Scott WN

更新日期：1981-12-01 00:00:00

abstract：:Purinergic G protein-coupled receptors (P2YR) and ion-conducting receptor-channels (P2XR) are present in the pituitary. However, their identification, expression within pituitary cell subpopulations, and the ability to elevate intracellular Ca2+ concentration ([Ca2+]i) in response to ATP stimulation were incompletely ...

journal_title：Endocrinology

authors： Koshimizu TA,Tomić M,Wong AO,Zivadinovic D,Stojilkovic SS

更新日期：2000-11-01 00:00:00

abstract：:The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...

journal_title：Endocrinology

authors： Packman PM,Rothchild JA

更新日期：1976-07-01 00:00:00

abstract：:A surge of GnRH release signals the LH surge that triggers ovulation. The GnRH surge is dependent on a switch in estradiol feedback from negative to positive and, in rodents, a daily neural signal, likely from the suprachiasmatic nuclei. Vasoactive intestinal polypeptide (VIP) may be involved in suprachiasmatic nuclei...

journal_title：Endocrinology

authors： Christian CA,Moenter SM

更新日期：2008-06-01 00:00:00

abstract：:In order to delineate the ages of onset and decline in sensitivity to growth hormone (GH) in rats, the ability of ovine GH in vitro to stimulate amino acid uptake and protein synthesis was studied in diaphragm muscle. GH (25 mug/ml) produced a significant, but small (12-17%), stimulation of alpha-aminoisobutyric acid ...

journal_title：Endocrinology

authors： Nutting DF

更新日期：1976-05-01 00:00:00

abstract：:We analyzed the nature of the thyroid hormone-binding proteins in bullfrog plasma using N-bromoacetyl-[125I]T3 as an affinity labeling probe. Polyacrylamide gel electrophoresis under nondenaturing conditions of the bullfrog N-bromoacetyl-[125I]T3-labeled plasma proteins revealed two proteins with specific binding to T...

journal_title：Endocrinology

authors： Yamauchi K,Kasahara T,Hayashi H,Horiuchi R

更新日期：1993-05-01 00:00:00

abstract：:COP9 signalosome subunit 5 (CSN5) plays a key role in carcinogenesis of multiple cancers and contributes to the stabilization of target proteins through deubiquitylation. However, the underlying role of CSN5 in thyroid carcinoma has not been reported. In this research, our data showed that CSN5 was overexpressed in th...

journal_title：Endocrinology

authors： Xie P,Wang H,Fang J,Du D,Tian Z,Zhen J,Liu Y,Ding Y,Fu B,Liu F,Huang D,Yu J

更新日期：2021-03-01 00:00:00

abstract：:Using a rat model of chronic central leptin infusion in which neuropeptide Y neurons develop leptin resistance, we examined whether leptin signal transduction mechanism in the hypothalamus is altered during central leptin infusion. Adult male rats were infused chronically into the lateral cerebroventricle with leptin ...

journal_title：Endocrinology

authors： Pal R,Sahu A

更新日期：2003-09-01 00:00:00

abstract：:Serum levels of progesterone in hysterectomized gilts were determined to evaluate the effects of exogenous 17 beta-estradiol (17 beta-E2) on the secretory activity of aging corpora lutea. Gilts were hysterectomized on day 6 of the estrous cycle and given im injections of 17 beta-E2 to mimic blood levels of endogenous ...

journal_title：Endocrinology

authors： Musah AI,Ford JJ,Anderson LL

更新日期：1984-11-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:We employed a short term system of dispersed adult mouse hypothalamic cells, as previously described in the rat, to examine the roles of calcium and calmodulin in SRIF release. Incubation studies were performed 24 h after hypothalamic cell dispersion. SRIF release, as determined by RIA was stimulated in a dose-depende...

journal_title：Endocrinology

authors： Richardson S,Twente S

更新日期：1985-07-01 00:00:00

abstract：:A study was conducted to determine the influence of conditions known to alter ACTH secretion on prolactin release by the pituitary. Dexamethasone or 0.9% NaCl was injected subcutaneously into intact male rats 4 hr before a 2-min ether stress. Other rats were submitted to the ether stress 2 weeks following adrenalectom...

journal_title：Endocrinology

authors： Harms PG,Langlier P,McCann SM

更新日期：1975-02-01 00:00:00

abstract：:Male and female Holtzman rats were raised from weaning on a vitamin D-deficient diet (-D). Control (+D) animals were raised on the same diet and orally given 70 IU vitamin D3 twice each week. Serum Ca levels fell at the same rate in -D males and females. In contrast, serum parathyroid hormone increased more rapidly in...

journal_title：Endocrinology

authors： Thomas ML,Forte LR

更新日期：1981-11-01 00:00:00

abstract：:Melatonin was shown to occur in rat plasma and urine after pinealectomy by bioassay, radioimmunoassay, and thin-layer chromatography. Total daily excretion of melatonin in pinealectomized rats was about 20% of control. Light-dark rhythms of plasma melatonin levels and urinary excretion rates disappeared after pinealec...

journal_title：Endocrinology

authors： Ozaki Y,Lynch HJ

更新日期：1976-08-01 00:00:00

abstract：:We previously demonstrated that the mitochondrial peripheral-type benzodiazepine receptor (PBR) is coupled to hormone-activated steroidogenesis by regulating the intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. In the present study we examined whether PBR is the site of horm...

journal_title：Endocrinology

authors： Boujrad N,Gaillard JL,Garnier M,Papadopoulos V

更新日期：1994-10-01 00:00:00

abstract：:The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal...

journal_title：Endocrinology

authors： Bringhurst FR,Potts JT Jr

更新日期：1981-01-01 00:00:00

abstract：:Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This response, which can be reversed by elevation of intraoocyte cAMP levels, is associated with interruption of gap junctional communication (GJC) within the ovarian follicle. In the present study, we examined the hypothesis that disruptio...

journal_title：Endocrinology

authors： Sela-Abramovich S,Edry I,Galiani D,Nevo N,Dekel N

更新日期：2006-05-01 00:00:00

abstract：:Molecular mechanisms underlying unloading-induced reduction of bone formation have not yet been fully understood. In vitro, Runx2 has been suggested to be involved in mechanical signaling in osteoblasts. However, the roles of Runx2 in vivo during the bone response to mechanical stimuli have not yet been known. The pur...

journal_title：Endocrinology

authors： Salingcarnboriboon R,Tsuji K,Komori T,Nakashima K,Ezura Y,Noda M

更新日期：2006-05-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...

journal_title：Endocrinology

authors： Foster DL,Jaffe RB,Niswender GD

更新日期：1975-01-01 00:00:00

abstract：:The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventr...

journal_title：Endocrinology

authors： van Houten M,Khan MN,Khan RJ,Posner BI

更新日期：1981-06-01 00:00:00