Studies on cholesterol esterase in the rat adrenal.

abstract：:The basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (Tg) were measured in normal male rats. Serum Tg concentrations (by RIA) in Sprague-Dawley adult males ranged from 70-680 ng/ml (mean +/- SD, 218 +/- 177). In male Fisher rats, basal serum Tg concentrations were 32-263 ng/ml. ...

journal_title：Endocrinology

authors： Izumi M,Larsen PR

更新日期：1978-07-01 00:00:00

abstract：:The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the endogenous GnRH signal required to induce and maintain a LH surge of full amplitude and duration. For this purpose, we assessed the effect of a competitive GnRH...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Caraty A,Padmanabhan V,Thrun LA,Karsch FJ

更新日期：1996-11-01 00:00:00

abstract：:The purpose of this study was to examine the relative roles of FSH and LH in stimulating testicular inhibin secretion in the male rhesus monkey. Recombinant human (rh) FSH and rhCG were used as the gonadotropic stimuli, and juvenile rhesus monkeys, in which the endocrine activity of the pituitary-testicular axis was b...

journal_title：Endocrinology

authors： Majumdar SS,Winters SJ,Plant TM

更新日期：1997-04-01 00:00:00

abstract：:Type 1 diabetes is caused by autoimmune destruction of β-cells. Although immunotherapy can restore self-tolerance thereby halting continued immune-mediated β-cell loss, residual β-cell mass and function is often insufficient for normoglycemia. Using a growth factor to boost β-cell mass can potentially overcome this ba...

journal_title：Endocrinology

authors： Hyslop CM,Tsai S,Shrivastava V,Santamaria P,Huang C

更新日期：2016-01-01 00:00:00

abstract：:We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. VDR messenger RNA (mRNA) was assayed by Northern blot, and VDR protein was determined immunocytochemically....

journal_title：Endocrinology

authors： Zineb R,Zhor B,Odile W,Marthe RR

更新日期：1998-04-01 00:00:00

abstract：:We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...

journal_title：Endocrinology

authors： Yonehara T,Kanasaki H,Yamamoto H,Fukunaga K,Miyazaki K,Miyamoto E

更新日期：2001-07-01 00:00:00

abstract：:Analysis of GH gene structure in the mouse permits evolutionary comparisons with GH gene structure in the rat and provides information about the mechanism responsible for heritable deficiencies of anterior pituitary hormones. The little mutation in mice is analogous to autosomal recessive, isolated, partial deficiency...

journal_title：Endocrinology

authors： Parks JS,Herd JE,Wurzel JM,Martial JA

更新日期：1982-05-01 00:00:00

abstract：:Mammalian ovaries contain sympathetic neurons expressing the low affinity neurotropin receptor (p75NTR). To date neither the role these neurons might play in ovarian physiology nor their embryological origin is known. Immunohistochemistry was used to detect postnatal changes in distribution and number of both p75NTR-p...

journal_title：Endocrinology

authors： Dees WL,Hiney JK,McArthur NH,Johnson GA,Dissen GA,Ojeda SR

更新日期：2006-08-01 00:00:00

abstract：:Linear growth results from proliferation and differentiation of chondrocytes within the growth plates and is regulated, in part, by the insulin-like growth factors (IGFs). IGF binding proteins (IGFBPs) also appear to play a significant, but yet unclear, role. To examine IGFBP production by chondrocytes, we isolated bo...

journal_title：Endocrinology

authors： Olney RC,Smith RL,Kee Y,Wilson DM

更新日期：1993-08-01 00:00:00

abstract：:We recently identified a 32 K mol wt insulin-like growth factor (IGF)-binding protein (BP) which is markedly increased in the serum of streptozotocin-diabetic rats and recognized by antiserum against the human amniotic fluid IGFBP (hIGFBP-1). In the present study we sought to confirm that this protein represents the r...

journal_title：Endocrinology

authors： Unterman TG,Oehler DT,Gotway MB,Morris PW

更新日期：1990-08-01 00:00:00

abstract：:Hyperaldosteronism is linked to the development and progression of several different cardiovascular diseases. Angiotensin (Ang) II increases aldosterone secretion and adrenal blood flow. Ang II peptide fragments are produced by various peptidases, and these Angs have diverse and vital physiologic roles. Due to the unc...

journal_title：Endocrinology

authors： Kopf PG,Campbell WB

更新日期：2013-12-01 00:00:00

abstract：:Recently, we have reported that retinoic acid (RA), similarly to retinol acetate, is able to reinitiate spermatogenesis in vitamin A-deficient rats. Here, we investigated the expression of RA receptors RAR alpha, RAR beta, RAR gamma, and retinoid X receptor RXR alpha by Northern blot analysis of poly(A)+ RNA of testes...

journal_title：Endocrinology

authors： van Pelt AM,van den Brink CE,de Rooij DG,van der Saag PT

更新日期：1992-07-01 00:00:00

abstract：:An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular locali...

journal_title：Endocrinology

authors： Jazín EE,Dickerman HW,Henrikson KP

更新日期：1988-02-01 00:00:00

abstract：:Bovine placental lactogen (bPL) was found to be as potent as human GH (hGH) in its ability to bind to soluble full-size recombinant hGH-binding protein (hGHBP) and to membrane-embedded hGH receptor in intact IM-9 human lymphocytes. bPL was also capable of forming a 1:2 complex with hGHBP, although the structure of thi...

journal_title：Endocrinology

authors： Vashdi-Elberg D,Staten NR,Sakal E,Krivi GG,Gertler A

更新日期：1995-03-01 00:00:00

abstract：:IL-18 was identified due to its ability to induce interferon-gamma (IFNgamma) production by T cells. It is a pleiotropic factor that shares structural features with IL-1 and functional activities with IL-12. IL-18 has a role in T cell development, where it has been demonstrated to act cooperatively with IL-12 to regul...

journal_title：Endocrinology

authors： Cornish J,Gillespie MT,Callon KE,Horwood NJ,Moseley JM,Reid IR

更新日期：2003-04-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:Central and peripheral humoral responses of the adrenocortical system were measured for 2 h after the application of several stimuli. Two min after the onset of the stresses of sham-adrenalectomy or laparotomy with intestinal traction there was a 4-6 fold increase in hypothalamic CRF content as compared to control con...

journal_title：Endocrinology

authors： Sato T,Sato M,Shinsako J,Dallman MF

更新日期：1975-08-01 00:00:00

abstract：:The effect of gonadotropins on phosphodiesterase activity of rat granulosa cells was studied in an in vitro model. Granulosa cells were prepared from hypophysectomized or intact, estrogen-primed immature female rats and treated with FSH, hCG, or (Bu)2cAMP in vitro. Phosphodiesterase activity was determined in cell hom...

journal_title：Endocrinology

authors： Conti M,Kasson BG,Hsueh AJ

更新日期：1984-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...

journal_title：Endocrinology

authors： Cheung AT,Ree D,Kolls JK,Fuselier J,Coy DH,Bryer-Ash M

更新日期：1998-12-01 00:00:00

abstract：:Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...

journal_title：Endocrinology

authors： Oshima H,Simons SS Jr

更新日期：1992-04-01 00:00:00

abstract：:Rat epididymal fat cells were isolated and incubated with 25 microunits insulin/ml for 15 minutes. Insulin induced a significant shift in the saturated/unsaturated fatty acid ratio of the cerebroside fraction isolated from fat cell ghosts. This change was due to a decrease of saturated fatty acids and an increase of u...

journal_title：Endocrinology

authors： Murray DK,Nelson DH

更新日期：1981-05-01 00:00:00

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:Thyroid hormones are of considerable importance for vertebrate reproductive function and during development. To further assess the role of these compounds in this capacity, we examined the expression pattern of the type 2 iodothyronine deiodinase (D2), which converts T(4) to the more active hormone T(3), in the rat ut...

journal_title：Endocrinology

authors： Galton VA,Martinez E,Hernandez A,St Germain EA,Bates JM,St Germain DL

更新日期：2001-05-01 00:00:00

abstract：:The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome, characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic s...

journal_title：Endocrinology

authors： Hutchins BI,Kotan LD,Taylor-Burds C,Ozkan Y,Cheng PJ,Gurbuz F,Tiong JD,Mengen E,Yuksel B,Topaloglu AK,Wray S

更新日期：2016-05-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a C cell neoplasm-secreting calcitonin. Surgery remains the only treatment as the primary tumor and metastases resist radio- and chemotherapies. MTC produces high amounts of prostaglandins (PGs). Nonsteroidal antiinflammatory drugs have an antitumoral effect, generally related to the ...

journal_title：Endocrinology

authors： Quidville V,Segond N,Pidoux E,Cohen R,Jullienne A,Lausson S

更新日期：2004-05-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin...

journal_title：Endocrinology

authors： Umehara T,Kawashima I,Kawai T,Hoshino Y,Morohashi KI,Shima Y,Zeng W,Richards JS,Shimada M

更新日期：2016-12-01 00:00:00

abstract：:The initiation of mammalian puberty requires an increase in pulsatile release of GnRH from the hypothalamus. This increase is brought about by coordinated changes in transsynaptic and glial-neuronal communication. As the neuronal and glial excitatory inputs to the GnRH neuronal network increase, the transsynaptic inhi...

journal_title：Endocrinology

authors： Ojeda SR,Lomniczi A,Mastronardi C,Heger S,Roth C,Parent AS,Matagne V,Mungenast AE

更新日期：2006-03-01 00:00:00

abstract：:Proxyfan is a histamine H3 receptor protean agonist that can produce a spectrum of pharmacological effects including agonist, inverse agonist, and antagonist. We have discovered that proxyfan (10 mg/kg orally) significantly improved glucose excursion after an ip glucose tolerance test in either lean or high-fat/choles...

journal_title：Endocrinology

authors： Henry MB,Zheng S,Duan C,Patel B,Vassileva G,Sondey C,Lachowicz J,Hwa JJ

更新日期：2011-03-01 00:00:00

abstract：:Recent data suggest that proinflammatory cytokines secreted from adipose tissue contribute to the morbidity associated with obesity. However, characterization of the cell types involved in inflammation and how these cells promote insulin resistance in human adipocytes are unclear. We simulated acute inflammation using...

journal_title：Endocrinology

authors： Chung S,Lapoint K,Martinez K,Kennedy A,Boysen Sandberg M,McIntosh MK

更新日期：2006-11-01 00:00:00