Abstract:
:Medullary thyroid cancer (MTC) is a C cell neoplasm-secreting calcitonin. Surgery remains the only treatment as the primary tumor and metastases resist radio- and chemotherapies. MTC produces high amounts of prostaglandins (PGs). Nonsteroidal antiinflammatory drugs have an antitumoral effect, generally related to the decrease of PG levels. We assessed the therapeutic potential of indomethacin in a model of human (TT cells) tumors in nude mice. Indomethacin (1.5 or 2.0 mg/kg body weight.d for 7 wk) inhibited tumor volume by 49 or 77%, respectively, and decreased the plasma level of CT. Although the terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling method revealed few apoptotic nuclei, the number of proliferating cells was significantly decreased (Ki-67 antigen study). Immunological effector recruitment and vascular network was not modified by treatment. The inducible synthesis enzyme, cyclooxygenase-2 (COX-2), was revealed only in infiltrating cells, both in treated and control tumors. The expression of the constitutive synthesis enzyme COX-1 was diminished, and the expression of 15-prostaglandin dehydrogenase, the key enzyme catabolizing PGs, was increased in treated tumors. Thus, our results demonstrated the potential of indomethacin, inhibitor of COX-1 and COX-2, to prevent MTC growth. The synthesis enzyme, COX-1, and the catabolism enzyme 15-prostaglandin dehydrogenase, could be involved in MTC development.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Quidville V,Segond N,Pidoux E,Cohen R,Jullienne A,Lausson Sdoi
10.1210/en.2003-0915subject
Has Abstractpub_date
2004-05-01 00:00:00pages
2561-71issue
5eissn
0013-7227issn
1945-7170pii
en.2003-0915journal_volume
145pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::The effects of leptin on the levels of CRF messenger RNA (mRNA) in the paraventricular hypothalamic nucleus (PVN), on the activation of the PVN CRF cells, and on the plasma levels of corticosterone were investigated in lean (+/?) and obese (ob/ob) C57BL/6J male mice. Murine leptin was s.c. infused using osmotic minipu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.4.5889
更新日期:1998-04-01 00:00:00
abstract::There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1394
更新日期:2015-10-01 00:00:00
abstract::The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T4. We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(fl/fl) mice. There wa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1698
更新日期:2015-02-01 00:00:00
abstract::Subcellular preparations from rat liver, brain, and kidney and from human liver were tested for their ability to desulfate T3 sulfate (T3SO4). Activity was found associated with the microsomal fraction: rat liver was the most active, hydrolyzing 76 pmol/min.mg protein of T3SO4 while preparations from rat kidney and br...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-4-1195
更新日期:1988-04-01 00:00:00
abstract::Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine. Forskolin mimicked the stimulatory effect on PLMT, and insulin inhibited this effe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-6-2421
更新日期:1987-06-01 00:00:00
abstract::In the murine Ob 17 preadipocyte cell line, the thyroid hormone T3 is an adipogenic factor necessary at an early stage for differentiation into adipocyte. We demonstrate here that this T3 dependence may involve a transient expression (at both the messenger RNA and the protein levels) of c-ErbA beta-type receptors (T3R...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.7.6860
更新日期:1999-07-01 00:00:00
abstract::Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0588
更新日期:2005-01-01 00:00:00
abstract::We have confirmed the serum calcium-raising effect of adrenalectomy in young male rats 5-6 h after parathyroidectomy that was first observed by others many years ago. (The phenomenon has also been reported in cats, dogs, and mice.) In addition, we have shown that adrenalectomy raises the serum ionized calcium as well ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-5-2259
更新日期:1991-05-01 00:00:00
abstract::Metalloproteinase inhibitors, such as tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2), play a key role in the regulation of metalloproteinases that modify extracellular matrix composition. Although expression of TIMP-1 within ovarian tissues has been well characterized, little information is available ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.2.7835290
更新日期:1995-02-01 00:00:00
abstract::PTH-related protein (PTHrP) is the principle mediator of the syndrome of humoral hypercalcemia of malignancy and has potential paracrine actions on smooth muscle, epithelial cell growth, and placental calcium transport. The human PTHrP gene is complex: a combination of three promoters, one 5' alternative splicing even...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.4.8625910
更新日期:1996-04-01 00:00:00
abstract::The insulin-like growth factor I (IGF-I) receptor is a transmembrane tyrosine kinase that mediates the growth-promoting effects of IGF-I and IGF-II. Changes in IGF-I receptor messenger RNA levels are reflected in cell surface receptor number, and modulation of IGF-I receptor levels affects tumorigenicity in numerous c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.10.7065
更新日期:1999-10-01 00:00:00
abstract::PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1046
更新日期:2014-08-01 00:00:00
abstract::Human thyroperoxidase (hTPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis and plays a major role in thyroid autoimmunity. Whereas hormonosynthesis occurs at the apical membrane of thyroid cells, TPO localizes mainly in the perinuclear membrane and ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.10.6265
更新日期:1998-10-01 00:00:00
abstract::Newborn male rats were treated SC with dexamethasone phosphate (100 microgram) or dexamethasone acetate (100 microgram) on postnatal day 1, dexamethasone phosphate (5.0 microgram) opn postnatal days 1, 2, 3, or the corresponding drug vehicle. All animals were sacrificed 65-70 days later at previously determined daily ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-3-1055
更新日期:1981-03-01 00:00:00
abstract::Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2066
更新日期:2013-04-01 00:00:00
abstract::Insulin-like growth factor (IGF) action in the brain is modulated by IGF-binding proteins (IGFBPs) whose abundance can be altered by other locally expressed growth factors. However, the mechanisms involved are unclear. We here employed the neuroblastoma cell line SK-N-MC as a model to define the mechanisms involved in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.7.6771
更新日期:1999-07-01 00:00:00
abstract::To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the expression of transforming growth factor-alpha (TGF alpha) in mouse uterus was investigated. Our results show that estrogen induces the expression of TGF alpha ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.4.1396310
更新日期:1992-10-01 00:00:00
abstract::Several studies have shown that insulin-like growth factor-binding proteins (IGF-BPs) modify IGF activity. To investigate their role in regulating growth, the number and size of IGF-BPs in porcine serum and the role of nutritional and endocrine factors in controlling their relative abundance were determined. IGF-BPs w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-1-501
更新日期:1989-07-01 00:00:00
abstract::We investigated the effect of epidermal growth factor (EGF) on collagen and protein synthesis in clone MC3T30-E1, a cell line which retains osteoblast-like characteristics. EGF at concentrations of 2-50 ng/ml significantly the hydroxyproline content of the cell layer. These effects were completely abolished by the add...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-6-1810
更新日期:1982-12-01 00:00:00
abstract::Prolonged fasting is associated with a number of changes in the thyroid axis manifested by low serum T3 and T4 levels and, paradoxically, low or normal TSH. This response is, at least partly, caused by suppression of proTRH gene expression in neurons of the hypothalamic paraventricular nucleus (PVN) and reduced hypoth...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.6.5209
更新日期:1997-06-01 00:00:00
abstract::We previously reported that dexamethasone (DEX) induces dose-dependent biphasic effects on steady state somatostatin (SS) messenger RNA (mRNA) levels in normal rat islet and islet SS-producing tumor cells (1027B2), characterized by stimulation at low doses and marked inhibition at high doses. The stimulatory effect is...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.6.7750460
更新日期:1995-06-01 00:00:00
abstract::We have studied the changes in thyroid hormone economy that occur in normal pregnant rats between 17-22 days of gestation. T4 and T3 decreased in all extrathyroidal tissues studied, namely plasma, liver, kidney, lung, heart, and skeletal muscle. The exception is the concentration of T3 in cerebral cortex, which remain...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-1-10
更新日期:1990-07-01 00:00:00
abstract::In view of recent reports on ovarian production and action of transforming growth factors (TGFs) and inhibin-related proteins (inhibin, activin, and follistatin), we have examined the effects of these hormones on the function of preovulatory follicles in vitro. Individual preovulatory follicles were obtained from PMSG...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-4-1857
更新日期:1989-10-01 00:00:00
abstract::IGF-I is an endocrine and paracrine regulator of skeletal homeostasis, principally by virtue of its anabolic effects on osteoblastic cells. In the current study, we examined the intracellular signaling pathways by which IGF-I promotes proliferation and survival in SaOS-2 human osteoblastic cells. Inhibition of each of...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0350
更新日期:2003-11-01 00:00:00
abstract::Dog thyroid slices released in their incubation medium prostaglandins E2 (PGE2), F2 alpha (PGF2 alpha), 15-keto-13,14-dihydro-F2 alpha, and thromboxane B2 (TxB2), as measured by direct RIA. This release could be inhibited by indomethacin and naproxen, indicating that it corresponded to a neosynthesis. Carbamylcholine ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-105-4-988
更新日期:1979-10-01 00:00:00
abstract::The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-6-2688
更新日期:1985-06-01 00:00:00
abstract::Analyses of FSH secretion suggest pulsatile, nonpulsatile, or compositely pulsatile and nonpulsatile release modes. This may reflect the reduced signal-to-noise ratio inherent in FSH pulse estimation procedures and/or immunological-biological assay inconsistencies. To address these issues, we sampled cavernous sinus a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.1.8644
更新日期:2002-01-01 00:00:00
abstract::Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1430
更新日期:2016-04-01 00:00:00
abstract::As the incidence of obesity continues to increase, the development of effective therapies is a high priority. The endocannabinoid system has emerged as an important influence on the regulation of energy homeostasis. The endocannabinoids anandamide and 2-arachidonoylglycerol act on cannabinoid receptor-1 (CB1) in the b...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2009-0046
更新日期:2009-06-01 00:00:00
abstract::Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and PAQR-5 [membrane progesterone (P4) receptor (PR) (mPR)α, mPRβ, and mPRγ], function as plasma mPRs coupled to G proteins in mammalian cells, but the characteristics of two other members, PAQR6 and PAQR9 (mPRδ and mPRε), remain unclear...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1772
更新日期:2013-01-01 00:00:00