Abstract:
:There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned with understanding the pathophysiological basis for how environmental influences acting during early development influence the risk of later noncommunicable diseases. Similarly, there is no global research or public health program built around the DOHaD paradigm that encompasses all aspects of environment. To better inform the global health efforts aimed at addressing the growing epidemic of chronic noncommunicable diseases of environmental origin, we propose a two-pronged approach: first, to make it clear that the current concept of DOHaD comprehensively includes a range of environmental factors and their relevance to disease occurrence not just throughout the life span but potentially across several generations; and second, to initiate the discussion of how adoption of DOHaD can promote a more realistic, accurate, and integrative approach to understanding environmental disruption of developmental programming and better inform clinical and policy interventions.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Heindel JJ,Balbus J,Birnbaum L,Brune-Drisse MN,Grandjean P,Gray K,Landrigan PJ,Sly PD,Suk W,Cory Slechta D,Thompson C,Hanson Mdoi
10.1210/EN.2015-1394subject
Has Abstractpub_date
2015-10-01 00:00:00pages
3416-21issue
10eissn
0013-7227issn
1945-7170journal_volume
156pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Recent studies have indicated that growth factors such as insulin-like growth factors (IGFs) increase the growth rate of cultured preimplantation embryos. We therefore hypothesized that the fallopian tube may produce IGFs which in turn participate in the regulation of preimplantation embryo development in vivo. In the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.5.8404650
更新日期:1993-11-01 00:00:00
abstract::The primary culture of rat luteal cells and their long-term maintenance have been difficult. Low cellular yields have limited the possibility for the study of gene regulation in luteal cells. The goal of this study was to develop a cell line to serve as a model by which to study the expression and regulation of variou...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.4.5929
更新日期:1998-04-01 00:00:00
abstract::Thyroid cell growth and function are regulated by hormones and growth factors binding to cell surface receptors that are coupled via G proteins, Gs and Gq, to the adenylyl cyclase and phospholipase C signal transduction systems, respectively. Activating mutations of the TSH receptor and G alpha s have been documented ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.8.5347
更新日期:1997-08-01 00:00:00
abstract::T3 is required for normal skeletal development, but its cellular targets in bone are unknown. T3 regulates target gene transcription via a specific nuclear receptor (T3R), which can heterodimerize with 9-cis-retinoic acid, 1 alpha, 25-dihydroxyvitamin D3, or retinoic acid receptors to modify T3 responsiveness. Serum-f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.6.7988420
更新日期:1994-12-01 00:00:00
abstract::The maximum amounts of angiotensins II and III that were confined to the kidney during intrarenal arterial administration in conscious dogs were determined to be 2 and 12 pmol/kg X min, respectively. These doses were infused chronically intrarenally to uninephrectomized dogs. A significant reduction in urinary volume ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-5-2160
更新日期:1985-11-01 00:00:00
abstract::A sensitive radioimmunoassay is described for the measurement of plasma concentrations of canine growth hormone (cGH) as low as 0.25 ng/ml. The assay utilizes enzymatically iodinated cGH and the double antibody technique. The mean plasma concentration of growth hormone in the normal dog after overnight fast is 1.75 pl...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-3-822
更新日期:1975-03-01 00:00:00
abstract::Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.9.6205
更新日期:1998-09-01 00:00:00
abstract::The rate at which the estrogen receptor (ER) is synthesized and degraded (turns over) in target cells is a major factor regulating the levels of ER and cell sensitivity to estrogen. We have used the ability of tamoxifen aziridine [(TAZ)(Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl]1,2-diphenyl-1-buten e] to affinity label t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-5-2038
更新日期:1986-11-01 00:00:00
abstract::Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1968
更新日期:2014-07-01 00:00:00
abstract::Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in on...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2019-00196
更新日期:2019-08-01 00:00:00
abstract::We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-1-98
更新日期:1988-07-01 00:00:00
abstract::Mineralocorticoid receptor (MR), highly expressed in the hippocampus, binds corticosteroid hormones and coordinately participates, with the glucocorticoid receptor, to the control of stress responses, memorization, and behavior. To investigate the impact of MR in neuronal survival, we generated murine embryonic stem (...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1436
更新日期:2012-03-01 00:00:00
abstract::The vertebrate adenohypophysis forms as a placode at the anterior margin of the neural plate, requiring both hedgehog (Hh) and fibroblast growth factor (Fgf) mediated cell-cell signaling for induction and survival of endocrine cell types. Using small molecule inhibitors to modulate signaling levels during zebrafish de...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0315
更新日期:2008-09-01 00:00:00
abstract::It is generally accepted that cholesterol affects dynamic membrane properties and the function of membrane bound proteins involved in secretion processes. In the present study we employed GH4C1 cells treated with human lipoprotein-deficient serum (h-LPDS), exogenous cholesterol and high density lipoprotein (HDL3) to i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.4.8462470
更新日期:1993-04-01 00:00:00
abstract::Enlargement of the chimeric ventral prostate gland (VP) was induced by directly implanting either fetal urogenital sinus mesenchyme (UGM) or intact fetal urogenital sinus (UGS) into the VP of intact adult rats. The macromolecular content in the chimeric prostate increased from 40-100% (UGM implants) to 200-300% (UGS i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-6-2437
更新日期:1986-06-01 00:00:00
abstract::Several studies have shown that insulin-like growth factor-binding proteins (IGF-BPs) modify IGF activity. To investigate their role in regulating growth, the number and size of IGF-BPs in porcine serum and the role of nutritional and endocrine factors in controlling their relative abundance were determined. IGF-BPs w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-1-501
更新日期:1989-07-01 00:00:00
abstract::11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0996
更新日期:2007-01-01 00:00:00
abstract::LA-PTH is a long-acting parathyroid hormone (PTH) peptide analogue in preclinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a methionine at position 8 (Met8) that is predicted to be critical for function. We assessed the impact of Met oxidation on the functional properties of LA-PTH and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa216
更新日期:2021-02-01 00:00:00
abstract::Purified rat Leydig cell cytosol was found to contain a protein kinase which was dependent on the presence of both calcium and phospholipids (phosphatidylserine and diolein), i.e. calcium/phospholipid-dependent protein kinase. The peak of Ca/phospholipid-dependent protein kinase was separated from type I and type II c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-1-119
更新日期:1985-07-01 00:00:00
abstract::CRF activity of synthetic vasopressins and pitressin was studied in an in vitro system of cultured rat adenohypophyseal cells using direct measurement of ACTH by radioimmunoassay. Pitressin (posterior pituitary extract) induced a dose-related secretion of ACTH whereas synthetic arginine or lysine vasopressin were devo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-4-936
更新日期:1976-04-01 00:00:00
abstract::We have found notable sex difference in peptidylarginine deiminase (EC 3.5.3.15) in rat pituitaries. Pituitaries collected from 3-week to 6-month-old male rats, and those from 3-week-old females showed negligible enzyme activities. The enzyme activity of female pituitaries increased markedly by 2 months, and even furt...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-6-2666
更新日期:1989-06-01 00:00:00
abstract::T3 and rT3 production rates in the fetus account for roughly only a third of the total T4 production rate; thus, the fate of the majority of T4 produced in the fetus is unknown (the "T4 disposal gap"). We developed sensitive and specific T4 sulfate (T4S) and T3 sulfate (T3S) RIAs to investigate the roles of these comp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.4.1396320
更新日期:1992-10-01 00:00:00
abstract::Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen, and insulin to muscle. Although angiotensin type 1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type 2 receptor blockade markedly restricts muscle microvascular bloo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00585
更新日期:2018-02-01 00:00:00
abstract::Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subsequent effects on systemic thyroid hormone levels have not been reported ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00065
更新日期:2018-07-01 00:00:00
abstract::The present study assesses the relationship between G-proteins and protein kinase-C (PKC) in the gonadotrope. Cells were depleted of PKC with 1 microM phorbol 12-myristate 13-acetate for 12 h, followed by medium 199-BSA for 6 h before treatment with vehicle, pertussis toxin (PTX), cholera toxin (CTX), or (Bu)2cAMP (dB...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.6.8243300
更新日期:1993-12-01 00:00:00
abstract::Experiments were conducted to obtain information on the possible transfer of TSH and thyroid hormones from mother rats to their infants via milk. The mothers were thyroidectomized by surgical or chemical (tapazole) means to eliminate maternal thyroid hormones from milk while increasing its content of TSH. Their pups w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-3-800
更新日期:1983-03-01 00:00:00
abstract::The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-1-7
更新日期:1976-07-01 00:00:00
abstract::Corticostatin-I (CSI) is the most potent of the corticostatic peptides isolated from rabbit lungs and neutrophils. CSI was localized in cells by immunohistochemistry using highly specific polyclonal antisera raised against the synthetic peptide. Western blot showed a single 4-kilodalton band, indicating that the antib...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.6.8504740
更新日期:1993-06-01 00:00:00
abstract::The contribution of the insulin receptor beta-subunit acidic domain, amino acids 1262-1291, to receptor function was analyzed. A mutant insulin receptor complementary DNA lacking this domain was created. Rat-1 fibroblasts were stably transfected with plasmids containing the mutant insulin receptor complementary DNA an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.3.8396020
更新日期:1993-09-01 00:00:00
abstract::In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-1-117
更新日期:1980-07-01 00:00:00