Abstract:
:CRF activity of synthetic vasopressins and pitressin was studied in an in vitro system of cultured rat adenohypophyseal cells using direct measurement of ACTH by radioimmunoassay. Pitressin (posterior pituitary extract) induced a dose-related secretion of ACTH whereas synthetic arginine or lysine vasopressin were devoid of CRF activity, even with the largest tested dose (4 mug/ml). No potentiation of the CRF activity of hypothalamic extract was observed with any vasopressin preparation studied. We concluded that: 1) the CRF activity of posterior pituitary extract is not due to vasopressin, and 2) the ACTH secretion induced by vasopressin administration in vivo is unlikely to be due to a direct effect of vasopressin on adenohypophyseal cells.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Yasuda N,Greer MAdoi
10.1210/endo-98-4-936subject
Has Abstractpub_date
1976-04-01 00:00:00pages
936-42issue
4eissn
0013-7227issn
1945-7170journal_volume
98pub_type
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