Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate.

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:Starvation depresses thyroid gland function. In addition, the peripheral turnover of thyroxine (T4) is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were isotopically equilibrated w...

journal_title：Endocrinology

authors： Ingbar DH,Galton VA

更新日期：1975-06-01 00:00:00

abstract：:The present study was conducted to elucidate the role of activin A in tubulogenesis of vascular endothelial cells. Activin A was produced in bovine aortic endothelial cells (BAEC). These cells also expressed the type I and type II activin receptors. When added to BAEC cultured in a collagen gel, activin A induced capi...

journal_title：Endocrinology

authors： Maeshima K,Maeshima A,Hayashi Y,Kishi S,Kojima I

更新日期：2004-08-01 00:00:00

abstract：:To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

journal_title：Endocrinology

authors： Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

更新日期：1995-12-01 00:00:00

abstract：:Molecular size heterogeneities of PRL and GH in mice of the high mammary tumor C3H/St strain and low mammary tumor C57BL/St strain were compared under different physiological states. At least three size variants, the big (void volume), the intermediate (dimeric), and the little (monomeric) forms, of both hormones were...

journal_title：Endocrinology

authors： Sinha YN

更新日期：1980-12-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha), a product of activated monocytes, induces tissue wasting in certain solid tumors in vivo and in in vitro model systems. Recent studies indicate that TNF alpha also regulates cell replication and expression of differentiated function in a variety of nonneoplastic cell systems. S...

journal_title：Endocrinology

authors： Centrella M,McCarthy TL,Canalis E

更新日期：1988-09-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:We report here the effects of antibodies to estrogen receptor (ER) on the binding of tritiated 5 alpha-androstane-3 beta-17 beta-diol and antiestrogens to receptor in calf uterine cytosol. The antibodies, prepared from a rabbit immunized with purified estradiol-receptor complex from calf uterine nuclei, were found to ...

journal_title：Endocrinology

authors： Garcia M,Greene G,Rochefort H,Jensen EV

更新日期：1982-04-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) was partially purified from incubation medium of calf fetal testes and injected into a BALB/c mouse, whose splenocytes were fused with Sp2/Ag8 myeloma cells. Hybridomas were screened for specific antibody production by double antibody precipitation of labeled AMH, which was obtained by inc...

journal_title：Endocrinology

authors： Vigier B,Picard JY,Josso N

更新日期：1982-01-01 00:00:00

abstract：:Posttranslational processing of proadrenomedullin generates two biologically active peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Sequence comparison of homologous proadrenomedullin genes in vertebrate evolution shows a high degree of stability in the reading frame for AM, whereas P...

journal_title：Endocrinology

authors： Martínez A,Bengoechea JA,Cuttitta F

更新日期：2006-07-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity and impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced by hyperglycemia, leads to myocardial fibrosis and impaired contractile function in the left...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Alloatti G,Vercellinatto I,Bardini P,Geuna S,Catalano MG,Danni O,Boccuzzi G

更新日期：2008-01-01 00:00:00

abstract：:COP9 signalosome subunit 5 (CSN5) plays a key role in carcinogenesis of multiple cancers and contributes to the stabilization of target proteins through deubiquitylation. However, the underlying role of CSN5 in thyroid carcinoma has not been reported. In this research, our data showed that CSN5 was overexpressed in th...

journal_title：Endocrinology

authors： Xie P,Wang H,Fang J,Du D,Tian Z,Zhen J,Liu Y,Ding Y,Fu B,Liu F,Huang D,Yu J

更新日期：2021-03-01 00:00:00

abstract：:In higher primates, FSH secretion appears to be regulated by a control system consistent with that described by the classical inhibin hypothesis. The purpose of the present experiment was to examine the time course of inhibin's action to suppress FSH secretion in the intact adult male rhesus monkey. To this end, five ...

journal_title：Endocrinology

authors： Ramaswamy S,Pohl CR,McNeilly AS,Winters SJ,Plant TM

更新日期：1998-08-01 00:00:00

abstract：:Estrogens stimulate cell proliferation in typical estrogen-responsive tissues including the anterior pituitary gland. Here we report that 17-beta estradiol (E2) has estrogen receptor-mediated mitogenic and antimitogenic actions on rat lactotrophs in primary culture, depending on the cell context. E2 did not affect bas...

journal_title：Endocrinology

authors： Kawashima K,Yamakawa K,Takahashi W,Takizawa S,Yin P,Sugiyama N,Kanba S,Arita J

更新日期：2002-07-01 00:00:00

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:PRL has been reported to exist as a number of mol wt and charge variants. We have attempted to determine the relationships among the charge and lower mol wt variants by two-dimensional gel analysis of pituitary and pituitary cell extracts. Silver-stained gels of the extracts showed three major charge isoforms of 24,00...

journal_title：Endocrinology

authors： Oetting WS,Walker AM

更新日期：1985-10-01 00:00:00

abstract：:Human proenkephalin generated by means of a recombinant vaccinia virus expression vector was used as the substrate for a putative processing enzyme obtained from bovine adrenal chromaffin granules. The adrenal enzyme successfully cleaved proenkephalin to generate low mol wt enkephalins as well as other enkephalin-cont...

journal_title：Endocrinology

authors： Lindberg I,Thomas G

更新日期：1990-01-01 00:00:00

abstract：:Anorexia is a debilitating manifestation of many malignancies. The etiology of cancer anorexia is poorly understood, and effective treatment options are limited. To investigate the role of central melanocortin receptor signaling in the pathogenesis of cancer anorexia, we assessed the effects on food intake of the mela...

journal_title：Endocrinology

authors： Wisse BE,Frayo RS,Schwartz MW,Cummings DE

更新日期：2001-08-01 00:00:00

abstract：:The nuclear orphan receptor human estrogen receptor-related receptor (ERR)-alpha is implicated in bone metabolism. We studied the effect of ERRalpha silencing in human mesenchymal stem cells (hMSCs) during osteoblastogenesis. We found that ERRalpha silencing led to an increase of bone sialoprotein and a decrease of os...

journal_title：Endocrinology

authors： Delhon I,Gutzwiller S,Morvan F,Rangwala S,Wyder L,Evans G,Studer A,Kneissel M,Fournier B

更新日期：2009-10-01 00:00:00

abstract：:We recently reported that fetal sheep corticotrophs (ACTH-producing cells) at 108 +/- 5 d (days) of gestation are relatively more responsive to CRH than to AVP, whereas those at 139 +/- 0 d (term = 145 d) and in the adult are more responsive to AVP. To further characterize these developmental changes, we used immunocy...

journal_title：Endocrinology

authors： Perez FM,Schwartz J,Rose JC

更新日期：1997-03-01 00:00:00

abstract：:An isolated perfused rabbit ovary preparation was used to determine the effects of cyanoketone, a potent inhibitor of 3 beta-hydroxysteroid dehydrogenase, on ovulation, ovum maturation and fertilizability, and steroid production. In the first experiment, cyanoketone (10(-4) M) was added to the perfusate of one ovary. ...

journal_title：Endocrinology

authors： Yoshimura Y,Hosoi Y,Bongiovanni AM,Santulli R,Atlas SJ,Wallach EE

更新日期：1987-06-01 00:00:00

abstract：:The monocarboxylate transporter Mct10 (Slc16a10; T-type amino acid transporter) facilitates the cellular transport of thyroid hormone (TH) and shows an overlapping expression with the well-established TH transporter Mct8. Because Mct8 deficiency is associated with distinct tissue-specific alterations in TH transport a...

journal_title：Endocrinology

authors： Müller J,Mayerl S,Visser TJ,Darras VM,Boelen A,Frappart L,Mariotta L,Verrey F,Heuer H

更新日期：2014-01-01 00:00:00

abstract：:Immunoaffinity adsorption techniques, utilizing specific antisera for hCG and its subunits bound to Sepharose 4B, have been employed to separate hCG alpha beta dimer and free subunits of hCG. As previously reported by this and a number of other laboratories, trophoblast cells (in vivo and in vitro) produce free alpha ...

journal_title：Endocrinology

authors： Cole LA,Hartle RJ,Laferla JJ,Ruddon RW

更新日期：1983-09-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that is thought to play a major role in the regulation of growth and differentiation of thyroid cells. However, little is known of its detailed mechanisms of action in thyrocytes. We have therefore studied the molecular mechanisms of TGF-beta1 ...

journal_title：Endocrinology

authors： Kang HC,Ohmori M,Harii N,Endo T,Onaya T

更新日期：2001-01-01 00:00:00

abstract：:Thyroid toxicity of iodide excess has been demonstrated in animals fed with an iodide-rich diet; in vitro iodide is cytotoxic, inhibits cell growth, and induces morphological changes in thyroid cells of some species. In this study, we investigated the effect of iodide excess in an immortalized thyroid cell line (TAD-2...

journal_title：Endocrinology

authors： Vitale M,Di Matola T,D'Ascoli F,Salzano S,Bogazzi F,Fenzi G,Martino E,Rossi G

更新日期：2000-02-01 00:00:00

abstract：:Estradiol imprinting plays an important role in the regulation of galanin (GAL) gene expression in the rat. In the anterior pituitary gland, GAL gene expression is greatly induced by estrogen. The relative involvement that the two estrogen receptor subtypes, alpha and beta, have in regulating this induction is not kno...

journal_title：Endocrinology

authors： Shen ES,Hardenburg JL,Meade EH,Arey BJ,Merchenthaler I,López FJ

更新日期：1999-06-01 00:00:00

abstract：:IGF-I and IGF-II play important roles in growth and development via interactions with cell-surface receptors; however, in nature, IGFs are sequestered by at least six soluble, high-affinity IGF-binding proteins (IGFBPs), namely IGFBPs 1-6. Herein, we demonstrate that the stromal cell-derived extracellular matrix-degra...

journal_title：Endocrinology

authors： Fowlkes JL,Serra DM,Bunn RC,Thrailkill KM,Enghild JJ,Nagase H

更新日期：2004-02-01 00:00:00

abstract：:Nitrogenous compounds were studied for their effect on cGMP levels in the thyroid. Several agents, including sodium nitrite and hydroxylamine, could generate a rise of over 100-fold in cGMP. At a concentration of 20 mM, HN2OH and NaNO2 significantly reduced cAMP levels previously generated by 0.5 mU/ml TSH. If the sli...

journal_title：Endocrinology

authors： Spaulding SW

更新日期：1979-09-01 00:00:00