The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.

abstract：:During the preovulatory and estradiol-progesterone-induced GnRH-LH surge, a subpopulation of GnRH neurons transiently expresses the transcription factor c-fos, which is a useful marker of cell activation. To further characterize this subpopulation of GnRH neurons, multiple immunohistochemical procedures were applied t...

journal_title：Endocrinology

authors： Eyigor O,Jennes L

更新日期：2000-02-01 00:00:00

abstract：:17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and it has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on ...

journal_title：Endocrinology

authors： Dai R,Edwards MR,Heid B,Ahmed SA

更新日期：2019-01-01 00:00:00

abstract：:We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...

journal_title：Endocrinology

authors： Song SY,Asakai R,Kenmotsu N,Taoka M,Isobe T,Yamakuni T

更新日期：1996-04-01 00:00:00

abstract：:Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...

journal_title：Endocrinology

authors： Hong MH,Sun H,Jin CH,Chapman M,Hu J,Chang W,Burnett K,Rosen J,Negro-Vilar A,Miner JN

更新日期：2008-03-01 00:00:00

abstract：:The rat uterine enzyme glycerylphosphorylcholine (GPC) diesterase found in the proestrous secretions was purified and characterized biochemically with respect to its subunit mol wt, native size, pI, and amino acid and carbohydrate composition. The 30-kDa protein was assessed to have a native mol wt of 105 kDa, as dete...

journal_title：Endocrinology

authors： Mitra J,Chowdhury M

更新日期：1991-09-01 00:00:00

abstract：:AtT20/D16v is a clonal strain of mouse pituitary tumor cells which synthesizes and secretes ACTH. Somatostatin, a hypothalamic tetradecapeptide, has been shown to inhibit the release of PRL, GH, and TSH from the pituitary gland. We have characterized specific binding sites for somatostatin on AtT20/D16v cells and demo...

journal_title：Endocrinology

authors： Richardson UI,Schonbrunn A

更新日期：1981-01-01 00:00:00

abstract：:The present experiments examined the relationship between cholera toxin and TSH stimulation of the adenylate cyclase system in bovine thyroid tissue. Preincubation of thyroid slices for 20 min at 4 C with a maximal concentration of cholera toxin (100 microgram/ml) did not impair the subsequent stimulation of cAMP by s...

journal_title：Endocrinology

authors： Holmes SD,Titus G,Chou M,Field JB

更新日期：1980-12-01 00:00:00

abstract：:Interleukin-1 (IL-1), one of the mediators of the interaction between the immune and the neuroendocrine system, is well known to modulate anterior pituitary hormone secretion. As IL-1 influences growth of various cell types, we investigated whether IL-1 is also a growth factor of pituitary cells. We demonstrate that I...

journal_title：Endocrinology

authors： Renner U,Newton CJ,Pagotto U,Sauer J,Arzt E,Stalla GK

更新日期：1995-08-01 00:00:00

abstract：:Testicular tissue of normal and hCG-stimulated European eels was incubated in vitro with tritiated progesterone or androstenedione as substrates. The following compounds were isolated and identified: 5 beta-androstane-3,17-dione; 17 beta-hydroxy-5 beta-androstan-3-one; androst-4-ene-3,11,17-trione (adrenosterone); 11 ...

journal_title：Endocrinology

authors： Eckstein B,Cohen S,Hilge V

更新日期：1982-03-01 00:00:00

abstract：:Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...

journal_title：Endocrinology

authors： Resnick CE,Fielder PJ,Rosenfeld RG,Adashi EY

更新日期：1998-03-01 00:00:00

abstract：:GnRH neurons were harvested from adult male rats in order to determine if LH or FSH directly altered the modalities of GnRH release and/or cellular GnRH content. Cultures received vehicle, 25 ng/ml LH, 125 ng/ml LH, 25 ng/ml FSH, or 125 ng/ml FSH, and media samples were collected before treatment, during the treatment...

journal_title：Endocrinology

authors： Melrose PA

更新日期：1987-07-01 00:00:00

abstract：:The present study was conducted to elucidate the possible molecular mechanisms involved in the antispermatogenic activity of l-CDB-4022, an indenopyridine. In this study 45-d-old male Sprague-Dawley rats were treated with a single oral dose of l-CDB-4022 (2.5 mg/kg) or vehicle, and blood and testes were collected at v...

journal_title：Endocrinology

authors： Koduri S,Hild SA,Pessaint L,Reel JR,Attardi BJ

更新日期：2008-04-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...

journal_title：Endocrinology

authors： Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:The molecular forms of GnRH in amphibia have not been characterized structurally. An antiserum to mammalian GnRH that shows appreciable cross-reactivity with chicken GnRH-I ([Gln8]GnRH), chicken GnRH-II ([His5,Trp7,Tyr8]GnRH), and salmon GnRH ([Trp7, Leu8]GnRH) was used in a RIA to detect GnRH-related peptides in an e...

journal_title：Endocrinology

authors： Conlon JM,Collin F,Chiang YC,Sower SA,Vaudry H

更新日期：1993-05-01 00:00:00

abstract：:Testicular LH receptor occupancy and steroidogenic responses were measured in adult male rats after intracardiac injections of [125I]iodo-hCG (0.5--5 x 10(6) cpm) mixed with known amounts of nonradioactive hCG to yield doses ranging from 10 ng to 300 micrograms. Uptake of the hormone by the testis was measured in the ...

journal_title：Endocrinology

authors： Huhtaniemi IT,Clayton RN,Catt KJ

更新日期：1982-09-01 00:00:00

abstract：:We studied the involvement of the cAMP pathway in the regulation of beta TC1 cell growth with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the activator of adenylate cyclase forskolin. We examined the effect of the increase in cAMP content on the serum-induced resumption of the cell cycle of ...

journal_title：Endocrinology

authors： Lavergne C,Breant B,Rosselin G

更新日期：1992-11-01 00:00:00

abstract：:The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in ch...

journal_title：Endocrinology

authors： Cheng S,Xing W,Pourteymoor S,Schulte J,Mohan S

更新日期：2016-01-01 00:00:00

abstract：:Human erythropoietin (EPO) is a glycoprotein hormone secreted from the kidney and controls red blood cell production. EPO has a wide clinical use in the treatment of anemia associated with renal disease, certain chronic diseases, and anemia related to chemotherapy and radiotherapy. One major issue regarding the clinic...

journal_title：Endocrinology

authors： Fares F,Ganem S,Hajouj T,Agai E

更新日期：2007-10-01 00:00:00

abstract：:Photoaffinity-labeled androgen-binding protein (ABP), present in cytosol prepared from the caput epididymidis of intact sexually mature rabbits, was produced using 17 beta-hydroxy-[1,2-3H]4,6-androstadien-3-one (delta 6-testosterone). Photo-labeled ABP could not be distinguished from unlabeled ABP by gel filtration ch...

journal_title：Endocrinology

authors： Danzo BJ,Taylor CA Jr,Eller BC

更新日期：1982-10-01 00:00:00

abstract：:The effects of hypophysectomy and GH on blood pressure and renin secretion were studied. Within 2 weeks after removal of the pituitary gland of rats, mean arterial blood pressure declined 30%, and heart rate fell 50%. No significant effect of hypophysectomy on blood volume or hematocrit was noted. Within 2 h after the...

journal_title：Endocrinology

authors： Honeyman TW,Goodman HM,Fray JC

更新日期：1983-05-01 00:00:00

abstract：:In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...

journal_title：Endocrinology

authors： Brock O,Bakker J

更新日期：2013-08-01 00:00:00

abstract：:Somatostatin was infused via the portal vein at a rate of 50 ng/min in a group of eight conscious dogs beginning 30 min before and continuing for 6 h after the ingestion of an 800-g fat-protein meal. The fasting and postprandial levels of plasma somatostatin-like immunoreactivity (SLI), insulin, glucagon, and triglyce...

journal_title：Endocrinology

authors： Schusdziarra V,Harris V,Arimura A,Unger RH

更新日期：1979-06-01 00:00:00

abstract：:Control of trabecular bone volume is mediated by local events. Recently, it has been shown that the cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha), and TNF beta [also called lymphotoxin (LT)] produced by immune cells all stimulate osteoclast activity, whereas the lymphokine interferon-gamma (I...

journal_title：Endocrinology

authors： Smith DD,Gowen M,Mundy GR

更新日期：1987-06-01 00:00:00

abstract：:An isolated perfused rabbit ovary preparation was used to determine the effects of cyanoketone, a potent inhibitor of 3 beta-hydroxysteroid dehydrogenase, on ovulation, ovum maturation and fertilizability, and steroid production. In the first experiment, cyanoketone (10(-4) M) was added to the perfusate of one ovary. ...

journal_title：Endocrinology

authors： Yoshimura Y,Hosoi Y,Bongiovanni AM,Santulli R,Atlas SJ,Wallach EE

更新日期：1987-06-01 00:00:00

abstract：:Variation in the onset of puberty among inbred strains of mice suggests that quantitative trait loci (QTLs) affect neurological and hormonal aspects of sexual maturation. Taking a novel approach toward identifying factors that regulate the hypothalamic-pituitary-gonadal (HPG) axis, we evaluated pubertal timing [as ass...

journal_title：Endocrinology

authors： Krewson TD,Supelak PJ,Hill AE,Singer JB,Lander ES,Nadeau JH,Palmert MR

更新日期：2004-10-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is a potent mediator of differentiation and maintenance of specific functions of osteoblasts. To detect novel targets for 1,25-(OH)2D3 action, we applied differential display PCR to human fetal osteoblast-like cells and identified the human analog of murine cystein rich pro...

journal_title：Endocrinology

authors： Schütze N,Lechner A,Groll C,Siggelkow H,Hüfner M,Köhrle J,Jakob F

更新日期：1998-04-01 00:00:00

abstract：:Studies were carried out to determine whether the actions of prolactin on the metabolism of the mammary gland may involve polyamines. In mouse mammary gland explants that were preincubated for 2 days with insulin plus hydrocortisone, the rate of [3H]leucine incorporation into casein was enhanced in a prolactin-like ma...

journal_title：Endocrinology

authors： Rillema JA,Linebaugh BE,Mulder JA

更新日期：1977-02-01 00:00:00

abstract：:Evidence is presented that in vitamin D deficiency there are aberrations of estrogen metabolism in the laying hen. Five White Leghorn hens, 35 weeks of age, all laying soft shelled eggs as a result of complete withdrawal of supplemental vitamin D3 (D3) from the diet, were found to have a 3-fold higher molar ratio of p...

journal_title：Endocrinology

authors： Tsang CP,Grunder AA

更新日期：1984-12-01 00:00:00

abstract：:Insulin is a potent regulator of Sp1 transcription factor. To examine if glucagon, which usually antagonizes insulin, regulates Sp1, we assessed the levels of Sp1 by Western blotting from H-411E cells exposed to glucagon with or without insulin. Glucagon alone (1.5 x 10(-9) to 1.5 x 10(-5) M) stimulated Sp1 accumulati...

journal_title：Endocrinology

authors： Keembiyehetty CN,Candelaria RP,Majumdar G,Raghow R,Martinez-Hernandez A,Solomon SS

更新日期：2002-04-01 00:00:00

abstract：:The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome, characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic s...

journal_title：Endocrinology

authors： Hutchins BI,Kotan LD,Taylor-Burds C,Ozkan Y,Cheng PJ,Gurbuz F,Tiong JD,Mengen E,Yuksel B,Topaloglu AK,Wray S

更新日期：2016-05-01 00:00:00