Effects of thyrotropin and cholera toxin on the thyroidal adenylate cyclase-adenosine 3',5'-monophosphate system.

abstract：:The adrenal medulla contains fenestrated capillaries that allow catecholamines and neuropeptides secreted by adrenal chromaffin cells (ACCs) to readily access the circulation. These capillaries may also allow bacterial products to enter the adrenal medulla and interact with ACCs during infection. One potential mediato...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2013-01-01 00:00:00

abstract：:Media from large vessel endothelial cells (pulmonary artery, aorta) contained intact connective tissue growth factor (CTGF) and a dominant 19-kDa band. N-terminal analysis of the 19-kDa band showed sequence corresponding to CTGF amino acid 181-190, suggesting that the 19-kDa band represented a proteolytic fragment of ...

journal_title：Endocrinology

authors： Boes M,Dake BL,Booth BA,Erondu NE,Oh Y,Hwa V,Rosenfeld R,Bar RS

更新日期：1999-04-01 00:00:00

abstract：:Recent evidence suggests that inflammation may be a common underlying cause of many obesity-associated conditions. To test whether obesity changes the response to inflammation, we investigated its effects on the acute phase of the inflammatory response to an endogenous pathogen, lipopolysaccharide (LPS). Diet-induced ...

journal_title：Endocrinology

authors： Pohl J,Woodside B,Luheshi GN

更新日期：2009-11-01 00:00:00

abstract：:PTH, via the PTH/PTH-related protein receptor type 1 that couples to both protein kinase A (PKA) and protein kinase C (PKC) pathways, and the canonical Wnt-beta-catenin signaling pathway play important roles in bone formation. In the present study we have examined the interaction between the PTH and Wnt signaling path...

journal_title：Endocrinology

authors： Tobimatsu T,Kaji H,Sowa H,Naito J,Canaff L,Hendy GN,Sugimoto T,Chihara K

更新日期：2006-05-01 00:00:00

abstract：:Hypothalamic proopiomelanocortin (POMC)-derived MSH peptides and the melanocortin receptor antagonist, agouti-related protein (AgRP), interact to regulate energy balance. Both POMC and AgRP neurons express estrogen receptors, but little is known about estrogen regulation of the melanocortin system in the primate. We h...

journal_title：Endocrinology

authors： Xiao E,Kim AJ,Dutia R,Conwell I,Ferin M,Wardlaw SL

更新日期：2010-03-01 00:00:00

abstract：:Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clock mutant mice on t...

journal_title：Endocrinology

authors： Sei H,Oishi K,Chikahisa S,Kitaoka K,Takeda E,Ishida N

更新日期：2008-07-01 00:00:00

abstract：:In order to investigate the physiological counterpart of the anatomical finding showing that the dorsal motor nucleus of the vagus nerve (DMX) is a source of efferent vagal fibers innervating the pancreas, unilateral electrical stimulation using monopolar electrodes (50 microA, 30 Hz, 0.2 msec) at a glycemia of 150 mg...

journal_title：Endocrinology

authors： Ionescu E,Rohner-Jeanrenaud F,Berthoud HR,Jeanrenaud B

更新日期：1983-03-01 00:00:00

abstract：:CRF dose-dependently enhanced corticosterone (B) secretion by rat adrenal slices including both cortex and medulla. Conversely, CRF did not exert any B response by fragments of adrenocortical autotransplants, which are completely deprived of chromaffin tissue. However, autotransplant quarters exhibited a dose-dependen...

journal_title：Endocrinology

authors： Andreis PG,Neri G,Mazzocchi G,Musajo F,Nussdorfer GG

更新日期：1992-07-01 00:00:00

abstract：:Oxytocin (OT) receptors (OTRs) mediate reproductive functions, including the initiation of labor and milk ejection. OTR messenger RNA levels are highly regulated, reaching the greatest concentration in the uterus at the end of gestation, and in the mammary gland during lactation. Factors directly effecting changes in ...

journal_title：Endocrinology

authors： Hoare S,Copland JA,Wood TG,Jeng YJ,Izban MG,Soloff MS

更新日期：1999-05-01 00:00:00

abstract：:The lactogen-dependent rat Nb2 lymphoma is a useful model to investigate PRL signaling pathways that lead to regulation of gene transcription. A primary mechanism coupled to PRL receptor (PRLR) activation in Nb2 cells involves phosphorylation by Jak-family tyrosine kinases of one or more signal transducers and activat...

journal_title：Endocrinology

authors： Borg KE,Zhang M,Hegge D,Stephen RL,Buckley DJ,Magnuson NS,Buckley AR

更新日期：1999-12-01 00:00:00

abstract：:Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety and efficacy has been studied in adults where the growth plate is fused and there is no longitudinal bone growth and little appositional growth. Although bisphosphonate use in the pediatric popula...

journal_title：Endocrinology

authors： Zhu ED,Louis L,Brooks DJ,Bouxsein ML,Demay MB

更新日期：2014-04-01 00:00:00

abstract：:The expression of the microsomal (M) antigen on the surface and in the cytoplasm of a strain of rat thyroid cells (FRTL-5) is under the regulation of TSH. In the present report the mechanism by which TSH induces such expression was investigated with the use of human microsomal antibody-positive serum and an indirect i...

journal_title：Endocrinology

authors： Chiovato L,Vitti P,Lombardi A,Ceccarelli P,Cucchi P,Marcocci C,Carayon P,Pinchera A

更新日期：1988-08-01 00:00:00

abstract：:Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...

journal_title：Endocrinology

authors： Adamson AD,Friedrichsen S,Semprini S,Harper CV,Mullins JJ,White MR,Davis JR

更新日期：2008-02-01 00:00:00

abstract：:The effect of synthetic atrial natriuretic factor (ANF) on adrenal steroidogenesis has been studied in primary culture of bovine adrenal cells. ANF-(8-33) produced a potent 40-70% inhibition of angiotensin II-, ACTH-, PGE1-, and forskolin-stimulated secretion of aldosterone production from zona glomerulosa cells with ...

journal_title：Endocrinology

authors： De Léan A,Racz K,Gutkowska J,Nguyen TT,Cantin M,Genest J

更新日期：1984-10-01 00:00:00

abstract：:Steroidogenic acute regulatory protein (StAR) synthesis and steroidogenesis are stimulated by activation of divergent signaling pathways in the adrenal cortex. The two major physiological regulators of aldosterone synthesis in the adrenal zona glomerulosa are angiotensin II (AII) and extracellular K+, which both media...

journal_title：Endocrinology

authors： Clark BJ,Combs R

更新日期：1999-10-01 00:00:00

abstract：:To investigate the physiological role of GRF and somatostatin (SRIF) in GH secretion in adult male rats, we prepared in vitro models using the perifusion system of cultured rat anterior pituitary cells exposed to various combinations of human GRF-(1-44)NH2 (hGRF) and SRIF. We studied the following three models on GRF ...

journal_title：Endocrinology

authors： Sato M,Takahara J,Fujioka Y,Niimi M,Irino S

更新日期：1988-10-01 00:00:00

abstract：:We have demonstrated previously that both rat and human liver microsomes contain a highly specific binding protein for the anabolic steroids stanozolol (ST) and danazol (DA). In this study we solubilized the male rat liver ST-binding protein (STBP) and investigated the following parameters: 1) pharmacological properti...

journal_title：Endocrinology

authors： Luzardo OP,Machín RP,Díaz-Chico BN,Fernández L

更新日期：2000-09-01 00:00:00

abstract：:The binding characteristics of 125I-labeled Leu15-gastrin and the molecular identification of the gastrin receptor was investigated in dispersed guinea pig gastric glands. The binding of [125I]gastrin to gastric glands was temperature dependent, saturable, and specific. At 37 C, the binding was rapid, became maximal w...

journal_title：Endocrinology

authors： Ramani N,Praissman M

更新日期：1989-04-01 00:00:00

abstract：:In rats, protein hydrolysates (peptones) stimulate cholecystokinin (CCK) release both in vivo and in a model of isolated vascularly perfused duodeno-jejunum. However, the mechanisms involved in peptone-induced stimulation of CCK cells are not well understood. In particular, the possibility that peptones may directly i...

journal_title：Endocrinology

authors： Cordier-Bussat M,Bernard C,Haouche S,Roche C,Abello J,Chayvialle JA,Cuber JC

更新日期：1997-03-01 00:00:00

abstract：:Recently, heterogeneity of POMC mRNA content between intermediate lobe melanotropes of the rat pituitary gland was demonstrated by in situ hybridization of tissue sections. In the present study the heterogeneity of POMC mRNA content in dispersed rat pituitary cells has been investigated. Acutely dispersed cells from a...

journal_title：Endocrinology

authors： Hatfield JM,Daikh DI,Adelman JP,Douglass J,Bond CT,Allen RG

更新日期：1989-03-01 00:00:00

abstract：:We have investigated the effects of iv administered noradrenergic agonists and antagonists on plasma GH concentration in the adolescent baboon, Papio papio, with the aim of defining the relative roles of adrenergic receptor subtypes (alpha 1, alpha 2, beta 1, and beta 2) in the regulation of GH release. Clonidine (0.0...

journal_title：Endocrinology

authors： McWilliam JR,Meldrum BS

更新日期：1983-01-01 00:00:00

abstract：:We previously reported that cAMP inhibits autocrine IGF-I gene expression in rat C6 glioma cells. In this study we examined the influence of cAMP on IGF-binding protein gene expression in C6 cells. cAMP potently inhibited IGF-binding protein-3 mRNA and, to a lesser extent, IGF-binding protein-4 mRNA and transiently st...

journal_title：Endocrinology

authors： Wang L,Ma X,Yeh LC,Adamo ML

更新日期：2001-09-01 00:00:00

abstract：:Administration of the preferential mu-opioid receptor agonist, morphine, and selective K-opioid receptor agonists elicits activation of the hypothalamus-pituitary-adrenocortical axis, although the site or the molecular mechanisms for these effects have not been determined. The expression ofFos, the protein product of ...

journal_title：Endocrinology

authors： Laorden ML,Castells MT,Martínez MD,Martínez PJ,Milanés MV

更新日期：2000-04-01 00:00:00

abstract：:The effect of active and passive immunization with luteinizing hormone-releasing hormone (LHRH) on serum LH and follicle-stimulating hormone (FSH) levels and the ultrastructure of the pituitary gonadotrophs was investigated in castrated male rats. Two weeks after castration, the animals were immunized with Glu1-LHRH c...

journal_title：Endocrinology

authors： Arimura A,Shino M,de la Cruz KG,Rennels EG,Schally AV

更新日期：1976-07-01 00:00:00

abstract：:We have previously shown that placental protein 12 (PP12) is synthesized and secreted by human term pregnancy decidua in vitro. In the present study, fragments of proliferative and secretory phase endometrium were cultured in media in the presence and absence of progesterone (P) and 17 beta-estradiol (E2) for 96 h. Th...

journal_title：Endocrinology

authors： Rutanen EM,Koistinen R,Sjöberg J,Julkunen M,Wahlström T,Bohn H,Seppälä M

更新日期：1986-03-01 00:00:00

abstract：:The population of LHRH neurons was examined in young and middle-aged female rats at two different time points associated with the LH surge on proestrus. More immunopositive LHRH neurons were detected in the brains of young but not middle-aged females killed on the evening of proestrus (1830-2030 h) compared with those...

journal_title：Endocrinology

authors： Rubin BS,King JC

更新日期：1994-01-01 00:00:00

abstract：:Angiotensin II (AngII) stimulates aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex. AngII also triggers the MAPK pathways (ERK1/2 and p38). Because ERK1/2 phosphorylation is a transient process, phosphatases could play a crucial role in the acute steroidogenic response. Here we show that the dual...

journal_title：Endocrinology

authors： Casal AJ,Ryser S,Capponi AM,Wang-Buholzer CF

更新日期：2007-11-01 00:00:00

abstract：:Plasma immunoreactive PRL responses to indoleamines and their metabolites were studied in urethane-anesthetized rats. All drugs were injected into the lateral ventricle and blood samples were serially collected from a jugular vein. Serotonin and melatonin caused a significant increase in plasma PRL with peak values at...

journal_title：Endocrinology

authors： Iwasaki Y,Kato Y,Ohgo S,Abe H,Imura H,Hirata F,Senoh S,Tokuyama T,Hayaishi O

更新日期：1978-07-01 00:00:00

abstract：:The insulin receptor, following insulin stimulation of cells, triggers formation of various signaling complexes. In rat HTC hepatoma cells overexpressing normal human insulin receptors (HTC-IR), p85 regulatory subunit of phosphatidylinositol-3-kinase (PI3K) forms signaling complexes containing the insulin receptor, in...

journal_title：Endocrinology

authors： Sung CK,Choi WS,Sanchez-Margalet V

更新日期：1998-05-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in oste...

journal_title：Endocrinology

authors： McCarthy TL,Centrella M,Canalis E

更新日期：1989-01-01 00:00:00