Angiotensin II and cyclic adenosine 3',5'-monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element.

abstract：:We have confirmed the serum calcium-raising effect of adrenalectomy in young male rats 5-6 h after parathyroidectomy that was first observed by others many years ago. (The phenomenon has also been reported in cats, dogs, and mice.) In addition, we have shown that adrenalectomy raises the serum ionized calcium as well ...

journal_title：Endocrinology

authors： Nishino K,Hirsch PF,Mahgoub A,Munson PL

更新日期：1991-05-01 00:00:00

abstract：:One of the hypotheses attempting to explain the etiology of the human disease X-linked hypophosphatemia (XLH) posits renal hypersensitivity to parathyroid hormone (PTH). These studies were designed to test this hypothesis in vivo, using the hemizygous hypophosphatemic (Hyp/Y) mouse as an animal model for XLH. Vehicle ...

journal_title：Endocrinology

authors： Kiebzak GM,Meyer RA Jr

更新日期：1982-03-01 00:00:00

abstract：:Mice lacking steroid 5 alpha-reductase 1 and 2 were produced by gene targeting and breeding. Male mice without 5 alpha-reductase 2 or without both enzymes had fully formed internal and external genitalia and were fertile, but had smaller prostates and seminal vesicles than controls. T accumulated to high levels in the...

journal_title：Endocrinology

authors： Mahendroo MS,Cala KM,Hess DL,Russell DW

更新日期：2001-11-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:Angiotensin II is a potent octapeptide vasoconstrictor and regulator of cardiovascular and electrolyte homeostasis. Angiotensinogen, the protein precursor of angiotensin II, is synthesized by the liver and many other organs of the adult rat. To determine whether angiotensin may be present in early fetal development we...

journal_title：Endocrinology

authors： Lee HU,Campbell DJ,Habener JF

更新日期：1987-10-01 00:00:00

abstract：:The effects of insulin treatment and dietary glucose on the responsiveness of adipose tissue to insulin and GH after hypophysectomy were studied. Male rats, 130-150 g, were hypophysectomized. Glucose metabolism was measured by determining the production of CO2 from [14C]glucose and the incorporation of glucose into li...

journal_title：Endocrinology

authors： Gause I,Isaksson O,Lindahl A,Edén S

更新日期：1985-03-01 00:00:00

abstract：:The insulin receptor, following insulin stimulation of cells, triggers formation of various signaling complexes. In rat HTC hepatoma cells overexpressing normal human insulin receptors (HTC-IR), p85 regulatory subunit of phosphatidylinositol-3-kinase (PI3K) forms signaling complexes containing the insulin receptor, in...

journal_title：Endocrinology

authors： Sung CK,Choi WS,Sanchez-Margalet V

更新日期：1998-05-01 00:00:00

abstract：:Aside from studies of a possible synergism between T3 and glucocorticoids in regulating GH mRNA, there have been few previous studies of the modulation by hormones and other factors of glucocorticoid hormone regulation of pituitary cell GH gene expression. We have employed a serum-free medium containing no exogenously...

journal_title：Endocrinology

authors： Gick GG,Bancroft C

更新日期：1987-05-01 00:00:00

abstract：:Estrogen-based hormone therapy (HT) in postmenopausal women may reduce the risk of Alzheimer's disease (AD), although HT remains controversial. One key concern with HT is the potential of adverse outcomes such as breast and uterine cancer. A promising strategy to maximize HT benefits and minimize HT risks is the use o...

journal_title：Endocrinology

authors： Carroll JC,Pike CJ

更新日期：2008-05-01 00:00:00

abstract：:Molecular mechanisms underlying unloading-induced reduction of bone formation have not yet been fully understood. In vitro, Runx2 has been suggested to be involved in mechanical signaling in osteoblasts. However, the roles of Runx2 in vivo during the bone response to mechanical stimuli have not yet been known. The pur...

journal_title：Endocrinology

authors： Salingcarnboriboon R,Tsuji K,Komori T,Nakashima K,Ezura Y,Noda M

更新日期：2006-05-01 00:00:00

abstract：:Nuclear binding of cytoplasmic estrogen receptors was measured in an in vitro cell-free system, using various mixtures of cytosols and nuclei from uteri of mature (6-9 month old) and senescent (24-25 month old) Wistar rats. Both nuclei and cytoplasmic receptors from senescent uteri were 25-35% less efficient in suppor...

journal_title：Endocrinology

authors： Chuknyiska RS,Haji M,Foote RH,Roth GS

更新日期：1985-02-01 00:00:00

abstract：:This study analyzes the role of the autonomic nervous system, the pituitary gland, ACTH, dexamethasone (DEX), and thyroid hormones in the regulation of 5'deiodinase (5'D) in the hypothalamus (HP) and adrenal gland (AG) of the rat. 5'D activity was analyzed in rats under basal conditions (22 C) and during cold exposure...

journal_title：Endocrinology

authors： Anguiano B,Quintanar A,Luna M,Navarro L,Ramírez del Angel A,Pacheco P,Valverde C

更新日期：1995-08-01 00:00:00

abstract：:Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...

journal_title：Endocrinology

authors： Glass AR,Vigersky RA,Rajatanavin R,Pardridge W,Smallridge RC,Wartofsky L,Burman KD

更新日期：1984-05-01 00:00:00

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:L-700,653 is a potent nonpeptidyl GH secretagogue consisting of a benzolactam structure: (4'-[[3(R)-[[3-[(2(S),3-dihydroxypropyl) amino]3-methyl-1-oxobutyl]amino]2,3,4,5-tetrahydro-2-oxo-1H-1-benzaze pin- 1-yl]methyl][1,1'-biphenyl]2-carboxamide hydrochloride). When administered sc by a Medi-Jector device at 0, 0.003,...

journal_title：Endocrinology

authors： Chang CH,Rickes EL,Marsilio F,McGuire L,Cosgrove S,Taylor J,Chen H,Feighner S,Clark JN,De Vita R

更新日期：1995-03-01 00:00:00

abstract：:A parotid hormone (PH-A beta) has been isolated and purified from porcine parotid glands. The biological effect of the hormone is the stimulation of a dentinal fluid transport (DFT) in molar teeth of rats. The method for purifying the PH-A beta includes: extraction at pH 7 and 5, ultrafiltration through Amicon membran...

journal_title：Endocrinology

authors： Tieche JM,Leonora J,Steinman RR

更新日期：1980-06-01 00:00:00

abstract：:The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) rev...

journal_title：Endocrinology

authors： Resko JA,Pleom JG,Stadelman HL

更新日期：1975-08-01 00:00:00

abstract：:We have demonstrated previously that both rat and human liver microsomes contain a highly specific binding protein for the anabolic steroids stanozolol (ST) and danazol (DA). In this study we solubilized the male rat liver ST-binding protein (STBP) and investigated the following parameters: 1) pharmacological properti...

journal_title：Endocrinology

authors： Luzardo OP,Machín RP,Díaz-Chico BN,Fernández L

更新日期：2000-09-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...

journal_title：Endocrinology

authors： Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:Immunosympathectomy produced by treatment of newborn rats with antibodies to nerve growth factor (NGF) delays ovarian development and disrupts estrous cyclicity. While these alterations have been ascribed to loss of sympathetic neurons innervating the ovary, the treatment also causes partial loss of ovarian sensory in...

journal_title：Endocrinology

authors： Lara HE,McDonald JK,Ahmed CE,Ojeda SR

更新日期：1990-11-01 00:00:00

abstract：:We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB(1)) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA) axis with respect to both gender and time of day. Blood samples were collected from conscious male and female rats every 5 min using an automated blood sampli...

journal_title：Endocrinology

authors： Atkinson HC,Leggett JD,Wood SA,Castrique ES,Kershaw YM,Lightman SL

更新日期：2010-08-01 00:00:00

abstract：:Several studies have shown that insulin-like growth factor-binding proteins (IGF-BPs) modify IGF activity. To investigate their role in regulating growth, the number and size of IGF-BPs in porcine serum and the role of nutritional and endocrine factors in controlling their relative abundance were determined. IGF-BPs w...

journal_title：Endocrinology

authors： McCusker RH,Campion DR,Jones WK,Clemmons DR

更新日期：1989-07-01 00:00:00

abstract：:We have recently reported evidence for the presence of stereospecific energy-dependent transport processes for T3 in rat tissues. These processes were responsible for maintenance of concentration differences of free L- and D-T3 across the cellular plasma and nuclear membranes. In rat liver, the free L-T3 concentration...

journal_title：Endocrinology

authors： Mooradian AD,Schwartz HL,Mariash CN,Oppenheimer JH

更新日期：1985-12-01 00:00:00

abstract：:The enteroendocrine and enteric nervous systems convey signals through an overlapping network of regulatory peptides that act either as circulating hormones or as localized neurotransmitters within the gastrointestinal tract. Because recent studies invoke an important role for vasoactive intestinal peptide (VIP) as a ...

journal_title：Endocrinology

authors： Yusta B,Holland D,Waschek JA,Drucker DJ

更新日期：2012-06-01 00:00:00

abstract：:GRK2 is a member of the G protein-coupled receptor kinase family that phosphorylates the activated form of beta-adrenergic and other G protein-coupled receptors and plays an important role in their desensitization and modulation. Alterations in thyroid hormone levels have been reported to lead to important changes in ...

journal_title：Endocrinology

authors： Penela P,Barradas M,Alvarez-Dolado M,Muñoz A,Mayor F Jr

更新日期：2001-03-01 00:00:00

abstract：:Thyroid hormone (T3) is required for postnatal skeletal growth. It exerts its effect by binding to nuclear receptors, TRs including TRα1 and TRβ1, which are present in most cell types. These cell types include chondrocytes and osteoblasts, the interactions of which are known to regulate endochondral bone formation. In...

journal_title：Endocrinology

authors： Desjardin C,Charles C,Benoist-Lasselin C,Riviere J,Gilles M,Chassande O,Morgenthaler C,Laloé D,Lecardonnel J,Flamant F,Legeai-Mallet L,Schibler L

更新日期：2014-08-01 00:00:00

abstract：:Follistatin (FS), which binds to the inhibin/activin beta A- or beta B-subunit is localized with and modulates the biological actions of activin in many systems. However, in contrast to the wide distribution of the activin beta-subunit proteins and messenger RNAs (mRNA) in the brain, demonstration of FS mRNA signal ha...

journal_title：Endocrinology

authors： Macconell LA,Barth S,Roberts VJ

更新日期：1996-05-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:To examine the role of androgen receptor (AR) in Sertoli cells (SC), we used a SC-specific AR knockout (S-AR-/y) mouse to further evaluate the chronological changes of seminiferous tubules and the molecular mechanisms of SC androgen/AR signals on spermatogenesis. Testes morphology began changing as early as postnatal ...

journal_title：Endocrinology

authors： Wang RS,Yeh S,Chen LM,Lin HY,Zhang C,Ni J,Wu CC,di Sant'Agnese PA,deMesy-Bentley KL,Tzeng CR,Chang C

更新日期：2006-12-01 00:00:00