Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice.

abstract：:Previously, three receptors, xTRHR1, xTRHR2, and xTRHR3, were cloned from brain tissue of Xenopus laevis with primers designed using sequences from the mammalian TRH receptor (TRHR) subtype 1. We expressed the Xenopus receptors in HEK 293EM cells and studied their binding and signaling properties using a series of TRH...

journal_title：Endocrinology

authors： Lu X,Bidaud I,Ladram A,Gershengorn MC

更新日期：2003-05-01 00:00:00

abstract：:High density lipoprotein (HDL) participates in reverse cholesterol transport and in the delivery of cholesterol to steroid-producing tissues. Scavenger receptor class B type I (SR-BI) was recently shown to bind HDL and mediate internalization of its cholesterol content. We have cloned the rat homolog of this receptor,...

journal_title：Endocrinology

authors： Johnson MS,Svensson PA,Helou K,Billig H,Levan G,Carlsson LM,Carlsson B

更新日期：1998-01-01 00:00:00

abstract：:Estrogen is generally considered to maintain bone mass through suppression of bone resorption. We have previously demonstrated that administration of pharmacological doses of estrogen increases bone formation in rats. Because such high doses of estrogen might induce bone formation through some mechanism other than the...

journal_title：Endocrinology

authors： Chow JW,Lean JM,Chambers TJ

更新日期：1992-05-01 00:00:00

abstract：:New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in total cellular glu...

journal_title：Endocrinology

authors： Asfari M,Janjic D,Meda P,Li G,Halban PA,Wollheim CB

更新日期：1992-01-01 00:00:00

abstract：:To elucidate the metabolic fate and possible role of androgens and their derivatives during primate fetal development, aromatase (AROM), 5 alpha-reductase (5 alpha R), and androgen receptor (AR; cytosolic) levels were assessed in the brain, heart (HRT), lung (LNG), and skeletal muscle (MUS) of fetal rhesus monkeys. An...

journal_title：Endocrinology

authors： Sholl SA,Goy RW,Kim KL

更新日期：1989-02-01 00:00:00

abstract：:Deciduomal reactions in response to artificial stimuli were induced on the tube-ligated uterine horns of unilateral pregnant hamsters. Serum progesterone levels were determined, and the changes of estrogen and progesterone receptors (ER and PR, respectively) were simultaneously studied in the deciduoma. After stimulat...

journal_title：Endocrinology

authors： Chen TJ,Hwang TC,Huang CC,Jow GM,Yu JY

更新日期：1989-07-01 00:00:00

abstract：:Exposure of the ileum to nutrients markedly inhibits several upper gastrointestinal functions. Hormonal peptides of the ileal wall, i.e. peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and neurotensin (NT), are thought to play a role in this negative feedback mechanism. The present study was conducted to comparativ...

journal_title：Endocrinology

authors： Dumoulin V,Moro F,Barcelo A,Dakka T,Cuber JC

更新日期：1998-09-01 00:00:00

abstract：:In order to investigate the physiological counterpart of the anatomical finding showing that the dorsal motor nucleus of the vagus nerve (DMX) is a source of efferent vagal fibers innervating the pancreas, unilateral electrical stimulation using monopolar electrodes (50 microA, 30 Hz, 0.2 msec) at a glycemia of 150 mg...

journal_title：Endocrinology

authors： Ionescu E,Rohner-Jeanrenaud F,Berthoud HR,Jeanrenaud B

更新日期：1983-03-01 00:00:00

abstract：:Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However, whether berberine exerts a regulatory effect on beta-cells via AMPK or other signaling pathways and counteracts glucolipotoxicity rem...

journal_title：Endocrinology

authors： Zhou L,Wang X,Shao L,Yang Y,Shang W,Yuan G,Jiang B,Li F,Tang J,Jing H,Chen M

更新日期：2008-09-01 00:00:00

abstract：:Endocrine regulation of uterine biology is critical for embryo receptivity and human reproduction. Uterine endometrium depends on extrinsic sex steroid input and hence likely has mechanisms that enable adaptation to hormonal variation. Emerging evidence suggests that sex steroid bioavailability in the endometrium is d...

journal_title：Endocrinology

authors： Zheng Y,Tabbaa ZM,Khan Z,Schoolmeester JK,El-Nashar S,Famuyide A,Keeney GL,Daftary GS

更新日期：2014-11-01 00:00:00

abstract：:The contribution of the insulin receptor beta-subunit acidic domain, amino acids 1262-1291, to receptor function was analyzed. A mutant insulin receptor complementary DNA lacking this domain was created. Rat-1 fibroblasts were stably transfected with plasmids containing the mutant insulin receptor complementary DNA an...

journal_title：Endocrinology

authors： Rolband GC,Williams JF,Webster NJ,Olefsky JM

更新日期：1993-09-01 00:00:00

abstract：:The effects of leptin on the levels of CRF messenger RNA (mRNA) in the paraventricular hypothalamic nucleus (PVN), on the activation of the PVN CRF cells, and on the plasma levels of corticosterone were investigated in lean (+/?) and obese (ob/ob) C57BL/6J male mice. Murine leptin was s.c. infused using osmotic minipu...

journal_title：Endocrinology

authors： Huang Q,Rivest R,Richard D

更新日期：1998-04-01 00:00:00

abstract：:GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor. Whereas GnRH inhibits the activity of the M-current in peripheral neurons, there is no direct evidence that the M-current is involved in the autoregulatory ...

journal_title：Endocrinology

authors： Xu C,Roepke TA,Zhang C,Rønnekleiv OK,Kelly MJ

更新日期：2008-05-01 00:00:00

abstract：:The CYP11A1 encodes cytochrome P450scc, catalyzing the first step of steroidogenesis in adrenals and gonads under the control of cAMP-mediated hormonal signals. The cAMP-induced activation of human CYP11A1 has been suggested to depend on the transcription factor cAMP-responsive element-binding protein (CREB), but the ...

journal_title：Endocrinology

authors： Guo IC,Huang CY,Wang CK,Chung BC

更新日期：2007-04-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:A rat medullary thyroid carcinoma, which was previously shown to produce high levels of immunoreactive cholecystokinin (CCK), was used to establish a stable cell line. Transplantable tumors were subjected to four series of alternate in vitro and in vivo passages. Cells were prepared from the fourth series of tumors un...

journal_title：Endocrinology

authors： Haun RS,Beinfeld MC,Roos BA,Dixon JE

更新日期：1989-08-01 00:00:00

abstract：:Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

journal_title：Endocrinology

authors： Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

更新日期：2019-12-01 00:00:00

abstract：:It has previously been reported that treatment of rat luteal cells and human granulosa luteal cells with hydrogen peroxide (H2O2) results in a significant inhibition of steroid production. The mechanism of inhibition in the former was found to be at the level of cholesterol transport into the mitochondria, whereas in ...

journal_title：Endocrinology

authors： Stocco DM,Wells J,Clark BJ

更新日期：1993-12-01 00:00:00

abstract：:A clonal cell line (44-2C) which synthesizes and secretes somatostatin, neurotensin, calcitonin (CT), and CT gene-related peptide and transiently expresses c-fos was used to characterize the mechanism of action of basic fibroblast growth factor (bFGF). bFGF had two modes of action: 1) short term incubation of 44-2C ce...

journal_title：Endocrinology

authors： Zeytin FN,Rusk SF,Raymond V,Mandell AJ

更新日期：1988-03-01 00:00:00

abstract：:This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16...

journal_title：Endocrinology

authors： Tilbrook AJ,de Kretser DM,Cummins JT,Clarke IJ

更新日期：1991-12-01 00:00:00

abstract：:During early pseudopregnancy, DNA synthesis and mitosis in the uterine endometrial stroma precede the development of uterine sensitivity to deciduogenic stimuli. Progesterone redirects the effects of estradiol on endometrial DNA synthesis from the luminal epithelium to the stroma. To determine the time and hormonal co...

journal_title：Endocrinology

authors： Moulton BC,Koenig BB

更新日期：1984-10-01 00:00:00

abstract：:Bioactive peptides are usually synthesized as inactive precursor proteins that yield bioactive products only after specific biosynthetic processing events. Large dense core vesicles (LDCV) are usually the site of storage of mature peptides. Atrial myocyte LDCV are rather unique in their storage of intact prohormone, p...

journal_title：Endocrinology

authors： Marx R,Mains RE

更新日期：1997-12-01 00:00:00

abstract：:FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this...

journal_title：Endocrinology

authors： Shibata EF,Matsuda JJ,Volk KA,Collison KA,Segaloff DL

更新日期：1992-08-01 00:00:00

abstract：:In a previous study we found that PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and IGF-II from cultured neonatal mouse calvaria. Since IGF-I and IGF-II stimulate osteoblast proliferation and collagen synthesis, these results suggested that increased release of IGFs during resorpti...

journal_title：Endocrinology

authors： Linkhart TA,Keffer MJ

更新日期：1991-03-01 00:00:00

abstract：:In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After rec...

journal_title：Endocrinology

authors： Anderson ST,Sawangjaroen K,Curlewis JD

更新日期：1996-08-01 00:00:00

abstract：:The aldo-keto reductase 1B7 (AKR1B7) encodes an aldose-reductase that has been reported as a detoxification enzyme until now. We have demonstrated that AKR1B7 is differently expressed in various mouse white adipose tissues depending on their location. Its expression is associated with a higher ratio of preadipocytes v...

journal_title：Endocrinology

authors： Tirard J,Gout J,Lefrançois-Martinez AM,Martinez A,Begeot M,Naville D

更新日期：2007-05-01 00:00:00

abstract：:The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...

journal_title：Endocrinology

authors： Clevenger CV,Sillman AL,Prystowsky MB

更新日期：1990-12-01 00:00:00

abstract：:Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We ...

journal_title：Endocrinology

authors： Sun X,Cappelletti M,Li Y,Karp CL,Divanovic S,Dey SK

更新日期：2014-10-01 00:00:00

abstract：:We have recently identified, characterized, and cloned a luteal microsomal 32-kDa phosphoprotein that we named PRAP (for PRL-receptor associated protein), and we have demonstrated that PRAP binds to the intracellular domain of the short but not the long form of the PRL receptor. In this study, we used PRAP cDNA to exa...

journal_title：Endocrinology

authors： Duan WR,Parmer TG,Albarracin CT,Zhong L,Gibori G

更新日期：1997-08-01 00:00:00

abstract：:Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and perit...

journal_title：Endocrinology

authors： Pini M,Gove ME,Sennello JA,van Baal JW,Chan L,Fantuzzi G

更新日期：2008-08-01 00:00:00