Interleukin-2 driven nuclear translocation of prolactin in cloned T-lymphocytes.

abstract：:The influence of periparturient secretion of PRL on cytological differentiation of mammary epithelial cells was studied in 17 multiparous, monotocous Holstein cows. Mammary tissue was obtained 10 days prepartum and 10 days postpartum from untreated cows and from cows treated with CB154 (2-Br-alpha-ergokryptin) or CB15...

journal_title：Endocrinology

authors： Akers RM,Bauman DE,Goodman GT,Capuco AV,Tucker HA

更新日期：1981-07-01 00:00:00

abstract：:We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the mechanisms involved are unknown. SK-N-MC cells were cultured with FGF-2 (50 ng/ml) and/or IGF-I (100 ng/ml) up to 48 h. Fluorescence-activated ce...

journal_title：Endocrinology

authors： Higgins S,Wong SH,Richner M,Rowe CL,Newgreen DF,Werther GA,Russo VC

更新日期：2009-09-01 00:00:00

abstract：:Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...

journal_title：Endocrinology

authors： Yang CR,Lowther KM,Lalioti MD,Seli E

更新日期：2016-01-01 00:00:00

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:To determine whether glucagon plays a significant role in the restitution of blood volume after hemorrhage, pentobarbital-anesthetized dogs were treated with somatostatin (SRIF). The administration of SRIF (14 micrograms/kg.h) prevented the increase in osmolality and the complete restitution of plasma protein and bloo...

journal_title：Endocrinology

authors： Byrnes GJ,Engeland WC,Gann DS

更新日期：1982-06-01 00:00:00

abstract：:The possibility that the responsiveness of plasma aldosterone concentration to angiotensin II alters with changes in sodium balance was investigated in male beagle dogs under conditions of controlled sodium and potassium intake. Angiotensin II was infused at four different rates (usually 3, 6, 12, and 24 ng/kg/min), e...

journal_title：Endocrinology

authors： Nicholls MG,Tree M,Brown JJ,Douglas BH,Fraser R,Hay GD,Lever AF,Morton JJ,Robertson JI

更新日期：1978-02-01 00:00:00

abstract：:The multifunctional cytokine tumor necrosis factor-alpha (TNF alpha) stimulates osteoclastic resorption. It is not known which steps in osteoclast formation are affected by TNF alpha. We have investigated the effects of recombinant human TNF alpha (rhTNF alpha) on osteoclast development and osteoclastic resorption in ...

journal_title：Endocrinology

authors： van der Pluijm G,Most W,van der Wee-Pals L,de Groot H,Papapoulos S,Löwik C

更新日期：1991-09-01 00:00:00

abstract：:The enteroendocrine and enteric nervous systems convey signals through an overlapping network of regulatory peptides that act either as circulating hormones or as localized neurotransmitters within the gastrointestinal tract. Because recent studies invoke an important role for vasoactive intestinal peptide (VIP) as a ...

journal_title：Endocrinology

authors： Yusta B,Holland D,Waschek JA,Drucker DJ

更新日期：2012-06-01 00:00:00

abstract：:To examine the molecular genetic basis for the age-related increase in PRL secretion and decrease in LH production in the rat, we measured steady state levels of PRL and LH beta mRNA in pituitary homogenates and cell lysates from monolayer adenohypophyseal cultures. These mRNA levels were compared with the correspondi...

journal_title：Endocrinology

authors： Stewart DA,Blackman MR,Kowatch MA,Danner DB,Roth GS

更新日期：1990-02-01 00:00:00

abstract：:We have studied regulation of the glucose transporter by thyroid hormone in ARL 15 cells, a thyroid hormone-responsive cell line derived from rat liver, T3 treatment (5 x 10(-8) M for 48 h) of confluent cell monolayers grown in thyroid hormone-deficient medium increased the rate of uptake of [3H] 2-deoxyglucose by 2.3...

journal_title：Endocrinology

authors： Weinstein SP,Watts J,Graves PN,Haber RS

更新日期：1990-03-01 00:00:00

abstract：:Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all p...

journal_title：Endocrinology

authors： Bagnasco M,Kalra PS,Kalra SP

更新日期：2002-02-01 00:00:00

abstract：:In order to elucidate potential sites of direct GH action on the kidney, we used in situ hybridization to localize GH receptor (GHR) gene expression during the course of development and in the adult rat. In order to illuminate potential interactions between GH and insulin-like growth factor-I (IGF-I) in regulating ren...

journal_title：Endocrinology

authors： Chin E,Zhou J,Bondy CA

更新日期：1992-12-01 00:00:00

abstract：:To evaluate the relative contribution of the GH/IGF axis to the development of peak bone mineral density (BMD), we measured skeletal changes in IGF-I knockout (KO), IGF-II KO, and GH-deficient lit/lit mice and their corresponding control mice at d 23 (prepubertal), 31 (pubertal), and 56 (postpubertal) in the entire fe...

journal_title：Endocrinology

authors： Mohan S,Richman C,Guo R,Amaar Y,Donahue LR,Wergedal J,Baylink DJ

更新日期：2003-03-01 00:00:00

abstract：:The effects of estrogens, androgens, and glucocorticoids on bone resorption were compared in organ culture. At a concentration of 10(-5) M, corticosterone, testosterone, dihydrotestosterone, dehydroepiandosterone, estradiol, ethinyl estradiol and estrone did not inhibit the release of 45Ca from 19-day fetal rat long b...

journal_title：Endocrinology

authors： Caputo CB,Meadows D,Raisz LG

更新日期：1976-04-01 00:00:00

abstract：:Dog thyroid slices released in their incubation medium prostaglandins E2 (PGE2), F2 alpha (PGF2 alpha), 15-keto-13,14-dihydro-F2 alpha, and thromboxane B2 (TxB2), as measured by direct RIA. This release could be inhibited by indomethacin and naproxen, indicating that it corresponded to a neosynthesis. Carbamylcholine ...

journal_title：Endocrinology

authors： Boeynaems JM,Waelbroeck M,Dumont JE

更新日期：1979-10-01 00:00:00

abstract：:The protein thiol-modifying agent arsenite, a potent activator of stress signaling, was used to examine the involvement of MAPKs in the regulation of cardiac substrate uptake. Arsenite strongly induced p38 MAPK phosphorylation in isolated rat cardiac myocytes but also moderately enhanced phosphorylation of p42/44 ERK ...

journal_title：Endocrinology

authors： Luiken JJ,Momken I,Habets DD,El Hasnaoui M,Coumans WA,Koonen DP,Glatz JF,Bonen A

更新日期：2006-11-01 00:00:00

abstract：:A soluble form of the amino-terminal extracellular (ecto-) domain of the human TSH receptor was generated. This protein was capable of binding TSH and autoimmune antibodies found in Graves' patients. A deletion mutant of the ectodomain lacking nine amino acids in the C-terminal region lost its ability to interact with...

journal_title：Endocrinology

authors： Osuga Y,Liang SG,Dallas JS,Wang C,Hsueh AJ

更新日期：1998-02-01 00:00:00

abstract：:Progesterone (P4) inhibits apoptosis of rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs), which were derived from rat granulosa cells. Defining the mechanism through which P4 mediates its action has been difficult because these cells do not express the classic nuclear P4 receptor. Previous st...

journal_title：Endocrinology

authors： Peluso JJ,Pappalardo A,Fernandez G,Wu CA

更新日期：2004-06-01 00:00:00

abstract：:Certain metabolic properties of hormonally responsive osteogenic sarcoma cells derived from a transplantable rat tumor have been compared with those of related normal rat bone cells. All studies were carried out on cells grown in monolayer culture. Normal rat bone cells derived by repeated collagenase/trypsin digestio...

journal_title：Endocrinology

authors： Partridge NC,Alcorn D,Michelangeli VP,Kemp BE,Ryan GB,Martin TJ

更新日期：1981-01-01 00:00:00

abstract：:In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then extracted, separated by...

journal_title：Endocrinology

authors： Rommerts FF,King SR,Span PN

更新日期：2001-12-01 00:00:00

abstract：:Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...

journal_title：Endocrinology

authors： Elfers CT,Roth CL

更新日期：2017-01-01 00:00:00

abstract：:On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...

journal_title：Endocrinology

authors： Galbiati M,Zanisi M,Messi E,Cavarretta I,Martini L,Melcangi RC

更新日期：1996-12-01 00:00:00

abstract：:PTH secretion is tightly regulated by extracellular calcium ([Ca2+]e) and in turn regulates calcium homeostasis through its action on target tissues. We investigated the mechanism and physiological significance of intracellular calcium ([Ca2+]i) levels in relation to the secretion of PTH in single bovine parathyroid c...

journal_title：Endocrinology

authors： Miki H,Maercklein PB,Fitzpatrick LA

更新日期：1995-07-01 00:00:00

abstract：:Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and hormones. The role...

journal_title：Endocrinology

authors： Pauliina Markkula S,Lyons D,Yueh CY,Riches C,Hurst P,Fielding B,Heisler LK,Evans ML

更新日期：2016-12-01 00:00:00

abstract：:Important enzymes for thyroid hormone metabolism, antioxidative defense, and intracellular redox control contain selenocysteine (Sec) in their active centers. Expression of these selenoproteins is tightly controlled, and a sex-specific phenotype is observed on disturbance of selenium (Se) transport in mice. Therefore,...

journal_title：Endocrinology

authors： Riese C,Michaelis M,Mentrup B,Götz F,Köhrle J,Schweizer U,Schomburg L

更新日期：2006-12-01 00:00:00

abstract：:GnRH was first identified as the hypothalamic decapeptide that promotes gonadotropin release from pituitary gonadotropes. Thereafter, direct stimulatory and inhibitory effects of GnRH on cell proliferation were demonstrated in a number of types of primary cultured cells and established cell lines. Recently, the effect...

journal_title：Endocrinology

authors： Enomoto M,Utsumi M,Park MK

更新日期：2006-01-01 00:00:00

abstract：:Profound somatotroph hypoplasia in the dwarf (dw/dw) rat is accompanied by an estrogen-dependent induction of prolactin secretion by the GH secretagogue, GHRP-6. Using electron microscopy, we demonstrated that the reduction in the somatotroph population in the dw/dw pituitary is accompanied by the presence of a morpho...

journal_title：Endocrinology

authors： Huerta-Ocampo I,Christian HC,Thompson NM,El-Kasti MM,Wells T

更新日期：2005-11-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of mal...

journal_title：Endocrinology

authors： Yu AM,Fukamachi K,Krausz KW,Cheung C,Gonzalez FJ

更新日期：2005-07-01 00:00:00