Adenovirally encoded prohormone convertase-1 functions in atrial myocyte large dense core vesicles.

abstract：:To elucidate the temporal profile of adaptive changes of the islets of Langerhans to the increased insulin demands of pregnancy, we have studied islet cell proliferation and insulin secretion during gestation in the rat. 5-Bromo-2'-deoxyuridine incorporation into dividing islet cells was significantly (P less than 0.0...

journal_title：Endocrinology

authors： Parsons JA,Brelje TC,Sorenson RL

更新日期：1992-03-01 00:00:00

abstract：:Using a rat model of chronic central leptin infusion in which neuropeptide Y neurons develop leptin resistance, we examined whether leptin signal transduction mechanism in the hypothalamus is altered during central leptin infusion. Adult male rats were infused chronically into the lateral cerebroventricle with leptin ...

journal_title：Endocrinology

authors： Pal R,Sahu A

更新日期：2003-09-01 00:00:00

abstract：:New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in total cellular glu...

journal_title：Endocrinology

authors： Asfari M,Janjic D,Meda P,Li G,Halban PA,Wollheim CB

更新日期：1992-01-01 00:00:00

abstract：:The Ca2+ response of individual cells to TRH was investigated in excitable pituitary GH3 and in nonexcitable Hela cells transfected with the TRH receptor complementary DNA (HelaR cells). GH3 cells typically responded to 1 microM TRH with an immediate transient [Ca2+]i spike (mean peak [Ca2+]i = 1.5 microM) followed by...

journal_title：Endocrinology

authors： Nelson EJ,Hinkle PM

更新日期：1994-09-01 00:00:00

abstract：:Angiotensin-II (Ang-II), K+, and ACTH are important stimulators of aldosterone secretion that require Ca2+ influx to be active. However, Ang-II and K+ are linked to the Ca2+ messenger system, while ACTH is coupled to the cAMP pathway. Peripheral-type binding sites for benzodiazepines are particularly abundant in stero...

journal_title：Endocrinology

authors： Python CP,Rossier MF,Vallotton MB,Capponi AM

更新日期：1993-04-01 00:00:00

abstract：:Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...

journal_title：Endocrinology

authors： Domann FE,Mitchen JM,Clifton KH

更新日期：1990-12-01 00:00:00

abstract：:Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a posttranscriptional regulator of genes that are essential for spermatid elongation and completion of spermatogenesis. It also prevents Leydig cells (LCs) from gonadotropin overstimulation of androgen production. In transgenic (Tg) mice carrying deletions...

journal_title：Endocrinology

authors： Kavarthapu R,Tsai-Morris CH,Fukushima M,Pickel J,Dufau ML

更新日期：2013-06-01 00:00:00

abstract：:1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] inhibits proliferation of normal and malignant prostate epithelial cells at least in part through inhibition of G1 to S phase cell cycle progression. The mechanisms of the antiproliferative effects of 1,25-(OH)2D3 have yet to be fully elucidated but are known to require the vita...

journal_title：Endocrinology

authors： Flores O,Burnstein KL

更新日期：2010-10-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:We developed a coculture system comprising primary rat adipocytes and L6 rat skeletal muscle cells to allow investigation of the effects of physiologically relevant mixtures of adipokines. We observed that coculture, or adipocyte-conditioned media, increased glucose uptake in muscle cells. An adipokine that could pote...

journal_title：Endocrinology

authors： Vu V,Kim W,Fang X,Liu YT,Xu A,Sweeney G

更新日期：2007-09-01 00:00:00

abstract：:High plasma levels of estradiol (E2) are associated with use of a place memory system over a response memory system. We examined whether infusing estradiol into the medial prefrontal cortex (mPFC) or anterior cingulate cortex (AC) could affect memory system bias in female rats. We also examined the ultrastructural dis...

journal_title：Endocrinology

authors： Almey A,Cannell E,Bertram K,Filardo E,Milner TA,Brake WG

更新日期：2014-11-01 00:00:00

abstract：:Exercise has a potent insulin-sensitivity enhancing effect on skeletal muscle, but the intracellular mechanisms that mediate this effect are not well understood. In muscle, Ras-related C3 botulinum toxin substrate 1 (Rac1) regulates both insulin- and contraction-stimulated glucose transport and is dysregulated in insu...

journal_title：Endocrinology

authors： Sylow L,Møller LL,D'Hulst G,Schjerling P,Jensen TE,Richter EA

更新日期：2016-08-01 00:00:00

abstract：:Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease ...

journal_title：Endocrinology

authors： Yoshizato H,Fujikawa T,Soya H,Tanaka M,Nakashima K

更新日期：1998-05-01 00:00:00

abstract：:Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues. However, whether berberine exerts a regulatory effect on beta-cells via AMPK or other signaling pathways and counteracts glucolipotoxicity rem...

journal_title：Endocrinology

authors： Zhou L,Wang X,Shao L,Yang Y,Shang W,Yuan G,Jiang B,Li F,Tang J,Jing H,Chen M

更新日期：2008-09-01 00:00:00

abstract：:Fetuin-A is a biomarker reported to be important in many metabolic disorders, including obesity, diabetes, and hepatic steatosis. Although it is well known that fetuin-A is increased in diabetes and nonalcoholic fatty liver disease (NAFLD), the levels of fetuin-A in diabetic patients with NAFLD are unknown. Furthermor...

journal_title：Endocrinology

authors： Ou HY,Wu HT,Hung HC,Yang YC,Wu JS,Chang CJ

更新日期：2012-07-01 00:00:00

abstract：:Estradiol imprinting plays an important role in the regulation of galanin (GAL) gene expression in the rat. In the anterior pituitary gland, GAL gene expression is greatly induced by estrogen. The relative involvement that the two estrogen receptor subtypes, alpha and beta, have in regulating this induction is not kno...

journal_title：Endocrinology

authors： Shen ES,Hardenburg JL,Meade EH,Arey BJ,Merchenthaler I,López FJ

更新日期：1999-06-01 00:00:00

abstract：:The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined whether they are mediated through prostaglandin-dependent pathways. Bone resorption, collagen, and non-collagen protein synthesis and inositol phosphate (IP) produ...

journal_title：Endocrinology

authors： Tatrai A,Foster S,Lakatos P,Shankar G,Stern PH

更新日期：1992-08-01 00:00:00

abstract：:cAMP has been shown to mediate the response of the parathyroid gland to a number of agonists and appears to take part in the regulation of this gland by divalent cations as well. We have studied the effects of the concentrations of free magnesium (Mg+2) and ionic calcium (Ca+2) on the kinetic properties of normal porc...

journal_title：Endocrinology

authors： Oldham SB,Rude RK,Molloy CT,Lipson LG

更新日期：1984-11-01 00:00:00

abstract：:The effect of diabetes mellitus on the synthesis and secretion of thyroid hormone ws investigated in mice with streptozotocin-induced diabetes. Thyroid glands were labeled in vivo with 131I for 2 h. In control animals, TSH stimulated the synthesis of PB127I and 131I-labeled iodothyronines and simultaneously decreased ...

journal_title：Endocrinology

authors： Bagchi N,Brown TR,Shivers B,Lucas S,Mack RE

更新日期：1981-11-01 00:00:00

abstract：:This paper describes experiments on cultured granulosa cells isolated from ovaries of immature rats designed to locate the site of action of androgens on FSH-induced aromatase activity. Treatment of cells during a 36-h induction period with (Bu)2cAMP, 8- BrcAMP , FSH, prostaglandin E2, or cholera toxin resulted in ind...

journal_title：Endocrinology

authors： Daniel SA,Armstrong DT

更新日期：1984-06-01 00:00:00

abstract：:Obesity is associated with systemic inflammation and elevated levels of TNFα, leading to impaired glucose tolerance. In humans, obesity is also associated with reduced nutrient-stimulated secretion of the intestinal incretin hormone, glucagon-like peptide-1 (GLP-1). We hypothesized that TNFα plays a direct role in the...

journal_title：Endocrinology

authors： Gagnon J,Sauvé M,Zhao W,Stacey HM,Wiber SC,Bolz SS,Brubaker PL

更新日期：2015-11-01 00:00:00

abstract：:The present study assesses the relationship between G-proteins and protein kinase-C (PKC) in the gonadotrope. Cells were depleted of PKC with 1 microM phorbol 12-myristate 13-acetate for 12 h, followed by medium 199-BSA for 6 h before treatment with vehicle, pertussis toxin (PTX), cholera toxin (CTX), or (Bu)2cAMP (dB...

journal_title：Endocrinology

authors： Barnes SJ,Conn PM

更新日期：1993-12-01 00:00:00

abstract：:T4-binding globulin (TBG), the principal carrier of thyroid hormone in serum, is a glycoprotein containing 20% carbohydrate. The importance of the carbohydrate moiety has been previously studied by enzymatic deglycosylation, which showed that deglycosylated TBG retains its original immunological an T4-binding properti...

journal_title：Endocrinology

authors： Murata Y,Magner JA,Refetoff S

更新日期：1986-04-01 00:00:00

abstract：:Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....

journal_title：Endocrinology

authors： Sellix MT,Murphy ZC,Menaker M

更新日期：2013-04-01 00:00:00

abstract：:A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...

journal_title：Endocrinology

authors： Katz J,Finlay TH,Tom C,Levitz M

更新日期：1980-12-01 00:00:00

abstract：:The vertebrate adenohypophysis forms as a placode at the anterior margin of the neural plate, requiring both hedgehog (Hh) and fibroblast growth factor (Fgf) mediated cell-cell signaling for induction and survival of endocrine cell types. Using small molecule inhibitors to modulate signaling levels during zebrafish de...

journal_title：Endocrinology

authors： Guner B,Ozacar AT,Thomas JE,Karlstrom RO

更新日期：2008-09-01 00:00:00

abstract：:Groups of female ferrets born in the laboratory received sc Silastic capsules containing testosterone (T), 5 alpha-dihydrotestosterone (DHT), 17 beta-estradiol (E), or no steroid for 15 days beginning on the day of birth; an additional group of male ferrets received empty sc capsules neonatally. All ferrets were gonad...

journal_title：Endocrinology

authors： Baum MJ,Gallagher CA,Martin JT,Damassa DA

更新日期：1982-09-01 00:00:00

abstract：:Regulation of galanin gene expression in the anterior pituitary (AP) is positively influenced by estrogen in rodents and undetermined in humans. The objective of this study was to investigate the mechanism behind estrogen induction of galanin by identifying any putative estrogen receptor (ER) binding sequences within ...

journal_title：Endocrinology

authors： Howard G,Peng L,Hyde JF

更新日期：1997-11-01 00:00:00

abstract：:Angiotensin II is a potent octapeptide vasoconstrictor and regulator of cardiovascular and electrolyte homeostasis. Angiotensinogen, the protein precursor of angiotensin II, is synthesized by the liver and many other organs of the adult rat. To determine whether angiotensin may be present in early fetal development we...

journal_title：Endocrinology

authors： Lee HU,Campbell DJ,Habener JF

更新日期：1987-10-01 00:00:00

abstract：:Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3. T4 binding was not affected by the flavonoid EMD 21388...

journal_title：Endocrinology

authors： Benvenga S,Cahnmann HJ,Robbins J

更新日期：1993-09-01 00:00:00