Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sens

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, because the developing brain is highly sensitive to estrogens. In the present study, we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes irreversible suppres...

journal_title：Endocrinology

authors： Minabe S,Ieda N,Watanabe Y,Inoue N,Uenoyama Y,Maeda KI,Tsukamura H

更新日期：2017-09-01 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...

journal_title：Endocrinology

authors： Gachkar S,Oelkrug R,Martinez-Sanchez N,Rial-Pensado E,Warner A,Hoefig CS,López M,Mittag J

更新日期：2017-06-01 00:00:00

abstract：:Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered i.p. or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hyp...

journal_title：Endocrinology

authors： Fu Y,Matta SG,Valentine JD,Sharp BM

更新日期：1997-05-01 00:00:00

abstract：:The paucity of clinical and preclinical studies investigating sex differences in sleep has resulted in mixed findings as to the exact nature of these differences. Although gonadal steroids are known to modulate sleep in females, less is known about males. Moreover, little evidence exists concerning the origin of these...

journal_title：Endocrinology

authors： Cusmano DM,Hadjimarkou MM,Mong JA

更新日期：2014-01-01 00:00:00

abstract：:The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their tissue and molecular targets are poorly understood. In this study, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model ...

journal_title：Endocrinology

authors： Shu L,Meng Q,Diamante G,Tsai B,Chen YW,Mikhail A,Luk H,Ritz B,Allard P,Yang X

更新日期：2019-02-01 00:00:00

abstract：:In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...

journal_title：Endocrinology

authors： Wiemers DO,Shao LJ,Ain R,Dai G,Soares MJ

更新日期：2003-01-01 00:00:00

abstract：:Previous studies have shown that estradiol indirectly stimulated the proliferation of oviduct epithelial cells in the quail. The present study was undertaken to investigate the effects of estradiol and other steroid hormones on the cAMP concentration. The ability of forskolin, a specific activator of the catalytic sub...

journal_title：Endocrinology

authors： Laugier C,Courion C,Pageaux JF,Fanidi A,Dumas MY,Sandoz D,Nemoz G,Prigent AF,Pacheco H

更新日期：1988-01-01 00:00:00

abstract：:Cathepsin-D has been previously reported to cleave intact PTH into PTH-(1-34) and -(35-84) in membranous fractions of rat and bovine kidney. Whether PTH degradation occurs by intact kidney cells, however, has not been examined in detail. We have, therefore, examined this possibility using an opossum kidney (OK) cell l...

journal_title：Endocrinology

authors： Yamaguchi T,Fukase M,Nishikawa M,Fujimi T,Fujita T

更新日期：1988-12-01 00:00:00

abstract：:Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In additi...

journal_title：Endocrinology

authors： Chawla A,Schwarz EJ,Dimaculangan DD,Lazar MA

更新日期：1994-08-01 00:00:00

abstract：:Protein iodination in the thyroid is largely confined to the surface of the epithelium. Intracellular iodine binding is insignificant. We have tested our hypothesis that the key mechanism in the control of intracellular iodination is the control of the intracellular availability of H2O2. The sites of iodination were i...

journal_title：Endocrinology

authors： Ekholm R,Björkman U

更新日期：1997-07-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00

abstract：:The calbindins are Ca-binding proteins whose expression is regulated by 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D3. The calbindins are found in high amounts in the proximal intestine (calbindin-D-9k) and the kidney (calbindin-D-28k), and they are thought to play a role in Ca transport by these tissu...

journal_title：Endocrinology

authors： Armbrecht HJ,Boltz M,Strong R,Richardson A,Bruns ME,Christakos S

更新日期：1989-12-01 00:00:00

abstract：:Estrogen regulates the function, growth, and proliferation of lactotropes in the pituitary. We report here that low-density lipoprotein (LDL) receptor (LDLR) gene expression and LDL uptake are strongly up-regulated by estrogen in pituitary somatolactotropic GH(3) cells. The uptake of LDL was significantly inhibited by...

journal_title：Endocrinology

authors： Smith PM,Cowan A,White BA

更新日期：2004-07-01 00:00:00

abstract：:Potassium deficiency produced by feeding mice a low potassium diet caused a marked decrease in plasma and testicular testosterone concentrations and a concomitant fall in the weight of seminal vesicles and in renal ornithine decarboxylase activity. All of these parameters were rapidly restored when potassium supply wa...

journal_title：Endocrinology

authors： Sánchez-Capelo A,Castells MT,Cremades A,Peñafiel R

更新日期：1996-09-01 00:00:00

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the endogenous GnRH signal required to induce and maintain a LH surge of full amplitude and duration. For this purpose, we assessed the effect of a competitive GnRH...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Caraty A,Padmanabhan V,Thrun LA,Karsch FJ

更新日期：1996-11-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or genetic disruption of sympathetic outflow to bone induces bone gain in rodents. These recent findings implied that ...

journal_title：Endocrinology

authors： Ma Y,Nyman JS,Tao H,Moss HH,Yang X,Elefteriou F

更新日期：2011-04-01 00:00:00

abstract：:Oxytocin (OT) has a dual action in the uterus: a uterotonic action on myometrial cells and a prostaglandin (PG)-releasing action on endometrial/decidual cells. It had not been determined whether the OT-binding sites or receptors on the myometrial and the endometrial/decidual membranes are of the same type or may repre...

journal_title：Endocrinology

authors： Chan WY,Chen DL,Manning M

更新日期：1993-03-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...

journal_title：Endocrinology

authors： den Boon FS,de Vries T,Baelde M,Joëls M,Karst H

更新日期：2019-04-01 00:00:00

abstract：:Human erythropoietin (EPO) is a glycoprotein hormone secreted from the kidney and controls red blood cell production. EPO has a wide clinical use in the treatment of anemia associated with renal disease, certain chronic diseases, and anemia related to chemotherapy and radiotherapy. One major issue regarding the clinic...

journal_title：Endocrinology

authors： Fares F,Ganem S,Hajouj T,Agai E

更新日期：2007-10-01 00:00:00

abstract：:Impaired wound healing of skin is one of the most serious complications of diabetes. However, the pathogenesis of this process is not known, and it is unclear whether impaired insulin signaling could directly affect skin physiology. To elucidate the role of insulin in skin, we studied skin insulin receptor (IR) null m...

journal_title：Endocrinology

authors： Wertheimer E,Spravchikov N,Trebicz M,Gartsbein M,Accili D,Avinoah I,Nofeh-Moses S,Sizyakov G,Tennenbaum T

更新日期：2001-03-01 00:00:00

abstract：:Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 thera...

journal_title：Endocrinology

authors： O'Sullivan U,Gluckman PD,Breier BH,Woodall S,Siddiqui RA,McCutcheon SN

更新日期：1989-11-01 00:00:00

abstract：:Levels of vasopressin, oxytocin, and neurophysin were measured by RIA in the hypothalamus, pituitary, and plasma of infant rats (2-30 days old). At all ages, ip injection of a hypertonic solution of 5 g/100 ml NaCl produced a marked increase in levels of vasopressin and neurophpysin in plasma, up to 21 microU/ml and 5...

journal_title：Endocrinology

authors： Singinq C,Robinson AG,Seif SM

更新日期：1980-09-01 00:00:00

abstract：:The rat esophagus shares some cellular features with skin squamous epithelium and striated muscle that express high levels of corticotropin-releasing factor type 2 (CRF2) receptors or their cognate ligand urocortin (Ucn) 1, 2, and 3. We investigated the expression and cell signaling of CRF2 receptors and ligands in th...

journal_title：Endocrinology

authors： Wu SV,Yuan PQ,Wang L,Peng YL,Chen CY,Taché Y

更新日期：2007-04-01 00:00:00

abstract：:We have previously reported that the acute injection of interleukin-1 beta (IL-1 beta) into the brain ventricles of intact female rats promptly decreases LHRH release and inhibits gene expression of this peptide in the medial preoptic area (MPOA). The present studies were therefore designed to determine whether contin...

journal_title：Endocrinology

authors： Rivest S,Lee S,Attardi B,Rivier C

更新日期：1993-12-01 00:00:00

abstract：:IGFs (IGF-I and IGF-II) are essential for development, and their bioactivities are tightly regulated by six related IGF-binding proteins (IGFBPs). IGFBP-5 is the most highly conserved binding protein and is expressed in several key developmental lineages as well as in multiple adult tissues including the mammary gland...

journal_title：Endocrinology

authors： Ning Y,Hoang B,Schuller AG,Cominski TP,Hsu MS,Wood TL,Pintar JE

更新日期：2007-05-01 00:00:00

abstract：:This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...

journal_title：Endocrinology

authors： Foster DL,Ebling FJ,Claypool LE,Woodfill CJ

更新日期：1988-09-01 00:00:00

abstract：:Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysacc...

journal_title：Endocrinology

authors： Coste SC,Heldwein KA,Stevens SL,Tobar-Dupres E,Stenzel-Poore MP

更新日期：2001-08-01 00:00:00