The mouse prolactin gene family locus.

abstract：:Growth hormone-releasing factor-like immunoreactivity (GRF-LI) was detected in partially purified extracts of rat hypothalamus and duodenum with a highly specific RIA for rat GRF (rGRF). The concentration of rGRF-LI in the rat hypothalamus was 32.5 fmol/mg dry weight (455 fmol or 3.18 ng/region), while the rat duodenu...

journal_title：Endocrinology

authors： Bruhn TO,Mason RT,Vale WW

更新日期：1985-10-01 00:00:00

abstract：:Androgens are the primary regulators of epididymal structure and functions. Principal cells are the major cell type of the tissue and are particularly sensitive to androgen removal. To distinguish the direct effects of androgens on this cell type, DNA microarrays were used to identify androgen-regulated genes in the m...

journal_title：Endocrinology

authors： Seenundun S,Robaire B

更新日期：2007-01-01 00:00:00

abstract：:The establishment of dominant ovarian follicles that are capable of ovulating fertilizable oocytes is a fundamental determinant of female fertility. This process is governed by pituitary gonadotropins as well as local ovarian factors. Within the follicle, estrogen acts in an autocrine/paracrine manner to enhance FSH a...

journal_title：Endocrinology

authors： Otsuka F,Moore RK,Wang X,Sharma S,Miyoshi T,Shimasaki S

更新日期：2005-08-01 00:00:00

abstract：:Induction of cyclin proteins is required for progression of cells through the G(1)-S and G(2)-M cell cycle checkpoints and is a primary mechanism by which mitogens regulate cell cycle progression. IGF-I and the epidermal growth factor (EGF)-related ligands are mitogens for mammary epithelial cells in vitro and are ess...

journal_title：Endocrinology

authors： Stull MA,Richert MM,Loladze AV,Wood TL

更新日期：2002-05-01 00:00:00

abstract：:Aldo-keto-reductase 1B7/mouse vas deferens protein (AKR1B7/MVDP) is expressed in rodent steroidogenic glands and in the mouse vas deferens. In steroidogenic organs, AKR1B7/MVDP scavenges isocaproaldehyde produced from the cholesterol side-chain cleavage reaction. Akr1b7/mvdp is responsive to ACTH in adrenals and to an...

journal_title：Endocrinology

authors： Martinez A,Val P,Sahut-Barnola I,Aigueperse C,Veyssière G,Lefrançois-Martinez AM

更新日期：2003-05-01 00:00:00

abstract：:A [3H]colchicine-binding assay was employed for estimating the relative amounts of soluble and polymerized tubulin present in an individual anterior pituitary lobe. Colchicine binding to these two tubulin pools was time dependent and dose responsive. Scatchard analysis of the binding revealed that [3H]colchicine bound...

journal_title：Endocrinology

authors： Ravindra R,Grosvenor CE

更新日期：1988-01-01 00:00:00

abstract：:Genetically obese Zucker rats, like obese humans, have normal or elevated circulating insulin-like growth factor-I (IGF-I) levels in the presence of low GH secretion. Hyperinsulinemia, increased energy status, or other nutritional factors associated with obesity could be responsible for these findings directly by incr...

journal_title：Endocrinology

authors： Melián E,Velasco B,Barrios R,Sanchez-Franco F

更新日期：1997-03-01 00:00:00

abstract：:The effects of hypophysectomy and GH on blood pressure and renin secretion were studied. Within 2 weeks after removal of the pituitary gland of rats, mean arterial blood pressure declined 30%, and heart rate fell 50%. No significant effect of hypophysectomy on blood volume or hematocrit was noted. Within 2 h after the...

journal_title：Endocrinology

authors： Honeyman TW,Goodman HM,Fray JC

更新日期：1983-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) comprise one of the largest subgroups in the TGF-β ligand superfamily. We have identified a functional BMP system equipped with the ligand (BMP4), receptors (BMP type II receptor, BMP type IA receptor, also called ALK3) and the signaling proteins, namely the mothers against decapenta...

journal_title：Endocrinology

authors： Rege J,Nishimoto HK,Nishimoto K,Rodgers RJ,Auchus RJ,Rainey WE

更新日期：2015-07-01 00:00:00

abstract：:The pancreatic polypeptide cell, the only mature endocrine cell in the fetal pig pancreas, produces equimolar amounts of two peptides, pancreatic polypeptide and pancreatic icosapeptide, from the same precursor. The amino acid sequence of pancreatic polypeptide is more homogeneous among species, whereas pancreatic ico...

journal_title：Endocrinology

authors： Amaratunga A,Tuch BE,Han XG,Georges P,Dean SK,Scott H

更新日期：2001-10-01 00:00:00

abstract：:The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it's potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by alpha-helical CRH attenuates conditioned fear ...

journal_title：Endocrinology

authors： Deak T,Nguyen KT,Ehrlich AL,Watkins LR,Spencer RL,Maier SF,Licinio J,Wong ML,Chrousos GP,Webster E,Gold PW

更新日期：1999-01-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00

abstract：:Intravascular injections of adrenocorticotropic hormone in hypophysectomized rats were approximately 3 times more effective in stimulating increases in plasma corticosteroid concentration when given at the offset rather than the onset of the daily photoperiod (12 h:12 h light-dark cycle). Reversal of the photoperiodic...

journal_title：Endocrinology

authors： Ottenweller JE,Meier AH,Ferrell BR,Horseman ND,Proctor A

更新日期：1978-11-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00

abstract：:The Rice H500 rat Leydig cell tumor is a well characterized model of humoral hypercalcemia of malignancy (HHM). Circulating concentrations of PTH-related protein (PTHRP) have not been reported in this or any other animal model of HHM. Taking advantage of the marked N-terminal amino acid homology between rodent and hum...

journal_title：Endocrinology

authors： Gaich G,Burtis WJ

更新日期：1990-09-01 00:00:00

abstract：:A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...

journal_title：Endocrinology

authors： Mroczkowski B,Reich M

更新日期：1993-01-01 00:00:00

abstract：:The effect of synthetic ovine CRF on ACTH secretion of dispersed, domestic fowl pituitary cells was investigated. Cells preincubated for 2 h, 16 h, or after 48-h culture were incubated briefly with CRF (up to 4 h). ACTH was bioassayed using isolated rat adrenocortical cells; ACTH-(1-24) served as the standard for expr...

journal_title：Endocrinology

authors： Carsia RV,Weber H,Perez FM Jr

更新日期：1986-01-01 00:00:00

abstract：:The nuclear receptor peroxisome proliferator-activated receptor (PPAR)gamma modulates the expression of numerous genes involved in glucose and lipid homeostasis and plays a critical role in adipocyte differentiation. Expression of uncoupling protein (UCP)1, which is necessary for thermogenesis, is strongly stimulated ...

journal_title：Endocrinology

authors： Sell H,Berger JP,Samson P,Castriota G,Lalonde J,Deshaies Y,Richard D

更新日期：2004-08-01 00:00:00

abstract：:The insulin receptor substrates (IRSs) are key proteins in signal transduction from the insulin receptor. Recently, we discovered a fourth member of this family, designated IRS-4, cloned its complementary DNA from the human embryonic kidney 293 cell line, and characterized its signaling properties in this cell line. A...

journal_title：Endocrinology

authors： Fantin VR,Lavan BE,Wang Q,Jenkins NA,Gilbert DJ,Copeland NG,Keller SR,Lienhard GE

更新日期：1999-03-01 00:00:00

abstract：:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...

journal_title：Endocrinology

authors： Naylor PH,Gilani SS,Milholland RJ,Rosen F

更新日期：1980-07-01 00:00:00

abstract：:FSH stimulates follicular growth through inducing granulosa cell proliferation. Our working hypothesis is that mitogenesis is facilitated by a locally produced growth/differentiation factor(s) that modulates FSH action in developing granulosa cells. The present study was undertaken to examine the effect of the related...

journal_title：Endocrinology

authors： Miró F,Hillier SG

更新日期：1996-02-01 00:00:00

abstract：:The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin...

journal_title：Endocrinology

authors： Nøhr MK,Pedersen MH,Gille A,Egerod KL,Engelstoft MS,Husted AS,Sichlau RM,Grunddal KV,Poulsen SS,Han S,Jones RM,Offermanns S,Schwartz TW

更新日期：2013-10-01 00:00:00

abstract：:The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...

journal_title：Endocrinology

authors： Hauner H

更新日期：1990-08-01 00:00:00

abstract：:Although factors that regulate cAMP and steroid production in granulosa cells of hen preovulatory follicles have been well studied, much less is known of the mechanisms that control steroidogenesis in the adjacent thecal layer. These studies were conducted to examine the involvement and interaction of cAMP and protein...

journal_title：Endocrinology

authors： Tilly JL,Johnson AL

更新日期：1989-09-01 00:00:00

abstract：:Attempts to assess human placental GH variant (hGH-V) and chorionic somatomammotropin (hCS) RNA in choriocarcinoma cell lines have been hampered by low levels of expression and limited sensitivity of RNA blotting analysis. We examined human choriocarcinoma BeWo, JAR, and JEG-3 cell lines as well as samples of complete...

journal_title：Endocrinology

authors： Lytras A,Bock ME,Dodd JG,Cattini PA

更新日期：1994-06-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar resul...

journal_title：Endocrinology

authors： Campbell WB,Pettinger WA

更新日期：1975-12-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...

journal_title：Endocrinology

authors： den Boon FS,de Vries T,Baelde M,Joëls M,Karst H

更新日期：2019-04-01 00:00:00

abstract：:The study of the biochemical mechanisms regulating the differentiation of the ovarian androgen-producing cells has been difficult because of the lack of a method for isolating the theca-interstitial cells (TIC) from the granulosa and other cell types. We report here a simple, rapid and reproducible method for obtainin...

journal_title：Endocrinology

authors： Magoffin DA,Erickson GF

更新日期：1988-05-01 00:00:00

abstract：:GH is believed to play a role in promoting insulin resistance in patients with diabetes and with GH excess. The means by which GH produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose ...

journal_title：Endocrinology

authors： Foster CM,Hale PM,Jing HW,Schwartz J

更新日期：1988-08-01 00:00:00