Measurement of circulating parathyroid hormone-related protein in rats with humoral hypercalcemia of malignancy using a two-site immunoradiometric assay.

abstract：:The effects of undernutrition on the timing of puberty and regulation of LH secretion by the inhibitory and stimulatory feedback action of estradiol were examined in female sheep. The first experiment determined that maintenance of low BW (ca., 20 kg, four lambs) between 10 and 45 weeks of age prevented initiation of ...

journal_title：Endocrinology

authors： Foster DL,Olster DH

更新日期：1985-01-01 00:00:00

abstract：:Limited proteolysis in vivo of insulin-like growth factor-binding protein-3 (IGFBP-3) by as yet unidentified serine proteases plays a key role in controlling the bioavailability of IGFBP-3-associated insulin-like growth factors (IGFs). Both the IGF system and the system of plasminogen activators (PAs) and their inhibi...

journal_title：Endocrinology

authors： Lalou C,Silve C,Rosato R,Segovia B,Binoux M

更新日期：1994-12-01 00:00:00

abstract：:Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...

journal_title：Endocrinology

authors： Sauter NS,Schulthess FT,Galasso R,Castellani LW,Maedler K

更新日期：2008-05-01 00:00:00

abstract：:Pancreatic membrane receptors for cholecystokinin (CCK) in obese and nonobese Zucker rats were compared with the use of a biologically active [125I]iodo-CCK-8 radioprobe. Membrane homogenates from obese rats bound half the amount of radioligand in 2 h as did membranes from lean rats (specifically bound, 7.0% vs. 14.0%...

journal_title：Endocrinology

authors： Praissman M,Izzo RS

更新日期：1986-08-01 00:00:00

abstract：:Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

journal_title：Endocrinology

authors： Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

更新日期：2008-11-01 00:00:00

abstract：:The effects of nerve activation and of the catecholamines epinephrine and norepinephrine on adrenal corticosteroid release were investigated in intact isolated perfused pig adrenals with preserved nerve supply. To study the contact zones of medullary and cortical tissues, porcine adrenals were examined on the histolog...

journal_title：Endocrinology

authors： Bornstein SR,Ehrhart-Bornstein M,Scherbaum WA,Pfeiffer EF,Holst JJ

更新日期：1990-08-01 00:00:00

abstract：:The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone (GHRH)-containing neurosecretory cells located in the hypothalamus. In this study we examined whether there is s...

journal_title：Endocrinology

authors： Argente J,Chowen JA,Zeitler P,Clifton DK,Steiner RA

更新日期：1991-05-01 00:00:00

abstract：:Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...

journal_title：Endocrinology

authors： Michael SD,Taguchi O,Nishizuka Y

更新日期：1981-06-01 00:00:00

abstract：:The brain has traditionally been considered to be a target site of peripheral steroid hormones. By contrast, new findings over the past decade have shown that the brain itself also has the capability of forming steroids de novo, the so-called neurosteroids. De novo neurosteroidogenesis in the brain from cholesterol is...

journal_title：Endocrinology

authors： Tsutsui K

更新日期：2008-06-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:The experimental induction of puberty by GnRH administration to prepubertal lambs increases serum bioactive FSH (B-FSH) as measured in the rat Sertoli cell aromatase induction bioassay. Serum immunoreactive FSH (I-FSH) levels are unchanged. The increase in serum B-FSH is associated with an increase in the proportion o...

journal_title：Endocrinology

authors： Hassing JM,Kletter GB,I'Anson H,Wood RI,Beitins IZ,Foster DL,Padmanabhan V

更新日期：1993-04-01 00:00:00

abstract：:Somatostatin has been demonstrated to negatively regulate pancreatic growth in vivo. In this study we used the AR4-2J rat pancreatic acinar tumor cell line to investigate the effect of a stable somatostatin analog, SMS 201-995 (SMS) on cell proliferation. SMS induced an antiproliferative effect on both serum or epider...

journal_title：Endocrinology

authors： Viguerie N,Tahiri-Jouti N,Ayral AM,Cambillau C,Scemama JL,Bastié MJ,Knuhtsen S,Estève JP,Pradayrol L,Susini C

更新日期：1989-02-01 00:00:00

abstract：:The enteroendocrine and enteric nervous systems convey signals through an overlapping network of regulatory peptides that act either as circulating hormones or as localized neurotransmitters within the gastrointestinal tract. Because recent studies invoke an important role for vasoactive intestinal peptide (VIP) as a ...

journal_title：Endocrinology

authors： Yusta B,Holland D,Waschek JA,Drucker DJ

更新日期：2012-06-01 00:00:00

abstract：:Pulmonary alveolar type 2 cells act as a reservoir of stem cells which can be induced to proliferate during periods of lung growth and repair after lung injury. Despite the importance of this process, the mechanisms that regulate type 2 cell proliferation have not been well characterized. We show in this study that in...

journal_title：Endocrinology

authors： Mouhieddine OB,Cazals V,Maitre B,Le Bouc Y,Chadelat K,Clement A

更新日期：1994-07-01 00:00:00

abstract：:During the preovulatory and estradiol-progesterone-induced GnRH-LH surge, a subpopulation of GnRH neurons transiently expresses the transcription factor c-fos, which is a useful marker of cell activation. To further characterize this subpopulation of GnRH neurons, multiple immunohistochemical procedures were applied t...

journal_title：Endocrinology

authors： Eyigor O,Jennes L

更新日期：2000-02-01 00:00:00

abstract：:We have previously reported that the acute injection of interleukin-1 beta (IL-1 beta) into the brain ventricles of intact female rats promptly decreases LHRH release and inhibits gene expression of this peptide in the medial preoptic area (MPOA). The present studies were therefore designed to determine whether contin...

journal_title：Endocrinology

authors： Rivest S,Lee S,Attardi B,Rivier C

更新日期：1993-12-01 00:00:00

abstract：:The existence of renin in a number of extrarenal tissues has been well documented, but the physiological role of extrarenal renin remains unknown. To study the physiological role of adrenal renin, we developed a serum-free culture system for adrenal capsular/zona glomrulosa explants. Explants showed good viability in ...

journal_title：Endocrinology

authors： Shier DN,Kusano E,Stoner GD,Franco-Saenz R,Mulrow PJ

更新日期：1989-07-01 00:00:00

abstract：:Cholecystokinin (CCK)/gastrin receptors were characterized in calf pancreatic plasma membranes from newborns, 28- and 119-day-old milk-fed preruminants, and 119-day-old weaned ruminants. Scatchard analysis of [125I]Bolton-Hunter reagent-[Thr28,Nle31]CCK-(25-33) binding indicated two classes of binding sites: high affi...

journal_title：Endocrinology

authors： Le Meuth V,Philouze-Rome V,Le Huerou-Luron I,Formal M,Vaysse N,Gespach C,Guilloteau P,Fourmy D

更新日期：1993-09-01 00:00:00

abstract：:The aim of our study was to isolate and identify novel proteins that are involved in the process of ovulation. To achieve this goal we used the technique of proteome analysis. Comparison of ovary protein patterns, obtained by high resolution two-dimensional gel electrophoresis from recombinant FSH (rFSH)- and rFSH + h...

journal_title：Endocrinology

authors： Brockstedt E,Peters-Kottig M,Badock V,Hegele-Hartung C,Lessl M

更新日期：2000-07-01 00:00:00

abstract：:To elucidate the ligand-receptor relationship of the natriuretic peptide system, which comprises at least three endogenous ligands, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and three receptors, the ANP-A receptor or guanylate cyclase-A (GC-A), the ANP-B r...

journal_title：Endocrinology

authors： Suga S,Nakao K,Hosoda K,Mukoyama M,Ogawa Y,Shirakami G,Arai H,Saito Y,Kambayashi Y,Inouye K

更新日期：1992-01-01 00:00:00

abstract：:The GH/IGF-I axis has both pre- and postpubertal metabolic effects. However, the differential effects of GH and/or IGF-I on animal physiology or the plasma proteome are still being unraveled. In this report, we analyzed several physiological effects along with the plasma proteome after treatment of mice with recombina...

journal_title：Endocrinology

authors： Ding J,List EO,Bower BD,Kopchick JJ

更新日期：2011-10-01 00:00:00

abstract：:In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...

journal_title：Endocrinology

authors： Gallardo N,Arribas C,Villar M,Ros M,Carrascosa JM,Martínez C,Andrés A

更新日期：2005-11-01 00:00:00

abstract：:cAMP has been shown to mediate the response of the parathyroid gland to a number of agonists and appears to take part in the regulation of this gland by divalent cations as well. We have studied the effects of the concentrations of free magnesium (Mg+2) and ionic calcium (Ca+2) on the kinetic properties of normal porc...

journal_title：Endocrinology

authors： Oldham SB,Rude RK,Molloy CT,Lipson LG

更新日期：1984-11-01 00:00:00

abstract：:Apoptosis is a physiological process by which multicellular organisms eliminate unwanted cells. Death factors such as Fas ligand induce apoptosis by triggering a series of intracellular protein-protein interactions mediated by defined motifs found in the signaling molecules. One of these motifs is the death effector d...

journal_title：Endocrinology

authors： Leo CP,Hsu SY,McGee EA,Salanova M,Hsueh AJ

更新日期：1998-12-01 00:00:00

abstract：:Testes of 29-35-day-old rats were separated into seminiferous tubules and interstitial tissue by collagenase treatment and examined by incubation studies with radioactive substrates. The activity of testosterone 5alpha-reductase/g protein in the interstitial tissue was 37 times greater than that in the tubules. The si...

journal_title：Endocrinology

authors： Yoshizaki K,Matsumoto K,Samuels LT

更新日期：1978-03-01 00:00:00

abstract：:We have compared the influence of insulin-like growth factor 1 (IGF-1) on pituitary gene expression in the rat cell lines GH4C1 and GH3. Incubation with IGF-1 increased PRL messenger RNA (mRNA) levels in GH4C1 cells by 4- to 5-fold but decreased the levels of PRL transcripts in GH3 cells. In addition, the levels of GH...

journal_title：Endocrinology

authors： Castillo AI,Aranda A

更新日期：1997-12-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00

abstract：:Glucose release from the liver is mediated by hypothalamic norepinephrine (NE) neuronal activity, but glucose itself (or a metabolite of it) exerts negative feedback effects on central NE activity. The aim of the present study was to investigate a possible role for insulin in these central glucose homeostatic mechanis...

journal_title：Endocrinology

authors： Smythe GA,Bradshaw JE,Nicholson MV,Grunstein HS,Storlien LH

更新日期：1985-10-01 00:00:00

abstract：:The effect of gonadotropins on phosphodiesterase activity of rat granulosa cells was studied in an in vitro model. Granulosa cells were prepared from hypophysectomized or intact, estrogen-primed immature female rats and treated with FSH, hCG, or (Bu)2cAMP in vitro. Phosphodiesterase activity was determined in cell hom...

journal_title：Endocrinology

authors： Conti M,Kasson BG,Hsueh AJ

更新日期：1984-06-01 00:00:00