Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development.


:The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone (GHRH)-containing neurosecretory cells located in the hypothalamus. In this study we examined whether there is sexual dimorphism in the expression of the SS and GHRH genes and, if so, at what developmental stage this becomes evident. To address these questions, we measured SS messenger RNA (mRNA) levels in neurons of the periventricular nucleus and GHRH mRNA levels in the arcuate nucleus and ventromedial nucleus of the hypothalamus in male and female rats at 10, 25, 35, and 75 days of age. Using in situ hybridization and a computerized image analysis system, we measured SS mRNA and GHRH mRNA signal levels in individual neurons and compared these levels among the different age groups. We found that male animals had significantly higher levels of SS mRNA than females at every age. Similarly, males had higher GHRH mRNA levels than females; however, this difference was statistically significant only at 10 and 75 days of age. Developmental changes in GHRH mRNA levels were similar for both sexes, with GHRH message levels increasing gradually over the course of maturation. SS mRNA signal levels also changed over the course of development in both male and female animals. In the male rat, SS mRNA levels increased significantly between 10 and 25 days of age and declined significantly between 35 and 75 days of age. In the female rat, SS mRNA levels increased gradually between 10 and 35 days of age, then, as in the male, declined significantly between days 35 and 75. We conclude that sex differences and age-dependent changes in the expression of the SS and GHRH genes may subserve the sexual dimorphism and developmental alterations in the pattern of GH secretion in the rat.






Argente J,Chowen JA,Zeitler P,Clifton DK,Steiner RA




Has Abstract


1991-05-01 00:00:00












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    pub_type: 杂志文章


    authors: Glass AR,Young RA,Anderson J

    更新日期:1986-06-01 00:00:00

  • Heparan sulfate proteoglycans regulate responses to oocyte paracrine signals in ovarian follicle morphogenesis.

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    pub_type: 杂志文章


    authors: Watson LN,Mottershead DG,Dunning KR,Robker RL,Gilchrist RB,Russell DL

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  • 17 beta-estradiol and parathyroid hormone potentiate each other's stimulatory effects on alkaline phosphatase activity in SaOS-2 cells in a differentiation-dependent manner.

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    pub_type: 杂志文章


    authors: Rao LG,Wylie JN,Sutherland MS,Murray TM

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  • Androgen Receptor Involvement in Rat Amelogenesis: An Additional Way for Endocrine-Disrupting Chemicals to Affect Enamel Synthesis.

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    pub_type: 杂志文章


    authors: Kao LW,Weisz J

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    pub_type: 杂志文章


    authors: Hinko A,Soloff MS

    更新日期:1993-01-01 00:00:00

  • Estrogen acidifies vaginal pH by up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells.

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    pub_type: 杂志文章


    authors: Gorodeski GI,Hopfer U,Liu CC,Margles E

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    pub_type: 杂志文章


    authors: Lee H,Struman I,Clapp C,Martial J,Weiner RI

    更新日期:1998-09-01 00:00:00

  • The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor.

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    authors: Maile LA,Clemmons DR

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    pub_type: 杂志文章


    authors: Yasuda N,Takebe K,Greer MA

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    authors: Haskins JT,Gudelsky GA,Moss RL,Porter JC

    更新日期:1981-03-01 00:00:00

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    authors: Maayan ML,Sellitto RV,Volpert EM

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  • RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice.

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  • To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals.

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  • Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

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  • Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility.

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    pub_type: 杂志文章


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    更新日期:2017-07-01 00:00:00