Abstract:
:Previous studies have shown that increased sodium chloride in drinking water failed to suppress serum renin activity (SRA) in the etheranesthetized rat. In the absence of anesthesia, sodium chloride decreased SRA by 76% and serum aldosterone by 72%. Deoxycorticosterone acetate, when given alone, produced similar results but was more effective in reducing SRA (96%) when combined with sodium chloride. However, if "light" ether anesthesia was administered prior to blood collection, there was a 10-fold increase in SRA and the effects of sodium chloride were blocked. Thus, in the absence of anesthesia, the renin-angiotensin-aldosterone system of the rat responds, as in other species, to a sodium load.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Campbell WB,Pettinger WAdoi
10.1210/endo-97-6-1394subject
Has Abstractpub_date
1975-12-01 00:00:00pages
1394-7issue
6eissn
0013-7227issn
1945-7170journal_volume
97pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0631
更新日期:2008-11-01 00:00:00
abstract::Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.5.7956920
更新日期:1994-11-01 00:00:00
abstract::In the gonads and adrenal glands, the transient increase in steroidogenesis after hormonal stimulation requires modulation of steroidogenic acute regulatory protein (Star) expression and activity in a tightly regulated process involving cAMP and Ca(2+). In Leydig cells, the cAMP and Ca(2+) pathways account for most if...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1767
更新日期:2013-01-01 00:00:00
abstract::Isolated growth hormone deficiency type II (IGHD2) is mainly caused by heterozygous splice-site mutations in intron 3 of the GH1 gene. A dominant-negative effect of the mutant GH lacking exon 3 on wild-type GH secretion has been proposed; however, the molecular mechanisms involved are elusive. To uncover the molecular...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2019-00306
更新日期:2019-11-01 00:00:00
abstract::In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1133
更新日期:2013-09-01 00:00:00
abstract::Fundamental complications of insulin resistance and type 2 diabetes include the development of nonalcoholic fatty liver disease and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very-low-density lipoprotein (VLDL) production. Recently, central glucagon-like peptide-2 receptor (GLP2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00416
更新日期:2018-09-01 00:00:00
abstract::Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1081
更新日期:2009-03-01 00:00:00
abstract::Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat that a 22% reduction in bone mineral density generated by ovariectomy was associated with a 2-fold reduction of transforming growth factor-beta 3 (TGF beta 3) messenger RNA expression in th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.5.8612550
更新日期:1996-05-01 00:00:00
abstract::Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqz033
更新日期:2020-02-01 00:00:00
abstract::Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.1.7375
更新日期:2000-01-01 00:00:00
abstract::The action of added insulin-like growth factor-I (IGF-I) and dihydrotestosterone (DHT) on steroid 5 alpha-reductase (5 alpha R) activity was studied using primary cultures of rat or human scrotal skin fibroblasts. Agents were added to cultured cells (2 x 10(5) cells) for 2 days, and enzyme activity was measured by the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.2.8344190
更新日期:1993-08-01 00:00:00
abstract::The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1125
更新日期:2004-05-01 00:00:00
abstract::The biosynthesis of various hypothalamic neuropeptides has been previously reported in anterior pituitary cells but not in intermediate lobe cells. We have recently demonstrated the occurrence of two somatostatin isoforms in the frog brain, namely somatostatin-14 (SS1) and [Pro(2),Met(13)]somatostatin-14 (SS2). In the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220406
更新日期:2002-09-01 00:00:00
abstract::Daily treatment with 1 mg of the GnRH antagonist [Ac-delta 3-Pro1,pC1-D-Phe2,D-Trp3,6,N alpha MeLeu7]-GnRH abolished mating behavior and disrupted spermatogenesis in male rats within 2 weeks. This was accompanied by a sharp decrease in plasma testosterone (T) levels as well as sexual organ weights while body weight re...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-5-1998
更新日期:1981-05-01 00:00:00
abstract::In young adult female rats, the patterns of inhibin subunit mRNA expression during the estrous cycle are regulated by cyclic changes in gonadotropin secretion and follicular development. Since there are distinct alterations in profiles of both hormone secretion and folliculogenesis during the reproductive lifespan of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.1.8419130
更新日期:1993-01-01 00:00:00
abstract::Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220321
更新日期:2002-11-01 00:00:00
abstract::Women with type 1 diabetes are subfertile. Diabetes negatively affects pregnancy by causing early miscarriage and poor prenatal outcomes. In this study we examine consequences of maternal type 1 diabetes on early embryo development, metabolic gene expression, and the pattern of insulin receptor (IR) and IGF-I receptor...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-0187
更新日期:2010-09-01 00:00:00
abstract::This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.5.7956910
更新日期:1994-11-01 00:00:00
abstract::Mast cells are involved in atopic disorders, often exacerbated by stress, and are located perivascularly close to sympathetic and sensory nerve endings. Mast cells are activated by electrical nerve stimulation and millimolar concentrations of neuropeptides, such as substance P (SP). Moreover, acute psychological stres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.1.5660
更新日期:1998-01-01 00:00:00
abstract::Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-5-1745
更新日期:1984-05-01 00:00:00
abstract::The ability of cultured midpregnancy mouse ovarian cells to synthesize progesterone de novo and from oxogenous pregnenolone has been assessed. The conversion of pregnenolone to progesterone is almost completely blocked by cyanoketone, a known inhibitor of delta5,3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-3-800
更新日期:1976-09-01 00:00:00
abstract::High-fat diet and intrauterine growth retardation may predispose to obesity, insulin resistance, and type 2 diabetes. Because prenatal ethanol (ETOH) exposure causes intrauterine growth retardation, we investigated its interactions with postnatal high-fat diet on glucose tolerance and adipocyte-derived hormones in the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220623
更新日期:2003-02-01 00:00:00
abstract::Estradiol (E) treatment of spayed macaques induces progestin receptors (PR) in pituitary gonadotropes, but not lactotropes. In contrast, levels of pituitary estrogen receptors (ER) remain constant in spayed or E-treated monkeys. In monkey pituitary cultures, the number of PR-positive cells varies depending on the dono...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-4-1907
更新日期:1991-04-01 00:00:00
abstract::To study the transcriptional regulation of the vasopressin gene in vitro, 3 kb of the 5' regulatory region of the rat vasopressin gene was isolated and subcloned, along with a series of various deletion mutants, into vectors containing the luciferase reporter gene. After transfecting these genes transiently into the h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.12.5639
更新日期:1997-12-01 00:00:00
abstract::We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-subunit by muscle electroporation in female BALB/c mice. The onset of orbital pathology is characterized by muscle inflammation, adipogenesis, and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1829
更新日期:2016-04-01 00:00:00
abstract::The effects of gamma-aminobutyric acid (GABA) on the spontaneous and TRH-induced TSH release were investigated in vitro on perifused rat pituitaries. The dynamic pattern of TSH release was measured in response to a 6-min pulse of TRH (10 nM) with or without GABA addition. GABA had no effect on spontaneous TSH release ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-3-980
更新日期:1987-09-01 00:00:00
abstract::Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhib...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-4-1697
更新日期:1986-10-01 00:00:00
abstract::To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-106-1-19
更新日期:1980-01-01 00:00:00
abstract::In mammals, adrenal medulla chromaffin cells constitute a fundamental component of the sympathetic nervous system outflow, producing most of the circulating adrenaline. We recently found that the rhesus monkey adrenal gland expresses several genes in a 24-h rhythmic pattern, including TH (the rate-limiting enzyme in c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0610
更新日期:2007-12-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.12.6336
更新日期:1998-12-01 00:00:00