Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock.

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...

journal_title：Endocrinology

authors： Abboud M,Puglisi DA,Davies BN,Rybchyn M,Whitehead NP,Brock KE,Cole L,Gordon-Thomson C,Fraser DR,Mason RS

更新日期：2013-09-01 00:00:00

abstract：:Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...

journal_title：Endocrinology

authors： Bai JX,Yan B,Zhao ZN,Xiao X,Qin WW,Zhang R,Jia LT,Meng YL,Jin BQ,Fan DM,Wang T,Yang AG

更新日期：2013-02-01 00:00:00

abstract：:The antral hormone gastrin and its intestinal relative, cholecystokinin (CCK), are pivotal in the regulation of gastric functions. Other gastric hormones like ghrelin, peptide YY (PYY), and islet amyloid polypeptide (IAPP), however, also contribute to the regulation of acid secretion, motility, and feeding. Because ga...

journal_title：Endocrinology

authors： Friis-Hansen L,Wierup N,Rehfeld JF,Sundler F

更新日期：2005-10-01 00:00:00

abstract：:The short loop feedback effect of PRL was studied in young (4-5 months of age) and old (24-26 months of age) ovariectomized rats after a single iv injection of bovine PRL (bPRL, 500 micrograms/100 g BW) or BSA (500 micrograms/100 g BW). Blood samples were collected via intraatrial cannula every 20 min for assay of PRL...

journal_title：Endocrinology

authors： Sarkar DK,Miki N,Meites J

更新日期：1983-10-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:Mitochondrial reactive oxygen species have been implicated in both diabetic complications and the progression of the underlying diabetic state. However, it is not clear whether mitochondria of diabetic origin are intrinsically altered to generate excess reactive oxygen species independent of the surrounding diabetic m...

journal_title：Endocrinology

authors： Herlein JA,Fink BD,O'Malley Y,Sivitz WI

更新日期：2009-01-01 00:00:00

abstract：:Iodine deficiency (ID) induces TSH-independent microvascular activation in the thyroid via the reactive oxygen species/nitric oxide-hypoxia-inducible factor-1α/vascular endothelial growth factor (VEGF) pathway. We hypothesized the additional involvement of mammalian target of rapamycin (mTOR) as a positive regulator o...

journal_title：Endocrinology

authors： Craps J,Joris V,De Jongh B,Sonveaux P,Horman S,Lengelé B,Bertrand L,Many MC,Colin IM,Gérard AC

更新日期：2016-06-01 00:00:00

abstract：:The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for transgender individuals dramatically alters estrogen and testosterone levels and consequently could have widespread consequences for cardiovascular health. Yet, no prec...

journal_title：Endocrinology

authors： Goetz TG,Mamillapalli R,Sahin C,Majidi-Zolbin M,Ge G,Mani A,Taylor HS

更新日期：2018-02-01 00:00:00

abstract：:The rat PTH molecule contains five sequence differences from either the bovine or the human hormone within the biologically active 1-34 region. A synthetic rat 1-34 peptide was tested for activity by in vitro activation of canine and rat renal adenylate cyclase and binding to canine renal membrane receptors. The mean ...

journal_title：Endocrinology

authors： Keutmann HT,Griscom AW,Nussbaum SR,Reiner BF,Goud AN,Potts JT Jr,Rosenblatt M

更新日期：1985-09-01 00:00:00

abstract：:Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agouti yellow and melanocortin 4 receptor knockout mice. To investigate t...

journal_title：Endocrinology

authors： Kublaoui BM,Holder JL Jr,Tolson KP,Gemelli T,Zinn AR

更新日期：2006-10-01 00:00:00

abstract：:The response of purified rat testicular peritubular myoid cells (PMC) to platelet-derived growth factor (PDGF) was studied. Freshly isolated PMC were devoid of measurable amounts of PDGF-binding sites. However, after 1 day in culture in serum-free conditions, specific high affinity receptors were detected. The estimat...

journal_title：Endocrinology

authors： Gnessi L,Emidi A,Scarpa S,Palleschi S,Ragano-Caracciolo M,Silvestroni L,Modesti A,Spera G

更新日期：1993-10-01 00:00:00

abstract：:Split hand/foot malformation (SHFM) is syndromic ectrodactyly often associated with mental retardation and/or craniofacial defects. Several clinical reports previously described urogenital dysplasia such as micropenis, hypospadias, and small testis in SHFM patients. Genetic lesions in the Dlx5 and Dlx6 (Dlx5/6) locus ...

journal_title：Endocrinology

authors： Nishida H,Miyagawa S,Vieux-Rochas M,Morini M,Ogino Y,Suzuki K,Nakagata N,Choi HS,Levi G,Yamada G

更新日期：2008-05-01 00:00:00

abstract：:In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After rec...

journal_title：Endocrinology

authors： Anderson ST,Sawangjaroen K,Curlewis JD

更新日期：1996-08-01 00:00:00

abstract：:Estradiol (E) treatment of spayed macaques induces progestin receptors (PR) in pituitary gonadotropes, but not lactotropes. In contrast, levels of pituitary estrogen receptors (ER) remain constant in spayed or E-treated monkeys. In monkey pituitary cultures, the number of PR-positive cells varies depending on the dono...

journal_title：Endocrinology

authors： Sprangers SA,Fahrenbach WH,Bethea CL

更新日期：1991-04-01 00:00:00

abstract：:A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...

journal_title：Endocrinology

authors： Wannemacher RW Jr,Pekarek RS,Thompson WL,Curnow RT,Beall FA,Zenser TV,DeRubertis FR,Beisel WR

更新日期：1975-03-01 00:00:00

abstract：:Bovine placental lactogen (bPL) has been isolated from bovine trophoblast and characterized as a 32 K mol wt protein which exists in three different forms which differ in their isoelectric point values and their amino acid compositions. Two of the three forms have been shown to have both bovine GH (bGH)- and bovine PR...

journal_title：Endocrinology

authors： Duello TM,Byatt JC,Bremel RD

更新日期：1986-09-01 00:00:00

abstract：:Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons. However, the relative contributions of the two functionally distinct kisspeptin neuron subpopulations to this critical regulation are not fully understood. Here we analyzed the specific projection pa...

journal_title：Endocrinology

authors： Yip SH,Boehm U,Herbison AE,Campbell RE

更新日期：2015-07-01 00:00:00

abstract：:The adrenal medulla contains fenestrated capillaries that allow catecholamines and neuropeptides secreted by adrenal chromaffin cells (ACCs) to readily access the circulation. These capillaries may also allow bacterial products to enter the adrenal medulla and interact with ACCs during infection. One potential mediato...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2013-01-01 00:00:00

abstract：:The effects of electrical stimulation of the brain on the ovarian venous plasma concentrations of estradiol (E2) and progesterone (P) were investigated in female rats hypophysectomized and adrenalectomized at 1000 h on the day of proestrus. Stimulation was applied during the proestrous critical period under pentobarbi...

journal_title：Endocrinology

authors： Kawakami M,Kubo K,Uemura T,Nagase M,Hayashi R

更新日期：1981-07-01 00:00:00

abstract：:A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...

journal_title：Endocrinology

authors： Ionut V,Castro AV,Woolcott OO,Stefanovski D,Iyer MS,Broussard JL,Mkrtchyan H,Burch M,Elazary R,Kirkman E,Bergman RN

更新日期：2014-04-01 00:00:00

abstract：:Binding of lactogenic hormones to particulate and solubilized microsomal membranes isolated from mammary glands of lactating mice is inhibited by direct addition of 10(-10) M or greater concentrations of triphenylethylene antiestrogens [i.e. tamoxifen (TAM), 4-hydroxy-tamoxifen, and Nafoxidine] to the binding assays. ...

journal_title：Endocrinology

authors： Biswas R,Vonderhaar BK

更新日期：1991-01-01 00:00:00

abstract：:The mechanisms underlying the glucose dependence of arginine vasopressin (AVP)-stimulated insulin secretion were examined in a hamster insulin-secreting cell line (HIT cells). At 1.67 mM glucose, 100 nM AVP stimulated biphasic changes in free cytosolic Ca2+ ([Ca2+]i) and insulin secretion. The initial spike of [Ca2+]i...

journal_title：Endocrinology

authors： Lu M,Soltoff SP,Yaney GC,Boyd AE 3rd

更新日期：1993-05-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00

abstract：:The Kiss1 gene and its product kisspeptin are important regulators of reproduction. In rodents, Kiss1 is expressed in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV)/rostral periventricular (PeN) nuclei. In the AVPV/PeN, females have more Kiss1 and tyrosine hydroxylase (TH) neurons than males. ...

journal_title：Endocrinology

authors： Semaan SJ,Murray EK,Poling MC,Dhamija S,Forger NG,Kauffman AS

更新日期：2010-12-01 00:00:00

abstract：:Recent evidence suggests that the aromatization of testosterone to estrogen is important for the organizing effects of neonatal testosterone on neuroendocrine responses to acute challenges. However, the extent to which neonatal inhibition of aromatase alters the stress-induced activation of neural pathways has not bee...

journal_title：Endocrinology

authors： Bingham B,Wang NX,Innala L,Viau V

更新日期：2012-04-01 00:00:00

abstract：:Vitellogenin (Vg) is a major yolk protein precursor in numerous oviparous animals. Numerous studies in bilateral oviparous animals have shown that Vg sequences are conserved across taxa and that Vgs are synthesized by somatic-cell lineages, transported to and accumulated in oocytes, and eventually used for supporting ...

journal_title：Endocrinology

authors： Shikina S,Chen CJ,Chung YJ,Shao ZF,Liou JY,Tseng HP,Lee YH,Chang CF

更新日期：2013-09-01 00:00:00

abstract：:Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals (NLSs) within the proteins and specific NLS-binding proteins. NLSs have been identified in the hinge region of both receptors. We have identified the cellular ...

journal_title：Endocrinology

authors： LaCasse EC,Lochnan HA,Walker P,Lefebvre YA

更新日期：1993-03-01 00:00:00