Involvement of ovarian innervation in steroid secretion.

abstract：:The effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on basal and TRH-induced TSH release, and the effects of IL-1 beta on the uptake of [125I]T3 and [125I]T4 and on nuclear binding of [125I]T3 were examined. Furthermore, the release of other anterior pituitary hormones in the pres...

journal_title：Endocrinology

authors： Wassen FW,Moerings EP,Van Toor H,De Vrey EA,Hennemann G,Everts ME

更新日期：1996-05-01 00:00:00

abstract：:Ghrelin is an acylated peptide recently isolated from rat stomach that potently stimulates GH release in vitro and in vivo in rat and man. Ghrelin specifically activates the receptor for the growth hormone secretagogues (GHS-Rla), and it has been proposed as the endogenous ligand mimicked by these synthetic compounds....

journal_title：Endocrinology

authors： Torsello A,Ghe' C,Bresciani E,Catapano F,Ghigo E,Deghenghi R,Locatelli V,Muccioli G

更新日期：2002-05-01 00:00:00

abstract：:Flavonoids are functional constituents of many fruits and vegetables. Some flavonoids have antidiabetic properties because they improve altered glucose and oxidative metabolisms of diabetic states. Procyanidins are flavonoids with an oligomeric structure, and it has been shown that they can improve the pathological ox...

journal_title：Endocrinology

authors： Pinent M,Blay M,Bladé MC,Salvadó MJ,Arola L,Ardévol A

更新日期：2004-11-01 00:00:00

abstract：:In teleosts, the pituitary contains a single glycoprotein gonadotropic hormone (GTH) composed of two dissimilar alpha- and beta-subunits. The European eel, Anguilla anguilla L, is sexually immature at the silver stage due to a deficiency in GTH synthesis and secretion. In previous studies we (S.D., YA.F.) have demonst...

journal_title：Endocrinology

authors： Counis R,Dufour S,Ribot G,Quérat B,Fontaine YA,Jutisz M

更新日期：1987-09-01 00:00:00

abstract：:The mechanisms by which bacterial endotoxin [lipopolysaccharide (LPS)] stimulates the hypothalamo-pituitary-adrenal axis (HPAA) have not been elucidated. The present study was designed to investigate the involvement of macrophages in plasma ACTH and corticosterone responses to LPS administration in rats using selectiv...

journal_title：Endocrinology

authors： Derijk R,Van Rooijen N,Tilders FJ,Besedovsky HO,Del Rey A,Berkenbosch F

更新日期：1991-07-01 00:00:00

abstract：:Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprec...

journal_title：Endocrinology

authors： Tsuchida K,Vaughan JM,Wiater E,Gaddy-Kurten D,Vale WW

更新日期：1995-12-01 00:00:00

abstract：:Addition of calcitonin gene-related peptide (CGRP), 1 X 10(-7) M, to cultured neonatal rat heart cells resulted in rapid increases in beating rate and cellular concentrations of cAMP. Calcitonin (1 X 10(-7) M), in contrast, had no significant effect on heart cell beating rate or cAMP content. CGRP-stimulated increases...

journal_title：Endocrinology

authors： Fisher RA,Robertson SM,Olson MS

更新日期：1988-07-01 00:00:00

abstract：:In an effort to define biochemical events relevant to the adipogenic action of GH, the effect of GH on expression of the cytoskeletal element vinculin was studied in 3T3-F442A preadipose cells. Results from Western blotting indicated that in serum-free medium 2 nM met-hGH induced an approximately 100% increase in vinc...

journal_title：Endocrinology

authors： Guller S,Corin RE,Yuan-Wu K,Sonenberg M

更新日期：1991-07-01 00:00:00

abstract：:The developmental patterns of thyroid-stimulating hormone (TSH) was examined in female Long-Evans rats by radioimmunoassay of pituitary and plasma from 5 through 80 days of age. The effects of hypothyroidism on normal TSH levels were examined in animals radiothyroidectomized at birth. Control animals showed a peak in ...

journal_title：Endocrinology

authors： Cons JM,Umezu M,Timiras PS

更新日期：1975-07-01 00:00:00

abstract：:Recent in vitro and in vivo evidence shows that secretion of parathyroid hormone (PTH) and calcitonin (CT) is stimulated by beta-adrenergic agonists and inhibited by beta-adrenergic antagonists. To assess the possible roles of adrenal medullary or adrenergic nerve terminal catecholamines in calcium homeostasis, we hav...

journal_title：Endocrinology

authors： Heath H 3rd

更新日期：1980-10-01 00:00:00

abstract：:Poor growth before birth increases the risk of non-insulin-dependent diabetes mellitus (NIDDM) and impairs insulin secretion relative to sensitivity. We investigated the effects of intrauterine growth restriction in sheep on insulin secretion, beta-cell mass, and function from before birth to young adulthood and its m...

journal_title：Endocrinology

authors： Gatford KL,Mohammad SN,Harland ML,De Blasio MJ,Fowden AL,Robinson JS,Owens JA

更新日期：2008-10-01 00:00:00

abstract：:Although the neurohypophyseal hormone oxytocin (OT) is best know for its role in reproduction, OT also stimulates natriuresis at physiological plasma levels. This effect is mediated via specific renal OT receptors (OTRs). In the present study, we have characterized rat renal OTR gene transcripts and assessed their reg...

journal_title：Endocrinology

authors： Breton C,Neculcea J,Zingg HH

更新日期：1996-07-01 00:00:00

abstract：:This investigation examined the effects of repeated injections of LH on ovarian function in the immature sheep approximately 12 weeks before the time of the first expected spontaneous ovulation. The frequency of endogenous LH pulses during the pretreatment period was approximately one pulse each 3 h. The first experim...

journal_title：Endocrinology

authors： Foster DL,Ryan KD,Papkoff H

更新日期：1984-09-01 00:00:00

abstract：:Ovarian follicular development is initiated by FSH secreted from the pituitary gland. The FSH-induced follicular development involves granulosa cell proliferation and differentiation. We demonstrated that a growth factor of epidermal growth factor (EGF) family epiregulin was rapidly induced in the primary culture of r...

journal_title：Endocrinology

authors： Sekiguchi T,Mizutani T,Yamada K,Yazawa T,Kawata H,Yoshino M,Kajitani T,Kameda T,Minegishi T,Miyamoto K

更新日期：2002-12-01 00:00:00

abstract：:Ghrelin, an endogenous ligand for the GH secretagogue receptor, induces GH secretion, food intake, and positive energy balance. Although ghrelin exhibits a variety of hormonal actions, the mechanisms regulating ghrelin expression and secretion remain unclear. To understand regulation of human ghrelin gene expression, ...

journal_title：Endocrinology

authors： Kanamoto N,Akamizu T,Tagami T,Hataya Y,Moriyama K,Takaya K,Hosoda H,Kojima M,Kangawa K,Nakao K

更新日期：2004-09-01 00:00:00

abstract：:IGF binding protein-3 (IGFBP-3), the most abundant circulating IGF binding protein, inhibits cell growth and induces apoptosis by both IGF-I-dependent and -independent pathways. The ability of IGFBP-3 to inhibit tumor growth has been demonstrated in many cancers including prostate cancer (PCa). High concentrations of ...

journal_title：Endocrinology

authors： Peng L,Malloy PJ,Wang J,Feldman D

更新日期：2006-10-01 00:00:00

abstract：:The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...

journal_title：Endocrinology

authors： Wehrenberg WB,Gaillard RC

更新日期：1989-01-01 00:00:00

abstract：:IL-6 abundance in amniotic fluid and uterine tissues increases in late gestation or with infection-associated preterm labor. A role in regulation of labor onset is suggested by observations that IL-6 increases expression of genes controlling prostaglandin synthesis and signaling in isolated uterine cells, but whether ...

journal_title：Endocrinology

authors： Robertson SA,Christiaens I,Dorian CL,Zaragoza DB,Care AS,Banks AM,Olson DM

更新日期：2010-08-01 00:00:00

abstract：:The TSH receptor (TSHR) is constitutively active and is further enhanced by TSH ligand binding or by stimulating TSHR antibodies (TSHR-Abs) as seen in Graves' disease. TSH is known to activate the thyroid epithelial cell via both Galphas-cAMP/protein kinase A/ERK and Galphaq-Akt/protein kinase C coupled signaling netw...

journal_title：Endocrinology

authors： Morshed SA,Latif R,Davies TF

更新日期：2009-01-01 00:00:00

abstract：:We investigated, in five cell strains per experiment, whether several cytokines known or believed to have effects on bone resorption were produced by nearly homogeneous strains of cultured normal human osteoblast-like (hOB) cells that display virtually the complete phenotype of the mature osteoblast. In unstimulated h...

journal_title：Endocrinology

authors： Chaudhary LR,Spelsberg TC,Riggs BL

更新日期：1992-05-01 00:00:00

abstract：:Throughout spermatogenesis, germ cells migrate from the basal to the adluminal compartment while remaining attached to Sertoli cells via actin-based adherens and intermediate filament-based anchoring junctions. However, the events that trigger deadhesion and adhesion remain largely unknown. As part of our continued ef...

journal_title：Endocrinology

authors： Lau AS,Mruk DD

更新日期：2003-04-01 00:00:00

abstract：:The levels of two steroid-binding proteins, progesterone-binding globulin (PBG) (1) and corticosteroid-binding globulin (CBG), present in the plasma of pregnant guinea pigs were determined just before and after parturition. Both PBG (3.37 +/- 2.1 microM) and CBG (10.1 +/- 1.7 microM) were present in high levels just b...

journal_title：Endocrinology

authors： Raymoure WJ,Kuhn RW

更新日期：1980-06-01 00:00:00

abstract：:Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all p...

journal_title：Endocrinology

authors： Bagnasco M,Kalra PS,Kalra SP

更新日期：2002-02-01 00:00:00

abstract：:Although Na+/H+ exchange is important to maintenance of pH and volume and thus placental-fetal homeostasis, regulation of the Na+/H+ exchange system is incompletely understood. We previously showed that Na+/H+ exchanger (NHE)1 and -3 and their regulatory factors NHERF1 and -2 were expressed in human and nonhuman prima...

journal_title：Endocrinology

authors： Pepe GJ,Burch MG,Albrecht ED

更新日期：2006-06-01 00:00:00

abstract：:Insulin acts directly as a mitogen on isolated embryonic tissues but has been shown to be inactive at physiological concentrations on several fetal cell types. Since insulin availability is obligatory for optimal fetal growth, we have investigated its mitogenic actions on chondrocytes isolated from the epiphyseal grow...

journal_title：Endocrinology

authors： Hill DJ,de Sousa D

更新日期：1990-05-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:The membrane fraction from the ovaries of pseudopregnant rats exhibits specific, high affinity binding of high density lipoproteins (HDL). Previous studies have indicated that HDL binding in this tissue is up-regulated by hCG and may be involved in supplying cholesterol as substrate for steroid hormone production. To ...

journal_title：Endocrinology

authors： Ferreri K,Menon KM

更新日期：1990-04-01 00:00:00

abstract：:Recent evidence suggests that inflammation may be a common underlying cause of many obesity-associated conditions. To test whether obesity changes the response to inflammation, we investigated its effects on the acute phase of the inflammatory response to an endogenous pathogen, lipopolysaccharide (LPS). Diet-induced ...

journal_title：Endocrinology

authors： Pohl J,Woodside B,Luheshi GN

更新日期：2009-11-01 00:00:00

abstract：:Mature 31- and 34-kDa inhibin A and B negatively regulate the release of FSH from the anterior pituitary; however, a direct comparison of these hormones in vivo has not been undertaken. The bioactivities of highly purified preparations of recombinant human 31-kDa inhibin A and B were determined in rat pituitary cells ...

journal_title：Endocrinology

authors： Makanji Y,Temple-Smith PD,Walton KL,Harrison CA,Robertson DM

更新日期：2009-10-01 00:00:00

abstract：:Brief exposure of male rats to estrogens during the neonatal period interrupts normal prostate development, alters epithelial cell differentiation, and predisposes this gland to hyperplasia and severe dysplasia analogous to prostatic intraepithelial neoplasia (PIN) with aging. Previous work demonstrated that the reduc...

journal_title：Endocrinology

authors： Woodham C,Birch L,Prins GS

更新日期：2003-11-01 00:00:00