Rab8B GTPase and junction dynamics in the testis.

abstract：:The mechanism by which the proto-oncogene, c-fos, is up-regulated in response to PGE2 in the mouse osteoblastic (MC3T3-E1) cell line was investigated using RT-PCR. c-fos messenger RNA up-regulation by dmPGE2 is rapid, starting 10 min post stimulation, and transient. The specific protein kinase A (PKA) inhibitor, H89, ...

journal_title：Endocrinology

authors： Fitzgerald J,Dietz TJ,Hughes-Fulford M

更新日期：2000-01-01 00:00:00

abstract：:After hormonal ablation, 90% of the secretory epithelial cells of the prostate undergo apoptosis, and the remaining cells are reorganized as the tissue is remodeled. Using differential display RT-PCR of total RNA extracted from the rat ventral prostate before and 4 days after castration, we have cloned and sequenced a...

journal_title：Endocrinology

authors： Morrissey C,Bennett S,Nitsche E,Guenette RS,Wong P,Tenniswood M

更新日期：1999-07-01 00:00:00

abstract：:Xenoestrogens from synthetic or natural origin represent an increasing risk of disrupted endocrine functions including the physiological activity of the hypothalamo-pituitary-gonad axis. Ethinyl estradiol (EE2) is a synthetic estrogen used in contraceptive pills, whereas zearalenone (ZEA) is a natural mycoestrogen fou...

journal_title：Endocrinology

authors： Kriszt R,Winkler Z,Polyák Á,Kuti D,Molnár C,Hrabovszky E,Kalló I,Szőke Z,Ferenczi S,Kovács KJ

更新日期：2015-11-01 00:00:00

abstract：:Sex difference in the number of neurons projecting axons from the lateral septum (LS) to the midbrain central gray (MCG) that are concerned with the lordosis-inhibiting system was investigated by injection of Fluoro-Gold (FG), a retrograde tracer, into the rostral MCG on the right side in male and female rats. Immunoh...

journal_title：Endocrinology

authors： Tsukahara S,Yamanouchi K

更新日期：2002-01-01 00:00:00

abstract：:The human breast cancer cell line MCF-7 responds to estrogens with increased progesterone receptor (PR) levels. In this study, we use dense amino acid density shift analyses to address directly the question of whether estrogen increases PR levels in MCF-7 cells by altering rates of receptor synthesis and/or degradatio...

journal_title：Endocrinology

authors： Nardulli AM,Greene GL,O'Malley BW,Katzenellenbogen BS

更新日期：1988-03-01 00:00:00

abstract：:Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...

journal_title：Endocrinology

authors： Hong MH,Sun H,Jin CH,Chapman M,Hu J,Chang W,Burnett K,Rosen J,Negro-Vilar A,Miner JN

更新日期：2008-03-01 00:00:00

abstract：:Polypeptide YY(3-36) (PYY(3-36)) is a gastrointestinal secreted molecule, agonist of neuropeptide Y (NPY) receptor subtypes Y2 and Y5, recently involved in the control of food intake. Notably, several factors with key roles in energy homeostasis conduct pleiotropic effects upon the reproductive axis. However, whether ...

journal_title：Endocrinology

authors： Fernandez-Fernandez R,Aguilar E,Tena-Sempere M,Pinilla L

更新日期：2005-03-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined. The aim of this study was to investigate the effect of BMP2 on the regulation of ...

journal_title：Endocrinology

authors： Bai L,Chang HM,Cheng JC,Chu G,Leung PCK,Yang G

更新日期：2017-10-01 00:00:00

abstract：:A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...

journal_title：Endocrinology

authors： Wannemacher RW Jr,Pekarek RS,Thompson WL,Curnow RT,Beall FA,Zenser TV,DeRubertis FR,Beisel WR

更新日期：1975-03-01 00:00:00

abstract：:In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...

journal_title：Endocrinology

authors： Chatzopoulou A,Roy U,Meijer AH,Alia A,Spaink HP,Schaaf MJ

更新日期：2015-05-01 00:00:00

abstract：:To study blood capillary growth in the hyperplastic thyroid gland, rats were fed 0.25% thiouracil in a low iodine diet for time intervals up to 100 days. Thyroids were fixed by vascular perfusion and embeded in Epon. Whole lobes were sectioned from pole to pole and slides were prepared of sections every 0.3 mm. Capill...

journal_title：Endocrinology

authors： Wollman SH,Herveg JP,Zeligs JD,Ericson LE

更新日期：1978-12-01 00:00:00

abstract：:We investigated the effects of thyroid status on nitric oxide synthase (NOS) gene expression in the rat hypothalamic paraventricular (PVN) and supraoptic nuclei (SON). Propylthiouracil (PTU)-induced hypothyroidism in male rats produced a highly significant reduction in NOS gene transcripts in the PVN and SON, as asses...

journal_title：Endocrinology

authors： Ueta Y,Levy A,Chowdrey HS,Lightman SL

更新日期：1995-10-01 00:00:00

abstract：:In the kidney, 11 beta-dehydrogenase (11 beta-DH) converts the active steroid cortisol to inactive cortisone (corticosterone to 11-dehydrocorticosterone in the rat). In man, congenital and acquired deficiency of 11 beta-dehydrogenase are rare causes of hypertension in which cortisol acts as a potent mineralocorticoid....

journal_title：Endocrinology

authors： Stewart PM,Whorwood CB,Barber P,Gregory J,Monder C,Franklyn JA,Sheppard MC

更新日期：1991-04-01 00:00:00

abstract：:The roles of alpha- and beta-subunits of human TSH (hTSH) were studied by investigating the inhibitory effects of monoclonal antibodies on the biological activity of hTSH. Four monoclonal antibodies directed toward different epitopes on the beta-subunit (hTSH beta) inhibited completely the receptor binding of hTSH to ...

journal_title：Endocrinology

authors： Endo Y,Tetsumoto T,Nagasaki H,Kashiwai T,Tamaki H,Amino N,Miyai K

更新日期：1990-07-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00

abstract：:The specific uptake by rat liver of human (hGH) and bovine (bGH) GHs labeled with 125I was studied by an in vivo procedure. A significant reduction of the uptake was observed when labeled hormones were injected together with different amounts of the corresponding native GH. This reduction was dose dependent, and the c...

journal_title：Endocrinology

authors： Turyn D,Dellacha JM

更新日期：1978-10-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:The activity of the Na+/H+ exchanger was studied by measuring the effects of intracellular pH (pHi) and extracellular Na+ [(Na+)o] on pHi recovery and 22Na uptake in rat adipocytes. The resting pHi was acidified from 7.30 +/- 0.02 to 6.99 +/- 0.01 with nigericin in the absence of (Na+)o. pHi recovery induced by 30 mM ...

journal_title：Endocrinology

authors： Arsenis G

更新日期：1995-07-01 00:00:00

abstract：:The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...

journal_title：Endocrinology

authors： Pescovitz OH,Berry SA,Laudon M,Ben-Jonathan N,Martin-Myers A,Hsu SM,Lambros TJ,Felix AM

更新日期：1990-11-01 00:00:00

abstract：:Physiological concentrations of L-T4 were found previously to stimulate Ca2+-ATPase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. In these previous studies, preincubation of intact cells or ghosts with testosterone (5 X 10(-11) M) conve...

journal_title：Endocrinology

authors： Lawrence WD,Osawa YM,Davis PJ,Blas SD

更新日期：1986-12-01 00:00:00

abstract：:Progesterone (P4) inhibits apoptosis of rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs), which were derived from rat granulosa cells. Defining the mechanism through which P4 mediates its action has been difficult because these cells do not express the classic nuclear P4 receptor. Previous st...

journal_title：Endocrinology

authors： Peluso JJ,Pappalardo A,Fernandez G,Wu CA

更新日期：2004-06-01 00:00:00

abstract：:The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absen...

journal_title：Endocrinology

authors： Meyer CW,Korthaus D,Jagla W,Cornali E,Grosse J,Fuchs H,Klingenspor M,Roemheld S,Tschöp M,Heldmaier G,De Angelis MH,Nehls M

更新日期：2004-05-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:A continuous flow incubation (perifusion) system was used to examine the effect of testosterone (T) and three of its 5alpha-reduced metabolites, dihydrotestosterone (DHT), 5alpha-androstane-3alpha, 17beta-diol (3alpha-Adiol) and its 3beta-epimer (3beta-Adiol) on LH and FSH release, induced by hypothalamic extract (HE)...

journal_title：Endocrinology

authors： Kao LW,Weisz J

更新日期：1975-02-01 00:00:00

abstract：:Recently, we demonstrated that estradiol (E(2)) modulates cross-talk between protein tyrosine kinases and norepinephrine (NE) receptor signaling in the hypothalamus (HYP) and preoptic area (POA), brain areas that govern female reproductive function. We are now investigating the identity of protein tyrosine kinase(s) t...

journal_title：Endocrinology

authors： Quesada A,Etgen AM

更新日期：2001-02-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...

journal_title：Endocrinology

authors： Taylor TB,Ramsdell JS

更新日期：1993-09-01 00:00:00

abstract：:IGF-I is an endocrine and paracrine regulator of skeletal homeostasis, principally by virtue of its anabolic effects on osteoblastic cells. In the current study, we examined the intracellular signaling pathways by which IGF-I promotes proliferation and survival in SaOS-2 human osteoblastic cells. Inhibition of each of...

journal_title：Endocrinology

authors： Grey A,Chen Q,Xu X,Callon K,Cornish J

更新日期：2003-11-01 00:00:00

abstract：:Intact handled rats were pretreated with the immunoglobulin G fractions from normal rabbit serum or antisera to ovine corticotropin-releasing factor (CRF) and/or vasopressin and subjected to restraint or formalin stress. The formalin-induced rise in plasma ACTH was reduced to 28% in rats pretreated with anti-CRF, to 5...

journal_title：Endocrinology

authors： Linton EA,Tilders FJ,Hodgkinson S,Berkenbosch F,Vermes I,Lowry PJ

更新日期：1985-03-01 00:00:00

abstract：:Bovine placental lactogen (bPL) was found to be as potent as human GH (hGH) in its ability to bind to soluble full-size recombinant hGH-binding protein (hGHBP) and to membrane-embedded hGH receptor in intact IM-9 human lymphocytes. bPL was also capable of forming a 1:2 complex with hGHBP, although the structure of thi...

journal_title：Endocrinology

authors： Vashdi-Elberg D,Staten NR,Sakal E,Krivi GG,Gertler A

更新日期：1995-03-01 00:00:00

abstract：:The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity. Several antagonists have been developed to decrease the orexigenic signaling, but none of these have been approved for the treatment of obesit...

journal_title：Endocrinology

authors： Hedegaard MA,Holst B

更新日期：2020-04-01 00:00:00