Abstract:
:Intact handled rats were pretreated with the immunoglobulin G fractions from normal rabbit serum or antisera to ovine corticotropin-releasing factor (CRF) and/or vasopressin and subjected to restraint or formalin stress. The formalin-induced rise in plasma ACTH was reduced to 28% in rats pretreated with anti-CRF, to 53% in those pretreated with antivasopressin, and to 16% in rats given both antibodies. Pretreatment of animals with anti-CRF, antivasopressin, or a combination of both antibodies also attenuated the ACTH response to restraint stress to 13%, 37%, and 12%, respectively, of those in normal rabbit serum-treated rats. Antiserum pretreatment did not reduce the restraint- or formalin-induced rise in plasma PRL in the same animals, however. We conclude, therefore, that both vasopressin and an ovine CRF-like peptide are physiologically relevant peptides involved in stress-induced ACTH release.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Linton EA,Tilders FJ,Hodgkinson S,Berkenbosch F,Vermes I,Lowry PJdoi
10.1210/endo-116-3-966subject
Has Abstractpub_date
1985-03-01 00:00:00pages
966-70issue
3eissn
0013-7227issn
1945-7170journal_volume
116pub_type
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