Blood capillary enlargement during the development of thyroid hyperplasia in the rat.

abstract：:Magnocellular hypothalamic neurons in the rat supraoptic nucleus (SON) normally produce either vasopressin (VP) or oxytocin (OT). Here we demonstrate that many magnocellular neurons in the SON of lactating rats synthesize both hormones at the same time. We show the colocalization of the messenger (m) RNA that encodes ...

journal_title：Endocrinology

authors： Mezey E,Kiss JZ

更新日期：1991-10-01 00:00:00

abstract：:Stanniocalcin (STC) is a new mammalian polypeptide hormone and appears to be a regulator of neuronal function. We have already shown that the induction of STC mRNA and protein expression by cAMP is integral to neuroblastoma cell differentiation, particularly neurite outgrowth. In this study, we examined the cAMP pathw...

journal_title：Endocrinology

authors： Yeung HY,Chan DK,Mak NK,Wagner GF,Wong CK

更新日期：2003-10-01 00:00:00

abstract：:The cell of origin of human null cell pituitary adenomas is disputed. Although these tumors, by definition, do not produce any of the anterior pituitary hormones in vivo, they have been shown to express gonadotropin subunit genes, release gonadotropin hormones in vitro, and express the gonadotroph-associated transcrip...

journal_title：Endocrinology

authors： Kumar TR,Graham KE,Asa SL,Low MJ

更新日期：1998-07-01 00:00:00

abstract：:In the present study epididymal epithelium was immortalized in transgenic mice by expressing simian virus 40 T antigen under a 5.0-kb mouse glutathione peroxidase 5 promoter (GPX5-Tag1). Epididymal tumorigenesis was associated with an increase in c-Myc expression, and a marked decrease in B-Myc expression, with a 500-...

journal_title：Endocrinology

authors： Sipilä P,Shariatmadari R,Huhtaniemi IT,Poutanen M

更新日期：2004-01-01 00:00:00

abstract：:The developmental patterns of thyroid-stimulating hormone (TSH) was examined in female Long-Evans rats by radioimmunoassay of pituitary and plasma from 5 through 80 days of age. The effects of hypothyroidism on normal TSH levels were examined in animals radiothyroidectomized at birth. Control animals showed a peak in ...

journal_title：Endocrinology

authors： Cons JM,Umezu M,Timiras PS

更新日期：1975-07-01 00:00:00

abstract：:Ca2+/calmodulin-dependent processes are altered by manipulations of the hypothalamic-pituitary-adrenal axis. In particular, adrenalectomy (ADX) attenuates hippocampal, but not cortical, calmodulin-dependent adenylate cyclase activity measured during the active (waking) phase of rats. The involvement of calmodulin- and...

journal_title：Endocrinology

authors： Gannon MN,Akompong T,Billingsley ML,McEwen BS

更新日期：1994-02-01 00:00:00

abstract：:Involvement of ionized cytosolic calcium ([Ca2+]i) and protein kinase-C (PKC) in GnRH-stimulated LH release was assessed by correlating measurable changes in [Ca2+]i and LH release in PKC-depleted and nondepleted gonadotropes. Primary cultures of anterior pituitary cells were loaded with the calcium-sensitive fluoresc...

journal_title：Endocrinology

authors： Waters SB,Conn PM

更新日期：1992-04-01 00:00:00

abstract：:Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...

journal_title：Endocrinology

authors： Hofland J,van Weerden WM,Steenbergen J,Dits NF,Jenster G,de Jong FH

更新日期：2012-12-01 00:00:00

abstract：:The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...

journal_title：Endocrinology

authors： Hirakawa T,Minegishi T,Abe K,Kishi H,Ibuki Y,Miyamoto K

更新日期：1999-11-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:Spontaneously hypertensive (SH) rats, extensively used as experimental models of essential human hypertension, display important alterations in the neuroendocrine reproductive axis, which manifest as markedly delayed puberty onset in females but whose basis remains largely unknown. We analyze herein in female SH rats:...

journal_title：Endocrinology

authors： Pinilla L,Castellano JM,Romero M,Tena-Sempere M,Gaytán F,Aguilar E

更新日期：2009-06-01 00:00:00

abstract：:The secretion of neurohypophyseal hormone and ACTH in the rat has been shown to exhibit circadian rhythms, with high values during the day and low values throughout the night. The neurohypophyseal hormone daily rhythm is altered by exposure to constant light and by pinealectomy. It was, thus, proposed that the observe...

journal_title：Endocrinology

authors： Yasin SA,Costa A,Besser GM,Hucks D,Grossman A,Forsling ML

更新日期：1993-03-01 00:00:00

abstract：:Carbonyl cyanide trifluoromethoxyphenylhydrazone (FCCP), a protonophore, and methylamine, a weak base, agents that dissipate hydrogen gradients across cellular membranes, were used to probe the coupling of hydrogen gradients to the processing and secretion of the glycoprotein hormone hCG by human choriocarcinoma cells...

journal_title：Endocrinology

authors： Peters BP,Krzesicki RF,Perini F,Ruddon RW

更新日期：1986-07-01 00:00:00

abstract：:We have previously demonstrated that, in prostate cancer cells, androgens up-regulate IGF-I receptor (IGF-IR) by inducing cAMP-response element-binding protein (CREB) activation and CREB-dependent IGF-IR gene transcription through androgen receptor (AR)-dependent membrane-initiated effects. This IGF-IR up-regulation i...

journal_title：Endocrinology

authors： Malaguarnera R,Sacco A,Morcavallo A,Squatrito S,Migliaccio A,Morrione A,Maggiolini M,Belfiore A

更新日期：2014-04-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:As the incidence of obesity continues to increase, the development of effective therapies is a high priority. The endocannabinoid system has emerged as an important influence on the regulation of energy homeostasis. The endocannabinoids anandamide and 2-arachidonoylglycerol act on cannabinoid receptor-1 (CB1) in the b...

journal_title：Endocrinology

authors： de Kloet AD,Woods SC

更新日期：2009-06-01 00:00:00

abstract：:Maternal obesity at conception increases the risk of offspring obesity, thus propagating an intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to high fat-diets, gaining greater body weight, fat mass, and additional metabolic sequelae compared to lean controls. In this report, we id...

journal_title：Endocrinology

authors： Shankar K,Zhong Y,Kang P,Lau F,Blackburn ML,Chen JR,Borengasser SJ,Ronis MJ,Badger TM

更新日期：2011-11-01 00:00:00

abstract：:Beta-adrenergic agonists and antagonists are widely used in many clinical situations to regulate beta-adrenergic stimulation. However, responsiveness to beta-stimulation may be reduced by the process of desensitization. We have established an in vivo mammalian model system, the rat lung, to study the cellular and bioc...

journal_title：Endocrinology

authors： Strasser RH,Stiles GL,Lefkowitz RJ

更新日期：1984-10-01 00:00:00

abstract：:Uterine epithelial cells (UEC) isolated from 6-week-old CF-1 mice were immortalized using retroviral-mediated transfection of SV40 large T-antigen. One line, WEG-1, retained epithelial morphology and reacted with antibodies to cytokeratins 18, 19, laminin, fibronectin, and beta-catenin. In addition, WEG-1 cells displa...

journal_title：Endocrinology

authors： Wegner CC,Cherington V,Clemens JW,Jacobs AL,Julian J,Surveyor GA,Bell EC,Carson DD

更新日期：1996-01-01 00:00:00

abstract：:Epidemiological evidence indicates that phytoestrogens inhibit cancer formation and growth, reduce cholesterol levels, and show benefits in treating osteoporosis. At least some of these activities are mediated through the interaction of phytoestrogens with estrogen receptors alpha and beta (ERalpha and ERbeta). Resver...

journal_title：Endocrinology

authors： Bowers JL,Tyulmenkov VV,Jernigan SC,Klinge CM

更新日期：2000-10-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Progesterone released by cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the cationic channel of sperm (CatSper) Ca2+ channel and controls multiple Ca2+-dependent responses essential for fertilization. We hypothesized that chemical UV filters may mimic the physiological action of pro...

journal_title：Endocrinology

authors： Rehfeld A,Dissing S,Skakkebæk NE

更新日期：2016-11-01 00:00:00

abstract：:Sertoli cell intracellular protein 1 (SCc1) and 2 (SCc2) are polypeptides found in rat Sertoli cell cultures incubated with either FSH or (Bu)2cAMP. They were first identified in [35S]methionine-labeled Sertoli cell lysates using two-dimensional gel electrophoresis. Here we extend these observations by showing that SC...

journal_title：Endocrinology

authors： Gregory CW,DePhilip RM

更新日期：1992-11-01 00:00:00

abstract：:The nonpeptide CRH antagonist antalarmin has been shown to block both behavioral and endocrine responses to CRH. However, it's potential activity in blunting behavioral and endocrine sequelae of stressor exposure has not been assessed. Because antagonism of central CRH by alpha-helical CRH attenuates conditioned fear ...

journal_title：Endocrinology

authors： Deak T,Nguyen KT,Ehrlich AL,Watkins LR,Spencer RL,Maier SF,Licinio J,Wong ML,Chrousos GP,Webster E,Gold PW

更新日期：1999-01-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:A binding protein for activin was purified from bovine pituitary by affinity chromatography on dextran sulfate-Sepharose CL-4B and activin-Affi-Gel 10. A 52,700-fold purification over the starting crude homogenate was achieved. The purified preparation showed two bands of 36 and 33 kilodalton in sodium dodecyl sulfate...

journal_title：Endocrinology

authors： Kogawa K,Nakamura T,Sugino K,Takio K,Titani K,Sugino H

更新日期：1991-03-01 00:00:00

abstract：:The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...

journal_title：Endocrinology

authors： Bianco AC,Silva JE

更新日期：1987-01-01 00:00:00

abstract：:While the potential role of insulin-like growth factor (IGF)-I in ovarian physiology has been extensively studied, relatively limited attention has been paid to IGF-II the very presence of which in the mature rat ovary has been questioned. In the present study, we have reevaluated rat ovarian IGF-II gene expression, i...

journal_title：Endocrinology

authors： Hernandez ER,Roberts CT Jr,Hurwitz A,LeRoith D,Adashi EY

更新日期：1990-12-01 00:00:00

abstract：:Galanin-like peptide (GALP), a 29-amino-acid neuropeptide, is located in the hypothalamic arcuate nucleus (ARC), binds to galanin receptor subtype 2, and induces food intake upon intracerebroventricular (icv) injection in rats. However, neural mechanisms underlying its orexigenic action remain unclear. We aimed to ide...

journal_title：Endocrinology

authors： Kuramochi M,Onaka T,Kohno D,Kato S,Yada T

更新日期：2006-04-01 00:00:00

abstract：:The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various transcriptional coregulators of MR is essential for understanding the compl...

journal_title：Endocrinology

authors： Kuppusamy M,Gomez-Sanchez EP,Beloate LN,Plonczynski M,Naray-Fejes-Toth A,Fejes-Toth G,Gomez-Sanchez CE

更新日期：2017-07-01 00:00:00