Hepatic messenger ribonucleic acid activity profile of rats subjected to alterations in thyroidal and adrenocortical states: evidence for significant interaction.

abstract：:The potential effects of insulin and insulin-like growth factor I (IGF-I) on mesangial cell (MC) metabolism and growth were examined. Radiolabeled insulin or IGF-I were incubated with cell membranes from rapidly proliferating (subconfluent) or nonproliferating (confluent) MC in the presence of increasing concentration...

journal_title：Endocrinology

authors： Abrass CK,Raugi GJ,Gabourel LS,Lovett DH

更新日期：1988-11-01 00:00:00

abstract：:Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...

journal_title：Endocrinology

authors： Ren R,Oakley RH,Cruz-Topete D,Cidlowski JA

更新日期：2012-11-01 00:00:00

abstract：:Elucidation of the role of Ca2+ in the secretion of insulin and glucagon is complicated by the presence of different types of cells in the pancreatic islets. Visualization of calcium in sections of guinea pig pancreas with the histochemical reagent glyoxal bis-2-hydroxyanil revealed the most intense staining in the en...

journal_title：Endocrinology

authors： Berggren PO,Ostenson CG,Petersson B,Hellman B

更新日期：1979-12-01 00:00:00

abstract：:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evalua...

journal_title：Endocrinology

authors： Montgomery DW,Krumenacker JS,Buckley AR

更新日期：1998-02-01 00:00:00

abstract：:In the rat a GH-binding protein (GHBP) exists that is derived from the GH receptor gene by an alternative messenger RNA splicing mechanism such that the transmembrane and intracellular domains of the GH receptor are replaced by a hydrophilic carboxy terminus. Previous immunohistochemical studies detailing the localiza...

journal_title：Endocrinology

authors： Lobie PE,García-Aragón J,Wang BS,Baumbach WR,Waters MJ

更新日期：1992-05-01 00:00:00

abstract：:The pharmacokinetics of TRH and its metabolite deamido-TRH (TRH-OH) were evaluated and compared. After a 60- to 90-min infusion of the appropriate peptide into rats, the MCR, half-life of disappearance (t 1/2), and volume of distribution were calculated. The MCR of TRH averaged 4 ml/min, whereas that of TRH-OH was 6.5...

journal_title：Endocrinology

authors： Safran M,Wu CF,Matys R,Alex S,Emerson CH

更新日期：1984-09-01 00:00:00

abstract：:Mammary epithelial cells isolated from pregnant, nonlactating heifers were grown in vitro using collagen substrates. Using these systems, the truncated form of insulin growth factor-1 (IGF-1) (des-3-IGF-1), IGF-1, and IGF-2 all stimulated a significant (0.5 to 1 fold) increase in cell proliferation (des-3-IGF-1 greate...

journal_title：Endocrinology

authors： McGrath MF,Collier RJ,Clemmons DR,Busby WH,Sweeny CA,Krivi GG

更新日期：1991-08-01 00:00:00

abstract：:Fibroblasts represent one of the in vivo sites of extrahepatic insulin-like growth factor I (IGF-I) production. In this study, cultured fibroblasts prepared from the skin of neonatal rats were used as a model to assess the role of serum in regulating IGF-I messenger RNA (mRNA) levels. IGF-I mRNA, as demonstrated by No...

journal_title：Endocrinology

authors： Lowe WL Jr,Kummer M,Karpen CW,Wu XD

更新日期：1990-12-01 00:00:00

abstract：:Type 1 transforming growth factor-beta (TGF beta 1) was found to be a potent inducer of the secretion of a 49,000 mol wt protein by normal rat kidney (NRK) cells. This protein was related to type 1 plasminogen activator inhibitor (PAI-1) on the basis of molecular mass, activity in the presence of sodium dodecyl sulfat...

journal_title：Endocrinology

authors： Newman MJ,Lane EA,Iannotti AM,Nugent MA,Pepinsky RB,Keski-Oja J

更新日期：1990-06-01 00:00:00

abstract：:In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...

journal_title：Endocrinology

authors： Wiemers DO,Shao LJ,Ain R,Dai G,Soares MJ

更新日期：2003-01-01 00:00:00

abstract：:Retinoic acid (RA) slows growth and induces differentiation of tumor cells through activation of RA receptors (RARs). However, melanoma cell lines display highly variable responsiveness to RA, which is a poorly understood phenomenon. By using Northern and Western blot analyses, we show that RA-resistant A375 and RA-re...

journal_title：Endocrinology

authors： Demary K,Wong L,Liou JS,Faller DV,Spanjaard RA

更新日期：2001-06-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...

journal_title：Endocrinology

authors： Ikegami K,Atsumi Y,Yorinaga E,Ono H,Murayama I,Nakane Y,Ota W,Arai N,Tega A,Iigo M,Darras VM,Tsutsui K,Hayashi Y,Yoshida S,Yoshimura T

更新日期：2015-02-01 00:00:00

abstract：:In dairy goats, treatments associating a progestogen and the equine chorionic gonadotropin (eCG) are the easiest way to induce and synchronize estrus and ovulation and to permit artificial insemination (AI) and/or out of season breeding. From the first treatment, the injection of eCG induces, in some females, the prod...

journal_title：Endocrinology

authors： Hervé V,Roy F,Bertin J,Guillou F,Maurel MC

更新日期：2004-01-01 00:00:00

abstract：:The proliferation and differentiation of testicular progenitor stem cells into highly specialized germ cells (spermatozoa) are largely controlled by the hormonally (FSH and testosterone) regulated adjacent supporting Sertoli cells. However, the factors involved in this control remain largely unknown. In the present st...

journal_title：Endocrinology

authors： Hellani A,Ji J,Mauduit C,Deschildre C,Tabone E,Benahmed M

更新日期：2000-08-01 00:00:00

abstract：:Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex steroids. However, the distribution, regulation, and functional si...

journal_title：Endocrinology

authors： Kim J,Semaan SJ,Clifton DK,Steiner RA,Dhamija S,Kauffman AS

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells. Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with G...

journal_title：Endocrinology

authors： Baratta M,Saleri R,Mainardi GL,Valle D,Giustina A,Tamanini C

更新日期：2002-02-01 00:00:00

abstract：:Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agouti yellow and melanocortin 4 receptor knockout mice. To investigate t...

journal_title：Endocrinology

authors： Kublaoui BM,Holder JL Jr,Tolson KP,Gemelli T,Zinn AR

更新日期：2006-10-01 00:00:00

abstract：:In fish spermatogenesis, the main action of progestins is generally regarded as the induction of sperm maturation. Our previous in vitro study demonstrated that a progestin, 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP), induced the initiation of meiosis in spermatogenesis in the Japanese eel (Anguilla japonica). In ...

journal_title：Endocrinology

authors： Ozaki Y,Higuchi M,Miura C,Yamaguchi S,Tozawa Y,Miura T

更新日期：2006-11-01 00:00:00

abstract：:Estrogen is generally considered to maintain bone mass through suppression of bone resorption. We have previously demonstrated that administration of pharmacological doses of estrogen increases bone formation in rats. Because such high doses of estrogen might induce bone formation through some mechanism other than the...

journal_title：Endocrinology

authors： Chow JW,Lean JM,Chambers TJ

更新日期：1992-05-01 00:00:00

abstract：:The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

journal_title：Endocrinology

authors： Edery M,Imagawa W,Larson L,Nandi S

更新日期：1985-01-01 00:00:00

abstract：:A model for the study of testicular function in experimental uremia induced by subtotal nephrectomy in mature male rats is described. Glomerular filtration rate was reduced by 87%, resulting in stable uremia for up to 13 weeks with characteristic biochemical changes and reduction in weight of testes, prostate, seminal...

journal_title：Endocrinology

authors： Handelsman DJ,Spaliviero JA,Turtle JR

更新日期：1985-11-01 00:00:00

abstract：:The Caenorhabditis elegans death susceptibility gene, ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), Ich-1long, and CPP32. These genes, which encode a family of related proteases, have been shown to induce apoptosis when transfected into eukaryo...

journal_title：Endocrinology

authors： Flaws JA,Kugu K,Trbovich AM,DeSanti A,Tilly KI,Hirshfield AN,Tilly JL

更新日期：1995-11-01 00:00:00

abstract：:In previous studies it was shown that bovine GH (bGH) suppressed and glucagon stimulated the level of 24- and 30- to 34-kilodalton insulin-like growth factor-binding proteins (IGFBPs) in the media of cultured rat hepatocytes. In the present study we have evaluated the regulation of IGFBP-1 gene expression in primary r...

journal_title：Endocrinology

authors： Kachra Z,Yang CR,Murphy LJ,Posner BI

更新日期：1994-11-01 00:00:00

abstract：:Experiments were carried out in castrate adult male rats to further examine whether endogenous opioids are involved in CRF-induced suppression of LH secretion. Serum LH levels in rats castrated 5 days earlier were significantly reduced by intracerebroventricular administration of homologous (rat) CRF (0.02-2 nmol) wit...

journal_title：Endocrinology

authors： Almeida OF,Nikolarakis KE,Herz A

更新日期：1988-03-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:Physiological concentrations of L-T4 were found previously to stimulate Ca2+-ATPase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. In these previous studies, preincubation of intact cells or ghosts with testosterone (5 X 10(-11) M) conve...

journal_title：Endocrinology

authors： Lawrence WD,Osawa YM,Davis PJ,Blas SD

更新日期：1986-12-01 00:00:00

abstract：:Recently, heterogeneity of POMC mRNA content between intermediate lobe melanotropes of the rat pituitary gland was demonstrated by in situ hybridization of tissue sections. In the present study the heterogeneity of POMC mRNA content in dispersed rat pituitary cells has been investigated. Acutely dispersed cells from a...

journal_title：Endocrinology

authors： Hatfield JM,Daikh DI,Adelman JP,Douglass J,Bond CT,Allen RG

更新日期：1989-03-01 00:00:00

abstract：:Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...

journal_title：Endocrinology

authors： Karpuzoglu E,Fenaux JB,Phillips RA,Lengi AJ,Elvinger F,Ansar Ahmed S

更新日期：2006-02-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...

journal_title：Endocrinology

authors： Cheung AT,Ree D,Kolls JK,Fuselier J,Coy DH,Bryer-Ash M

更新日期：1998-12-01 00:00:00