Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling.

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting cAMP-dependent calmodulin, and blocking voltage-sensitive Ca2+ channels on the secretion of ACTH by perifused dispersed rat anterior pituitary cells. The cells were stimulated with synthetic arginine vasopr...

journal_title：Endocrinology

authors： Won JG,Oki Y,Orth DN

更新日期：1990-02-01 00:00:00

abstract：:Important enzymes for thyroid hormone metabolism, antioxidative defense, and intracellular redox control contain selenocysteine (Sec) in their active centers. Expression of these selenoproteins is tightly controlled, and a sex-specific phenotype is observed on disturbance of selenium (Se) transport in mice. Therefore,...

journal_title：Endocrinology

authors： Riese C,Michaelis M,Mentrup B,Götz F,Köhrle J,Schweizer U,Schomburg L

更新日期：2006-12-01 00:00:00

abstract：:Recombinant interleukin-1 alpha and -beta (Il-1 alpha and -beta) have been evaluated for their abilities to stimulate ACTH and catecholamine secretion in the intact adult male rat. Additionally, the role of adrenergic-dependent pathways in mediating Il-1-induced ACTH release has been assessed. The iv or intracerebrove...

journal_title：Endocrinology

authors： Rivier C,Vale W,Brown M

更新日期：1989-12-01 00:00:00

abstract：:To investigate the possibility that a common phenomenon might exist by which glucocorticoids influence responses to thyroid hormones, the cytosol levels of four proteins were measured after 2 days of treatment with L-T3 (T3; 50 micrograms/100 g. day 2) and/or cortisone (2 mg/100 g./day) in adult male hypothyroid rats....

journal_title：Endocrinology

authors： Shapiro LE,Sachchidananda J

更新日期：1982-08-01 00:00:00

abstract：:Impaired wound healing of skin is one of the most serious complications of diabetes. However, the pathogenesis of this process is not known, and it is unclear whether impaired insulin signaling could directly affect skin physiology. To elucidate the role of insulin in skin, we studied skin insulin receptor (IR) null m...

journal_title：Endocrinology

authors： Wertheimer E,Spravchikov N,Trebicz M,Gartsbein M,Accili D,Avinoah I,Nofeh-Moses S,Sizyakov G,Tennenbaum T

更新日期：2001-03-01 00:00:00

abstract：:Levels of bovine placental lactogen (bPL) have been measured in the serum of dairy and beef cattle and in the milk and amniotic fluid of pregnant animals with a highly specific radioimmunoassay. In both dairy and beef cows, serum bPL levels remain low (less than 50 ng/ml) during the first two trimesters and then rise ...

journal_title：Endocrinology

authors： Bolander FF,Ulberg LC,Fellows RE

更新日期：1976-11-01 00:00:00

abstract：:In granulosa cells derived from medium-sized porcine follicles, certain androgens have been shown to inhibit FSH-stimulated progesterone synthesis. To determine the site at which this inhibition takes place, the effects of androgens on FSH- and (Bu)2cAMP-stimulated pregnenolone and progesterone syntheses were examined...

journal_title：Endocrinology

authors： Lischinsky A,Evans G,Armstrong DT

更新日期：1983-12-01 00:00:00

abstract：:Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...

journal_title：Endocrinology

authors： Michael SD,Taguchi O,Nishizuka Y

更新日期：1981-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a powerful orexigenic factor, and alphaMSH is a melanocortin (MC) peptide that induces satiety by activating the MC4 receptor subtype. Genetic models with disruption of MC4 receptor signaling are associated with obesity. In the present study, a 7-day intracerebroventricular infusion to male rat...

journal_title：Endocrinology

authors： Raposinho PD,Castillo E,d'Alleves V,Broqua P,Pralong FP,Aubert ML

更新日期：2000-12-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00

abstract：:The initial steps involved in mediating the transduction of PTH signal via its G protein-coupled receptors are well understood and occur through the activation of cAMP and phospholipase C pathways. However, the cellular and molecular mechanisms for subsequent receptor desensitization are less well understood. Recently...

journal_title：Endocrinology

authors： Miles RR,Sluka JP,Santerre RF,Hale LV,Bloem L,Boguslawski G,Thirunavukkarasu K,Hock JM,Onyia JE

更新日期：2000-01-01 00:00:00

abstract：:The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated proliferation of mouse embryonic fibroblasts (MEFs) prepared from DHCR24(-/-)...

journal_title：Endocrinology

authors： Lu X,Kambe F,Cao X,Yoshida T,Ohmori S,Murakami K,Kaji T,Ishii T,Zadworny D,Seo H

更新日期：2006-06-01 00:00:00

abstract：:Hypoxia, a common stressor in prematurity, leads to sexually dimorphic, short- and long-term effects on the adult hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. We hypothesized that these effects are due to stress-induced increases in testosterone during early postnatal life. We ev...

journal_title：Endocrinology

authors： Gehrand AL,Phillips J,Malott K,Raff H

更新日期：2020-07-01 00:00:00

abstract：:Thyroid hormones play a major role in body homeostasis, regulating energy expenditure and cardiovascular function. Given that obese people or athletes might consider rapid weight loss as beneficial, voluntary intoxication with T4 preparations is a growing cause for thyrotoxicosis. However, the long-lasting effects of ...

journal_title：Endocrinology

authors： Hoefig CS,Harder L,Oelkrug R,Meusel M,Vennström B,Brabant G,Mittag J

更新日期：2016-07-01 00:00:00

abstract：:Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 thera...

journal_title：Endocrinology

authors： O'Sullivan U,Gluckman PD,Breier BH,Woodall S,Siddiqui RA,McCutcheon SN

更新日期：1989-11-01 00:00:00

abstract：:Exposure of adipocytes to glucocorticoid hormones in vitro causes inhibition of glucose transport and metabolsim. Maximal inhibition of glucose oxidations is reduced from 42-50 to 22-25 to 5-8% in young, mature, and senescent rat adipocytes, respectively. Percent values also reflect absolute reductions since basal lev...

journal_title：Endocrinology

authors： Roth GS,Livingston JN

更新日期：1976-09-01 00:00:00

abstract：:A rat medullary thyroid carcinoma, which was previously shown to produce high levels of immunoreactive cholecystokinin (CCK), was used to establish a stable cell line. Transplantable tumors were subjected to four series of alternate in vitro and in vivo passages. Cells were prepared from the fourth series of tumors un...

journal_title：Endocrinology

authors： Haun RS,Beinfeld MC,Roos BA,Dixon JE

更新日期：1989-08-01 00:00:00

abstract：:Antisera to porcine relaxin were produced in rabbits injected with different fractions that had been separated by polyacrylamide gel electrophoresis (PAGE). Analyses by agar double immunodiffusion demonstrated that the different fractions of relaxin separated by PAGE have similar antigenic sites and the individual fra...

journal_title：Endocrinology

authors： Larkin LH,Fields PA,Oliver RM

更新日期：1977-09-01 00:00:00

abstract：:Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to glucocorticoid effects on functional end points. To investigate the po...

journal_title：Endocrinology

authors： Pariante CM,Pearce BD,Pisell TL,Sanchez CI,Po C,Su C,Miller AH

更新日期：1999-09-01 00:00:00

abstract：:Leptin, a pleiotropic adipokine, is a central regulator of appetite and weight and a key immunomodulatory protein. Although inborn leptin deficiency causes weight gain, it is unclear whether induced leptin deficiency in adult wild-type animals would be orexigenic. Previous work with a potent competitive leptin antagon...

journal_title：Endocrinology

authors： Elinav E,Niv-Spector L,Katz M,Price TO,Ali M,Yacobovitz M,Solomon G,Reicher S,Lynch JL,Halpern Z,Banks WA,Gertler A

更新日期：2009-07-01 00:00:00

abstract：:Enhanced epinephrine secretion from adrenal chromaffin cells (ACCs) is an important homeostatic response to severe systemic inflammation during sepsis. Evidence suggests that increased activation of ACCs by preganglionic sympathetic neurons and direct alterations in ACC function contribute to this response. However, t...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2014-01-01 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) is the major IGF binding protein-4 (IGFBP-4) protease in follicular fluid, consistent with its proposed role in folliculogenesis. Despite growing interest, almost nothing is known about how PAPP-A expression is regulated in any tissue. Here we show that FSH and oocytes re...

journal_title：Endocrinology

authors： Matsui M,Sonntag B,Hwang SS,Byerly T,Hourvitz A,Adashi EY,Shimasaki S,Erickson GF

更新日期：2004-08-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit...

journal_title：Endocrinology

authors： Dijk W,Mattijssen F,de la Rosa Rodriguez M,Loza Valdes A,Loft A,Mandrup S,Kalkhoven E,Qi L,Borst JW,Kersten S

更新日期：2017-05-01 00:00:00

abstract：:The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1 (GLP-1), produced in the intestinal endocrine L cells. We found previously that the bipartite transcription factor beta-catenin/T cell factor (cat/TCF), the major effector of the canonical Wnt signaling pathway, activates intestinal glu ex...

journal_title：Endocrinology

authors： Yi F,Sun J,Lim GE,Fantus IG,Brubaker PL,Jin T

更新日期：2008-05-01 00:00:00

abstract：:In the present study, we have investigated the cellular mechanisms of androgen-induced antral follicular growth arrest and the possible involvement of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) in this process, using a chronically androgenized rat model. We hypothesize that hyperandrogenism induces a...

journal_title：Endocrinology

authors： Kim JY,Xue K,Cao M,Wang Q,Liu JY,Leader A,Han JY,Tsang BK

更新日期：2013-08-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Sulfonylureas are drugs widely used in the treatment of patients with type 2 diabetes mellitus. In addition to their pancreatic effect of stimulating insulin secretion, many studies suggest that sulfonylureas also have extrapancreatic actions. We have previously reported that gliclazide, a second-generation sulfonylur...

journal_title：Endocrinology

authors： Rodríguez E,Pulido N,Romero R,Arrieta F,Panadero A,Rovira A

更新日期：2004-02-01 00:00:00