Abstract:
:The specific uptake by rat liver of human (hGH) and bovine (bGH) GHs labeled with 125I was studied by an in vivo procedure. A significant reduction of the uptake was observed when labeled hormones were injected together with different amounts of the corresponding native GH. This reduction was dose dependent, and the concentration of native hormone that prevents 50% of the liver uptake of the labeled hormone was close to 12 microgram/100 g BW. In normal rats, only native hGH or bGH significantly decreased the liver uptake of [125I]iodo-bGH, while bovine PRL (oPRL) or heat-denatured bGH were inactive. The highest inhibition of the uptake of [125I]iodo-hGH by rat liver was obtained when this labeled hormone was injected either together with hGH or with bGH plus oPRL while partial displacement was observed with bGH or oPRL. These data suggest that hGH binds to both somatotropic and lactogenic sites in the liver of normal rats. In hypophysectomized animals, only the somatogenic binding sites could be detected.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Turyn D,Dellacha JMdoi
10.1210/endo-103-4-1190subject
Has Abstractpub_date
1978-10-01 00:00:00pages
1190-5issue
4eissn
0013-7227issn
1945-7170journal_volume
103pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-1-103
更新日期:1981-01-01 00:00:00
abstract::Endocannabinoids act as a major neuromodulatory system in a variety of physiological and behavioral functions. Three major lines of evidence suggest that the endocannabinoid system interacts with gonadal hormones. First, the endocannabinoid system is implicated in behaviors and physiological functions that are known t...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2011-1643
更新日期:2012-03-01 00:00:00
abstract::The rapid and temporary suppression of reproductive behavior is often assumed to be an important feature of the adaptive acute stress response. However, how this suppression operates at the mechanistic level is poorly understood. The enzyme aromatase converts testosterone to estradiol in the brain to activate reproduc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1341
更新日期:2011-11-01 00:00:00
abstract::The TSH receptor (TSHR) is constitutively active and is further enhanced by TSH ligand binding or by stimulating TSHR antibodies (TSHR-Abs) as seen in Graves' disease. TSH is known to activate the thyroid epithelial cell via both Galphas-cAMP/protein kinase A/ERK and Galphaq-Akt/protein kinase C coupled signaling netw...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0878
更新日期:2009-01-01 00:00:00
abstract::The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cort...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.12.8553
更新日期:2001-12-01 00:00:00
abstract::We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.1.4832
更新日期:1997-01-01 00:00:00
abstract::PTH, via the PTH/PTH-related protein receptor type 1 that couples to both protein kinase A (PKA) and protein kinase C (PKC) pathways, and the canonical Wnt-beta-catenin signaling pathway play important roles in bone formation. In the present study we have examined the interaction between the PTH and Wnt signaling path...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1627
更新日期:2006-05-01 00:00:00
abstract::T3 is required for normal skeletal development, but its cellular targets in bone are unknown. T3 regulates target gene transcription via a specific nuclear receptor (T3R), which can heterodimerize with 9-cis-retinoic acid, 1 alpha, 25-dihydroxyvitamin D3, or retinoic acid receptors to modify T3 responsiveness. Serum-f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.6.7988420
更新日期:1994-12-01 00:00:00
abstract::In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.5.7720640
更新日期:1995-05-01 00:00:00
abstract::The issue of how progesterone affects mammary gland growth is controversial, and the mechanism governing the effects of the hormone remains mostly unknown. We have previously shown that G protein-coupled receptor 30 (GPR30) is a progestin target gene whose expression correlates with progestin-induced growth inhibition...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2001-211445
更新日期:2002-09-01 00:00:00
abstract::Previous studies have shown that estradiol indirectly stimulated the proliferation of oviduct epithelial cells in the quail. The present study was undertaken to investigate the effects of estradiol and other steroid hormones on the cAMP concentration. The ability of forskolin, a specific activator of the catalytic sub...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-1-158
更新日期:1988-01-01 00:00:00
abstract::The antral hormone gastrin and its intestinal relative, cholecystokinin (CCK), are pivotal in the regulation of gastric functions. Other gastric hormones like ghrelin, peptide YY (PYY), and islet amyloid polypeptide (IAPP), however, also contribute to the regulation of acid secretion, motility, and feeding. Because ga...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0938
更新日期:2005-10-01 00:00:00
abstract::We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-5-1715
更新日期:1988-05-01 00:00:00
abstract::The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-6-2247
更新日期:1984-06-01 00:00:00
abstract::A cell-free system was used to characterize the binding reaction between the progesterone receptor and nuclear acceptor sites prepared from rat placenta. Two forms of receptor-acceptor complex were examined. One was extracted from nuclei by exposure to 0.6 M KCl; the other type was resistant to salt extraction. Kineti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-1-28
更新日期:1987-07-01 00:00:00
abstract::Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa175
更新日期:2020-11-01 00:00:00
abstract::Dynamic bone histomorphometry, [3H]thymidine radioautography, and Northern analysis for bone matrix proteins and insulin-like growth factor-I (IGF-I) were performed in calvariae of ovariectomized (OVX) and estrogen-treated OVX rats. Treatment of OVX rats with diethylstilbestrol (DES) for 2 weeks reduced the periosteal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.2.1639030
更新日期:1992-08-01 00:00:00
abstract::Sex differences in liver gene expression are determined by pituitary growth hormone secretion patterns, which regulate sex-dependent liver transcription factors and establish sex-specific chromatin states. Hypophysectomy (hypox) identifies two major classes of liver sex-biased genes, defined by their sex-dependent pos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00949
更新日期:2019-05-01 00:00:00
abstract::In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.4.8137730
更新日期:1994-04-01 00:00:00
abstract::The intermediary role of the putative inhibitory regulatory membrane protein "Ni" in the "antigonadal" activity of the neurohypophysial hormones was investigated in vitro with the use of a primary culture of rat testicular cells. To this end, use was made of the pertussis toxin (PT) probe, an exotoxin of Bordetella pe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-2-839
更新日期:1984-08-01 00:00:00
abstract::Apolipoprotein A-IV (apo A-IV) is a satiety factor involved in the control of food intake and body weight. Our previous studies demonstrated that apo A-IV is present in areas of the hypothalamus where leptin acts to influence energy homeostasis. In the present studies, we found that leptin-deficient obese (ob/ob) mice...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-1596
更新日期:2007-06-01 00:00:00
abstract::Fibrosis (extracellular matrix accumulation) is the final end point in diabetic cardiomyopathy. The current study evaluated the therapeutic effects of the antifibrotic hormone relaxin (RLX) in streptozotocin-treated transgenic mRen-2 rats, which undergo pathological and functional features similar to human diabetes. T...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0250
更新日期:2008-07-01 00:00:00
abstract::Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin β...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1393
更新日期:2012-12-01 00:00:00
abstract::Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.8.8938
更新日期:2002-08-01 00:00:00
abstract::Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1421
更新日期:2013-02-01 00:00:00
abstract::The ability of cells to directly respond to glucocorticoids and aldosterone is a function of GR and MR expression, and coexpression of 11beta-hydroxysteroid dehydrogenases (11betaHSDs), which convert glucocorticoids and their 11-ketometabolites into either receptor inactive or active derivatives. The aim of the presen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.1.8583
更新日期:2002-01-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic neuropeptide synthesized in the hypothalamus. A Leu34Phe missense mutation in proCART has been found in an obese family in humans. Here we show that humans bearing the Leu34Phe mutation in proCART have severely diminished levels of bioactive CART,...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0812
更新日期:2006-01-01 00:00:00
abstract::3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1678
更新日期:2008-06-01 00:00:00
abstract::The effect of diabetes mellitus on the synthesis and secretion of thyroid hormone ws investigated in mice with streptozotocin-induced diabetes. Thyroid glands were labeled in vivo with 131I for 2 h. In control animals, TSH stimulated the synthesis of PB127I and 131I-labeled iodothyronines and simultaneously decreased ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-5-1428
更新日期:1981-11-01 00:00:00
abstract::The temporal aspects of gonadotropin release were studied in infantile (14-day-old) female rats. Blood samples were collected using vena cava cannulae at 10-, 15-, 20-, or 30-min intervals and assayed for either LH alone or for both LH and FSH. Within individual animals, blood LH levels exhibited a degree of variabili...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-105-5-1064
更新日期:1979-11-01 00:00:00