G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells.

abstract：:PTH-related protein (PTHrP), the major mediator of hypercalcemia of malignancy, reduces tubular phosphate (Pi) reabsorption through its PTH-like renotropic actions. Another peptide detected in tumoral cells, transforming growth factor-beta (TGF beta), has been shown to considerably suppress the sodium-dependent Pi tra...

journal_title：Endocrinology

authors： Law F,Rizzoli R,Bonjour JP

更新日期：1993-07-01 00:00:00

abstract：:Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis t...

journal_title：Endocrinology

authors： Molnár CS,Vida B,Sipos MT,Ciofi P,Borsay BÁ,Rácz K,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z,Hrabovszky E

更新日期：2012-11-01 00:00:00

abstract：:There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans. However, the roles of two other tachykinins, substance P (SP) and neurokinin A, which act primarily via NK1R and NK2R, respecti...

journal_title：Endocrinology

authors： Fergani C,Mazzella L,Coolen LM,McCosh RB,Hardy SL,Newcomb N,Grachev P,Lehman MN,Goodman RL

更新日期：2016-12-01 00:00:00

abstract：:Using a 0-32% continuous metrizamide density gradient, interstitial cells could be separated into five distinct bands. Cells localized in bands 1 (B1), 2 (B2), and 3 (B3) were isolated and incubated for 1h with or without human chorionic gonadotropin (hCG). Both B2 and B3 cells responded to hCG with increased cyclic A...

journal_title：Endocrinology

authors： Lin T,Lincoln TM,Brown N,Murono EP,Osterman J,Nankin HR

更新日期：1982-10-01 00:00:00

abstract：:The calcium-dependent class of cell adhesion molecules known as cadherins mediate homotypic cell interactions in most epithelia. We have now investigated the expression and distribution of cadherins and cadherin-associated molecules in the developing and maturing rat testis. E-Cadherin was not detected in the seminife...

journal_title：Endocrinology

authors： Byers SW,Sujarit S,Jegou B,Butz S,Hoschutzky H,Herrenknecht K,MacCalman C,Blaschuk OW

更新日期：1994-02-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00

abstract：:Neuronal remodeling in response to deafferenting lesions in the brain can be enhanced by estradiol (E2). Astrocytes are among the targets of E2 in complex interactions with neurons and may support or inhibit neuronal remodeling. In ovariectomized female rats given entorhinal cortex lesions, E2 replacement inhibited th...

journal_title：Endocrinology

authors： Rozovsky I,Wei M,Stone DJ,Zanjani H,Anderson CP,Morgan TE,Finch CE

更新日期：2002-02-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:The effect of beta-endorphin upon plasma arg8-vasopressin release was studied in vivo in rabbits and in vitro in rat neural lobes. Following intravenous administration of 200 mug/kg synthetic beta-endorphin plasma AVP rose significantly by five minutes after injection and remained elevated for twenty-five minutes comp...

journal_title：Endocrinology

authors： Weitzman RE,Fisher DA,Minick S,Ling N,Guillemin R

更新日期：1977-11-01 00:00:00

abstract：:Sodium butyrate (NaB), a dietary micronutrient, is a potent growth inhibitor that initiates cell differentiation in many cell types, including prostate cancer cells. The molecular mechanisms by which these effects occur remain largely unknown. In this study, we investigated the effects of NaB on the expression of IGF ...

journal_title：Endocrinology

authors： Tsubaki J,Hwa V,Twigg SM,Rosenfeld RG

更新日期：2002-05-01 00:00:00

abstract：:The calbindins are Ca-binding proteins whose expression is regulated by 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D3. The calbindins are found in high amounts in the proximal intestine (calbindin-D-9k) and the kidney (calbindin-D-28k), and they are thought to play a role in Ca transport by these tissu...

journal_title：Endocrinology

authors： Armbrecht HJ,Boltz M,Strong R,Richardson A,Bruns ME,Christakos S

更新日期：1989-12-01 00:00:00

abstract：:Cytosols of whole testicular homogenates from the Syrian golden hamster contained specific binding sites for [3H]triamcinolone acetonide that exhibited limited capacity and high affinity binding characteristic of glucocorticoid receptors in other target tissues. The receptor complex sedimented as an 8.6S binder in low...

journal_title：Endocrinology

authors： Ortlip SA,Li SA,Li JJ

更新日期：1981-11-01 00:00:00

abstract：:The present experiments examined the relationship between cholera toxin and TSH stimulation of the adenylate cyclase system in bovine thyroid tissue. Preincubation of thyroid slices for 20 min at 4 C with a maximal concentration of cholera toxin (100 microgram/ml) did not impair the subsequent stimulation of cAMP by s...

journal_title：Endocrinology

authors： Holmes SD,Titus G,Chou M,Field JB

更新日期：1980-12-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:Neuropeptide Y (NPY) is highly expressed in the hypothalamus, where it regulates feeding and energy homeostasis. Interestingly, NPY and its receptors are also expressed in peripheral tissues with roles in metabolism, including pancreatic islets. In islets, NPY is known to suppress insulin secretion acutely. In additio...

journal_title：Endocrinology

authors： Machida Y,Bruinsma C,Hallinger DR,Roper SM,Garcia E,Trevino MB,Nadler J,Ahima R,Imai Y

更新日期：2014-12-01 00:00:00

abstract：:In an attempt to further define the optimum experimental conditions for the in vitro study of PRL endocrinology, the effect of extracellular leucine concentration on PRL secretion was assessed. Rat pituitary cells, maintained in short term monolayer culture, were washed free of serum and placed in Minimum Essential Me...

journal_title：Endocrinology

authors： Cross M,Walker AM

更新日期：1984-01-01 00:00:00

abstract：:Bone morphogenetic protein (BMP)-4 is a key mediator of anterior pituitary organogenesis. However, through inappropriate expression patterns, BMP-4 is also pathogenic in a pituitary adenoma subtype-specific context. In these cases, increase or decrease in BMP-4 in lactotroph- and corticotroph-derived adenomas, respect...

journal_title：Endocrinology

authors： Yacqub-Usman K,Duong CV,Clayton RN,Farrell WE

更新日期：2012-08-01 00:00:00

abstract：:Compelling evidence indicates a crucial role of prostaglandin F2α (PGF2α) in parturition. Both the maternal and fetal sides of the fetal membranes synthesize PGF2α, which exerts effects via the prostaglandin F2α receptor (FP) that is coupled to the activation of protein kinase C (PKC). Cyclooxygenase-2 (COX-2) catalyz...

journal_title：Endocrinology

authors： Guo CM,Kasaraneni N,Sun K,Myatt L

更新日期：2012-10-01 00:00:00

abstract：:The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

journal_title：Endocrinology

authors： Edery M,Imagawa W,Larson L,Nandi S

更新日期：1985-01-01 00:00:00

abstract：:Adrenals express a high level of neutral cholesteryl ester hydrolase (CEH) activity, and male rats have greater activity than females; however, the identity of the enzyme(s) responsible for this activity and the basis for the sex differences are unknown. Using mice in which hormone-sensitive lipase (HSL) was inactivat...

journal_title：Endocrinology

authors： Kraemer FB,Shen WJ,Natu V,Patel S,Osuga J,Ishibashi S,Azhar S

更新日期：2002-03-01 00:00:00

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00

abstract：:Intact 23 kilodalton (kDa), rat PRL is enzymatically cleaved in many target tissues to a 16 kDa (16K PRL) and an 8 kDa fragment. After reduction of an internal disulfide bond the fragments are released. 16K PRL was shown to be a potent mitogen on mammary epithelial cells via PRL receptors. Since estradiol-induced prol...

journal_title：Endocrinology

authors： Ferrara N,Clapp C,Weiner R

更新日期：1991-08-01 00:00:00

abstract：:An estrogen (E2)-dependent 90,000-92,000 M(r) protein is synthesized and released by the sheep oviduct in a temporally and regionally specific manner during the first few days of pregnancy, where it associates with the embryo. The present study was undertaken to further define the nature of this protein and its regula...

journal_title：Endocrinology

authors： DeSouza MM,Murray MK

更新日期：1995-06-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknow...

journal_title：Endocrinology

authors： Wang X,Cahill CM,Piñeyro MA,Zhou J,Doyle ME,Egan JM

更新日期：1999-10-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:The PRL-stimulating effect of metoclopramide (2-methoxy-5-chloroprocainamide) was examined in normal and adrenalectomized male rats pretreated with DL-p-chlorophenylalanine methyl ester (PCPA), an inhibitor of serotonin biosynthesis. PCPA significantly reduced the hypothalamic content of serotonin, increased basal PRL...

journal_title：Endocrinology

authors： Fang VS,Shian LR

更新日期：1981-05-01 00:00:00

abstract：:The mechanism by which aluminum chloride stimulates de novo bone formation is unknown. To evaluate the role of bone remodeling and mature osteoblastic function in aluminum-induced neoosteogenesis, we compared the osteogenic effects of aluminum in normal beagles to those in animals with low turnover osteomalacia induce...

journal_title：Endocrinology

authors： Quarles LD,Drezner MK

更新日期：1992-07-01 00:00:00

abstract：:Epidermal growth factor (EGF) and TGFalpha are well known for their activities in the ovary. Both factors initiate signal transduction by binding to the common EGF receptor that has been demonstrated in the ovary across vertebrates from fish to humans. Using zebrafish as the model, we demonstrated in the present study...

journal_title：Endocrinology

authors： Pang Y,Ge W

更新日期：2002-01-01 00:00:00

abstract：:Obesity is often associated with an impairment of the hypothalamic-pituitary-gonadal axis. The leptin-deficient ob/ob mouse model is characterized by a morbid obesity with a sterility in males and females that is corrected by continuous leptin treatment. Since ob/ob mice are maintained on the C57BL/6J inbred genetic b...

journal_title：Endocrinology

authors： Ewart-Toland A,Mounzih K,Qiu J,Chehab FF

更新日期：1999-02-01 00:00:00