The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells.

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00

abstract：:The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells. Previous work showed dynamic changes in the GnRH-glial-capillary network in the median eminence under different ...

journal_title：Endocrinology

authors： Yin W,Wu D,Noel ML,Gore AC

更新日期：2009-12-01 00:00:00

abstract：:Melatonin was shown to occur in rat plasma and urine after pinealectomy by bioassay, radioimmunoassay, and thin-layer chromatography. Total daily excretion of melatonin in pinealectomized rats was about 20% of control. Light-dark rhythms of plasma melatonin levels and urinary excretion rates disappeared after pinealec...

journal_title：Endocrinology

authors： Ozaki Y,Lynch HJ

更新日期：1976-08-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:Adenylate cyclase of rat renal cortex was inhibited by angiotensin II (AII). Inhibition required Na+ (100-200 mM) and GTP (10(-8)-10(-4) M) and was opposed by the receptor antagonist [1-sarcosine, 8-isoleucine]AII. The EC50 value (+/- SE)for inhibition by AII was 3.7 +/- 1.2 nM, and the maximum inhibition (+/- SE) was...

journal_title：Endocrinology

authors： Woodcock EA,Johnston CI

更新日期：1982-11-01 00:00:00

abstract：:A RIA for mouse placental lactogen-I (mPL-I) was developed using recombinant mPL-I as the standard, radioligand, and antigen for antiserum production. Displacement curves for dilutions of serum and placental extracts from pregnant mice were parallel to the recombinant mPL-I standard curve. Serum from male and nonpregn...

journal_title：Endocrinology

authors： Ogren L,Southard JN,Colosi P,Linzer DI,Talamantes F

更新日期：1989-11-01 00:00:00

abstract：:Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...

journal_title：Endocrinology

authors： Murray I,Havel PJ,Sniderman AD,Cianflone K

更新日期：2000-03-01 00:00:00

abstract：:Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrat...

journal_title：Endocrinology

authors： Key LL Jr,Carnes DL Jr,Weichselbaum R,Anast CS

更新日期：1983-02-01 00:00:00

abstract：:Epididymal adipocytes were isolated from Fischer 344 rats aged 3, 6, 12, and 24 months, to study the mechanisms responsible for age-dependent diminution in cellular adrenergic responsiveness. Messenger RNA (mRNA) levels for the beta 1-, beta 2-, and beta 3-adrenergic receptors (ARs) were compared across age groups and...

journal_title：Endocrinology

authors： Gettys TW,Rohlfs EM,Prpic V,Daniel KW,Taylor IL,Collins S

更新日期：1995-05-01 00:00:00

abstract：:Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data in vivo. Hence, the objective of our study was to examine the...

journal_title：Endocrinology

authors： Audette MC,Challis JR,Jones RL,Sibley CP,Matthews SG

更新日期：2011-09-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:Lipoprotein lipase (LPL) is a key regulator of triglyceride clearance. Its coordinated regulation during feeding and fasting is critical for maintaining lipid homeostasis and energy supply. Angiopoietin-like (Angptl)3 and Angptl4 are secreted proteins that have been demonstrated to regulate triglyceride metabolism by ...

journal_title：Endocrinology

authors： Köster A,Chao YB,Mosior M,Ford A,Gonzalez-DeWhitt PA,Hale JE,Li D,Qiu Y,Fraser CC,Yang DD,Heuer JG,Jaskunas SR,Eacho P

更新日期：2005-11-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：:Stat proteins are SH2 domain-containing transcription factors that are activated by various cytokines and growth factors. In a previous work, we have identified Stat 5B as a substrate of the insulin receptor based on yeast two-hybrid and mammalian cell transfection studies. In the present study, we have approached the...

journal_title：Endocrinology

authors： Sawka-Verhelle D,Tartare-Deckert S,Decaux JF,Girard J,Van Obberghen E

更新日期：2000-06-01 00:00:00

abstract：:The CRH-binding protein (CRH-BP) antagonizes the ACTH-releasing activity of the neuropeptide CRH in vitro. However, the function of CRH-BP in vivo and the molecular mechanisms that regulate CRH-BP expression are not well understood. In this study, the rat CRH-BP gene was characterized, and CRH-BP promoter sequences we...

journal_title：Endocrinology

authors： Cortright DN,Goosens KA,Lesh JS,Seasholtz AF

更新日期：1997-05-01 00:00:00

abstract：:Neuropeptide Y (NPY) is highly expressed in the hypothalamus, where it regulates feeding and energy homeostasis. Interestingly, NPY and its receptors are also expressed in peripheral tissues with roles in metabolism, including pancreatic islets. In islets, NPY is known to suppress insulin secretion acutely. In additio...

journal_title：Endocrinology

authors： Machida Y,Bruinsma C,Hallinger DR,Roper SM,Garcia E,Trevino MB,Nadler J,Ahima R,Imai Y

更新日期：2014-12-01 00:00:00

abstract：:Previous studies have demonstrated that estradiol-17beta and estradiol-17alpha both induce short-latency effects on spatial memory in rats, estradiol-17alpha being at least as potent as its 17beta isomer. To determine whether the mechanisms underlying these behavioral responses might include effects on hippocampal syn...

journal_title：Endocrinology

authors： MacLusky NJ,Luine VN,Hajszan T,Leranth C

更新日期：2005-01-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:P19 EPI-7, a differentiated murine embryonal carcinoma cell line with an epithelioid morphology, does not require external growth factors for proliferation under clonal and subconfluent conditions. At saturation density, however, cells become quiescent in the G1/G0 phase of the cell cycle from which they can be restim...

journal_title：Endocrinology

authors： van Zoelen EJ,Koornneef I,Holthuis JC,Ward-van Oostwaard TM,Feijen A,de Poorter TL,Mummery CL,van Buul-Offers SC

更新日期：1989-04-01 00:00:00

abstract：:Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...

journal_title：Endocrinology

authors： Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

更新日期：2001-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic neuropeptide synthesized in the hypothalamus. A Leu34Phe missense mutation in proCART has been found in an obese family in humans. Here we show that humans bearing the Leu34Phe mutation in proCART have severely diminished levels of bioactive CART,...

journal_title：Endocrinology

authors： Yanik T,Dominguez G,Kuhar MJ,Del Giudice EM,Loh YP

更新日期：2006-01-01 00:00:00

abstract：:The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various transcriptional coregulators of MR is essential for understanding the compl...

journal_title：Endocrinology

authors： Kuppusamy M,Gomez-Sanchez EP,Beloate LN,Plonczynski M,Naray-Fejes-Toth A,Fejes-Toth G,Gomez-Sanchez CE

更新日期：2017-07-01 00:00:00

abstract：:To investigate trafficking in neuroendocrine cells, green fluorescent protein (GFP) tags were fused to various portions of the preproneuropeptide Y (NPY) precursor. Two neuroendocrine cell lines, AtT-20 corticotrope tumor cells and PC-12 pheochromocytoma cells, along with primary anterior pituitary cells, were examine...

journal_title：Endocrinology

authors： El Meskini R,Jin L,Marx R,Bruzzaniti A,Lee J,Emeson R,Mains R

更新日期：2001-02-01 00:00:00

abstract：:Some 17 alpha-alkylated androgens used as anabolic agents, such as stanozolol (ST) and danazol (DA), have specific effects on the liver that are not exerted by testosterone. This gives rise to the possibility that a steroid-binding protein, other than the androgen receptor, could modulate the intracellular actions of ...

journal_title：Endocrinology

authors： Fernández L,Chirino R,Boada LD,Navarro D,Cabrera N,del Rio I,Díaz-Chico BN

更新日期：1994-03-01 00:00:00

abstract：:Androgens are the primary regulators of epididymal structure and functions. Principal cells are the major cell type of the tissue and are particularly sensitive to androgen removal. To distinguish the direct effects of androgens on this cell type, DNA microarrays were used to identify androgen-regulated genes in the m...

journal_title：Endocrinology

authors： Seenundun S,Robaire B

更新日期：2007-01-01 00:00:00

abstract：:To determine whether glucagon plays a significant role in the restitution of blood volume after hemorrhage, pentobarbital-anesthetized dogs were treated with somatostatin (SRIF). The administration of SRIF (14 micrograms/kg.h) prevented the increase in osmolality and the complete restitution of plasma protein and bloo...

journal_title：Endocrinology

authors： Byrnes GJ,Engeland WC,Gann DS

更新日期：1982-06-01 00:00:00

abstract：:Male Wistar rats were treated with 50 mg 3,3',4,4'-tetrachlorobiphenyl (TCB)/kg BW or vehicle. After 4 days, the livers were isolated and perfused for 90 min with 2 nM [125I]T3 or 10 nM [125I]T4 in Krebs-Ringer medium containing 1% albumin. Deiodination and conjugation products and remaining substrates were determined...

journal_title：Endocrinology

authors： Beetstra JB,van Engelen JG,Karels P,van der Hoek HJ,de Jong M,Docter R,Krenning EP,Hennemann G,Brouwer A,Visser TJ

更新日期：1991-02-01 00:00:00

abstract：:The influence of GH and several other pituitary hormones on the secretion and intracellular content of immunoreactive somatostatin (IRS) in cultured hypothalamic cells was examined. Hypothalamic cells prepared from 17-day-old rat embryos and maintained as reaggregate monolayers for 12 days in vitro were used. Short te...

journal_title：Endocrinology

authors： Robbins RJ,Leidy JW Jr,Landon RM

更新日期：1985-08-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00