Abstract:
:Adenylate cyclase of rat renal cortex was inhibited by angiotensin II (AII). Inhibition required Na+ (100-200 mM) and GTP (10(-8)-10(-4) M) and was opposed by the receptor antagonist [1-sarcosine, 8-isoleucine]AII. The EC50 value (+/- SE)for inhibition by AII was 3.7 +/- 1.2 nM, and the maximum inhibition (+/- SE) was 23 +/- 3%. Inhibition was specific for AII, since both AI and AIII, at concentrations up to 1 microM, were ineffective in producing inhibition. The maximum decrease (+/- SE) in adenylate cyclase activity was from 2.45 +/- 0.08 to 1.78 +/- 0.1 pmol.min/mg protein. A similar absolute decrease was observed when adenylate cyclase was stimulated by calcitonin, vasopressin, or isoproterenol. The inhibition of PTH-stimulated activity [16.7 +/- 0.5 (+/- SE) to 12.2 +/- 0.7 pmol.min/mg protein) was significantly greater than the inhibition of basal activity. Therefore, at least some of the inhibitory angiotensin receptors are coupled to adenylate cyclase molecules which also coupled to receptors for PTH.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Woodcock EA,Johnston CIdoi
10.1210/endo-111-5-1687subject
Has Abstractpub_date
1982-11-01 00:00:00pages
1687-91issue
5eissn
0013-7227issn
1945-7170journal_volume
111pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Leptin, a recently-discovered hormonal product of the obese gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety and improves reproductive performance if injected into mice lacking circulating leptin. Therefore, we tested the hypothesis that leptin signals metabolic informati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.8.5311
更新日期:1997-08-01 00:00:00
abstract::The role of anti-Müllerian hormone (AMH) during gonad development has been studied extensively in many species of mammal, bird, reptile, and fish but remains unresolved in amphibians. In male mammalian embryos, Sox9 activates AMH expression, which initiates regression of the Müllerian ducts. However, Sox9 (Sry-related...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2053
更新日期:2015-05-01 00:00:00
abstract::Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1038
更新日期:2011-02-01 00:00:00
abstract::Nuclear proteins extracted from purified nuclei with 0.4M KCl at pH 7.4 OR 8.5 are able to bind L-triiodothyronine (T3) giving rise to nuclear thyroid hormone binding protein-T3 (NTBP-T3) complexes. Binding is maximum in 3 h at 20 C. It is thermolabile even at 36 C, inhibited by p-hydroxymercuribenzoate and markedly e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1201
更新日期:1975-05-01 00:00:00
abstract::Aprotinin caused a dose-dependent inhibition of [125I]hCG binding to its receptor in plasma membranes prepared from luteinized rat ovaries. Displacement of [125I]hCG from its receptor by aprotinin was temperature dependent, with an ID50 of 300 microM at 4 C and an ID50 of 3700 microM at 22 C. Equilibrium binding data ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-3-946
更新日期:1987-03-01 00:00:00
abstract::A surge of GnRH release signals the LH surge that triggers ovulation. The GnRH surge is dependent on a switch in estradiol feedback from negative to positive and, in rodents, a daily neural signal, likely from the suprachiasmatic nuclei. Vasoactive intestinal polypeptide (VIP) may be involved in suprachiasmatic nuclei...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1098
更新日期:2008-06-01 00:00:00
abstract::Type 1 diabetes is caused by autoimmune destruction of β-cells. Although immunotherapy can restore self-tolerance thereby halting continued immune-mediated β-cell loss, residual β-cell mass and function is often insufficient for normoglycemia. Using a growth factor to boost β-cell mass can potentially overcome this ba...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1549
更新日期:2016-01-01 00:00:00
abstract::Studies were undertaken to evaluate the effects of chronic morphine exposure on the negative and positive feedback effects of estradiol (E2) on LH and FSH secretion in ovariectomized rats. Two days of E2 exposure reduced at 1000 h and stimulated at 1600 h the serum LH concentration at each dose tested. Chronic exposur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-5-1799
更新日期:1987-05-01 00:00:00
abstract::Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents. The reduction in adiposity is related to decreased food intake and increased energy expenditure. However, the molecular mechanisms through which TPM induces weight loss are contradictory and remain to be clarified. Whether TPM treatme...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1272
更新日期:2012-09-01 00:00:00
abstract::Epigenetic aberrations, including DNA methylation, histone modifications, and micro-RNA dysregulation, are now well established in the development and progression of ovarian cancer, and their gradual accumulation is associated with advancing disease stage and grade. Epigenetic aberrations are relatively stable, associ...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2009-0404
更新日期:2009-09-01 00:00:00
abstract::The ratio of oligomeric (big) to monomeric (little) human (h)GH forms in plasma exceeds that in the pituitary gland severalfold. To investigate whether delayed metabolic clearance of oligomers could explain this discrepancy, we measured MCR, distribution volumes, and degradation rates of radio-labeled hGH22K dimer, hG...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-4-1497
更新日期:1986-10-01 00:00:00
abstract::Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1996
更新日期:2012-07-01 00:00:00
abstract::The expression of the microsomal (M) antigen on the surface and in the cytoplasm of a strain of rat thyroid cells (FRTL-5) is under the regulation of TSH. In the present report the mechanism by which TSH induces such expression was investigated with the use of human microsomal antibody-positive serum and an indirect i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-2-1140
更新日期:1988-08-01 00:00:00
abstract::The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three different strains of the cell line D1, D16v, and D16:16, respectively, were analyzed. In initial studies CRF and phorbol esters were used as secretagogues to examine...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.6.1332850
更新日期:1992-12-01 00:00:00
abstract::Deciduomal reactions in response to artificial stimuli were induced on the tube-ligated uterine horns of unilateral pregnant hamsters. Serum progesterone levels were determined, and the changes of estrogen and progesterone receptors (ER and PR, respectively) were simultaneously studied in the deciduoma. After stimulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-1-302
更新日期:1989-07-01 00:00:00
abstract::In the present work a chimeric receptor containing the intracellular domain of the insulin receptor-related receptor (IRR) and the extracellular domain of the colony stimulating factor-1 (CSF-1) receptor was expressed in 3T3-L1 adipocytes and compared with the parallel chimeric receptor containing the cytoplasmic doma...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.8.6165
更新日期:1998-08-01 00:00:00
abstract::Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity. We now report the cloning and sequencing of a full-length murine endoglin complementary DNA of 2902 base pairs which hybridizes ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.6.8194490
更新日期:1994-06-01 00:00:00
abstract::The action of the cyclic peptide polymyxin B (a well known inhibitor of protein kinase C) on adrenal steroid synthesis was examined with Y-1 adrenal tumor cells. Polymyxin B produces a biphasic effect on the stimulation of steroid synthesis by 2 nM ACTH in these cells, with inhibition at low concentrations (less than ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-1-290
更新日期:1987-07-01 00:00:00
abstract::In the present study epididymal epithelium was immortalized in transgenic mice by expressing simian virus 40 T antigen under a 5.0-kb mouse glutathione peroxidase 5 promoter (GPX5-Tag1). Epididymal tumorigenesis was associated with an increase in c-Myc expression, and a marked decrease in B-Myc expression, with a 500-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0831
更新日期:2004-01-01 00:00:00
abstract::Osteoclasts are bone-resorbing cells whose normal function depends in part upon their ability to migrate over the bone surface to initiate new sites of bone resorption. The growth factor/cytokine, colony-stimulating factor-1 (CSF-1), potently stimulates osteoclast motility, in a c-src-dependent fashion. The intracellu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.6.7480
更新日期:2000-06-01 00:00:00
abstract::The observation that angiotensin III is present in the circulation of the rat in amounts similar to those of angiotensin II has led to the notion that it may, in part, be formed by the action of converting enzyme on des-Asp-angiotensin I without the prior formation of angiotensin II. This possibility was studied in co...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-2-406
更新日期:1981-02-01 00:00:00
abstract::In male rats maintained on a 12 h light-dark schedule (6 AM-6 PM), there is a nyctohemeral cycle of plasma prolactin which consists of a nadir at 11:30 AM and an apogee at approximately 11:30 PM. In rats exposed to constant darkness, this rhythm persists for 7 days. Seven days of constant light, however, reverses this...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1230
更新日期:1975-05-01 00:00:00
abstract::Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.4.7895660
更新日期:1995-04-01 00:00:00
abstract::Corticotropin-releasing factor-like immunoreactivity (CRF) and plasma ACTH were measured in rats bearing bilateral lesions of the paraventricular nucleus (PVN). Four to 6 days after stereotaxic surgery, CRF-like immunoreactivity content of the stalk-median eminence was reduced by 87-90% and the ACTH response to a 3-mi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-1-57
更新日期:1984-01-01 00:00:00
abstract::Leucine-rich repeat-containing G protein-coupled receptor (LGR)-5 is a recently identified marker of stem cells in adult intestinal epithelium and hair follicles. Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions. Lgr5 is highly expressed in the uteri...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0690
更新日期:2009-11-01 00:00:00
abstract::GH-releasing factor (GRF) is a hypothalamic peptide that stimulates the secretion of pituitary GH. The possibility of feedback effects of GRF within the central nervous system was studied in conscious freely moving male rats with indwelling iv and intracerebroventricular (icv) cannulae. Animals were injected icv or iv...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-5-1872
更新日期:1986-05-01 00:00:00
abstract::The rapid, nongenomic effects of estrogen are increasingly recognized as playing an important role in several aspects of estrogen action. Rapid activation of the mitogen-activated protein kinase (MAPK) signaling pathway by estrogen is among the more recently identified of these effects. To explore the role of estrogen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.6.8071
更新日期:2001-06-01 00:00:00
abstract::With advancing age, 60-80% of the follicles of the mouse thyroid gland turn "cold", i.e. they lose their normal capacity to iodinate thyroglobulin (Tgb). Cold follicles are morphologically characterized by their large size, by deeply periodic acid-Schiff-stained colloid and by flat epithelial cells. We investigated th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-5-1758
更新日期:1987-05-01 00:00:00
abstract::GH secretion is markedly blunted in obesity; however, the mechanism(s) mediating this response remains to be elucidated. In the present study we examined the involvement of the two hypothalamic GH-regulatory hormones, GH-releasing factor (GRF) and somatostatin (SRIF), using the genetically obese male Zucker rat. Spont...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-3087
更新日期:1990-12-01 00:00:00
abstract::Prader-Willi syndrome (PWS) has a biphasic clinical phenotype with failure to thrive in the neonatal period followed by hyperphagia and severe obesity commencing in childhood among other endocrinological and neurobehavioral abnormalities. The syndrome results from loss of function of several clustered, paternally expr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0371
更新日期:2005-10-01 00:00:00