The metabolic clearance, distribution, and degradation of dimeric and monomeric growth hormone (GH): implications for the pattern of circulating GH forms.

abstract：:Thyroid hormones regulate bone homeostasis, and exogenously induced hyperthyroidism and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), a determinant of bone mass. Here, we assessed the role of Dkk1 in thyroid hormone-induced changes in bone...

journal_title：Endocrinology

authors： Tsourdi E,Colditz J,Lademann F,Rijntjes E,Köhrle J,Niehrs C,Hofbauer LC,Rauner M

更新日期：2019-03-01 00:00:00

abstract：:This study uses a high purity cell culture system to extend previous observations of factors controlling the end of the Sertoli cell proliferative phase. Thyroid hormone, retinoic acid, and testosterone were assessed for their ability to halt the proliferative phase and regulate the expression of markers associated wi...

journal_title：Endocrinology

authors： Buzzard JJ,Wreford NG,Morrison JR

更新日期：2003-09-01 00:00:00

abstract：:The issue of how progesterone affects mammary gland growth is controversial, and the mechanism governing the effects of the hormone remains mostly unknown. We have previously shown that G protein-coupled receptor 30 (GPR30) is a progestin target gene whose expression correlates with progestin-induced growth inhibition...

journal_title：Endocrinology

authors： Ahola TM,Manninen T,Alkio N,Ylikomi T

更新日期：2002-09-01 00:00:00

abstract：:Frequent blood sampling via intraatrial cannula revealed daily rhythms of TSH and thyroid hormones in both male and female Wistar rats. Thermic ablation of the biological clock, i.e. the suprachiasmatic nucleus (SCN), eliminated the diurnal peak in circulating TSH and thyroid hormones. In addition, SCN lesions produce...

journal_title：Endocrinology

authors： Kalsbeek A,Fliers E,Franke AN,Wortel J,Buijs RM

更新日期：2000-10-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...

journal_title：Endocrinology

authors： Montuenga LM,Mariano JM,Prentice MA,Cuttitta F,Jakowlew SB

更新日期：1998-09-01 00:00:00

abstract：:We have recently identified gonadotropes as target cells for ATP action via ATP receptors of the P2U subtype. The present studies have used gonadotrope-derived alpha T3-1 cells to examine the possible signaling mechanisms subserving ATP action in gonadotropes. Addition of ATP produced a biphasic intracellular Ca2+ (Ca...

journal_title：Endocrinology

authors： Chen ZP,Kratzmeier M,Poch A,Xu S,McArdle CA,Levy A,Mukhopadhyay AK,Lightman SL

更新日期：1996-01-01 00:00:00

abstract：:The site(s) of the negative feedback action of estrogen on gonadotropin secretion were studied in the ovariectomized rhesus monkey by observing the serum LH and FSH responses to intravenous GnRH injections at various times after implantation of Silastic capsules filled with estrogen. Circulating estrogen concentration...

journal_title：Endocrinology

authors： Weick RF,Pitelka V,Thompson DL

更新日期：1983-05-01 00:00:00

abstract：:The marked up-regulation of oxytocin (OT) receptors in rabbit amnion at term was reproduced in cultured amnion cells by raising intracellular cAMP levels. (Bu)2AMP, forskolin, or cholera toxin caused 2- to 8-fold increases in specific binding of iodinated OT antagonist. The rise in OT receptors involves activation of ...

journal_title：Endocrinology

authors： Hinko A,Soloff MS

更新日期：1993-01-01 00:00:00

abstract：:To identify genes involved in regulated insulin secretion, we have established and characterized two sublines derived from the mouse pancreatic beta-cell line MIN6, designated B1 and C3. They have a similar insulin content, but differ in their secretory properties. B1 responded to glucose in a concentration- and cell ...

journal_title：Endocrinology

authors： Lilla V,Webb G,Rickenbach K,Maturana A,Steiner DF,Halban PA,Irminger JC

更新日期：2003-04-01 00:00:00

abstract：:The Djungarian hamster displays photoperiodic variations in gonadal size synchronized to the seasons by the nightly secretion of the pineal hormone melatonin. In short photoperiod (SP), the gonads regress in size, and circulating sex steroids levels decline. Thus, the brain is subject to seasonal variations of both me...

journal_title：Endocrinology

authors： Bolborea M,Laran-Chich MP,Rasri K,Hildebrandt H,Govitrapong P,Simonneaux V,Pévet P,Steinlechner S,Klosen P

更新日期：2011-10-01 00:00:00

abstract：:In the testis the mesenchymally derived peritubular cells produce a paracrine factor, PModS, that mediates mesenchymal-epithelial interactions and modulates Sertoli cell functions essential for the process of spermatogenesis. PModS has a more dramatic effect on Sertoli cell differentiated functions in vitro than any r...

journal_title：Endocrinology

authors： Norton JN,Vigne JL,Skinner MK

更新日期：1994-01-01 00:00:00

abstract：:Acromegaly is associated with an increased incidence of cardiovascular disease. Transgenic mice expressing bovine GH (bGH) gene have previously been used to examine the effects of chronic GH stimulation on cardiovascular function. Results concerning systolic blood pressure (SBP) in bGH mice are conflicting. We hypothe...

journal_title：Endocrinology

authors： Jara A,Benner CM,Sim D,Liu X,List EO,Householder LA,Berryman DE,Kopchick JJ

更新日期：2014-03-01 00:00:00

abstract：:Amplification of insulin secretion by cAMP is mediated by protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac). Using selective activators, we determined how each effector influences the cytosolic free Ca(2+) concentration ([Ca(2+)]c) and insulin secretion in mouse islets. Alone PKA activator ...

journal_title：Endocrinology

authors： Henquin JC,Nenquin M

更新日期：2014-09-01 00:00:00

abstract：:Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3-4.5 month old) preobese mutant mice. These mutants had normal body weights, lean body mass, serum lep...

journal_title：Endocrinology

authors： Akhter N,Odle AK,Allensworth-James ML,Haney AC,Syed MM,Cozart MA,Chua S,Kineman R,Childs GV

更新日期：2012-10-01 00:00:00

abstract：:In vitro addition of rat insulin (200, 400 or 800 muU/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total NADPH/NADP and inhibition of glucose oxidation via the pentose phosphate shunt (PPS). NADH an...

journal_title：Endocrinology

authors： Ammon HP,Verspohl E

更新日期：1976-12-01 00:00:00

abstract：:Intravenous (i.v.) administration of TRF (1 mg/kg) increases the LD50 of pentobarbital (PB) by 25% while the same dose of somatostatin results in a 30% reduction in PB LD50. A similar increase of PB LD50 by TRF was observed in hypophysectomized rats. Mortality was completely abolished in rats receiving TRF (1 mg/kg) t...

journal_title：Endocrinology

authors： Brown M,Vale W

更新日期：1975-05-01 00:00:00

abstract：:Male rats of five different strains (Simonsen albino, Wistar, Long-Evans, Holtzman Sprague-Dawley, and Charles River Sprague-Dawley) were tested for their response to the U.S. Biochemical Corp. Remington low iodine diet containing 15-18 microgram I/kg. Measurements made after the diet had been fed for 28-30 days indic...

journal_title：Endocrinology

authors： Okamura K,Taurog A,Krulich L

更新日期：1981-08-01 00:00:00

abstract：:The N-terminal fragment of PRL (16K PRL) is an antiangiogenic factor that, in vitro, inhibits several components of angiogenesis including basic fibroblast growth factor (bFGF)-induced cell division, migration, and organization of capillary endothelial cells. An essential step in the regulation of angiogenesis is the ...

journal_title：Endocrinology

authors： Lee H,Struman I,Clapp C,Martial J,Weiner RI

更新日期：1998-09-01 00:00:00

abstract：:Limited proteolysis in vivo of insulin-like growth factor-binding protein-3 (IGFBP-3) by as yet unidentified serine proteases plays a key role in controlling the bioavailability of IGFBP-3-associated insulin-like growth factors (IGFs). Both the IGF system and the system of plasminogen activators (PAs) and their inhibi...

journal_title：Endocrinology

authors： Lalou C,Silve C,Rosato R,Segovia B,Binoux M

更新日期：1994-12-01 00:00:00

abstract：:Both starvation and feeding of a low protein diet have dramatic effects on serum thyroid hormone concentrations and on the serum binding proteins for thyroid hormones in rats. We examined whether similar changes might be seen in another model of undernutrition, namely underfeeding without alteration of dietary composi...

journal_title：Endocrinology

authors： Glass AR,Young RA,Anderson J

更新日期：1986-06-01 00:00:00

abstract：:GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...

journal_title：Endocrinology

authors： Constantin S,Wray S

更新日期：2016-08-01 00:00:00

abstract：:Daily nocturnal (N) and diurnal (D) surges of PRL are characteristic of a pseudopregnancy (psp) induced by cervical stimulation (CS). These semicircadian surges persist for 13-14 days, after which time they cease, and psp ends. The purpose of this study was to describe the involvement of the ovarian steroids in the ma...

journal_title：Endocrinology

authors： Gorospe WC,Freeman ME

更新日期：1981-04-01 00:00:00

abstract：:In this study the hypothesis that the LHRH neurosecretory system of the prepubertal female monkey has the capacity to function in a manner comparable to that of monkeys in more mature stages of development was tested. Using push-pull perfusion in the stalk-median eminence, effects of electrical stimulation of the medi...

journal_title：Endocrinology

authors： Claypool LE,Watanabe G,Terasawa E

更新日期：1990-12-01 00:00:00

abstract：:Hypoxia, a common stressor in prematurity, leads to sexually dimorphic, short- and long-term effects on the adult hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. We hypothesized that these effects are due to stress-induced increases in testosterone during early postnatal life. We ev...

journal_title：Endocrinology

authors： Gehrand AL,Phillips J,Malott K,Raff H

更新日期：2020-07-01 00:00:00

abstract：:The extensive colocalization of insulin receptor (IR) and insulin-like growth factor-I receptor (IGFR) messenger RNAs during central nervous system development, together with the effects of insulin and IGF-I in neurogenesis, raises the question of how stage- and factor-specific signaling occurs. Thus, it is necessary ...

journal_title：Endocrinology

authors： García-de Lacoba M,Alarcón C,de la Rosa EJ,de Pablo F

更新日期：1999-01-01 00:00:00

abstract：:Tumor progression largely depends on blood supply and neovessel formation, and angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), a major proangiogenic molecule, stimulates angiogenesis via promoting endothelial proliferation, survival and migration. VEGF has ...

journal_title：Endocrinology

authors： Ye C,Feng C,Wang S,Wang KZ,Huang N,Liu X,Lin Y,Li M

更新日期：2004-02-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:TRH is a potent stimulator of pituitary TSH release, but its function in the physiological regulation of thyroid activity is still controversial. The purpose of the present study was to investigate TRH and catecholamine secretion into hypophysial portal blood of hypothyroid and hyperthyroid rats, and in rats bearing p...

journal_title：Endocrinology

authors： Rondeel JM,de Greef WJ,van der Schoot P,Karels B,Klootwijk W,Visser TJ

更新日期：1988-07-01 00:00:00

abstract：:Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine. Forskolin mimicked the stimulatory effect on PLMT, and insulin inhibited this effe...

journal_title：Endocrinology

authors： Kelly KL,Wong EH

更新日期：1987-06-01 00:00:00

abstract：:The epidermis has a great potential as a bioreactor to produce proteins with systemic action. However, the consequences of ectopic epidermal protein overexpression need to be carefully addressed to avoid both local and systemic adverse effects. Thus, the long-term effects of leptin on skin physiology have not been stu...

journal_title：Endocrinology

authors： Rico L,Del Rio M,Bravo A,Ramirez A,Jorcano JL,Page MA,Larcher F

更新日期：2005-10-01 00:00:00