Decreased serum 3,5,3'-triiodothyronine (T3) and abnormal serum binding of T3 in calorie-deficient rats: adaptation after chronic underfeeding.

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:To investigate the role of the C18 substituents in the agonist/antagonist properties of mineralocorticoids, the activities of certain C18-substituted progesterone (P) derivatives were examined. These compounds were characterized by an unsaturated side-chain in the case of 18-vinylprogesterone (18VP) and 18-ethynylprog...

journal_title：Endocrinology

authors： Souque A,Fagart J,Couette B,Davioud E,Sobrio F,Marquet A,Rafestin-Oblin ME

更新日期：1995-12-01 00:00:00

abstract：:The biosynthesis of various hypothalamic neuropeptides has been previously reported in anterior pituitary cells but not in intermediate lobe cells. We have recently demonstrated the occurrence of two somatostatin isoforms in the frog brain, namely somatostatin-14 (SS1) and [Pro(2),Met(13)]somatostatin-14 (SS2). In the...

journal_title：Endocrinology

authors： Tostivint H,Vieau D,Chartrel N,Boutelet I,Galas L,Fournier A,Lihrmann I,Vaudry H

更新日期：2002-09-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:A clonal cell line (44-2C) which synthesizes and secretes somatostatin, neurotensin, calcitonin (CT), and CT gene-related peptide and transiently expresses c-fos was used to characterize the mechanism of action of basic fibroblast growth factor (bFGF). bFGF had two modes of action: 1) short term incubation of 44-2C ce...

journal_title：Endocrinology

authors： Zeytin FN,Rusk SF,Raymond V,Mandell AJ

更新日期：1988-03-01 00:00:00

abstract：:Steady state levels of plasma membrane receptors (measured in radioligand assays) result from processes that contribute to the production of receptors (synthesis, recycling, and unmasking) as well as those that contribute to the loss of receptors (degradation, internalization, and inactivation). Accordingly, we have p...

journal_title：Endocrinology

authors： Braden TD,Conn PM

更新日期：1990-05-01 00:00:00

abstract：:The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three different strains of the cell line D1, D16v, and D16:16, respectively, were analyzed. In initial studies CRF and phorbol esters were used as secretagogues to examine...

journal_title：Endocrinology

authors： Woods MD,Shipston MJ,Mullens EL,Antoni FA

更新日期：1992-12-01 00:00:00

abstract：:GnRH was first identified as the hypothalamic decapeptide that promotes gonadotropin release from pituitary gonadotropes. Thereafter, direct stimulatory and inhibitory effects of GnRH on cell proliferation were demonstrated in a number of types of primary cultured cells and established cell lines. Recently, the effect...

journal_title：Endocrinology

authors： Enomoto M,Utsumi M,Park MK

更新日期：2006-01-01 00:00:00

abstract：:Lanosterol 14alpha-demethylase (CYP51) responds to cholesterol feedback regulation through sterol regulatory element binding proteins (SREBPs). The proximal promoter of CYP51 contains a conserved region with clustered regulatory elements: GC box, cAMP-response elements (CRE-like), and sterol regulatory element (SRE). ...

journal_title：Endocrinology

authors： Fink M,Acimovic J,Rezen T,Tansek N,Rozman D

更新日期：2005-12-01 00:00:00

abstract：:In the rat a GH-binding protein (GHBP) exists that is derived from the GH receptor gene by an alternative messenger RNA splicing mechanism such that the transmembrane and intracellular domains of the GH receptor are replaced by a hydrophilic carboxy terminus. Previous immunohistochemical studies detailing the localiza...

journal_title：Endocrinology

authors： Lobie PE,García-Aragón J,Wang BS,Baumbach WR,Waters MJ

更新日期：1992-05-01 00:00:00

abstract：:Pituitary GH secretion is pulsatile in man and the rat, but evidence of pulsatility in the GH-dependent somatomedins (insulin-like growth factors) has not been described. In this study serum immunoreactive somatomedin-C periodicity was examined in 10 chronically cannulated unstressed rats. Blood samples were taken at ...

journal_title：Endocrinology

authors： Baxter RC,Zaltsman Z,Oliver JR,Willoughby JO

更新日期：1983-08-01 00:00:00

abstract：:The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) rev...

journal_title：Endocrinology

authors： Resko JA,Pleom JG,Stadelman HL

更新日期：1975-08-01 00:00:00

abstract：:Previous studies have demonstrated that uterine progesterone (P) receptor is under dual hormonal control; estradiol (E2) induces the synthesis of cytosolic P receptor, and P induces the loss of its own receptor and antagonizes E2-induced P receptor replenishment. The objective of this study was to examine the contribu...

journal_title：Endocrinology

authors： Okulicz WC

更新日期：1986-06-01 00:00:00

abstract：:The iodothyronine deiodinases, D1, D2, and D3, all contain selenium (Se) in the form of selenocysteine at their active sites, and they play crucial roles in determining the circulating and intracellular levels of the active thyroid hormone (TH), T3. However, not only are serum T3 levels normal in Se-deficient rats but...

journal_title：Endocrinology

authors： Bates JM,Spate VL,Morris JS,St Germain DL,Galton VA

更新日期：2000-07-01 00:00:00

abstract：:A miniature thermoelectric probe was used to record continuously tissue blood flow in the anterior pituitary gland of anesthetized dogs. The output of the flow probe is linear in the range of tissue blood flow encountered in the pituitary. Probe placement required minimal tissue trauma, and zero blood flow was recorde...

journal_title：Endocrinology

authors： Kopaniky DR,Gann DS

更新日期：1975-09-01 00:00:00

abstract：:The effects of undernutrition on the timing of puberty and regulation of LH secretion by the inhibitory and stimulatory feedback action of estradiol were examined in female sheep. The first experiment determined that maintenance of low BW (ca., 20 kg, four lambs) between 10 and 45 weeks of age prevented initiation of ...

journal_title：Endocrinology

authors： Foster DL,Olster DH

更新日期：1985-01-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:We investigated the role of peritubular cell-Sertoli cell interactions in the control of Sertoli cell function by androgens. Decreased FSH-inducible aromatase activity and increased secretion of androgen-binding protein (ABP) were used as parameters of androgen action on Sertoli cells. It is demonstrated that cocultur...

journal_title：Endocrinology

authors： Verhoeven G,Cailleau J

更新日期：1988-10-01 00:00:00

abstract：:Sex chromosome imbalance in males is linked to a supernumerary X chromosome, a condition resulting in Klinefelter syndrome (KS; 47, XXY). KS patients suffer from infertility, hypergonadotropic hypogonadism, and cognitive impairments. Mechanisms of KS pathophysiology are poorly understood and require further exploratio...

journal_title：Endocrinology

authors： Wistuba J,Luetjens CM,Stukenborg JB,Poplinski A,Werler S,Dittmann M,Damm OS,Hämäläinen T,Simoni M,Gromoll J

更新日期：2010-06-01 00:00:00

abstract：:PRL has been reported to exist as a number of mol wt and charge variants. We have attempted to determine the relationships among the charge and lower mol wt variants by two-dimensional gel analysis of pituitary and pituitary cell extracts. Silver-stained gels of the extracts showed three major charge isoforms of 24,00...

journal_title：Endocrinology

authors： Oetting WS,Walker AM

更新日期：1985-10-01 00:00:00

abstract：:GnRH is detectable in the cerebrospinal fluid (CSF), but its source remains unidentified. Previous studies have harvested CSF for GnRH analysis from the median eminence region, but it is unknown whether GnRH in CSF is restricted to this region. If CSF-GnRH plays a physiological role, through volume transmission, to co...

journal_title：Endocrinology

authors： Caraty A,Skinner DC

更新日期：2008-10-01 00:00:00

abstract：:We showed that insulin appears in the chick embryo before beta-cells are recognizable, as well as in the egg constituents even before fertilization. Acid-ethanol extracts of 2- to 8-day-old embryos were gel-filtered on Sephadex G-50. The peak of immunoreactive insulin chromatographed in a position corresponding to tha...

journal_title：Endocrinology

authors： De Pablo F,Roth J,Hernandez E,Pruss RM

更新日期：1982-12-01 00:00:00

abstract：:In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...

journal_title：Endocrinology

authors： Brock O,Bakker J

更新日期：2013-08-01 00:00:00

abstract：:Mouse uterine estrogen receptor (ER) was purified about 11,000-fold from normal mouse uteri by affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified ER demonstrated a major component of 65,000 mol wt with minor fragments of the 54,000- and 37,000-dalton species, as judged b...

journal_title：Endocrinology

authors： Horigome T,Golding TS,Quarmby VE,Lubahn DB,McCarty K Sr,Korach KS

更新日期：1987-12-01 00:00:00

abstract：:In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be en...

journal_title：Endocrinology

authors： Zdanowicz MM,Moyse J,Wingertzahn MA,O'Connor M,Teichberg S,Slonim AE

更新日期：1995-11-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

journal_title：Endocrinology

authors： Chopra IJ,Wu SY,Nakamura Y,Solomon DH

更新日期：1978-04-01 00:00:00

abstract：:We characterized four antipeptide polyclonal antibodies (abs) able to specifically recognize each thyroid hormone receptor (TR) isoform. The abs immunoprecipitated both the in vitro synthesized receptor and the receptor expressed in E. coli and their specificity was confirmed by competition studies and immunohistochem...

journal_title：Endocrinology

authors： Falcone M,Miyamoto T,Fierro-Renoy F,Macchia E,DeGroot LJ

更新日期：1992-11-01 00:00:00

abstract：:The follicular phase rise in circulating estradiol causes a suppression of GnRH pulse amplitude and an increase in pulse frequency before stimulation of the preovulatory GnRH surge in the ewe. Studies in which samples were collected at 10-min intervals were found unsuitable to determine whether GnRH secretion is exclu...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Mauger D,Karsch FJ

更新日期：1995-04-01 00:00:00

abstract：:Mechanisms underlying lymphocyte infiltration of the thyroid gland and orbit in Graves' disease (GD) are poorly understood. The IGF-I receptor (IGF-IR) is a newly recognized self-antigen that, when activated in GD fibroblasts by IGF-I or GD-IgGs, provokes the expression of IL-16 and RANTES (regulated upon activation, ...

journal_title：Endocrinology

authors： Gianoukakis AG,Douglas RS,King CS,Cruikshank WW,Smith TJ

更新日期：2006-04-01 00:00:00