Pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin.

abstract：:Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...

journal_title：Endocrinology

authors： Barreiro ML,Gaytan F,Castellano JM,Suominen JS,Roa J,Gaytan M,Aguilar E,Dieguez C,Toppari J,Tena-Sempere M

更新日期：2004-11-01 00:00:00

abstract：:It is generally accepted that cholesterol affects dynamic membrane properties and the function of membrane bound proteins involved in secretion processes. In the present study we employed GH4C1 cells treated with human lipoprotein-deficient serum (h-LPDS), exogenous cholesterol and high density lipoprotein (HDL3) to i...

journal_title：Endocrinology

authors： Lasa M,Perez-Caballero FJ,Usera F,Chiloeches A,Montes A,Toro MJ

更新日期：1993-04-01 00:00:00

abstract：:We previously identified a highly conserved specificity protein 1 (Sp1) DNA element in mammalian PTH promoters that acted as an enhancer of gene transcription and bound Sp1 and Sp3 proteins present in parathyroid gland nuclear extracts. More recently, a nuclear factor (NF)-Y element (NF-Y(prox)) was also described by ...

journal_title：Endocrinology

authors： Alimov AP,Park-Sarge OK,Sarge KD,Malluche HH,Koszewski NJ

更新日期：2005-08-01 00:00:00

abstract：:Early postnatal hyperalimentation has long-term implications for obesity and developing renal disease. Suppressor of cytokine signaling (SOCS) 3 inhibits phosphorylation of signal transducer and activator of transcription (STAT) 3 and ERK1/2 and thereby plays a pivotal role in mediating leptin resistance. In addition,...

journal_title：Endocrinology

authors： Alcazar MA,Boehler E,Rother E,Amann K,Vohlen C,von Hörsten S,Plank C,Dötsch J

更新日期：2012-03-01 00:00:00

abstract：:The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cort...

journal_title：Endocrinology

authors： Soegiarto DW,Kiachopoulos S,Schipani E,Jüppner H,Erben RG,Lanske B

更新日期：2001-12-01 00:00:00

abstract：:The ability of different LH-like hormones, such as hCG, PMSG/equine (e) CG, ovine (o) LH, eLH, and rat (r) LH, to bind to and stimulate steroidogenesis in two types of rat gonadal cells was studied under the same experimental conditions. In both Leydig and granulosa cells, the maximal steroidogenic responses elicited ...

journal_title：Endocrinology

authors： Rani CS,Moudgal NR

更新日期：1985-02-01 00:00:00

abstract：:In songbirds, singing behavior is controlled by a discrete network of interconnected brain nuclei known collectively as the song control system. Both the development of this system and the expression of singing behavior in adulthood are strongly influenced by sex steroid hormones. Although both androgenic and estrogen...

journal_title：Endocrinology

authors： Bernard DJ,Bentley GE,Balthazart J,Turek FW,Ball GF

更新日期：1999-10-01 00:00:00

abstract：:With advancing age, 60-80% of the follicles of the mouse thyroid gland turn "cold", i.e. they lose their normal capacity to iodinate thyroglobulin (Tgb). Cold follicles are morphologically characterized by their large size, by deeply periodic acid-Schiff-stained colloid and by flat epithelial cells. We investigated th...

journal_title：Endocrinology

authors： Gerber H,Peter HJ,Studer H

更新日期：1987-05-01 00:00:00

abstract：:The effects of epidermal growth factor (EGF) on glycogen metabolism and the binding of [125I]iodo-EGF to receptors in fetal rat hepatocytes have been examined. The actions of EGF have been compared with those of insulin-like growth factor I (IGF-I) and insulin. EGF (0.1-45 nM) stimulated dose-dependent increases in [1...

journal_title：Endocrinology

authors： Freemark M

更新日期：1986-08-01 00:00:00

abstract：:Livers from fed rats (180-240 g) were perfused noncyclically with a hemoglobin-free medium in vitro to determine whether vasoactive intestinal peptide (VIP) increases hepatic glucose production through a cAMP- or a Ca(2+)-dependent mechanism. Glucose output did not increase, but cAMP increased maximally during 10(-9) ...

journal_title：Endocrinology

authors： Saito K,Yamatani K,Manaka H,Takahashi K,Tominaga M,Sasaki H

更新日期：1992-04-01 00:00:00

abstract：:Bovine granulosa cells seeded in the presence of serum on extracellular matrix-coated dishes proliferate actively when exposed to serum-free medium supplemented with insulin (2 microgram/ml), fibroblast growth factor (FGF, 100 ng/ml), and high density lipoprotein (HDL, 30 microgram protein/ml). The final density of th...

journal_title：Endocrinology

authors： Savion N,Lui GM,Laherty R,Gospodarowicz D

更新日期：1981-08-01 00:00:00

abstract：:We recently reported that chronic 17β-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERα), and independently of ERβ. Here, we have explored the respective roles of membrane vs ...

journal_title：Endocrinology

authors： Valéra MC,Fontaine C,Lenfant F,Cabou C,Guillaume M,Smirnova N,Kim SH,Chambon P,Katzenellenbogen JA,Katzenellenbogen BS,Payrastre B,Arnal JF

更新日期：2015-11-01 00:00:00

abstract：:The mechanisms whereby tissue sensitivity to PRL is controlled are not well understood. Here we report that expression of mRNA and protein for members of the SOCS/CIS/JAB family of cytokine signaling inhibitors is increased by PRL administration in ovary and adrenal gland of the lactating rat deprived of circulating P...

journal_title：Endocrinology

authors： Tam SP,Lau P,Djiane J,Hilton DJ,Waters MJ

更新日期：2001-11-01 00:00:00

abstract：:A competitive protein-binding (CPB) assay, suitable for measuring corticosterone levels in 20 mul of mouse plasma or 100 mg of brain, is described. The postnatal development of adrenocortical function was determined in C57BL/10 and DBA/1 mice by CPB assay of basal and stressinduced levels of plasma corticosterone and ...

journal_title：Endocrinology

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1976-06-01 00:00:00

abstract：:IGF-binding protein-3 (IGFBP-3) is the major circulating carrier protein for IGF, and also acts as a potent antiproliferative agent in various cell types. Recently, IGFBP-3 was reported to mediate high glucose-induced apoptosis in mesangial cells and podocytes. In this study, we investigated the role of IGFBP-3 in hig...

journal_title：Endocrinology

authors： Yoo EG,Lee WJ,Kim JH,Chae HW,Hyun SE,Kim DH,Kim HS,Oh Y

更新日期：2011-08-01 00:00:00

abstract：:Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role of endogenous relaxin in the pathogenesis of primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old relaxin (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/...

journal_title：Endocrinology

authors： Hewitson TD,Mookerjee I,Masterson R,Zhao C,Tregear GW,Becker GJ,Samuel CS

更新日期：2007-02-01 00:00:00

abstract：:Fasting in rodents is characterized by decreases in serum T4 and T3 levels but no compensatory increase in serum TSH level. The types 1 and 2 deiodinases (D1 and D2) are postulated to play key roles in mediating these changes. However, serum T4 and T3 levels in fasted 5'-deiodinase-deficient mice decreased by at least...

journal_title：Endocrinology

authors： Galton VA,Hernandez A,St Germain DL

更新日期：2014-08-01 00:00:00

abstract：:The synthesis and accumulation of prostatein, a major secretory protein of the rat ventral prostate, was examined in organ culture conditions. For the quantitation of this protein in the medium, a sensitive enzyme immunoassay was developed. The rat ventral prostate could be maintained in organ culture in defined mediu...

journal_title：Endocrinology

authors： Martikainen P,Härkönen P,Vanhala T,Mäkelä S,Viljanen M,Suominen J

更新日期：1987-08-01 00:00:00

abstract：:Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...

journal_title：Endocrinology

authors： Hampel U,Klonisch T,Sel S,Schulze U,Garreis F,Seitmann H,Zouboulis CC,Paulsen FP

更新日期：2013-06-01 00:00:00

abstract：:TSH initiates its action by binding to specific membrane receptors' thyroid cells and induces activation of the adenylate cyclase-cAMP cascade. The factors involved in the regulation of TSH receptors are poorly known, except for the TSH dose-dependent regulatory effect. The fact that the thyroid gland of Graves' patie...

journal_title：Endocrinology

authors： Denereaz N,Lemarchand-Beraud T

更新日期：1995-04-01 00:00:00

abstract：:Our research programs required the preparation of hypophysectomized and orchidectomized rhesus monkeys. This afforded us the possibility to characterize and compare levels of the gonadotropin and inhibin subunit mRNAs in pituitaries from intact and castrate monkeys. Eighteen adult male monkeys, four of which had been ...

journal_title：Endocrinology

authors： Attardi B,Marshall GR,Zorub DS,Winters SJ,Miklos J,Plant TM

更新日期：1992-03-01 00:00:00

abstract：:We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pu...

journal_title：Endocrinology

authors： Mukhina S,Liu D,Guo K,Raccurt M,Borges-Bendris S,Mertani HC,Lobie PE

更新日期：2006-04-01 00:00:00

abstract：:T4 dynamically regulates the levels of type II iodothyronine 5'-deiodinase in the brain. Using an astrocyte cell culture model, we have shown that thyroxine increases inactivation of this enzyme through a mechanism using the actin cytoskeleton. In the absence of T4, the filamentous actin (F-actin) stress fibers are ab...

journal_title：Endocrinology

authors： Farwell AP,Leonard JL

更新日期：1992-08-01 00:00:00

abstract：:Anorexia is a debilitating manifestation of many malignancies. The etiology of cancer anorexia is poorly understood, and effective treatment options are limited. To investigate the role of central melanocortin receptor signaling in the pathogenesis of cancer anorexia, we assessed the effects on food intake of the mela...

journal_title：Endocrinology

authors： Wisse BE,Frayo RS,Schwartz MW,Cummings DE

更新日期：2001-08-01 00:00:00

abstract：:Recent work in sheep has identified a neuronal subpopulation in the arcuate nucleus that coexpresses kisspeptin, neurokinin B, and dynorphin (referred to here as KNDy cells) and that mediate the negative feedback influence of progesterone on GnRH secretion. We hypothesized that sex differences in progesterone negative...

journal_title：Endocrinology

authors： Cheng G,Coolen LM,Padmanabhan V,Goodman RL,Lehman MN

更新日期：2010-01-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:Poor growth before birth increases the risk of non-insulin-dependent diabetes mellitus (NIDDM) and impairs insulin secretion relative to sensitivity. We investigated the effects of intrauterine growth restriction in sheep on insulin secretion, beta-cell mass, and function from before birth to young adulthood and its m...

journal_title：Endocrinology

authors： Gatford KL,Mohammad SN,Harland ML,De Blasio MJ,Fowden AL,Robinson JS,Owens JA

更新日期：2008-10-01 00:00:00

abstract：:The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...

journal_title：Endocrinology

authors： Wong EH,Tan CH,Khoo HE,Ng FH,Lim KL,Ciaraldi TP

更新日期：1995-04-01 00:00:00

abstract：:The procession of round spermatids through stages VII and VIII of the rat spermatogenic cycle is critically dependent on testosterone (T). When intratesticular T levels are reduced, round spermatids appear to slough from the seminiferous epithelium, resulting in the disappearance of elongated spermatids. We hypothesiz...

journal_title：Endocrinology

authors： Perryman KJ,Stanton PG,Loveland KL,McLachlan RI,Robertson DM

更新日期：1996-09-01 00:00:00

abstract：:Carbohydrate metabolism in pregnancy reflects the balance between counterregulatory hormones, which induce insulin resistance, and lactogenic hormones, which stimulate beta-cell proliferation and insulin production. Here we explored the interactions of prolactin (PRL) and glucocorticoids in the regulation of beta-cell...

journal_title：Endocrinology

authors： Arumugam R,Horowitz E,Lu D,Collier JJ,Ronnebaum S,Fleenor D,Freemark M

更新日期：2008-11-01 00:00:00