The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone.

abstract：:Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunor...

journal_title：Endocrinology

authors： Chihara K,Arimura A,Kubli-Garfias C,Schally AV

更新日期：1979-12-01 00:00:00

abstract：:The effect of active and passive immunization with luteinizing hormone-releasing hormone (LHRH) on serum LH and follicle-stimulating hormone (FSH) levels and the ultrastructure of the pituitary gonadotrophs was investigated in castrated male rats. Two weeks after castration, the animals were immunized with Glu1-LHRH c...

journal_title：Endocrinology

authors： Arimura A,Shino M,de la Cruz KG,Rennels EG,Schally AV

更新日期：1976-07-01 00:00:00

abstract：:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexame...

journal_title：Endocrinology

authors： Naylor PH,Gilani SS,Milholland RJ,Rosen F

更新日期：1980-07-01 00:00:00

abstract：:Mutations of the monocarboxylate transporter 8 gene (MCT8, SLC16A2) cause the Allan-Herndon-Dudley syndrome, an X-linked syndrome of severe intellectual deficit and neurological impairment. Mct8 transports thyroid hormones (T4 and T3), and the Allan-Herndon-Dudley syndrome is likely caused by lack of T3 transport to n...

journal_title：Endocrinology

authors： Grijota-Martínez C,Díez D,Morreale de Escobar G,Bernal J,Morte B

更新日期：2011-04-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity. We now report the cloning and sequencing of a full-length murine endoglin complementary DNA of 2902 base pairs which hybridizes ...

journal_title：Endocrinology

authors： St-Jacques S,Cymerman U,Pece N,Letarte M

更新日期：1994-06-01 00:00:00

abstract：:To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV...

journal_title：Endocrinology

authors： Punjabi M,Arnold M,Rüttimann E,Graber M,Geary N,Pacheco-López G,Langhans W

更新日期：2014-05-01 00:00:00

abstract：:We previously reported a cooperative effect between insulin-like growth factor I (IGF-I) and 1,25-dihydroxy-vitamin D3 [1,25-(OH)2D3] in murine clonal osteoblastic cells, MCT3T3-E1. In the present study, the possible mechanism of interaction between these hormones was investigated. The effect of IGF-I on 1,25-(OH)2D3 ...

journal_title：Endocrinology

authors： Kurose H,Yamaoka K,Okada S,Nakajima S,Seino Y

更新日期：1990-04-01 00:00:00

abstract：:Bromocriptine, a dopamine agonist, inhibited secretion of PRL and did not affect GH release from rat anterior pituitary cells in culture. The reversal of this inhibition of PRL release by butaclamol, a dopamine antagonist, was stereospecific; 10 nM d-butaclamol completely reversed the inhibition caused by 10 nM bromoc...

journal_title：Endocrinology

authors： West B,Dannies PS

更新日期：1979-04-01 00:00:00

abstract：:Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies demonstrated the substantial protective role of 17β-estradiol (E2) in several types of neuron. However, most studies examined cell body protection, and the role of 17β-E2 in axonal degeneration of retinal ganglion cells (RGC) remain...

journal_title：Endocrinology

authors： Kitaoka Y,Munemasa Y,Hayashi Y,Kuribayashi J,Koseki N,Kojima K,Kumai T,Ueno S

更新日期：2011-07-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:We investigated the contribution of corticotropin-releasing factor (CRF) receptors types 1 and 2 (CRF(1) and CRF(2)) in mediating the ACTH response to shock, alcohol injection, or endotoxemia in the rat. Peptidic (Astressin B and Astressin(2)-B) and nonpeptidic (NBI 30775) CRF antagonists were injected iv before the s...

journal_title：Endocrinology

authors： Rivier CL,Grigoriadis DE,Rivier JE

更新日期：2003-06-01 00:00:00

abstract：:Carbonyl cyanide trifluoromethoxyphenylhydrazone (FCCP), a protonophore, and methylamine, a weak base, agents that dissipate hydrogen gradients across cellular membranes, were used to probe the coupling of hydrogen gradients to the processing and secretion of the glycoprotein hormone hCG by human choriocarcinoma cells...

journal_title：Endocrinology

authors： Peters BP,Krzesicki RF,Perini F,Ruddon RW

更新日期：1986-07-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:The enzyme glutamate decarboxylase-65 (GAD65) is a major autoantigen in autoimmune diabetes. The mechanism whereby autoreactivity to GAD65, an intracellular protein, is triggered is unknown, and it is possible that immunoreactive GAD65 is released by injured pancreatic islet beta-cells. There is a great need for metho...

journal_title：Endocrinology

authors： Waldrop MA,Suckow AT,Marcovina SM,Chessler SD

更新日期：2007-10-01 00:00:00

abstract：:Certain metabolic properties of hormonally responsive osteogenic sarcoma cells derived from a transplantable rat tumor have been compared with those of related normal rat bone cells. All studies were carried out on cells grown in monolayer culture. Normal rat bone cells derived by repeated collagenase/trypsin digestio...

journal_title：Endocrinology

authors： Partridge NC,Alcorn D,Michelangeli VP,Kemp BE,Ryan GB,Martin TJ

更新日期：1981-01-01 00:00:00

abstract：:The presence of estrogen receptors (ERs) in nonneural cells in brain, including glia, ependyma, and endothelia, has not previously been documented with electron microscopy. This study employed immunocytochemistry to investigate whether ER immunoreactivity (ER-ir) is present in glial, ependymal, or endothelial cells in...

journal_title：Endocrinology

authors： Langub MC Jr,Watson RE Jr

更新日期：1992-01-01 00:00:00

abstract：:The hormonal requirements for lactogenesis were investigated using explant cultures of mammary tissue obtained from cows at 30-40 days prepartum. Hormones used were insulin, hydrocortisone, and prolactin, and parameters examined were radioactive acetate incorporation into fatty acids, secretory response ratings, and h...

journal_title：Endocrinology

authors： Collier RJ,Bauman DE,Hays RL

更新日期：1977-04-01 00:00:00

abstract：:We have investigated, in young and aged rats, tuberoinfundibular dopaminergic (TIDA) and nigrostriatal neurons of the brain, and the role of the testes and anterior pituitary (AP) on 1) the in situ activity of tyrosine hydroxylase (TH), 2) translation of TH mRNA, as reflected by the mass of TH, and 3) transcription of...

journal_title：Endocrinology

authors： Aguila-Mansilla N,Kedzierski W,Porter JC

更新日期：1991-08-01 00:00:00

abstract：:We studied the involvement of the cAMP pathway in the regulation of beta TC1 cell growth with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the activator of adenylate cyclase forskolin. We examined the effect of the increase in cAMP content on the serum-induced resumption of the cell cycle of ...

journal_title：Endocrinology

authors： Lavergne C,Breant B,Rosselin G

更新日期：1992-11-01 00:00:00

abstract：:Gap junctions were observed on the lateral plasma membrane of the typical thyroid epithelial cell in freeze-fracture preparations of rat thyroid gland. The gap junctions were 0.1 to 0.4 mum in diameter and were composed of closely packed, approximately 80 nm particles. They were located from 1 to 6 mum from the apical...

journal_title：Endocrinology

authors： Tice LW,Carter RC,Wollman SH

更新日期：1976-03-01 00:00:00

abstract：:Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...

journal_title：Endocrinology

authors： Castroneves LA,Jugo RH,Maynard MA,Lee JS,Wassner AJ,Dorfman D,Bronson RT,Ukomadu C,Agoston AT,Ding L,Luongo C,Guo C,Song H,Demchev V,Lee NY,Feldman HA,Vella KR,Peake RW,Hartigan C,Kellogg MD,Desai A,Salvatore D

更新日期：2014-10-01 00:00:00

abstract：:A growing body of information now supports the existence of a complete intraovarian insulin-like growth Factor I (IGF-I) system replete with ligands, receptors, and binding protein(s). However, studies concerned with the regulation of ovarian IGF-I gene expression remain scarce. It was thus the objective of this commu...

journal_title：Endocrinology

authors： Botero LF,Roberts CT Jr,LeRoith D,Adashi EY,Hernandez ER

更新日期：1993-06-01 00:00:00

abstract：:An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...

journal_title：Endocrinology

authors： Henrikson KP,Jazin EE,Greenwood JA,Dickerman HW

更新日期：1990-01-01 00:00:00

abstract：:GH is believed to play a role in promoting insulin resistance in patients with diabetes and with GH excess. The means by which GH produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose ...

journal_title：Endocrinology

authors： Foster CM,Hale PM,Jing HW,Schwartz J

更新日期：1988-08-01 00:00:00

abstract：:Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...

journal_title：Endocrinology

authors： Cho E,Montgomery RB,Mostaghel EA

更新日期：2014-11-01 00:00:00

abstract：:Control of trabecular bone volume is mediated by local events. Recently, it has been shown that the cytokines interleukin-1 (IL-1), tumor necrosis factor alpha (TNF alpha), and TNF beta [also called lymphotoxin (LT)] produced by immune cells all stimulate osteoclast activity, whereas the lymphokine interferon-gamma (I...

journal_title：Endocrinology

authors： Smith DD,Gowen M,Mundy GR

更新日期：1987-06-01 00:00:00

abstract：:In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...

journal_title：Endocrinology

authors： Khan A,Hong-Lie C,Landau BR

更新日期：1995-05-01 00:00:00

abstract：:Ghrelin stimulates and leptin inhibits appetite by modulating neuropeptide Y (NPY) signaling in the hypothalamus. Analysis of plasma ghrelin and leptin by sensitive radioimmunoassays showed that the two peripheral hormones are secreted in pulsatile fashion in rats consuming ad libitum rat chow. Fasting augmented all p...

journal_title：Endocrinology

authors： Bagnasco M,Kalra PS,Kalra SP

更新日期：2002-02-01 00:00:00