The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep.

abstract：:The subunit structure of mammalian cytoplasmic progesterone receptors (PR) has been difficult to study because these proteins are subject to in vitro proteolysis; the structure of nuclear PR is unknown. We have now developed an in situ photoaffinity labeling method for PR that permits study of their subunits with mini...

journal_title：Endocrinology

authors： Horwitz KB,Alexander PS

更新日期：1983-12-01 00:00:00

abstract：:We analyzed the nature of the thyroid hormone-binding proteins in bullfrog plasma using N-bromoacetyl-[125I]T3 as an affinity labeling probe. Polyacrylamide gel electrophoresis under nondenaturing conditions of the bullfrog N-bromoacetyl-[125I]T3-labeled plasma proteins revealed two proteins with specific binding to T...

journal_title：Endocrinology

authors： Yamauchi K,Kasahara T,Hayashi H,Horiuchi R

更新日期：1993-05-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:Despite the specificity inferred by its name, glycogen synthase kinase (GSK)-3beta is an important kinase with a plethora of significant cellular targets, including cytoskeletal proteins and transcription factors, and its activity is regulated by phosphorylation on tyrosine/serine residues. As part of our efforts to d...

journal_title：Endocrinology

authors： Liao X,Thrasher JB,Holzbeierlein J,Stanley S,Li B

更新日期：2004-06-01 00:00:00

abstract：:TRH is a potent stimulator of pituitary TSH release, but its function in the physiological regulation of thyroid activity is still controversial. The purpose of the present study was to investigate TRH and catecholamine secretion into hypophysial portal blood of hypothyroid and hyperthyroid rats, and in rats bearing p...

journal_title：Endocrinology

authors： Rondeel JM,de Greef WJ,van der Schoot P,Karels B,Klootwijk W,Visser TJ

更新日期：1988-07-01 00:00:00

abstract：:Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...

journal_title：Endocrinology

authors： Szawka RE,Ribeiro AB,Leite CM,Helena CV,Franci CR,Anderson GM,Hoffman GE,Anselmo-Franci JA

更新日期：2010-07-01 00:00:00

abstract：:Female Wistar-Furth rats were implanted sc with GH3 rat pituitary tumor cells. Tumors were palpable by 4 weeks, and animals were killed periodically from 5-9 weeks. Tumor-bearing rats (n = 10) were heavier than their respective controls, reaching a weight of 372 +/- 3 by 9 weeks vs. 195 +/- 5 g in controls (mean +/- S...

journal_title：Endocrinology

authors： Yamashita S,Slanina S,Kado H,Melmed S

更新日期：1986-03-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in the ovary, uterus,...

journal_title：Endocrinology

authors： Douglas NC,Tang H,Gomez R,Pytowski B,Hicklin DJ,Sauer CM,Kitajewski J,Sauer MV,Zimmermann RC

更新日期：2009-08-01 00:00:00

abstract：:The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the thyroid glands of rats. Eighteen hours after injection of a relatively small dose, iodination in the thyroid remained inhibited by more than 90%. We previously s...

journal_title：Endocrinology

authors： Taurog A,Dorris ML

更新日期：1989-06-01 00:00:00

abstract：:The ontogeny of expression of the CRF gene in the paraventricular hypothalamic nucleus and POMC gene in the pituitary was studied in rats using in situ hybridization histochemistry and Northern blotting techniques, respectively. CRF mRNA was first detected on day 17 of gestation (E17) in the paraventricular nucleus of...

journal_title：Endocrinology

authors： Grino M,Young WS 3rd,Burgunder JM

更新日期：1989-01-01 00:00:00

abstract：:Retinoic acid (RA), a naturally occurring metabolite of vitamin A, plays an essential role in regulating cellular growth, differentiation, and death in a variety of tissues, particularly during fetal development. However, essentially nothing is known of the effects of RA on fetal gametogenesis. Using a recently valida...

journal_title：Endocrinology

authors： Morita Y,Tilly JL

更新日期：1999-06-01 00:00:00

abstract：:Rat melanin-concentrating hormone (MCH) is a homolog of the peptide first isolated from salmon pituitary glands which produces melanosome aggregation within melanophores of teleost fish as well as interacting with the hypothalamic-pituitary axis. We have previously characterized the rat and human MCH counterparts as i...

journal_title：Endocrinology

authors： Parkes D,Vale W

更新日期：1992-10-01 00:00:00

abstract：:19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present stud...

journal_title：Endocrinology

authors： Funder JW,Adam WR

更新日期：1981-07-01 00:00:00

abstract：:The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in this model are scanty and contradictory. In the present study, we inves...

journal_title：Endocrinology

authors： Nguyen-Yamamoto L,Deal CL,Finkelstein JA,Van Vliet G

更新日期：1994-03-01 00:00:00

abstract：:The role of 11 beta,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al (F enol aldehyde) as an intermediate in the biological conversion of cortisol to a 17-deoxy-21-oic acid was studied in vitro with mouse liver as the source of enzyme. The substrate, [1,2-3H]F enol aldehyde, was synthesized and found to contain cis and tr...

journal_title：Endocrinology

authors： Singer CJ,Iohan F,Monder C

更新日期：1986-09-01 00:00:00

abstract：:The metabolism of cholesterol sulfate (5-cholesten-3 beta-ol sodium sulfate) and cholesterol to pregnenolone sulfate and pregnenolone, respectively, in human fetal adrenal mitochondria has been investigated. Cholesterol sulfate (50 microM) was converted efficiently to pregnenolone sulfate (5-pregnen-3 beta-ol-20-one s...

journal_title：Endocrinology

authors： Mason JI,Hemsell PG

更新日期：1982-07-01 00:00:00

abstract：:In order to elucidate potential sites of direct GH action on the kidney, we used in situ hybridization to localize GH receptor (GHR) gene expression during the course of development and in the adult rat. In order to illuminate potential interactions between GH and insulin-like growth factor-I (IGF-I) in regulating ren...

journal_title：Endocrinology

authors： Chin E,Zhou J,Bondy CA

更新日期：1992-12-01 00:00:00

abstract：:Four 1-yr-old, i.e. immature, monkeys (M. fascicularis) were treated with testosterone. For the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. Four similarly aged monkeys served as untreated controls. The t...

journal_title：Endocrinology

authors： Marshall GR,Wickings EJ,Nieschlag E

更新日期：1984-06-01 00:00:00

abstract：:Many aspects of reproductive function are corrected in hypogonadal mice with preoptic area grafts (HPG/POA). Gonadotropin release and gonadal development are dependent on the presence of GnRH cells within the grafts and GnRH innervation of the median eminence. This study examined the effect of a known modulator of GnR...

journal_title：Endocrinology

authors： Saitoh Y,Silverman AJ,Gibson MJ

更新日期：1991-05-01 00:00:00

abstract：:Recombinant interleukin-1 alpha and -beta (Il-1 alpha and -beta) have been evaluated for their abilities to stimulate ACTH and catecholamine secretion in the intact adult male rat. Additionally, the role of adrenergic-dependent pathways in mediating Il-1-induced ACTH release has been assessed. The iv or intracerebrove...

journal_title：Endocrinology

authors： Rivier C,Vale W,Brown M

更新日期：1989-12-01 00:00:00

abstract：:We have measured the concentrations of vasopressin in sequential samples of cerebrospinal fluid (CSF) obtained from fetal lambs between 108 and 130 days gestation. There was a clear and significant (F = 4.46; P less than 0.005) rhythm in vasopressin concentrations in the CSF of nine fetuses, characterized by a mean tr...

journal_title：Endocrinology

authors： Stark RI,Daniel SS

更新日期：1989-06-01 00:00:00

abstract：:The roles of steroids in zebrafish sex differentiation, gonadal development, and function of the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant zebrafish to explore such processes. Fdx1b is an essential electron-providing cofactor to mitochondrial steroidogenic enzymes, which are cruci...

journal_title：Endocrinology

authors： Oakes JA,Li N,Wistow BRC,Griffin A,Barnard L,Storbeck KH,Cunliffe VT,Krone NP

更新日期：2019-10-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) has a biphasic clinical phenotype with failure to thrive in the neonatal period followed by hyperphagia and severe obesity commencing in childhood among other endocrinological and neurobehavioral abnormalities. The syndrome results from loss of function of several clustered, paternally expr...

journal_title：Endocrinology

authors： Stefan M,Ji H,Simmons RA,Cummings DE,Ahima RS,Friedman MI,Nicholls RD

更新日期：2005-10-01 00:00:00

abstract：:To examine the mechanism of estrogen's direct stimulation of steroidogenesis in the rabbit corpus luteum, we tested the hypothesis that the effect of estrogen on progestin production occurs at the site of processing of the precursor for pregnenolone (i.e. cholesterol) in the mitochondrion. For this purpose, we manipul...

journal_title：Endocrinology

authors： Holt JA,Wittmaack FM,Schreiber JR,Ghosh DK,Menon KM

更新日期：1988-05-01 00:00:00

abstract：:Leptin, a circulating 16-kDa protein secreted by adipocytes, decreases body weight by reducing food intake and enhancing energy utilization. Leptin receptors that share homology to the glycoprotein gp130 have been recently cloned. In addition, differentially spliced leptin receptor messenger RNAs have been identified....

journal_title：Endocrinology

authors： Liu C,Liu XJ,Barry G,Ling N,Maki RA,De Souza EB

更新日期：1997-08-01 00:00:00

abstract：:Fibrosis (extracellular matrix accumulation) is the final end point in diabetic cardiomyopathy. The current study evaluated the therapeutic effects of the antifibrotic hormone relaxin (RLX) in streptozotocin-treated transgenic mRen-2 rats, which undergo pathological and functional features similar to human diabetes. T...

journal_title：Endocrinology

authors： Samuel CS,Hewitson TD,Zhang Y,Kelly DJ

更新日期：2008-07-01 00:00:00

abstract：:Permanent effects of postnatal gonads on dopamine (DA)-mediated regulation of PRL secretion were examined in adult male rats of the Wistar-Imamichi strain. Rats were bilaterally orchidectomized at varying postnatal days, i.e. 8 h after birth [neonatal castration (NC)] or at 1, 2, 3, 4, or 6 weeks of age, and subjected...

journal_title：Endocrinology

authors： Watanobe H,Takebe K

更新日期：1987-06-01 00:00:00

abstract：:Both Snell (Pit-1(dw) or (dwj), dw/dw) and Ames (Prophet of Pit-1(df), df/df) dwarf mice fail to produce prolactin (PRL) as well as GH due to deficient transcription factor Pit-1 activity and have reduced numbers of hypothalamic PRL-inhibiting area A12 tuberoinfundibular dopaminergic (TIDA) neurons. It has been report...

journal_title：Endocrinology

authors： Phelps CJ

更新日期：2004-12-01 00:00:00

abstract：:The hypothalamic hormone, GnRH, is released and transported to the anterior pituitary in a pulsatile manner, where it binds to specific high-affinity receptors and regulates gonadotropin biosynthesis and secretion. The frequency of GnRH pulses changes under various physiological conditions, and varying GnRH pulse freq...

journal_title：Endocrinology

authors： Kaiser UB,Jakubowiak A,Steinberger A,Chin WW

更新日期：1997-03-01 00:00:00