11 beta,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al: an intermediate in the biological 17-dehydroxylation of cortisol.

abstract：:Thyroid hormones are of considerable importance for vertebrate reproductive function and during development. To further assess the role of these compounds in this capacity, we examined the expression pattern of the type 2 iodothyronine deiodinase (D2), which converts T(4) to the more active hormone T(3), in the rat ut...

journal_title：Endocrinology

authors： Galton VA,Martinez E,Hernandez A,St Germain EA,Bates JM,St Germain DL

更新日期：2001-05-01 00:00:00

abstract：:Melatonin receptors in lizard brain were identified and characterized using 125I-labeled melatonin ([125I]MEL) after solubilization with the detergent digitonin. Saturation studies of solubilized material revealed a high affinity binding site, with an apparent equilibrium dissociation constant of 181 +/- 45 pM. Bindin...

journal_title：Endocrinology

authors： Rivkees SA,Conron RW Jr,Reppert SM

更新日期：1990-09-01 00:00:00

abstract：:The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all f...

journal_title：Endocrinology

authors： Dunn JF,Wilson JD

更新日期：1975-06-01 00:00:00

abstract：:Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that these neurons, abbreviated as...

journal_title：Endocrinology

authors： Lehman MN,Coolen LM,Goodman RL

更新日期：2010-08-01 00:00:00

abstract：:Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stim...

journal_title：Endocrinology

authors： Zmora N,Stubblefield J,Golan M,Servili A,Levavi-Sivan B,Zohar Y

更新日期：2014-05-01 00:00:00

abstract：:Activins stimulate FSH synthesis and secretion by pituitary gonadotrope cells. Activin A induction of porcine and murine FSHβ (Fshb) gene transcription in immortalized gonadotropes is dependent on homolog of Drosophila mothers against decapentaplegic (SMAD) proteins as well as the forkhead transcription factor L2 (FOX...

journal_title：Endocrinology

authors： Lamba P,Wang Y,Tran S,Ouspenskaia T,Libasci V,Hébert TE,Miller GJ,Bernard DJ

更新日期：2010-11-01 00:00:00

abstract：:Cross talks between the vascular and immune system play a critical role in vascular diseases, in particular in atherosclerosis. The osteoclast-associated receptor (OSCAR) is a regulator of osteoclast differentiation and dendritic cell maturation. Whether OSCAR plays a role in vascular biology and has an impact on athe...

journal_title：Endocrinology

authors： Goettsch C,Rauner M,Sinningen K,Helas S,Al-Fakhri N,Nemeth K,Hamann C,Kopprasch S,Aikawa E,Bornstein SR,Schoppet M,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：:To assess the consequences of prolonged exposure to elevated levels of LH/human chorionic gonadotropin (hCG) in the female, we developed a transgenic (TG) mouse model (hCGbeta+) that overexpresses the hCGbeta-subunit cDNA. Because of the promoter used, ubiquitin C, the transgene is expressed in multiple tissues, inclu...

journal_title：Endocrinology

authors： Rulli SB,Kuorelahti A,Karaer O,Pelliniemi LJ,Poutanen M,Huhtaniemi I

更新日期：2002-10-01 00:00:00

abstract：:At menopause, the dramatic loss of ovarian estradiol (E2) necessitates the adaptation of estrogen-sensitive neurons in the hypothalamus to an estrogen-depleted environment. We developed a rat model to test the "critical window" hypothesis of the effects of timing and duration of E2 treatment after deprivation on the h...

journal_title：Endocrinology

authors： Yin W,Maguire SM,Pham B,Garcia AN,Dang NV,Liang J,Wolfe A,Hofmann HA,Gore AC

更新日期：2015-08-01 00:00:00

abstract：:Whereas the stimulatory effect of interleukin-6 (IL-6) on the hypothalamic-pituitary-adrenal (HPA) axis is well established, its mode of action in this axis has yet to be fully elucidated. To further study the role of IL-6 in the HPA axis, we compared the expression of IL-6 messenger RNA (mRNA) in the rat hypothalamus...

journal_title：Endocrinology

authors： Muramami N,Fukata J,Tsukada T,Kobayashi H,Ebisui O,Segawa H,Muro S,Imura H,Nakao K

更新日期：1993-12-01 00:00:00

abstract：:The effect of conditioned vs. fresh culture medium on the dopaminergic inhibition of TSH and PRL secretion by primary cultures of male rat anterior pituitary cells has been studied. In the presence of conditioned medium (that had been in contact with the cells over the 3-day culture period) 10(-6) M dopamine (DA) inhi...

journal_title：Endocrinology

authors： Foord SM,Peters JR,Dieguez C,Shewring G,Hall R,Scanlon MF

更新日期：1986-04-01 00:00:00

abstract：:Constitutive nitric oxide synthase (cNOS) was immunolocalized to study its role in osmotic regulation. Immunoreactivity was observed in all major hypothalamic osmoregulatory structures, the organum vasculosum laminae terminalis, subfornical organ, median preoptic nucleus, and supraoptic and paraventricular nuclei. The...

journal_title：Endocrinology

authors： Wang H,Morris JF

更新日期：1996-05-01 00:00:00

abstract：:The original objective of this study was to use available distribution volume (V) and deca constant (k) estimates for rat LH and FSH to determine the amounts of these hormones synthesized and released during a dynamic secretory event, the postpartum preovulatory surge. The problem was approached by 1) determining the ...

journal_title：Endocrinology

authors： Diebel ND,Bogdanove EM

更新日期：1978-09-01 00:00:00

abstract：:In adult male rhesus monkeys, 1 day of fasting leads to a profound suppression of LH secretion that is rapidly reversed with refeeding. To test the hypothesis that changes in insulin secretion during fasting and refeeding mediate the changes in LH secretion, blood samples for LH measurement were obtained between 0900-...

journal_title：Endocrinology

authors： Williams NI,Lancas MJ,Cameron JL

更新日期：1996-06-01 00:00:00

abstract：:The adipose conversion of 3T3-L1 fibroblasts depends on serum factors, one of which has been identified as GH. Human serum extracts obtained by heat treatment do not contain intact GH, as shown by RIA, but still support adipose conversion. After organic solvent extraction followed by reversed phase HPLC, two adipogeni...

journal_title：Endocrinology

authors： Schiwek DR,Löffler G

更新日期：1987-02-01 00:00:00

abstract：:Nonesterified fatty acids (NEFAs) have been recently shown in the rat to be involved in steroid hormone expression, having effects on plasma transport and intracellular activity. This study examines the influence of saturated and unsaturated NEFAs on estradiol (E2) binding to cytosol from human uterus, breast, and mel...

journal_title：Endocrinology

authors： Benassayag C,Vallette G,Hassid J,Raymond JP,Nunez EA

更新日期：1986-01-01 00:00:00

abstract：:Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...

journal_title：Endocrinology

authors： Aroor AR,Sowers JR,Bender SB,Nistala R,Garro M,Mugerfeld I,Hayden MR,Johnson MS,Salam M,Whaley-Connell A,Demarco VG

更新日期：2013-07-01 00:00:00

abstract：:Mammary gland is an organ that undergoes cycles of growth, differentiation, and function during pregnancy and lactation. Although it is known that the gland enhances its sensitivity to insulin during lactation, it remains to be investigated whether this increased sensitivity develops during pregnancy and which are the...

journal_title：Endocrinology

authors： Carrascosa JM,Ramos P,Molero JC,Herrera E

更新日期：1998-02-01 00:00:00

abstract：:An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7M) had no effect on basal gastrin levels but ...

journal_title：Endocrinology

authors： Hayes JR,Johnson DG,Koerker D,Williams RH

更新日期：1975-06-01 00:00:00

abstract：:131I therapy is a widely accepted treatment for differentiated thyroid cancers which can accumulate iodide. We evaluated the efficiency of 131I therapy against tumors which are transfected with the Na+/I- symporter (NIS) gene. We transfected the rat NIS cDNA expression vector into malignantly transformed rat thyroid c...

journal_title：Endocrinology

authors： Shimura H,Haraguchi K,Miyazaki A,Endo T,Onaya T

更新日期：1997-10-01 00:00:00

abstract：:Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify...

journal_title：Endocrinology

authors： Doig CL,Fletcher RS,Morgan SA,McCabe EL,Larner DP,Tomlinson JW,Stewart PM,Philp A,Lavery GG

更新日期：2017-06-01 00:00:00

abstract：:Effect of cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) on [125I]T3 binding to nuclei was investigated in vitro. CTBP and nuclei were prepared from rat kidney. CTBP was inactivated by incubating with charcoal and activated by incubating with NADPH or with NADP and dithiothreitol. Two complexes of CT...

journal_title：Endocrinology

authors： Hashizume K,Miyamoto T,Kobayashi M,Suzuki S,Ichikawa K,Yamauchi K,Ohtsuka H,Takeda T

更新日期：1989-06-01 00:00:00

abstract：:Neuropeptide Y (NPY), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. Because both genetic (e.g. in obese ob/ob mice) and acquired leptin deficiency (e.g. fasting in normal mice) increase hypothalamic NPY accumulation, and as leptin ad...

journal_title：Endocrinology

authors： Schwartz MW,Erickson JC,Baskin DG,Palmiter RD

更新日期：1998-05-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...

journal_title：Endocrinology

authors： Yang YW,Robbins AR,Nissley SP,Rechler MM

更新日期：1991-02-01 00:00:00

abstract：:Cell proliferation, terminal differentiation, and angiogenesis occur during cycles of follicular and luteal development. In other paradigms, mac25, a potent tumor inhibitor is strongly induced in senescent epithelial cells, whereas CTGF stimulates angiogenesis and wound healing. Using in situ hybridization and immunoh...

journal_title：Endocrinology

authors： Wandji SA,Gadsby JE,Barber JA,Hammond JM

更新日期：2000-07-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase activity and reductase mRNA level were determined in adrenals from hamsters treated with ACTH, with or without cycloheximide or aminoglutethimide. Both reductase activity and reductase mRNA level were similarly enhanced by ACTH administration compared to levels...

journal_title：Endocrinology

authors： Lehoux JG,Lefebvre A,De Médicis E,Bélisle S,Bellabarba D

更新日期：1989-07-01 00:00:00

abstract：:We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) ca...

journal_title：Endocrinology

authors： Bhonagiri P,Pattar GR,Horvath EM,Habegger KM,McCarthy AM,Elmendorf JS

更新日期：2009-04-01 00:00:00

abstract：:Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding...

journal_title：Endocrinology

authors： MacKay H,Patterson ZR,Abizaid A

更新日期：2017-04-01 00:00:00

abstract：:Ghrelin is a peptide hormone primarily produced in the previously unidentified X/A endocrine cells of the stomach. Extensive studies have focused on the effects of ghrelin on growth hormone release and appetite regulation. However, the mechanisms regulating ghrelin secretion are less understood. In the present study, ...

journal_title：Endocrinology

authors： Gagnon J,Anini Y

更新日期：2012-08-01 00:00:00

abstract：:UMR106-06 cells predominantly express the C1a isoform of the rat calcitonin (CT) receptor (CTR). We have compared the homologous regulation of the C1a CTR endogenously expressed in UMR106-06 cells with the cloned C1a CTR in transfected HEK 293 cells, in which expression is driven by a heterologous promoter. It was fou...

journal_title：Endocrinology

authors： Findlay DM,Houssami S,Christopoulos G,Sexton PM

更新日期：1996-11-01 00:00:00