Abstract:
:The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all four genotypes (normal male, normal female, carrier Tfm females, and Tfm males) were resistant to androgen. However, at 3 weeks of age the capacity to develop a tamase response appears in normal and carrier Tfm animals given androgen and rapidly rise to maximal levels. The level in the normal animal is regulated thereafter primarly by the level of circulating androgen. In contrast, the tamase response in the Tfm male of all ages and under all androgen regimens was minimal.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Dunn JF,Wilson JDdoi
10.1210/endo-96-6-1571subject
Has Abstractpub_date
1975-06-01 00:00:00pages
1571-8issue
6eissn
0013-7227issn
1945-7170journal_volume
96pub_type
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