Yolk formation in a stony coral Euphyllia ancora (Cnidaria, Anthozoa): insight into the evolution of vitellogenesis in nonbilaterian animals.

abstract：:The interaction of alloxan and cyclic AMP on glucose-induced insulin secretion was studied with the use of isolated rat islet perifusion. Simultaneous perifusion with cyclic AMP and alloxan did not protect the islets against the effect of alloxan. However, addition of dibutyryl cyclic AMP to the alloxan solution produ...

journal_title：Endocrinology

authors： Tomita T,Scarpelli DG

更新日期：1977-05-01 00:00:00

abstract：:Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

journal_title：Endocrinology

authors： Naulé L,Maione L,Kaiser UB

更新日期：2021-01-01 00:00:00

abstract：:We studied the direct effects of glucocorticoids on plasminogen activator (PA) production by rat granulosa cells. PA production was assayed by culturing rat granulosa cells on [125I]fibrin plates and determining the extent of fibrinolysis after addition of the specific substrate plasminogen. In granulosa cells from pr...

journal_title：Endocrinology

authors： Wang C,Leung A

更新日期：1989-04-01 00:00:00

abstract：:Recent studies using twins and inbred strains of mice reveal evidence for genetic mechanisms contributing to variation in circulating levels of IGF-I, IGF-II, and IGF binding protein (IGFBP)-3. To examine the hypothesis that serum IGFBP-5 levels have a strong heritable component, we intercrossed two inbred strains of ...

journal_title：Endocrinology

authors： Mohan S,Masinde G,Li X,Baylink DJ

更新日期：2003-08-01 00:00:00

abstract：:L-Asparaginase (ASNase), a drug widely used in the treatment of acute lymphoblastic leukemia, has been reported to decrease serum T4-binding globulin (TBG) levels, while results of serum albumin determinations were conflicting. This effect in vivo has been attributed to depressed liver protein synthesis, but this hypo...

journal_title：Endocrinology

authors： Bartalena L,Martino E,Antonelli A,Pacchiarotti A,Robbins J,Pinchera A

更新日期：1986-09-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), the predominant IGF carrier protein in circulation, is posttranslationally modified in vivo by IGFBP-3 protease(s) into a number of fragments. Based on the ascertained and predicted recognition sites for known IGFBP-3 proteases, FLAG-epitope tagged intact I...

journal_title：Endocrinology

authors： Devi GR,Yang DH,Rosenfeld RG,Oh Y

更新日期：2000-11-01 00:00:00

abstract：:To study the transcriptional regulation of the vasopressin gene in vitro, 3 kb of the 5' regulatory region of the rat vasopressin gene was isolated and subcloned, along with a series of various deletion mutants, into vectors containing the luciferase reporter gene. After transfecting these genes transiently into the h...

journal_title：Endocrinology

authors： Iwasaki Y,Oiso Y,Saito H,Majzoub JA

更新日期：1997-12-01 00:00:00

abstract：:The alphaVbeta3 integrin is an important determinant of IGF-I-stimulated receptor phosphorylation and biological actions. Blocking ligand occupancy of alphaVbeta3 with the distintegrin echistatin reduces IGF-I-stimulated receptor phosphorylation, and it inhibits cellular migration and DNA synthesis responses to IGF-I....

journal_title：Endocrinology

authors： Maile LA,Clemmons DR

更新日期：2002-11-01 00:00:00

abstract：:Fibroblasts represent one of the in vivo sites of extrahepatic insulin-like growth factor I (IGF-I) production. In this study, cultured fibroblasts prepared from the skin of neonatal rats were used as a model to assess the role of serum in regulating IGF-I messenger RNA (mRNA) levels. IGF-I mRNA, as demonstrated by No...

journal_title：Endocrinology

authors： Lowe WL Jr,Kummer M,Karpen CW,Wu XD

更新日期：1990-12-01 00:00:00

abstract：:Estrogen unresponsiveness among primate species can result from overexpression of a heterogeneous nuclear ribonucleoprotein (hnRNP) that competes with estrogen receptor (ER) for binding to the estrogen-response element (ERE). This hnRNP has been coined the "ERE-binding protein" (ERE-BP). The ERE-BP is a member of the ...

journal_title：Endocrinology

authors： Chen H,Stuart W,Hu B,Nguyen L,Huang G,Clemens TL,Adams JS

更新日期：2005-10-01 00:00:00

abstract：:The human breast cancer cell line MCF-7 responds to estrogens with increased progesterone receptor (PR) levels. In this study, we use dense amino acid density shift analyses to address directly the question of whether estrogen increases PR levels in MCF-7 cells by altering rates of receptor synthesis and/or degradatio...

journal_title：Endocrinology

authors： Nardulli AM,Greene GL,O'Malley BW,Katzenellenbogen BS

更新日期：1988-03-01 00:00:00

abstract：:The mammalian suprachiasmatic nucleus is the site of the circadian rhythm generator. The degrees of expression there of several neuropeptides, including vasopressin and vasoactive intestinal polypeptide, follow a diurnal rhythm. The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and m...

journal_title：Endocrinology

authors： Young WS 3rd,Kovács K,Lolait SJ

更新日期：1993-08-01 00:00:00

abstract：:Several observations suggest that GH stimulates sebaceous gland growth and development. Therefore, we studied the effects of GH and insulin-like growth factors (IGFs), alone and with androgen, on sebaceous epithelial cell (sebocyte) growth and differentiation in vitro. The rat preputial cell culture model system was u...

journal_title：Endocrinology

authors： Deplewski D,Rosenfield RL

更新日期：1999-09-01 00:00:00

abstract：:Activin A is a gonadal protein originally isolated from follicular fluid and is recognized as a local regulator of granulosa cell differentiation. Whether activin A promotes folliculogenesis, however, still remains unclarified. The present study was designed to elucidate the effect of activin A on follicular growth in...

journal_title：Endocrinology

authors： Yokota H,Yamada K,Liu X,Kobayashi J,Abe Y,Mizunuma H,Ibuki Y

更新日期：1997-11-01 00:00:00

abstract：:The structural elements of 19-norprogestogens which may be essential for binding to progesterone and estradiol-17beta(E2) receptors were investigated in the rabbit uterine cytosol. The kinetic study showed that 19-nor-progestogens are competitive inhibitors of progesterone-receptor (8S) binding and E2-receptor binding...

journal_title：Endocrinology

authors： Tamaya T,Nioka S,Furuta N,Shimura T,Takano N

更新日期：1977-06-01 00:00:00

abstract：:Mammary glands from second generation vitamin D-deficient mice and rats were examined for their ability to make the major milk proteins, casein and alpha-lactalbumin, both in vivo and in vitro. The glands from the rachitic animals were morphologically indistinguishable from those of age-matched controls. When placed i...

journal_title：Endocrinology

authors： Bhattacharjee M,Wientroub S,Vonderhaar BK

更新日期：1987-09-01 00:00:00

abstract：:Type I iodothyronine 5' deiodinase (5'DI) contains selenocysteine, encoded by a UGA codon, and this amino acid is essential for maximum catalytic efficiency in this enzyme. We recently showed that translation of UGA as selenocysteine in this protein requires a specific sequence of about 250 nucleotides in the 3' untra...

journal_title：Endocrinology

authors： Berry MJ,Maia AL,Kieffer JD,Harney JW,Larsen PR

更新日期：1992-10-01 00:00:00

abstract：:To determine if CRH and glucocorticoids are respectively required for hypophagia and catabolism in malnutrition, we have subjected wild-type (WT) and CRH knockout (KO) mice to dietary protein deprivation. Compared with WT mice, CRH KO mice exhibited greater decreases in food intake and negligible change in plasma cort...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-08-01 00:00:00

abstract：:Continuous labeling of primary cultures of human syncytiotrophoblasts with [125I]iodoepidermal growth factor (iodo-EGF) at 37 C revealed a progressive increase in intracellular EGF with 5% of total label observed in intracellular organelles at 2 min and 88% by 60 min. Detailed analysis by electron microscope radioauto...

journal_title：Endocrinology

authors： Lai WH,Guyda HJ,Bergeron JJ

更新日期：1986-01-01 00:00:00

abstract：:The ontogenic changes in the somatotroph's responsiveness to TRH were examined in enzymatically dissociated rat pituitary cells in primary monolayer culture. Exposure to TRH (10(-8) M) caused a significant increase in GH release in cultured pituitary cells from rats ranging in age from -1 day (20 days of gestational a...

journal_title：Endocrinology

authors： Welsh JB,Cuttler L,Szabo M

更新日期：1986-11-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at a high level in the fetal pituitary and decreases profoundly between embryonic day 19 and postnatal day 1 (PN1), with a further decrease from PN1 to PN4. In this series of experiments, we investigated the hypothesis that dopamine 2 receptor (Dr...

journal_title：Endocrinology

authors： Winters SJ,Ghooray DT,Yang RQ,Holmes JB,O'Brien AR,Morgan J,Moore JP Jr

更新日期：2014-07-01 00:00:00

abstract：:The question of whether maternal melatonin could be transported in milk to suckling rats was investigated because melatonin is probably not produced in these animals during the first 10 days of life. [3H]Melatonin was found to be rapidly transferred from the maternal circulation into lactating mammary tissue, and the ...

journal_title：Endocrinology

authors： Reppert SM,Klein DC

更新日期：1978-02-01 00:00:00

abstract：:We have investigated the effects of veratridine, a Na+ channel activator, and ouabain, an inhibitor of Na+-K+-ATPase, on short term (1-h) PRL release from primary cultures of rat anterior pituitary cells and from the rat anterior pituitary cell line GH4C1 in culture. Both compounds should increase intracellular Na+. V...

journal_title：Endocrinology

authors： Scammell JG,Dannies PS

更新日期：1983-10-01 00:00:00

abstract：:Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...

journal_title：Endocrinology

authors： Varayoud J,Ramos JG,Bosquiazzo VL,Muñoz-de-Toro M,Luque EH

更新日期：2008-11-01 00:00:00

abstract：:Whole saliva collected from rat, mouse, and human sources was found to contain high concentrations of transforming growth factor-alpha (TGF alpha) when analyzed by RIA. The concentrations of TGF alpha in unstimulated human saliva (age, 30-45 yr; n = 10; 1.5 +/- 3.1 nM) was reduced with age (age, 55-70 yr; n = 10; 0.4 ...

journal_title：Endocrinology

authors： Humphreys-Beher MG,Macauley SP,Chegini N,van Setten G,Purushotham K,Stewart C,Wheeler TT,Schultz GS

更新日期：1994-02-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:The extent thyroid hormone receptors (TRs) bind to AGGTCA-related motifs as monomers and/or homodimers, and as heterodimers with retinoid X receptors (RXRs) depends on the number, spacing, and orientation of these half-sites. Here we show that recombinant RXR alpha affects TR binding to DNA in diverse ways; it enhance...

journal_title：Endocrinology

authors： Ribeiro RC,Apriletti JW,Yen PM,Chin WW,Baxter JD

更新日期：1994-11-01 00:00:00

abstract：:The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a high-glucose milieu. Rat IRPTCs were cultured in monolayer. ANG and ANG mRNA expre...

journal_title：Endocrinology

authors： Zhang SL,Chen X,Wei CC,Filep JG,Tang SS,Ingelfinger JR,Chan JS

更新日期：2002-12-01 00:00:00