Abstract:
:The mammalian suprachiasmatic nucleus is the site of the circadian rhythm generator. The degrees of expression there of several neuropeptides, including vasopressin and vasoactive intestinal polypeptide, follow a diurnal rhythm. The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and mobilization of intracellular calcium, is expressed in this nucleus. This study used double simultaneous hybridization histochemistry to show that V1a receptor transcripts are present in both vasopressin and vasoactive intestinal polypeptide neurons and that their levels follow a diurnal rhythm. Furthermore, the expression of the V1a receptor is 12 h out of phase from that of vasopressin. However, the receptor's diurnal rhythm is still maintained in the vasopressin-deficient Brattleboro rat, indicating that the V1a receptor's rhythm is independent of any vasopressin feedback.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Young WS 3rd,Kovács K,Lolait SJdoi
10.1210/endo.133.2.8344200subject
Has Abstractpub_date
1993-08-01 00:00:00pages
585-90issue
2eissn
0013-7227issn
1945-7170journal_volume
133pub_type
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