Abstract:
:Tobacco smoking favorably influences the course of Hashimoto thyroiditis, possibly through the antiinflammatory proprieties of nicotine. In this study we tested anatabine, another tobacco alkaloid, in a model of experimental autoimmune thyroiditis. Experimental autoimmune thyroiditis was induced by different doses of thyroglobulin, to produce a disease of low, moderate, or high severity, in 88 CBA/J female mice: 43 drank anatabine supplemented water and 45 regular water. Mice were bled after immunization and killed to assess thyroid histopathology, thyroglobulin antibodies, T(4), and thyroid RNA expression of 84 inflammatory genes. We also stimulated in vitro a macrophage cell line with interferon-γ or lipopolysaccharide plus or minus anatabine to quantitate inducible nitric oxide synthase and cyclooxygenase 2 protein expression. Anatabine reduced the incidence and severity of thyroiditis in the moderate disease category: only 13 of 21 mice (62%) developed thyroid infiltrates when drinking anatabine as compared with 22 of 23 (96%) controls (relative risk 0.59, P = 0.0174). The median thyroiditis severity was 0.5 and 2.0 in anatabine and controls, respectively (P = 0.0007 by Wilcoxon rank sum test). Anatabine also reduced the antibody response to thyroglobulin on d 14 (P = 0.029) and d 21 (P = 0.045) after immunization and improved the recovery of thyroid function on d 21 (P = 0.049). In the thyroid transcriptome, anatabine restored expression of IL-18 and IL-1 receptor type 2 to preimmunization levels. Finally, anatabine suppressed in a dose-dependent manner macrophage production of inducible nitric oxide synthase and cyclooxygenase 2. Anatabine ameliorates disease in a model of autoimmune thyroiditis, making the delineation of its mechanisms of action and potential clinical utility worthwhile.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Caturegli P,De Remigis A,Ferlito M,Landek-Salgado MA,Iwama S,Tzou SC,Ladenson PWdoi
10.1210/en.2012-1452subject
Has Abstractpub_date
2012-09-01 00:00:00pages
4580-7issue
9eissn
0013-7227issn
1945-7170pii
en.2012-1452journal_volume
153pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::GH has physiological functions in many tissues, but the cellular targets for direct effects of GH remain ill defined in complex tissues such as the growth plate in which the contribution of direct vs. indirect actions of GH remains controversial. The Janus kinase (Jak)-signal transducer and activator of transcription ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0985
更新日期:2009-08-01 00:00:00
abstract::Sulfonylureas are drugs widely used in the treatment of patients with type 2 diabetes mellitus. In addition to their pancreatic effect of stimulating insulin secretion, many studies suggest that sulfonylureas also have extrapancreatic actions. We have previously reported that gliclazide, a second-generation sulfonylur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0755
更新日期:2004-02-01 00:00:00
abstract::The factors controlling the synthesis and degradation of the insulin-like growth factor-binding proteins (IGFBPs) during pregnancy are poorly understood. To clarify the roles of nutritional factors in the regulation of fetal and maternal IGFBP production, we examined the effects of fasting, refeeding, and glucose admi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.4.1382960
更新日期:1992-10-01 00:00:00
abstract::Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-20
更新日期:1976-01-01 00:00:00
abstract::Neuropeptide Y (NPY) peptide concentrations in the arcuate nucleus have recently been shown to be modulated by gonadal steroids in the male rat. The present study was designed to determine whether NPY messenger RNA (mRNA)-synthesizing cells in the arcuate nucleus (Arc) of the male rat are regulated by testosterone (T)...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.1.8419120
更新日期:1993-01-01 00:00:00
abstract::Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-6-2856
更新日期:1986-12-01 00:00:00
abstract::The developmental appearance and regulation of hypothalamic vasopressin (prepropressophysin) mRNA was studied using quantitated in situ hybridization techniques. Vasopressin mRNA levels in the supraoptic nuclei were reliably detected on day 16 of gestation, while mRNA in the suprachiasmatic nuclei (SCN) was detectable...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-6-2483
更新日期:1987-06-01 00:00:00
abstract::The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2016-1944
更新日期:2017-05-01 00:00:00
abstract::Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1916
更新日期:2017-07-01 00:00:00
abstract::In view of recent reports on ovarian production and action of transforming growth factors (TGFs) and inhibin-related proteins (inhibin, activin, and follistatin), we have examined the effects of these hormones on the function of preovulatory follicles in vitro. Individual preovulatory follicles were obtained from PMSG...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-4-1857
更新日期:1989-10-01 00:00:00
abstract::Continuous labeling of primary cultures of human syncytiotrophoblasts with [125I]iodoepidermal growth factor (iodo-EGF) at 37 C revealed a progressive increase in intracellular EGF with 5% of total label observed in intracellular organelles at 2 min and 88% by 60 min. Detailed analysis by electron microscope radioauto...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-1-413
更新日期:1986-01-01 00:00:00
abstract::Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high-fat, high-sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent l...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00213
更新日期:2017-09-01 00:00:00
abstract::This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-3-1636
更新日期:1988-09-01 00:00:00
abstract::Although the pituitary-grafted rat is a classic model of chronic PRL excess, the presence of somatotropes in grafted pituitary tissue indicates a potential for GH secretion. The current study was designed to investigate GH-releasing hormone (GRH)-induced GH secretion and beta-adrenergic inhibition of GH release in ani...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-5-2273
更新日期:1989-11-01 00:00:00
abstract::Testerone (T) concentrations in the plasma, gonads, and adrenals were measured by radioimmunoassay in 188 male and 160 female rabbit fetuses. Determinations were performed daily from the 20th to the 31st day of gestation and were correlated with the maternal plasma concentration of T. The T content of both testes rema...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-5-1263
更新日期:1976-11-01 00:00:00
abstract::More than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone (LHRH) and follicle stimulating hormone-releasing hormone (FSHRH) activities in search for LHRH and FSHRH which differ from the decapeptide (pyro)Glu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 (I). Among the porcine fractions te...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-2-380
更新日期:1976-02-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) is a neuropeptide related to vasoactive intestinal peptide-secretin-glucagon which stimulates adenylate cyclase in cultured rat pituitary cells and stimulates LH and FSH release in vitro and in vivo. Because the cAMP-protein kinase-A pathway regulates the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.3.7915230
更新日期:1994-09-01 00:00:00
abstract::Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2004
更新日期:2013-10-01 00:00:00
abstract::Recent studies have demonstrated that passive immunization of neonatal rats to GRF inhibited their somatic growth through the suppression of GH secretion. In this study, we investigated the changes in pituitary GRF receptor (GRFR) expression in GRF antibody (GRF-ab) treated rats. Neonatal rats were treated from day 1 ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.6.8641220
更新日期:1996-06-01 00:00:00
abstract::Prolactinomas are the most prevalent functional pituitary adenomas. Dopamine D2 receptor (D2R) agonists, such as bromocriptine are the first line of therapy; however, drug intolerance/resistance to D2R agonists exists. Apart from D2R agonists, there is no established medical therapy for prolactinomas; therefore, ident...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1760
更新日期:2008-08-01 00:00:00
abstract::There is considerable evidence that CRH can suppress food intake. As hypothalamic CRH, a main site of CRH expression, is also negatively regulated by glucocorticoids, it is unclear whether anorexia and weight loss in adrenal insufficiency are attributable to elevated CRH or to decreased glucocorticoid levels. To disti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.1.6416
更新日期:1999-01-01 00:00:00
abstract::Liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor that belongs to the NR5A subgroup of nuclear receptors. LRH-1 induces key genes to regulate metabolic process, ovarian function, cancer cell proliferation, and steroidogenesis. In the breast, LRH-1 modulates and synergizes with endogenous estrogen signalin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1948
更新日期:2014-05-01 00:00:00
abstract::Media from large vessel endothelial cells (pulmonary artery, aorta) contained intact connective tissue growth factor (CTGF) and a dominant 19-kDa band. N-terminal analysis of the 19-kDa band showed sequence corresponding to CTGF amino acid 181-190, suggesting that the 19-kDa band represented a proteolytic fragment of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.4.6633
更新日期:1999-04-01 00:00:00
abstract::Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Usi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.4.5926
更新日期:1998-04-01 00:00:00
abstract::The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-4-1048
更新日期:1975-04-01 00:00:00
abstract::Despite the specificity inferred by its name, glycogen synthase kinase (GSK)-3beta is an important kinase with a plethora of significant cellular targets, including cytoskeletal proteins and transcription factors, and its activity is regulated by phosphorylation on tyrosine/serine residues. As part of our efforts to d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1519
更新日期:2004-06-01 00:00:00
abstract::Our research programs required the preparation of hypophysectomized and orchidectomized rhesus monkeys. This afforded us the possibility to characterize and compare levels of the gonadotropin and inhibin subunit mRNAs in pituitaries from intact and castrate monkeys. Eighteen adult male monkeys, four of which had been ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.3.1537290
更新日期:1992-03-01 00:00:00
abstract::Although factors that regulate cAMP and steroid production in granulosa cells of hen preovulatory follicles have been well studied, much less is known of the mechanisms that control steroidogenesis in the adjacent thecal layer. These studies were conducted to examine the involvement and interaction of cAMP and protein...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-3-1691
更新日期:1989-09-01 00:00:00
abstract::Atrial Natriuretic Factor (ANF) has been demonstrated within the central nervous system (CNS), where it has been implicated in the regulation of blood pressure, fluid and electrolyte balance. To explore the effect of acute plasma vol expansion on the activation of CNS ANF, changes in ANF levels of CSF drawn from the c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2587
更新日期:1990-11-01 00:00:00
abstract::The present experiments examined the relationship between cholera toxin and TSH stimulation of the adenylate cyclase system in bovine thyroid tissue. Preincubation of thyroid slices for 20 min at 4 C with a maximal concentration of cholera toxin (100 microgram/ml) did not impair the subsequent stimulation of cAMP by s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-6-2076
更新日期:1980-12-01 00:00:00