Glucocorticoid replacement, but not corticotropin-releasing hormone deficiency, prevents adrenalectomy-induced anorexia in mice.

abstract：:PTH stimulates bone formation and increases hematopoietic stem cells through mechanisms as yet uncertain. The purpose of this study was to identify mechanisms by which PTH links actions on cells of hematopoietic origin with osteoblast-mediated bone formation. C57B6 mice (10 d) were nonlethally irradiated and then admi...

journal_title：Endocrinology

authors： Koh AJ,Novince CM,Li X,Wang T,Taichman RS,McCauley LK

更新日期：2011-12-01 00:00:00

abstract：:Immunoreactive LHRH was detected in hypothalamic and extrahypothalamic brain extracts of the rat, bird (pigeon and chicken), reptile (tortoise and lizard), amphibian (frog and toad), teleost (cichid), and elasmobranch (dogfish) and in the whole brain of the cyclostome (bagfish). The concentration of hypothalamic immun...

journal_title：Endocrinology

authors： King JA,Millar RP

更新日期：1980-03-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is known to be involved in maintaining glucose homeostasis, and AVP-resistance is observed in poorly controlled non-insulin-dependent diabetes mellitus subjects, resulting in a lowered plasma volume. Recently we reported that V1a vasopressin receptor-deficient (V1aR(-/-)) mice exhibited a de...

journal_title：Endocrinology

authors： Aoyagi T,Birumachi J,Hiroyama M,Fujiwara Y,Sanbe A,Yamauchi J,Tanoue A

更新日期：2007-05-01 00:00:00

abstract：:Addition of calcitonin gene-related peptide (CGRP), 1 X 10(-7) M, to cultured neonatal rat heart cells resulted in rapid increases in beating rate and cellular concentrations of cAMP. Calcitonin (1 X 10(-7) M), in contrast, had no significant effect on heart cell beating rate or cAMP content. CGRP-stimulated increases...

journal_title：Endocrinology

authors： Fisher RA,Robertson SM,Olson MS

更新日期：1988-07-01 00:00:00

abstract：:Glucocorticoids and nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory and immune diseases. Nitric oxide (NO) has a diversity of physiological functions, but its excess production has been implicated in the inflammatory process. The present study was designed to elucidate th...

journal_title：Endocrinology

authors： Katsuyama K,Shichiri M,Kato H,Imai T,Marumo F,Hirata Y

更新日期：1999-05-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) improves glucose metabolism and growth in patients with leprechaunism. We investigated signal transduction through IGF-I receptor in comparison with epidermal growth factor (EGF) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprec...

journal_title：Endocrinology

authors： Takahashi Y,Tobe K,Kadowaki H,Katsumata D,Fukushima Y,Yazaki Y,Akanuma Y,Kadowaki T

更新日期：1997-02-01 00:00:00

abstract：:3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...

journal_title：Endocrinology

authors： Piehl S,Heberer T,Balizs G,Scanlan TS,Smits R,Koksch B,Köhrle J

更新日期：2008-06-01 00:00:00

abstract：:Leptin, a recently-discovered hormonal product of the obese gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety and improves reproductive performance if injected into mice lacking circulating leptin. Therefore, we tested the hypothesis that leptin signals metabolic informati...

journal_title：Endocrinology

authors： Spicer LJ,Francisco CC

更新日期：1997-08-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:A binding protein for activin was purified from bovine pituitary by affinity chromatography on dextran sulfate-Sepharose CL-4B and activin-Affi-Gel 10. A 52,700-fold purification over the starting crude homogenate was achieved. The purified preparation showed two bands of 36 and 33 kilodalton in sodium dodecyl sulfate...

journal_title：Endocrinology

authors： Kogawa K,Nakamura T,Sugino K,Takio K,Titani K,Sugino H

更新日期：1991-03-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:Androgens are the primary regulators of epididymal structure and functions. Principal cells are the major cell type of the tissue and are particularly sensitive to androgen removal. To distinguish the direct effects of androgens on this cell type, DNA microarrays were used to identify androgen-regulated genes in the m...

journal_title：Endocrinology

authors： Seenundun S,Robaire B

更新日期：2007-01-01 00:00:00

abstract：:We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pu...

journal_title：Endocrinology

authors： Mukhina S,Liu D,Guo K,Raccurt M,Borges-Bendris S,Mertani HC,Lobie PE

更新日期：2006-04-01 00:00:00

abstract：:Continuous labeling of primary cultures of human syncytiotrophoblasts with [125I]iodoepidermal growth factor (iodo-EGF) at 37 C revealed a progressive increase in intracellular EGF with 5% of total label observed in intracellular organelles at 2 min and 88% by 60 min. Detailed analysis by electron microscope radioauto...

journal_title：Endocrinology

authors： Lai WH,Guyda HJ,Bergeron JJ

更新日期：1986-01-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:To find out whether the hippocampus is involved in central nervous system-mediated glucoregulation, we injected saline, neostigmine, dopamine, norepinephrine, bombesin, beta-endorphin, somatostatin, and prostaglandin F2 alpha into the dorsal hippocampus in anesthetized fed rats. After injection of dopamine, norepineph...

journal_title：Endocrinology

authors： Uemura K,Iguchi A,Yatomi A,Miura H,Honmura A,Yanase M,Sakamoto N

更新日期：1989-05-01 00:00:00

abstract：:In developed countries, the increasing incidence of obesity is a serious health problem. Leptin exposure in the perinatal period affects long-term regulation of appetite and energy expenditure, but control of leptin production in utero is unclear. This study investigated perirenal adipose tissue (PAT) and placental le...

journal_title：Endocrinology

authors： O'Connor DM,Blache D,Hoggard N,Brookes E,Wooding FB,Fowden AL,Forhead AJ

更新日期：2007-08-01 00:00:00

abstract：:To identify factors that regulate the tempo of growth and puberty, the present study examined how the environment influenced the timing of menarche and first ovulation in rhesus monkeys and how these events were related to differential rates of growth. Spring-born females were raised from 12 months of age under natura...

journal_title：Endocrinology

authors： Wilson ME,Gordon TP,Rudman CG,Tanner JM

更新日期：1988-12-01 00:00:00

abstract：:In seasonally breeding species, an animal's photoperiodic history (the daylength or photoperiod previously experienced) influences the reproductive response to new photoperiods. However, this has only been examined over a relatively narrow range of photoperiods. We assessed whether Djungarian hamsters (Phodopus sungor...

journal_title：Endocrinology

authors： Rivkees SA,Hall DA,Weaver DR,Reppert SM

更新日期：1988-06-01 00:00:00

abstract：:We have previously described FSH receptor-mediated influx of 45Ca++ in cultured Sertoli cells from immature rats and receptor-enriched proteoliposomes via activation of voltage-sensitive and voltage-independent calcium channels. We have further shown that this effect of FSH does not require cholera toxin- or pertussis...

journal_title：Endocrinology

authors： Grasso P,Santa-Coloma TA,Reichert LE Jr

更新日期：1991-06-01 00:00:00

abstract：:The issue of what starts the circadian clock ticking was addressed by studying the developmental appearance of the daily rhythm in the expression of two genes in the zebrafish pineal gland that are part of the circadian clock system. One encodes the photopigment exorhodopsin and the other the melatonin synthesizing en...

journal_title：Endocrinology

authors： Vuilleumier R,Besseau L,Boeuf G,Piparelli A,Gothilf Y,Gehring WG,Klein DC,Falcón J

更新日期：2006-05-01 00:00:00

abstract：:As the incidence of obesity continues to increase, the development of effective therapies is a high priority. The endocannabinoid system has emerged as an important influence on the regulation of energy homeostasis. The endocannabinoids anandamide and 2-arachidonoylglycerol act on cannabinoid receptor-1 (CB1) in the b...

journal_title：Endocrinology

authors： de Kloet AD,Woods SC

更新日期：2009-06-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...

journal_title：Endocrinology

authors： Haines CD,Harvey PA,Luczak ED,Barthel KK,Konhilas JP,Watson PA,Stauffer BL,Leinwand LA

更新日期：2012-09-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00

abstract：:Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunor...

journal_title：Endocrinology

authors： Chihara K,Arimura A,Kubli-Garfias C,Schally AV

更新日期：1979-12-01 00:00:00

abstract：:The Elovl3 gene belongs to the Elovl gene family, which encodes for enzymes involved in the elongation of very long chain fatty acids. The recognized role for the enzyme is to control the elongation of saturated and monounsaturated fatty acids up to 24 carbons in length. Elovl3 was originally identified as a highly ex...

journal_title：Endocrinology

authors： Brolinson A,Fourcade S,Jakobsson A,Pujol A,Jacobsson A

更新日期：2008-06-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) is stored in atrial myocytes as a 15-17K prohormone, but circulates in plasma as a 3K, carboxy (C)-terminal fragment of the prohormone. The tissue location at which the cleavage of pro-ANF to its hormonal form occurs is unknown. In the present study, an immunological approach was taken ...

journal_title：Endocrinology

authors： Wildey GM,Fischman AJ,Fallon JT,Matsueda GR,Zisfein JB,Preibisch G,Seipke G,Homcy CJ,Graham RM

更新日期：1988-10-01 00:00:00

abstract：:We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet beta-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. The effects of 1-2 d culture of both rat INS 832/13 cells and hu...

journal_title：Endocrinology

authors： El-Assaad W,Buteau J,Peyot ML,Nolan C,Roduit R,Hardy S,Joly E,Dbaibo G,Rosenberg L,Prentki M

更新日期：2003-09-01 00:00:00

abstract：:The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase)...

journal_title：Endocrinology

authors： Woitowich NC,Philibert KD,Leitermann RJ,Wungjiranirun M,Urban JH,Glucksman MJ

更新日期：2016-02-01 00:00:00