Involvement of the hippocampus in central nervous system-mediated glucoregulation in rats.

abstract：:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...

journal_title：Endocrinology

authors： Blackard WG,Guzelian PS,Small ME

更新日期：1978-08-01 00:00:00

abstract：:We have investigated the physiological regulation and functional significance of brain-derived neurotrophic factor (BDNF) in the endocrine melanotrope cells of the pituitary pars intermedia of the amphibian Xenopus laevis, which can adapt its skin color to the light intensity of its environment. In black-adapted anima...

journal_title：Endocrinology

authors： Kramer BM,Cruijsen PM,Ouwens DT,Coolen MW,Martens GJ,Roubos EW,Jenks BG

更新日期：2002-04-01 00:00:00

abstract：:In the present study epididymal epithelium was immortalized in transgenic mice by expressing simian virus 40 T antigen under a 5.0-kb mouse glutathione peroxidase 5 promoter (GPX5-Tag1). Epididymal tumorigenesis was associated with an increase in c-Myc expression, and a marked decrease in B-Myc expression, with a 500-...

journal_title：Endocrinology

authors： Sipilä P,Shariatmadari R,Huhtaniemi IT,Poutanen M

更新日期：2004-01-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Initiation of folliculogenesis through the induction of primordial follicle development in the ovary has an important role in determining the fertility and reproductive fitness of most mammalian species. The factors that control this critical process are largely unknown. The hypothesis tested in the current study was ...

journal_title：Endocrinology

authors： Parrott JA,Skinner MK

更新日期：1999-09-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...

journal_title：Endocrinology

authors： Yang YW,Robbins AR,Nissley SP,Rechler MM

更新日期：1991-02-01 00:00:00

abstract：:Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...

journal_title：Endocrinology

authors： Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

更新日期：2019-12-01 00:00:00

abstract：:The regulation of cholecystokinin octapeptide (CCK-8) secretion was studied using a fetal cerebral cortical cell culture system. After 2-3 weeks in culture, the cells were utilized for short-term release experiments. CCK-8 was measured by RIA and its identity was confirmed by HPLC. Depolarization of the cells with K+ ...

journal_title：Endocrinology

authors： Abucham J,Reichlin S

更新日期：1991-12-01 00:00:00

abstract：:Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...

journal_title：Endocrinology

authors： Cho E,Montgomery RB,Mostaghel EA

更新日期：2014-11-01 00:00:00

abstract：:Although GH plays a key role in postnatal growth, prenatal growth is thought to be GH independent. However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetal tissues as early as fetal stage E12. The aim of the present study was to investigate tissue-specific production of the GHR/BP...

journal_title：Endocrinology

authors： Edmondson SR,Werther GA,Russell A,LeRoith D,Roberts CT Jr,Beck F

更新日期：1995-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiol...

journal_title：Endocrinology

authors： Rettori V,Milenkovic L,Aguila MC,McCann SM

更新日期：1990-05-01 00:00:00

abstract：:To determine whether 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] regulates PTH secretion, we have tested its effects in both short term incubations (30-120 min) and long term primary cell cultures (24-96 h) of bovine parathyroid cells. In short term incubations, 10(-11)-10(-7) M 1,25-(OH)2D3 had no consistent effect on PT...

journal_title：Endocrinology

authors： Cantley LK,Russell J,Lettieri D,Sherwood LM

更新日期：1985-11-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:Most studies of lipoprotein requirements for steroid secretion by the adrenal have examined the mixed cell population of the whole gland; none have examined lipoprotein requirements of guinea pig adrenocortical cells. In this study the effect of exogenous lipoprotein on the ability of cells from each of the different ...

journal_title：Endocrinology

authors： Black VH

更新日期：1987-02-01 00:00:00

abstract：:Decidual/trophoblast PRL-related protein (d/tPRP) is a member of the PRL gene family and is dually expressed in uterine and placental tissues in a highly coordinated pattern during pregnancy. In the present study, we describe the isolation and characterization of the d/tPRP gene. A lambda DASH II Wistar-Kyoto rat geno...

journal_title：Endocrinology

authors： Orwig KE,Dai G,Rasmussen CA,Soares MJ

更新日期：1997-06-01 00:00:00

abstract：:Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis for the KP/NKB/DYN (KNDy) neuron concept; in both sexes, KNDy neu...

journal_title：Endocrinology

authors： Hrabovszky E,Sipos MT,Molnár CS,Ciofi P,Borsay BÁ,Gergely P,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z

更新日期：2012-10-01 00:00:00

abstract：:Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate production and intracellular Ca2+ mobilization. Nonhydrolyzable ATP derivatives, ADP and GTP, were also as effective in magnitude as ATP, whereas neither AMP n...

journal_title：Endocrinology

authors： Okajima F,Sho K,Kondo Y

更新日期：1988-08-01 00:00:00

abstract：:T3 stimulates in vitro GH secretion, whereas somatomedins have been shown to suppress GH. We, therefore, tested the effects of a recombinant human insulin-like growth factor analog (IGF-I; Thr 59) on T3-induced GH secretion. Pituitary monolayer cultures were derived from 4- to 7-week surgically thyroidectomized male r...

journal_title：Endocrinology

authors： Melmed S,Yamashita S

更新日期：1986-04-01 00:00:00

abstract：:Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and i...

journal_title：Endocrinology

authors： Davidson RK,Kanojia S,Spaeth JM

更新日期：2021-02-01 00:00:00

abstract：:Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the N222D mutation. Me...

journal_title：Endocrinology

authors： Prabhu Y,Blanco EH,Liu M,Peinado JR,Wheeler MC,Gekakis N,Arvan P,Lindberg I

更新日期：2014-07-01 00:00:00

abstract：:The objectives of this study were to investigate the presence of immunoreactive GnRH (irGnRH) in scleractinian coral, Euphyllia ancora, study its seasonal variation, and evaluate its biological activity. irGnRH was detected and quantified in coral polyps. The biological activity of coral irGnRH was tested on pituitary...

journal_title：Endocrinology

authors： Twan WH,Hwang JS,Lee YH,Jeng SR,Yueh WS,Tung YH,Wu HF,Dufour S,Chang CF

更新日期：2006-01-01 00:00:00

abstract：:We studied the estrogen-dependent expression of epidermal growth factor (EGF), transforming growth factor (TGF) alpha, and EGF receptor gene transcripts in human fallopian tubes in vivo and in vitro. Competitive polymerase chain reaction (PCR) was performed on the fallopian tube RNA samples from the postmenopausal wom...

journal_title：Endocrinology

authors： Adachi K,Kurachi H,Homma H,Adachi H,Imai T,Sakata M,Higashiguchi O,Yamaguchi M,Morishige K,Sakoyama Y

更新日期：1995-05-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on renin release is controversial. Several reports state that ANP inhibits renin secretion, while others have shown no effect. We investigated the effect of synthetic rat ANP with 24 amino acids (atriopeptin III) on renin release in vitro in a dynamic superfusion system o...

journal_title：Endocrinology

authors： Takagi M,Takagi M,Franco-Saenz R,Mulrow PJ

更新日期：1988-04-01 00:00:00

abstract：:Bone morphogenetic protein (BMP)-4 is a key mediator of anterior pituitary organogenesis. However, through inappropriate expression patterns, BMP-4 is also pathogenic in a pituitary adenoma subtype-specific context. In these cases, increase or decrease in BMP-4 in lactotroph- and corticotroph-derived adenomas, respect...

journal_title：Endocrinology

authors： Yacqub-Usman K,Duong CV,Clayton RN,Farrell WE

更新日期：2012-08-01 00:00:00

abstract：:Using a sensitive method for the simultaneous measurement of TSH subunit mRNAs, we have investigated their hormonal regulation in the pituitary glands of normal and hypothyroid rats. Oligodeoxyribonucleotides (probes) complementary to coding regions of rat alpha- and TSH beta-subunit mRNAs were synthesized. These prob...

journal_title：Endocrinology

authors： Carr FE,Ridgway EC,Chin WW

更新日期：1985-09-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:Both serotonin (5-HT) and opiates exert a stimulatory effect on PRL secretion. Some evidence suggests that the action of opiates may be elicited through serotonergic neurons. We tested this hypothesis in the present study by evaluating the effect of perturbation of the serotonergic system on PRL secretion induced by f...

journal_title：Endocrinology

authors： Pan JT,Teo KL

更新日期：1989-10-01 00:00:00

abstract：:The mechanisms by which bacterial endotoxin [lipopolysaccharide (LPS)] stimulates the hypothalamo-pituitary-adrenal axis (HPAA) have not been elucidated. The present study was designed to investigate the involvement of macrophages in plasma ACTH and corticosterone responses to LPS administration in rats using selectiv...

journal_title：Endocrinology

authors： Derijk R,Van Rooijen N,Tilders FJ,Besedovsky HO,Del Rey A,Berkenbosch F

更新日期：1991-07-01 00:00:00