Lipoprotein requirements for secretion of ultraviolet-absorbing corticosteroids by guinea pig adrenocortical cells in vitro: inner versus outer cortices; zona glomerulosa versus zona fasciculata.

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00

abstract：:We have previously shown that in reaggregate cell cultures of 14-day-old female rat pituitary, LHRH is capable of stimulating lactotrophs to enter the S-phase of the cell cycle, and that this effect is mediated by paracrine growth factors secreted from gonadotrophs. In the present report we describe the isolation, pur...

journal_title：Endocrinology

authors： Tilemans D,Andries M,Proost P,Devreese B,Van Beeumen J,Denef C

更新日期：1994-07-01 00:00:00

abstract：:In the setting of insulin resistance, agonists of peroxisome proliferator-activated receptor (PPAR)-gamma restore insulin action in muscle and promote lipid redistribution. Mice with muscle-specific knockout of PPARgamma (MuPPARgammaKO) develop excess adiposity, despite reduced food intake and normal glucose disposal ...

journal_title：Endocrinology

authors： Norris AW,Hirshman MF,Yao J,Jessen N,Musi N,Chen L,Sivitz WI,Goodyear LJ,Kahn CR

更新日期：2008-11-01 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...

journal_title：Endocrinology

authors： Boylan JM,Gruppuso PA

更新日期：2002-11-01 00:00:00

abstract：:Fetal adrenal steroid hydroxylase activity and messenger RNA (mRNA) expression increases concurrent with the preterm rise in fetal plasma cortisol during late gestation in sheep. By placing bilateral lesions of the fetal paraventricular nuclei (PVN) we have previously demonstrated that the fetal PVN is necessary for t...

journal_title：Endocrinology

authors： Myers DA,McDonald TJ,Nathanielsz PW

更新日期：1992-07-01 00:00:00

abstract：:Exposure of quiescent bovine parathyroid cells to serum or a serum substitute caused an elevation in [3H] thymidine incorporation, followed by an increase in cell number. This was preceded by a rapid transient rise in c-myc and c-fos proto-oncogene mRNA levels. Alterations in the medium calcium concentration had no ef...

journal_title：Endocrinology

authors： Kremer R,Bolivar I,Goltzman D,Hendy GN

更新日期：1989-08-01 00:00:00

abstract：:Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from ...

journal_title：Endocrinology

authors： Kawai M,Naruse M,Yoshimoto T,Naruse K,Shionoya K,Tanaka M,Morishita Y,Matsuda Y,Demura R,Demura H

更新日期：1996-01-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:The expression of genes encoding key hepatic gluconeogenic enzymes, including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), is regulated at the transcriptional level by a network of transcription factors and cofactors, including cAMP response element-binding protein (CREB). It has been ...

journal_title：Endocrinology

authors： Seo HY,Kim MK,Min AK,Kim HS,Ryu SY,Kim NK,Lee KM,Kim HJ,Choi HS,Lee KU,Park KG,Lee IK

更新日期：2010-02-01 00:00:00

abstract：:We investigated the effect of glucocorticoid on the generation of osteoclasts. In mouse bone marrow culture systems, dexamethasone, a synthetic glucocorticoid analog, enhanced osteoclast-like cell formation induced by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in a dose-dependent manner. Conversely, dexamethasone inhibit...

journal_title：Endocrinology

authors： Shuto T,Kukita T,Hirata M,Jimi E,Koga T

更新日期：1994-03-01 00:00:00

abstract：:Molecular mechanisms underlying unloading-induced reduction of bone formation have not yet been fully understood. In vitro, Runx2 has been suggested to be involved in mechanical signaling in osteoblasts. However, the roles of Runx2 in vivo during the bone response to mechanical stimuli have not yet been known. The pur...

journal_title：Endocrinology

authors： Salingcarnboriboon R,Tsuji K,Komori T,Nakashima K,Ezura Y,Noda M

更新日期：2006-05-01 00:00:00

abstract：:B-cell lymphoma 2 (BCL2) family kin (BFK) is a recently identified novel protein that is similar to proteins of the BCL2 family. In the present study, we discovered that the mouse Bfk transcript is expressed at the highest level in the epididymis. Two transcripts of 0.9 and 2.6 kb in size were identified, with alterna...

journal_title：Endocrinology

authors： Pujianto DA,Damdimopoulos AE,Sipilä P,Jalkanen J,Huhtaniemi I,Poutanen M

更新日期：2007-07-01 00:00:00

abstract：:Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...

journal_title：Endocrinology

authors： Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

更新日期：1997-11-01 00:00:00

abstract：:In the present study we have examined the effects of FSH, forskolin, and (Bu)2cAMP on messenger RNA (mRNA) levels for all known subunits of cAMP-dependent protein kinase in rat Sertoli cells, using newly developed complementary DNA (cDNA) probes. mRNAs for the three regulatory subunits [RI alpha, RII51, (RII beta), an...

journal_title：Endocrinology

authors： Oyen O,Sandberg M,Eskild W,Levy FO,Knutsen G,Beebe S,Hansson V,Jahnsen T

更新日期：1988-06-01 00:00:00

abstract：:A basic somatomedin preparation results in a 2-fold stimulation of incorporation of both [3H]leucine into protein and 35SO4 into glycosaminoglycans by cultured chick sternal chondrocytes. The stimulation is seen in the presence of 20 mM 4-methylumbelliferyl-beta-D-xyloside alone but is not observable in the presence o...

journal_title：Endocrinology

authors： Kemp SF,Hintz RL

更新日期：1980-03-01 00:00:00

abstract：:Atrial Natriuretic Factor (ANF) has been demonstrated within the central nervous system (CNS), where it has been implicated in the regulation of blood pressure, fluid and electrolyte balance. To explore the effect of acute plasma vol expansion on the activation of CNS ANF, changes in ANF levels of CSF drawn from the c...

journal_title：Endocrinology

authors： Cameron VA,Espiner EA

更新日期：1990-11-01 00:00:00

abstract：:Aprotinin caused a dose-dependent inhibition of [125I]hCG binding to its receptor in plasma membranes prepared from luteinized rat ovaries. Displacement of [125I]hCG from its receptor by aprotinin was temperature dependent, with an ID50 of 300 microM at 4 C and an ID50 of 3700 microM at 22 C. Equilibrium binding data ...

journal_title：Endocrinology

authors： Wilks JW,Hui OJ

更新日期：1987-03-01 00:00:00

abstract：:Using a 0-32% continuous metrizamide density gradient, interstitial cells could be separated into five distinct bands. Cells localized in bands 1 (B1), 2 (B2), and 3 (B3) were isolated and incubated for 1h with or without human chorionic gonadotropin (hCG). Both B2 and B3 cells responded to hCG with increased cyclic A...

journal_title：Endocrinology

authors： Lin T,Lincoln TM,Brown N,Murono EP,Osterman J,Nankin HR

更新日期：1982-10-01 00:00:00

abstract：:Cysteamine [2-aminoethanethiol (CySH)] reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily assayable, releasable PRL. This would represent a previously unrecognized mechanism for secretory re...

journal_title：Endocrinology

authors： Lorenson MY,Jacobs LS

更新日期：1984-10-01 00:00:00

abstract：:We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pu...

journal_title：Endocrinology

authors： Mukhina S,Liu D,Guo K,Raccurt M,Borges-Bendris S,Mertani HC,Lobie PE

更新日期：2006-04-01 00:00:00

abstract：:Up-regulation of maternal islet function is essential to accommodate the increased demand for insulin during pregnancy. Previously, we suggested that lactogenic activity regulates islet function during pregnancy. However, this hypothesis was based on the effect of homologous PRLs on islets, since the homologous placen...

journal_title：Endocrinology

authors： Brelje TC,Scharp DW,Lacy PE,Ogren L,Talamantes F,Robertson M,Friesen HG,Sorenson RL

更新日期：1993-02-01 00:00:00

abstract：:Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We report that GIP receptor messenger RNA and protein are present in nor...

journal_title：Endocrinology

authors： Bollag RJ,Zhong Q,Phillips P,Min L,Zhong L,Cameron R,Mulloy AL,Rasmussen H,Qin F,Ding KH,Isales CM

更新日期：2000-03-01 00:00:00

abstract：:Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...

journal_title：Endocrinology

authors： Ramaswamy S,Dwarki K,Ali B,Gibbs RB,Plant TM

更新日期：2013-05-01 00:00:00

abstract：:We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily. They form heterodimer with a retinoid X receptor, recruit transcriptional cofactor...

journal_title：Endocrinology

authors： Lim HJ,Moon I,Han K

更新日期：2004-06-01 00:00:00

abstract：:The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...

journal_title：Endocrinology

authors： Pescovitz OH,Berry SA,Laudon M,Ben-Jonathan N,Martin-Myers A,Hsu SM,Lambros TJ,Felix AM

更新日期：1990-11-01 00:00:00

abstract：:TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...

journal_title：Endocrinology

authors： Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:Glucocorticoid hormones are involved in functional differentiation of GH-producing somatotrophs. Glucocorticoid treatment prematurely induces GH expression in mammals and birds in a process requiring protein synthesis and Rat sarcoma (Ras) signaling. The objective of this study was to investigate mechanisms through wh...

journal_title：Endocrinology

authors： Ellestad LE,Puckett SA,Porter TE

更新日期：2015-03-01 00:00:00

abstract：:Insulinopenic diabetes mellitus in the rat is associated with reduced circulating levels of insulin-like growth factor-I (IGF-I), resulting primarily from decreased IGF-I synthesis in liver and extrahepatic sites. Plasma GH levels in these animals are also suppressed, with loss of episodic secretion and decreased pitu...

journal_title：Endocrinology

authors： Olchovsky D,Bruno JF,Gelato MC,Song J,Berelowitz M

更新日期：1991-02-01 00:00:00

abstract：:The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

journal_title：Endocrinology

authors： Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

更新日期：2020-03-01 00:00:00

abstract：:Graves' hyperthyroidism is an organ-specific autoimmune disease mediated by stimulatory autoantibodies against the TSH receptor (TSHR; thyroid-stimulating antibodies), causing thyroid hyperplasia and hyperthyroidism. Development of this ailment is well known to be under polygenic and environmental control. For example...

journal_title：Endocrinology

authors： Nagayama Y,McLachlan SM,Rapoport B,Oishi K

更新日期：2004-11-01 00:00:00