Abstract:
:We have examined the expression, postnatal ontogeny, and localization of mouse GH (mGH) and its relative expression during pregnancy, lactation, and weaning in the mouse. mGH mRNA and protein was expressed predominantly in the epithelial component of the mammary gland, and maximal expression was observed during the pubertal period. Autocrine mGH expression dramatically decreased during late pregnancy and lactation. Concordantly, autocrine mGH expression is repressed during forced differentiation of mouse HC11 mammary epithelial cells in culture. Forced expression of mGH in HC11 cells abrogated lactogenic differentiation as indicated by reduced expression of beta-casein and reduced expression and loss of lateral epithelial localization of E-cadherin. Forced expression of mGH in mouse mammary epithelial cells increased cell survival and proliferation and consequently increased the size of mammary acinar-like structures formed in three-dimensional Matrigel. Thus, autocrine mGH expression in the mouse mammary epithelial cell is maximal at puberty and prevents mammary epithelial cell differentiation. Autocrine GH will therefore participate in mammary morphogenic processes at puberty.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Mukhina S,Liu D,Guo K,Raccurt M,Borges-Bendris S,Mertani HC,Lobie PEdoi
10.1210/en.2005-1082subject
Has Abstractpub_date
2006-04-01 00:00:00pages
1819-29issue
4eissn
0013-7227issn
1945-7170pii
en.2005-1082journal_volume
147pub_type
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