Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization.

abstract：:Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Usi...

journal_title：Endocrinology

authors： Prescott JL,Tindall DJ

更新日期：1998-04-01 00:00:00

abstract：:Native PRL and des-amido forms 1, 2, and 3 were tested for their individual immunochemical and receptor-binding abilities. The results show that deamidation of either secreted mouse PRL or stored ovine PRL alters their binding in a radioreceptor assay. For each accumulated deamidation there was a statistically signifi...

journal_title：Endocrinology

authors： Haro LS,Talamantes FJ

更新日期：1985-01-01 00:00:00

abstract：:Morphological plasticity in response to estradiol is a hallmark of astrocytes in the arcuate nucleus. The functional consequences of these morphological changes have remained relatively unexplored. Here we report that in the arcuate nucleus estradiol significantly increased the protein levels of the two enzymes in the...

journal_title：Endocrinology

authors： Blutstein T,Baab PJ,Zielke HR,Mong JA

更新日期：2009-07-01 00:00:00

abstract：:A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...

journal_title：Endocrinology

authors： Mroczkowski B,Reich M

更新日期：1993-01-01 00:00:00

abstract：:Primary astroglial cells produce insulin-like growth factor (IGF)-binding proteins (IGFBPs), which modulate the biological activity of IGFs on the developing astroglia. Alterations in the synthesis of astroglial IGFBPs by hormones and growth factors may, therefore, influence the paracrine regulatory actions of IGFs. T...

journal_title：Endocrinology

authors： Bradshaw SL,Han VK

更新日期：1993-10-01 00:00:00

abstract：:Regulation of the number of pituitary vasopressin (VP) receptors plays an important role in controlling pituitary responsiveness during alterations of the hypothalamic pituitary adrenal axis. The mechanisms regulating these VP receptors were studied by analysis of the effects of adrenalectomy and glucocorticoid admini...

journal_title：Endocrinology

authors： Rabadan-Diehl C,Makara G,Kiss A,Lolait S,Zelena D,Ochedalski T,Aguilera G

更新日期：1997-12-01 00:00:00

abstract：:The activity of hepatic NADPH cytochrome c reductase, an enzyme important in drug and steroid metabolism, increases rapidly during the perinatal period in rats. However, the regulation of this increase is not well understood. To investigate the role of hormones in the development of NADPH cytochrome c reductase activi...

journal_title：Endocrinology

authors： Kriz BM,Gates JA,Read FE,Fong BB

更新日期：1982-06-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:This study was performed to test the hypothesis that reflex increases in heart rate, PRA, and plasma concentrations of vasopressin, angiotensin-II, ACTH, and cortisol are reduced during pregnancy. The hypothesis was tested by measuring, in pregnant and nonpregnant conscious dogs, changes in arterial and atrial pressur...

journal_title：Endocrinology

authors： Brooks VL,Keil LC

更新日期：1994-11-01 00:00:00

abstract：:A thyroid transcription factor-1 (TTF-1)-binding element in the rat TSH receptor (TSHR) promoter, between -189 and -175 basepairs (bp), is important for both thyroid-specific expression and thyroid-specific TSH/cAMP autoregulation of the TSHR. The identification of an up-stream TTF-1-binding site and its relationship ...

journal_title：Endocrinology

authors： Ohmori M,Shimura H,Shimura Y,Ikuyama S,Kohn LD

更新日期：1995-01-01 00:00:00

abstract：:It has previously been established that neuropeptide-Y (NPY) is a potent inhibitor of alpha MSH release from the pars intermedia of the amphibian Xenopus laevis. The location of binding sites for NPY in the pars intermedia of the pituitary has now been studied with light microscopic autoradiography, using a dispersed ...

journal_title：Endocrinology

authors： De Rijk EP,Cruijsen PM,Jenks BG,Roubos EW

更新日期：1991-02-01 00:00:00

abstract：:Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter expressed in many cell types, including neurons. Mutations that inactivate transport activity of MCT8 cause severe X-linked psychomotor retardation in male patients, a syndrome originally described as the Allan-Herndon-Dudley syndrome....

journal_title：Endocrinology

authors： Braun D,Schweizer U

更新日期：2015-12-01 00:00:00

abstract：:Experiments were conducted to investigate the actions of glucocorticoids and insulin on the induction of a specific mRNA (p33-mRNA) expressed in rat H4 hepatoma cells. Previous studies have found a 10-fold increase in this mRNA following 60 min of insulin addition. In the present study, dexamethasone (Dex) induced the...

journal_title：Endocrinology

authors： Messina JL

更新日期：1989-02-01 00:00:00

abstract：:Fibroblasts represent one of the in vivo sites of extrahepatic insulin-like growth factor I (IGF-I) production. In this study, cultured fibroblasts prepared from the skin of neonatal rats were used as a model to assess the role of serum in regulating IGF-I messenger RNA (mRNA) levels. IGF-I mRNA, as demonstrated by No...

journal_title：Endocrinology

authors： Lowe WL Jr,Kummer M,Karpen CW,Wu XD

更新日期：1990-12-01 00:00:00

abstract：:Reduced cellular immune responses and altered cytokine production by cells from mice exposed to thermal injury are minimized if dehydroepiandrosterone (DHEA) is administered after experimental burn injury in mice. An analysis of similar tests of immune function developed by mice given the antiglucocorticoid, 17 beta-h...

journal_title：Endocrinology

authors： Araneo B,Daynes R

更新日期：1995-02-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:Certain metabolic properties of hormonally responsive osteogenic sarcoma cells derived from a transplantable rat tumor have been compared with those of related normal rat bone cells. All studies were carried out on cells grown in monolayer culture. Normal rat bone cells derived by repeated collagenase/trypsin digestio...

journal_title：Endocrinology

authors： Partridge NC,Alcorn D,Michelangeli VP,Kemp BE,Ryan GB,Martin TJ

更新日期：1981-01-01 00:00:00

abstract：:We have cloned a type of cDNA for a functional glandular kallikrein, designated as mouse Klk21 (mKlk21), from the adult mouse testis cDNA library. mKlk21 was expressed in the kidney, submaxillary glands, and testis of the mouse. In the testis, mKlk21 mRNA was detectable at 4 wk of postnatal development and became more...

journal_title：Endocrinology

authors： Matsui H,Takahashi T

更新日期：2001-11-01 00:00:00

abstract：:Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with ...

journal_title：Endocrinology

authors： Turgeon MO,Silander TL,Doycheva D,Liao XH,Rigden M,Ongaro L,Zhou X,Joustra SD,Wit JM,Wade MG,Heuer H,Refetoff S,Bernard DJ

更新日期：2017-04-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...

journal_title：Endocrinology

authors： den Boon FS,de Vries T,Baelde M,Joëls M,Karst H

更新日期：2019-04-01 00:00:00

abstract：:Three different experimental approaches were used to assess the regions on the beta-subunit of human FSH (hFSH beta) that may be altered or masked by its association with the alpha-subunit of hFSH (hFSH alpha) in the heterodimeric hFSH molecule. In a direct approach, we tested whether synthetic peptides corresponding ...

journal_title：Endocrinology

authors： Vakharia DD,Dias JA,Andersen TT

更新日期：1991-04-01 00:00:00

abstract：:Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...

journal_title：Endocrinology

authors： Hong MH,Sun H,Jin CH,Chapman M,Hu J,Chang W,Burnett K,Rosen J,Negro-Vilar A,Miner JN

更新日期：2008-03-01 00:00:00

abstract：:Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As in mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction...

journal_title：Endocrinology

authors： Lu H,Zhao C,Zhu B,Zhang Z,Ge W

更新日期：2020-12-01 00:00:00

abstract：:The possibility that chronic, multigenerational exposure to environmental estrogens selects for adaptive hormone-response phenotypes is a critical unanswered question. Embryos/larvae of killifish from an estrogenic-polluted environment (New Bedford Harbor, MA [NBH]) compared with those from a reference site overexpres...

journal_title：Endocrinology

authors： Cotter KA,Nacci D,Champlin D,Yeo AT,Gilmore TD,Callard GV

更新日期：2016-06-01 00:00:00

abstract：:A 28,000 mol wt vitamin D-dependent calcium-binding protein (CaBP), first isolated from avian intestine, has recently been shown to exist in kidney and other tissues. To study the mechanism regulating the production of renal CaBP, we used primary cultures of chick kidney cells as an in vitro model. Renal cortical tubu...

journal_title：Endocrinology

authors： Craviso GL,Garrett KP,Clemens TL

更新日期：1987-03-01 00:00:00

abstract：:Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...

journal_title：Endocrinology

authors： Glass AR,Vigersky RA,Rajatanavin R,Pardridge W,Smallridge RC,Wartofsky L,Burman KD

更新日期：1984-05-01 00:00:00

abstract：:Our previous work suggests that persistent protein malnutrition in immature domestic fowl (Gallus gallus domesticus) alters ACTH-adrenocortical cell interaction, possibly including ACTH receptors. To investigate this possibility, we measured some ACTH receptor parameters in isolated adrenocortical cells from normal an...

journal_title：Endocrinology

authors： Carsia RV,Weber H

更新日期：1988-02-01 00:00:00

abstract：:Recent in vitro and in vivo evidence shows that secretion of parathyroid hormone (PTH) and calcitonin (CT) is stimulated by beta-adrenergic agonists and inhibited by beta-adrenergic antagonists. To assess the possible roles of adrenal medullary or adrenergic nerve terminal catecholamines in calcium homeostasis, we hav...

journal_title：Endocrinology

authors： Heath H 3rd

更新日期：1980-10-01 00:00:00

abstract：:Explants from nonmenstrual endometria cultured in the absence of ovarian hormones undergo tissue breakdown. Addition of estradiol and progesterone (EP) prevents proteolysis. Explants include stromal and epithelial compartments which play different but complementary roles in endometrial physiology, including tissue rem...

journal_title：Endocrinology

authors： Gaide Chevronnay HP,Lemoine P,Courtoy PJ,Marbaix E,Henriet P

更新日期：2010-09-01 00:00:00

abstract：:Estrogens have been shown to have positive and negative effects on anxiety and depressive-like behaviors, perhaps explained by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. The ERbeta agonist, diarylpropionitrile (DPN) has been shown to have anxiolytic properties in rats. DPN exists...

journal_title：Endocrinology

authors： Weiser MJ,Wu TJ,Handa RJ

更新日期：2009-04-01 00:00:00