Kit-ligand/stem cell factor induces primordial follicle development and initiates folliculogenesis.

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic neuropeptide synthesized in the hypothalamus. A Leu34Phe missense mutation in proCART has been found in an obese family in humans. Here we show that humans bearing the Leu34Phe mutation in proCART have severely diminished levels of bioactive CART,...

journal_title：Endocrinology

authors： Yanik T,Dominguez G,Kuhar MJ,Del Giudice EM,Loh YP

更新日期：2006-01-01 00:00:00

abstract：:Analysis of GH gene structure in the mouse permits evolutionary comparisons with GH gene structure in the rat and provides information about the mechanism responsible for heritable deficiencies of anterior pituitary hormones. The little mutation in mice is analogous to autosomal recessive, isolated, partial deficiency...

journal_title：Endocrinology

authors： Parks JS,Herd JE,Wurzel JM,Martial JA

更新日期：1982-05-01 00:00:00

abstract：:This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal blood. Using alert, normally behaving, ovariectomized ewes, we sampled hypophyseal portal blood at 10-min intervals beginni...

journal_title：Endocrinology

authors： Battaglia DF,Bowen JM,Krasa HB,Thrun LA,Viguié C,Karsch FJ

更新日期：1997-10-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...

journal_title：Endocrinology

authors： Cheung AT,Ree D,Kolls JK,Fuselier J,Coy DH,Bryer-Ash M

更新日期：1998-12-01 00:00:00

abstract：:Glucocorticoid feedback inhibition at the level of the brain is extremely complex, involving feedback at both hypothalamic and suprahypothalamic levels. The hippocampus has been implicated as a suprahypothalamic mediator of such feedback, based on numerous lesion, stimulation, and steroid implantation studies. These r...

journal_title：Endocrinology

authors： Sapolsky RM,Armanini MP,Sutton SW,Plotsky PM

更新日期：1989-12-01 00:00:00

abstract：:A competitive protein-binding (CPB) assay, suitable for measuring corticosterone levels in 20 mul of mouse plasma or 100 mg of brain, is described. The postnatal development of adrenocortical function was determined in C57BL/10 and DBA/1 mice by CPB assay of basal and stressinduced levels of plasma corticosterone and ...

journal_title：Endocrinology

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1976-06-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:Exposure of adipocytes to glucocorticoid hormones in vitro causes inhibition of glucose transport and metabolsim. Maximal inhibition of glucose oxidations is reduced from 42-50 to 22-25 to 5-8% in young, mature, and senescent rat adipocytes, respectively. Percent values also reflect absolute reductions since basal lev...

journal_title：Endocrinology

authors： Roth GS,Livingston JN

更新日期：1976-09-01 00:00:00

abstract：:The purpose of this study is to establish a primary LHRH cell culture system using embryonic olfactory placode and to examine whether LHRH cells derived from olfactory placode and the migratory pathway of LHRH neurons mature in vitro. Six monkey fetuses at the ages of E34-E36 were delivered surgically and the area inc...

journal_title：Endocrinology

authors： Terasawa E,Quanbeck CD,Schulz CA,Burich AJ,Luchansky LL,Claude P

更新日期：1993-11-01 00:00:00

abstract：:In this study the hypothesis that the LHRH neurosecretory system of the prepubertal female monkey has the capacity to function in a manner comparable to that of monkeys in more mature stages of development was tested. Using push-pull perfusion in the stalk-median eminence, effects of electrical stimulation of the medi...

journal_title：Endocrinology

authors： Claypool LE,Watanabe G,Terasawa E

更新日期：1990-12-01 00:00:00

abstract：:The cell of origin of human null cell pituitary adenomas is disputed. Although these tumors, by definition, do not produce any of the anterior pituitary hormones in vivo, they have been shown to express gonadotropin subunit genes, release gonadotropin hormones in vitro, and express the gonadotroph-associated transcrip...

journal_title：Endocrinology

authors： Kumar TR,Graham KE,Asa SL,Low MJ

更新日期：1998-07-01 00:00:00

abstract：:Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...

journal_title：Endocrinology

authors： Felton RG,Steiner CC,Durrant BS,Keisler DH,Milnes MR,Tubbs CW

更新日期：2015-12-01 00:00:00

abstract：:To assess the possible source of progesterone in the fetal fluids of pregnant sheep, we measured the changes in progesterone concentrations in amniotic fluid (AF) and allantoic fluid (ALF) during pregnancy and compared these values with those in the maternal and fetal circulations. In acute experiments, the concentrat...

journal_title：Endocrinology

authors： Power SG,Patrick JE,Carson GD,Challis JR

更新日期：1982-02-01 00:00:00

abstract：:The possibility of direct pituitary effects of sex steroids on gonadotropin gene expression and synthesis was studied in male rats. The animals were treated with a potent GnRH antagonist, Ac-D-pClPhe-D-pClPhe-D-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-D-Ala-+ ++NH2CH3COOH (Org 30276; 0.5 mg/kg BW, sc, twice daily) for 10 days. G...

journal_title：Endocrinology

authors： Perheentupa A,Huhtaniemi I

更新日期：1990-06-01 00:00:00

abstract：:IGF-II has been reported to decrease neonatal islet cell apoptosis and in vitro adult islet cell necrosis and apoptosis, but the usefulness of IGF-II in a transplantation setting is unknown. We evaluated the effect of in vitro IGF-II incubations on microencapsulated rat islet survival both in vitro and in minimal mass...

journal_title：Endocrinology

authors： Robitaille R,Dusseault J,Henley N,Rosenberg L,Hallé JP

更新日期：2003-07-01 00:00:00

abstract：:Artificial copulomimetic cervical stimulation (CS) induces an immediate release of oxytocin (OT) and prolactin (PRL) followed by a daily PRL rhythm characterized by nocturnal and diurnal surges. Although we have shown that the initial release of PRL is induced by the immediate release of OT, we tested whether the PRL ...

journal_title：Endocrinology

authors： Helena CV,McKee DT,Bertram R,Walker AM,Freeman ME

更新日期：2009-07-01 00:00:00

abstract：:Using a rat model of chronic central leptin infusion in which neuropeptide Y neurons develop leptin resistance, we examined whether leptin signal transduction mechanism in the hypothalamus is altered during central leptin infusion. Adult male rats were infused chronically into the lateral cerebroventricle with leptin ...

journal_title：Endocrinology

authors： Pal R,Sahu A

更新日期：2003-09-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis adapts to periods of chronic or repeated stress. We have now investigated whether there is any differential effect of repeated immobilization stress on CRH and arginine vasopressin (AVP) gene transcription in the hypothalamic paraventricular nucleus (PVN), using probes for both ...

journal_title：Endocrinology

authors： Ma XM,Levy A,Lightman SL

更新日期：1997-10-01 00:00:00

abstract：:In vivo and in vitro evidence indicates that FSH is a primary regulator of testicular inhibin production. However, recent reports suggest that LH may also promote inhibin secretion in vivo. To investigate whether LH regulates inhibin subunit messenger RNA (mRNA) expression as well, we examined the effects of hypophyse...

journal_title：Endocrinology

authors： Krummen LA,Morelos BS,Bhasin S

更新日期：1990-09-01 00:00:00

abstract：:The Jar choriocarcinoma cell line was used as an in vitro placental cell model to determine the effects of polypeptide growth factors on hCG beta secretion. Epidermal and fibroblast growth factor (FGF) treatment of serum-free cultures stimulated hCG beta secretion 2.5- and 4.0-fold over basal serum-free control levels...

journal_title：Endocrinology

authors： Oberbauer AM,Linkhart TA,Mohan S,Longo LD

更新日期：1988-12-01 00:00:00

abstract：:This study was aimed at testing the hypothesis that different forms of fibronectin (FN), produced as a consequence of the alternative splicing of the precursor messenger RNA, play specific roles during development of the ovarian follicle. In particular, we were interested in determining the effect of the ED-I (also te...

journal_title：Endocrinology

authors： Colman-Lerner A,Fischman ML,Lanuza GM,Bissell DM,Kornblihtt AR,Barañao JL

更新日期：1999-06-01 00:00:00

abstract：:Maintenance of male golden hamsters on short photoperiod leads to testicular regression due to pineal gland-mediated inhibition of the hypothalamo-hypophyseal reproductive system. This study clarifies the dynamics of the action of GnRH at the pituitary level after short photoperiod-induced gonadal regression. In Exp 1...

journal_title：Endocrinology

authors： Pieper DR

更新日期：1984-11-01 00:00:00

abstract：:The effects of FFA on circulating LH and GH concentrations in ovariectomized ewe lambs were investigated. Lambs (n = 14) were weaned at 2.5 months, ovariectomized at 6.5 months, and used at 8.5 months of age. From weaning until day 0 of the experiment, lambs were fed to maintain body weights (23 kg). On day 0, serum F...

journal_title：Endocrinology

authors： Estienne MJ,Schillo KK,Hileman SM,Green MA,Hayes SH,Boling JA

更新日期：1990-04-01 00:00:00

abstract：:Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids) and some unique brain-specific steroids. Neurosteroids are thought to mediate their action through ion gated channel receptors such as gamma-aminobutyric acid(A) and N-methyl-D-aspartate rathe...

journal_title：Endocrinology

authors： Compagnone NA,Bulfone A,Rubenstein JL,Mellon SH

更新日期：1995-11-01 00:00:00

abstract：:Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address this issue we compared plasma calcitriol levels and renal 25-h...

journal_title：Endocrinology

authors： Almond JR,Bales CW,Lobaugh B,Klotman PE,Drezner MK

更新日期：1989-05-01 00:00:00

abstract：:FSH promotes the differentiation of ovarian follicular granulosa cells via a cAMP-dependent mechanism. Based upon the presence of a prominent phospholipid/diolein/Ca2+-independent myelin basic protein kinase activity in soluble extracts of proliferating immature rat granulosa cells, we determine whether this activity ...

journal_title：Endocrinology

authors： Das S,Maizels ET,DeManno D,St Clair E,Adam SA,Hunzicker-Dunn M

更新日期：1996-03-01 00:00:00

abstract：:We have recently demonstrated that 17beta-estradiol (E2) opposes cytokine-dependent increase of inducible nitric oxide synthase (iNOS) activity in rat smooth muscle cells and proposed that this effect might be associated to an antiinflammatory activity of this hormone. In the present study, we examine the E2 effects o...

journal_title：Endocrinology

authors： Cuzzocrea S,Santagati S,Sautebin L,Mazzon E,Calabrò G,Serraino I,Caputi AP,Maggi A

更新日期：2000-04-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:Phorbol ester receptors in GH4C1 rat pituitary cells have been studied using [3H]phorbol 12,13-dibutyrate (PDBu). Binding to intact cells was of higher affinity at 37 C than at 4 C (Kd, approximately 8 or approximately 34 nM, respectively). The dissociation rate (measured at 4 C) of PDBu from cells equilibrated at 37 ...

journal_title：Endocrinology

authors： Jaken S

更新日期：1985-12-01 00:00:00

abstract：:Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subsequent effects on systemic thyroid hormone levels have not been reported ...

journal_title：Endocrinology

authors： Ferrara SJ,Bourdette D,Scanlan TS

更新日期：2018-07-01 00:00:00