Abstract:
:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Blackard WG,Guzelian PS,Small MEdoi
10.1210/endo-103-2-548subject
Has Abstractpub_date
1978-08-01 00:00:00pages
548-53issue
2eissn
0013-7227issn
1945-7170journal_volume
103pub_type
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