Abstract:
:The issue of what starts the circadian clock ticking was addressed by studying the developmental appearance of the daily rhythm in the expression of two genes in the zebrafish pineal gland that are part of the circadian clock system. One encodes the photopigment exorhodopsin and the other the melatonin synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT2). Significant daily rhythms in AANAT2 mRNA abundance were detectable for several days after fertilization in animals maintained in a normal or reversed lighting cycle providing 12 h of light and 12 h of dark. In contrast, these rhythms do not develop if animals are maintained in constant lighting or constant darkness from fertilization. In contrast to exorhodopsin, rhythmicity of AANAT2 can be initiated by a pulse of light against a background of constant darkness, by a pulse of darkness against a background of constant lighting, or by single light-to-dark or dark-to-light transitions. Accordingly, these studies indicate that circadian clock function in the zebrafish pineal gland can be initiated by minimal photic cues, and that single photic transitions can be used as an experimental tool to dissect the mechanism that starts the circadian clock in the pineal gland.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Vuilleumier R,Besseau L,Boeuf G,Piparelli A,Gothilf Y,Gehring WG,Klein DC,Falcón Jdoi
10.1210/en.2005-1565subject
Has Abstractpub_date
2006-05-01 00:00:00pages
2273-9issue
5eissn
0013-7227issn
1945-7170pii
en.2005-1565journal_volume
147pub_type
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