Glycosylation of thyroglobulin--its role in secretion, iodination, and stability.

abstract：:Recent observations suggest a role for interleukin-1 (IL-1), a polypeptide product of macrophage/monocytic cells, in the immune-mediated destruction of pancreatic islet beta-cells observed in type 1 diabetes. In this study, we investigated the effects of IL-1 on both alpha- and beta-cell secretory functions in rat isl...

journal_title：Endocrinology

authors： Rabinovitch A,Pukel C,Baquerizo H

更新日期：1988-06-01 00:00:00

abstract：:NG108-15 cells, which have a rounding-up morphology when cultured in serum-supplemented medium, extend neurites when stimulated for 3 d with angiotensin II (Ang II). The aim of the present study was to investigate whether growth factor receptors are necessary for mediating the effects of Ang II. A 3-d treatment with A...

journal_title：Endocrinology

authors： Plouffe B,Guimond MO,Beaudry H,Gallo-Payet N

更新日期：2006-10-01 00:00:00

abstract：:Pineal denervation by superior cervical ganglionectomy (Gx) decreased high affinity binding of estradiol (E2) to the pineal cytosol of female rats and of testosterone to the cytosol of male rats by 40 and 26% and by 75 and 80%, 5 and 14 days after sugery; hormone binding remained unchanged up to 24 h after surgery. Bi...

journal_title：Endocrinology

authors： Cardinali DP,Gómez E,Rosner JM

更新日期：1976-04-01 00:00:00

abstract：:Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We ...

journal_title：Endocrinology

authors： Sun X,Cappelletti M,Li Y,Karp CL,Divanovic S,Dey SK

更新日期：2014-10-01 00:00:00

abstract：:Incubation of bovine corpus luteum slices at 37 C with luteinizing hormone showed that 10.0 microng LH/ml caused a maximum rise in tissue cyclic AMP content within 15 min. Slices incubated with 1.0 or 0.1 microng LH/ml showed a much more gradual accumulation of this nucleotide. In the absence of added LH, a marked dec...

journal_title：Endocrinology

authors： Ling WY,Marsh JM

更新日期：1977-06-01 00:00:00

abstract：:The effects of estrogen on the synthesis of pituitary PRL mRNA and PRL and the release of PRL into plasma were investigated in male and female normal and hypogonadal (hpg) mice. Because the hpg mouse is totally deficient in hypothalamic GnRH, it provides an excellent model for investigating the effects of estrogen and...

journal_title：Endocrinology

authors： Stanley HF,Curtis A,Sheward WJ,Roberts JL,Fink G

更新日期：1986-12-01 00:00:00

abstract：:GHRH stimulates GH secretion in chickens as in mammals. However, nothing is known about the chicken GHRH receptor (GHRH-R). Here we report the cDNA sequence of chicken GHRH-R. Comparison of the cDNA sequence with the chicken genome localized the GHRH-R gene to chicken chromosome 2 and indicated that the chicken GHRH-R...

journal_title：Endocrinology

authors： Porter TE,Ellestad LE,Fay A,Stewart JL,Bossis I

更新日期：2006-05-01 00:00:00

abstract：:Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis because a loss-of-function mutation in the SOST gene results in sclerosteosis featured with massive bone growth in humans. To understand the function of SOST in developmental skeletal tissue formation, we examined SOST ...

journal_title：Endocrinology

authors： Ohyama Y,Nifuji A,Maeda Y,Amagasa T,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Explants from nonmenstrual endometria cultured in the absence of ovarian hormones undergo tissue breakdown. Addition of estradiol and progesterone (EP) prevents proteolysis. Explants include stromal and epithelial compartments which play different but complementary roles in endometrial physiology, including tissue rem...

journal_title：Endocrinology

authors： Gaide Chevronnay HP,Lemoine P,Courtoy PJ,Marbaix E,Henriet P

更新日期：2010-09-01 00:00:00

abstract：:Adult Leydig cells are derived from proliferating stem/progenitor Leydig cells in the infant testis and subsequent differentiation to steroidogenic cells in adult mice. Leydig cell proliferation in the infant testis occurs primarily in response to increased levels of LH that induce Leydig cell expression of neuregulin...

journal_title：Endocrinology

authors： Umehara T,Kawashima I,Kawai T,Hoshino Y,Morohashi KI,Shima Y,Zeng W,Richards JS,Shimada M

更新日期：2016-12-01 00:00:00

abstract：:In teleosts, the pituitary contains a single glycoprotein gonadotropic hormone (GTH) composed of two dissimilar alpha- and beta-subunits. The European eel, Anguilla anguilla L, is sexually immature at the silver stage due to a deficiency in GTH synthesis and secretion. In previous studies we (S.D., YA.F.) have demonst...

journal_title：Endocrinology

authors： Counis R,Dufour S,Ribot G,Quérat B,Fontaine YA,Jutisz M

更新日期：1987-09-01 00:00:00

abstract：:We previously have described molecular mechanisms converging at the Nur response element-signal transducer and activator of transcription (STAT) composite site responsible for synergistic activation of the proopiomelanocortin (POMC) gene promoter by leukemia inhibitory factor (LIF) and CRH. In this study, we asked how...

journal_title：Endocrinology

authors： Latchoumanin O,Mynard V,Devin-Leclerc J,Dugué MA,Bertagna X,Catelli MG

更新日期：2007-01-01 00:00:00

abstract：:The rapid and temporary suppression of reproductive behavior is often assumed to be an important feature of the adaptive acute stress response. However, how this suppression operates at the mechanistic level is poorly understood. The enzyme aromatase converts testosterone to estradiol in the brain to activate reproduc...

journal_title：Endocrinology

authors： Dickens MJ,Cornil CA,Balthazart J

更新日期：2011-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose etiology is presently unknown. Probably the most consistent and widespread deficit seen in this syndrome is that of the basal forebrain cholinergic system. We have previously demonstrated that estradiol (E2) modulates the function of these neur...

journal_title：Endocrinology

authors： Singh M,Meyer EM,Simpkins JW

更新日期：1995-05-01 00:00:00

abstract：:The endocrine-disrupting chemical bisphenol A (BPA) increases adipose tissue mass in vivo and promotes adipogenesis in vitro; however, mechanisms explaining BPA's obesogenic effect remain unknown. We investigated the effects of gestational BPA and its analog, bisphenol S (BPS), exposure on the adipogenic differentiati...

journal_title：Endocrinology

authors： Pu Y,Gingrich JD,Steibel JP,Veiga-Lopez A

更新日期：2017-11-01 00:00:00

abstract：:To investigate the respective role in PRL secretion of gamma-aminobutyric acid (GABA), either derived from the central nervous system or circulating in plasma, experiments were performed using ethanolamine-O-sulfate (EOS), a specific inhibitor of GABA catabolism. Intracerebroventricular injection of EOS (2 mg/kg) indu...

journal_title：Endocrinology

authors： Apud JA,Racagni G,Iuliano E,Cocchi D,Casanueva F,Müller EE

更新日期：1981-04-01 00:00:00

abstract：:PTH, via the PTH/PTH-related protein receptor type 1 that couples to both protein kinase A (PKA) and protein kinase C (PKC) pathways, and the canonical Wnt-beta-catenin signaling pathway play important roles in bone formation. In the present study we have examined the interaction between the PTH and Wnt signaling path...

journal_title：Endocrinology

authors： Tobimatsu T,Kaji H,Sowa H,Naito J,Canaff L,Hendy GN,Sugimoto T,Chihara K

更新日期：2006-05-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:We have recently demonstrated that GnRH-stimulated gonadotropin secretion is augmented by coadministration with neuropeptide-Y (NPY) in anterior pituitaries removed in the afternoon from proestrous, but not metestrous, rats. To test the hypothesis that these effects of NPY are due to an interaction with progesterone (...

journal_title：Endocrinology

authors： Knox KL,Bauer-Dantoin AC,Levine JE,Schwartz NB

更新日期：1995-01-01 00:00:00

abstract：:The temporal aspects of gonadotropin release were studied in infantile (14-day-old) female rats. Blood samples were collected using vena cava cannulae at 10-, 15-, 20-, or 30-min intervals and assayed for either LH alone or for both LH and FSH. Within individual animals, blood LH levels exhibited a degree of variabili...

journal_title：Endocrinology

authors： Frawley LS,Henricks DM

更新日期：1979-11-01 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...

journal_title：Endocrinology

authors： Gachkar S,Oelkrug R,Martinez-Sanchez N,Rial-Pensado E,Warner A,Hoefig CS,López M,Mittag J

更新日期：2017-06-01 00:00:00

abstract：:Progesterone modulates estrogen-stimulated responses in the uterus. Calbindin-D 9k (CaBP9k), a 17 beta-estradiol-responsive gene expressed in the uterus, was used as a marker to examine the interactions between endogenous progesterone and estradiol in the rat. The variations in uterine CaBP9k messenger RNAs (mRNAs) du...

journal_title：Endocrinology

authors： L'Horset F,Blin C,Brehier A,Thomasset M,Perret C

更新日期：1993-02-01 00:00:00

abstract：:The hypothesis that hydrogen peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). Luteal regression was induced during midpseudopregnancy by injection of 500 micrograms prostaglandin F2 alpha (P...

journal_title：Endocrinology

authors： Riley JC,Behrman HR

更新日期：1991-04-01 00:00:00

abstract：:Isolated granulosa cells and theca from proestrous hamsters alone and in recombination, were cultured in order to study steroidogenic capacity of this tissue. Cells from medium size antral follicles (100-300 mum diam.) and large preovulatory follicles (500 plus mum diam.) were used. Steroids were measured by radioimmu...

journal_title：Endocrinology

authors： Makris A,Ryan KJ

更新日期：1975-03-01 00:00:00

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:We have previously shown that placental protein 12 (PP12) is synthesized and secreted by human term pregnancy decidua in vitro. In the present study, fragments of proliferative and secretory phase endometrium were cultured in media in the presence and absence of progesterone (P) and 17 beta-estradiol (E2) for 96 h. Th...

journal_title：Endocrinology

authors： Rutanen EM,Koistinen R,Sjöberg J,Julkunen M,Wahlström T,Bohn H,Seppälä M

更新日期：1986-03-01 00:00:00

abstract：:Mutations in Na(+)-glucose transporters (SGLT)-2 and hepatocyte nuclear factor (HNF)-1alpha genes have been related to renal glycosuria and maturity-onset diabetes of the young 3, respectively. However, the expression of these genes have not been investigated in type 1 and type 2 diabetes. Here in kidney of diabetic r...

journal_title：Endocrinology

authors： Freitas HS,Anhê GF,Melo KF,Okamoto MM,Oliveira-Souza M,Bordin S,Machado UF

更新日期：2008-02-01 00:00:00

abstract：:Maintenance of cell polarity is essential for Sertoli cell and blood-testis barrier (BTB) function and spermatogenesis; however, the signaling mechanisms that regulate the integrity of the cytoskeleton and polarity of Sertoli cells are not fully understood. Here, we demonstrate that rapamycin-insensitive component of ...

journal_title：Endocrinology

authors： Dong H,Chen Z,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Lin Y,Yuan W,Zhao AZ,Bai X

更新日期：2015-11-01 00:00:00

abstract：:Ghrelin is a gastric peptide that regulates appetite and GH secretion. Circulating ghrelin levels are elevated by fasting and suppressed postprandially. However, the mechanisms regulating circulating ghrelin levels are unclear. Oxyntomodulin is an anorexic peptide hormone released from L cells in the gut. We investiga...

journal_title：Endocrinology

authors： Patterson M,Murphy KG,Patel SR,Patel NA,Greenwood HC,Cooke JH,Campbell D,Bewick GA,Ghatei MA,Bloom SR

更新日期：2009-08-01 00:00:00

abstract：:The insulin receptor substrates (IRSs) are key proteins in signal transduction from the insulin receptor. Recently, we discovered a fourth member of this family, designated IRS-4, cloned its complementary DNA from the human embryonic kidney 293 cell line, and characterized its signaling properties in this cell line. A...

journal_title：Endocrinology

authors： Fantin VR,Lavan BE,Wang Q,Jenkins NA,Gilbert DJ,Copeland NG,Keller SR,Lienhard GE

更新日期：1999-03-01 00:00:00