Role of central nervous system-derived or circulating gamma-aminobutyric acid on prolactin secretion in the rat.

abstract：:Testicular tissue of normal and hCG-stimulated European eels was incubated in vitro with tritiated progesterone or androstenedione as substrates. The following compounds were isolated and identified: 5 beta-androstane-3,17-dione; 17 beta-hydroxy-5 beta-androstan-3-one; androst-4-ene-3,11,17-trione (adrenosterone); 11 ...

journal_title：Endocrinology

authors： Eckstein B,Cohen S,Hilge V

更新日期：1982-03-01 00:00:00

abstract：:Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks....

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-11-01 00:00:00

abstract：:The follicular phase rise in circulating estradiol causes a suppression of GnRH pulse amplitude and an increase in pulse frequency before stimulation of the preovulatory GnRH surge in the ewe. Studies in which samples were collected at 10-min intervals were found unsuitable to determine whether GnRH secretion is exclu...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Mauger D,Karsch FJ

更新日期：1995-04-01 00:00:00

abstract：:Slices of normal mammary tissue from pregnant and lactating mice and slices of neoplastic (MXT) mouse mammary tissue were superfused with estradiol (E2) and estrone (E1) each labeled with a different isotope. Isotope concentrations in tissue and perfusate at the steady state were used to calculate fractions and rates ...

journal_title：Endocrinology

authors： De Ryck LM,Raus JC

更新日期：1983-07-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase up to several thousand-fold in human sepsis, and immunoneutralization improves survival in two animal models of this disease. Herein, we analyzed inflammation-mediated calcitonin I gene (CALC I) expression in human adipocyte ...

journal_title：Endocrinology

authors： Linscheid P,Seboek D,Nylen ES,Langer I,Schlatter M,Becker KL,Keller U,Müller B

更新日期：2003-12-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00

abstract：:Defining the molecular genetics of diabetes gives new insight into the underlying etiology and so should help improve treatment. The genetic etiology is now known for most patients with beta-cell monogenic diabetes, allowing genetic classification. We review how this genetic knowledge alters treatment. Patients with a...

journal_title：Endocrinology

authors： Hattersley AT,Pearson ER

更新日期：2006-06-01 00:00:00

abstract：:We have recently identified, characterized, and cloned a luteal microsomal 32-kDa phosphoprotein that we named PRAP (for PRL-receptor associated protein), and we have demonstrated that PRAP binds to the intracellular domain of the short but not the long form of the PRL receptor. In this study, we used PRAP cDNA to exa...

journal_title：Endocrinology

authors： Duan WR,Parmer TG,Albarracin CT,Zhong L,Gibori G

更新日期：1997-08-01 00:00:00

abstract：:Gonadotropin subunit gene expression is regulated by gonadal, hypothalamic, and locally derived hormones. In particular, activin rapidly (within hours) acts at the gonadotrope to selectively increase the expression of FSH beta messenger RNA (mRNA). A family of activin receptors (ActRI, ActRII, and ActRIIB) has been id...

journal_title：Endocrinology

authors： Dalkin AC,Gilrain JT,Marshall JC

更新日期：1994-09-01 00:00:00

abstract：:We have investigated the ability of fetal rat skin to heal an excisional wound in vitro. Skin from the backs of E17-E19 rats was wounded using a 1-mm diameter cutting needle and suspended in culture on a 6-pin cradle for 72 h. Neither contraction nor epithelial closure was observed within wounds created in skin from E...

journal_title：Endocrinology

authors： Belford DA

更新日期：1997-09-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:Translocator protein (TSPO) is a mitochondrial outer membrane protein of unknown function with high physiological expression in steroidogenic cells. Using TSPO gene-deleted mice, we recently demonstrated that TSPO function is not essential for steroidogenesis. The first link between TSPO and steroidogenesis was establ...

journal_title：Endocrinology

authors： Tu LN,Zhao AH,Stocco DM,Selvaraj V

更新日期：2015-03-01 00:00:00

abstract：:Although reovirus infection may lead to changes in endocrine function in vivo, little is known about the precise interaction of reovirus with endocrine cells. In this study we have examined the effects of reovirus infection on two types of endocrine cells, GH4C1 cells and RINm5F cells. Both type 1 reovirus and type 3 ...

journal_title：Endocrinology

authors： Maratos-Flier E,Goodman MJ,Fields BN,Kahn CR

更新日期：1985-06-01 00:00:00

abstract：:Female Wistar-Furth rats were implanted sc with GH3 rat pituitary tumor cells. Tumors were palpable by 4 weeks, and animals were killed periodically from 5-9 weeks. Tumor-bearing rats (n = 10) were heavier than their respective controls, reaching a weight of 372 +/- 3 by 9 weeks vs. 195 +/- 5 g in controls (mean +/- S...

journal_title：Endocrinology

authors： Yamashita S,Slanina S,Kado H,Melmed S

更新日期：1986-03-01 00:00:00

abstract：:Endocannabinoids act as a major neuromodulatory system in a variety of physiological and behavioral functions. Three major lines of evidence suggest that the endocannabinoid system interacts with gonadal hormones. First, the endocannabinoid system is implicated in behaviors and physiological functions that are known t...

journal_title：Endocrinology

authors： Gorzalka BB,Dang SS

更新日期：2012-03-01 00:00:00

abstract：:We reported previously that chromogranin A (Chga) knockout (KO) mice are hypertensive and hyperadrenergic. Here we sought to determine the basis of such alterations by probing physiological, biochemical, and pharmacological responses to perturbations of the autonomic nervous system. In the conscious state, KO mice had...

journal_title：Endocrinology

authors： Gayen JR,Gu Y,O'Connor DT,Mahata SK

更新日期：2009-11-01 00:00:00

abstract：:It is assumed that after complete bilateral adrenalectomy (ADX), no adrenal tissue will redevelop and adrenal hormone levels will remain low and unaffected by stress. However, anecdotal observations in animals and in patients suggest that under some unknown circumstances the opposite can occur. Herein, we studied whet...

journal_title：Endocrinology

authors： Gotlieb N,Albaz E,Shaashua L,Sorski L,Matzner P,Rosenne E,Amram B,Benbenishty A,Golomb E,Ben-Eliyahu S

更新日期：2018-01-01 00:00:00

abstract：:Subcutaneous implantation of a silastic tubing containing crystalline estradiol in castrated female rats results in a circadian rhythm of LH release. Under such conditions, blockade of serotonin (5-HT) biosynthesis by p-chlorophenylalanine (PCPA) completely inhibits the afternoon elevation of plasma LH. Gonadotropin p...

journal_title：Endocrinology

authors： Héry M,Laplante E,Kordon C

更新日期：1976-08-01 00:00:00

abstract：:In rat ovary, androgen receptor (AR) is predominantly expressed in granulosa cells and is developmentally regulated. However, the exact mechanism that is responsible for the regulation of AR in granulosa cells has not been elucidated. The aim of this study was to examine 1) the levels of AR messenger RNA (mRNA) expres...

journal_title：Endocrinology

authors： Tetsuka M,Hillier SG

更新日期：1996-10-01 00:00:00

abstract：:The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons h...

journal_title：Endocrinology

authors： Brown J,Sagante A,Mayer T,Wright A,Bugescu R,Fuller PM,Leinninger G

更新日期：2018-09-01 00:00:00

abstract：:GH promotes the conversion of cultured preadipose 3T3 cells into adipose cells. The serum of most animals also promotes this differentiation. In order to determine the extent to which GH is responsible for the adipogenic activity of serum, we used a specific antiserum able to suppress completely the adipogenic activit...

journal_title：Endocrinology

authors： Nixon T,Green H

更新日期：1984-02-01 00:00:00

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta) has been shown to influence the growth and differentiation of many widely varied cell types in vitro, including some that are endocrinologically active. We have investigated the previously unknown effects of this unique growth factor in the differentiated rat thyroid follicul...

journal_title：Endocrinology

authors： Morris JC 3rd,Ranganathan G,Hay ID,Nelson RE,Jiang NS

更新日期：1988-09-01 00:00:00

abstract：:Human proenkephalin generated by means of a recombinant vaccinia virus expression vector was used as the substrate for a putative processing enzyme obtained from bovine adrenal chromaffin granules. The adrenal enzyme successfully cleaved proenkephalin to generate low mol wt enkephalins as well as other enkephalin-cont...

journal_title：Endocrinology

authors： Lindberg I,Thomas G

更新日期：1990-01-01 00:00:00

abstract：:Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of mal...

journal_title：Endocrinology

authors： Yu AM,Fukamachi K,Krausz KW,Cheung C,Gonzalez FJ

更新日期：2005-07-01 00:00:00

abstract：:The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell sorting. Purified A cells lack secretory activity in 1-h incubation at 1.4 mM glucose. Their release mechanism can be activated by arginine, alanine, and glutamine,...

journal_title：Endocrinology

authors： Pipeleers DG,Schuit FC,Van Schravendijk CF,Van de Winkel M

更新日期：1985-09-01 00:00:00

abstract：:3-Iodothyronamine (3-T 1 AM) and thyronamine (T AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T(3)) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less ...

journal_title：Endocrinology

authors： Piehl S,Heberer T,Balizs G,Scanlan TS,Smits R,Koksch B,Köhrle J

更新日期：2008-06-01 00:00:00

abstract：:Recent observations suggest a role for interleukin-1 (IL-1), a polypeptide product of macrophage/monocytic cells, in the immune-mediated destruction of pancreatic islet beta-cells observed in type 1 diabetes. In this study, we investigated the effects of IL-1 on both alpha- and beta-cell secretory functions in rat isl...

journal_title：Endocrinology

authors： Rabinovitch A,Pukel C,Baquerizo H

更新日期：1988-06-01 00:00:00

abstract：:This study examined the requirement for 17 beta-estradiol (E) and relaxin (R) during the preparturient period (approximately the last 30 h of gestation) for normal parturition and pup survival in the rat. On the evening of day 21 of pregnancy, primiparous Sprague-Dawley rats were bilaterally ovariectomized or sham ope...

journal_title：Endocrinology

authors： Cheah SH,Sherwood OD

更新日期：1988-05-01 00:00:00