Potential role for human cytochrome P450 3A4 in estradiol homeostasis.

abstract：:To determine whether altered noradrenergic activation of the hypothalamo-pituitary-adrenal (HPA) axis contributes to the attenuated neuroendocrine response to stress observed during lactation, the effect of intracerebroventricular injection of the alpha1-agonist methoxamine (100 microg) was compared between virgin and...

journal_title：Endocrinology

authors： Windle RJ,Brady MM,Kunanandam T,Da Costa AP,Wilson BC,Harbuz M,Lightman SL,Ingram CD

更新日期：1997-09-01 00:00:00

abstract：:A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...

journal_title：Endocrinology

authors： Clark SA,Chick WL

更新日期：1990-04-01 00:00:00

abstract：:Previous studies indicate that magnesium, like calcium, stimulates the release of calcitonin (CT) from the thyroid gland. On the other hand, C-cell hyperplasia has been noted in magnesium-deficient dogs and rats. To explore further possible interrelationships between magnesium and CT, 21-day-old Sprague-Dawley male ra...

journal_title：Endocrinology

authors： Anast CS,Gardner DW

更新日期：1985-06-01 00:00:00

abstract：:In humans, the incidence and severity of abdominal aortic aneurysms (AAA) are greater in males than in females. Chronic infusion of angiotensin II (AngII) into apolipoprotein E-deficient (apoE(-/-)) mice promotes atherosclerosis and causes the formation of AAAs. Just as human males are more susceptible to developing A...

journal_title：Endocrinology

authors： Henriques TA,Huang J,D'Souza SS,Daugherty A,Cassis LA

更新日期：2004-08-01 00:00:00

abstract：:Isolated bone cells are often described according to the presence of PTH- and calcitonin (CT)-sensitive adenylate cyclase activities. Osteoblasts are thought to be cells with PTH-sensitive adenylate cyclase but without CT response, and osteoclasts are thought to be CT-sensitive cells. We have studied the adenylate cyc...

journal_title：Endocrinology

authors： Gutierrez GE,Mundy GR,Katz MS

更新日期：1984-12-01 00:00:00

abstract：:Ovarian cancer in women is a complex and deadly disease, where the molecular events that initiate and control tumor formation remain poorly defined. Therefore, mouse models provide one approach for determining the mechanisms by which specific oncogenic factors cause ovarian surface epithelial cell and granulosa cell t...

journal_title：Endocrinology

authors： Mullany LK,Richards JS

更新日期：2012-04-01 00:00:00

abstract：:Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it in white adipose tissue (WAT), but knowledge of the mechanisms underlying the inhibitory effect of central leptin on the insulin-dependent glucose uptake in WAT is limited. After 7 d intracerebroventricular leptin tre...

journal_title：Endocrinology

authors： Bonzón-Kulichenko E,Fernández-Agulló T,Moltó E,Serrano R,Fernández A,Ros M,Carrascosa JM,Arribas C,Martínez C,Andrés A,Gallardo N

更新日期：2011-04-01 00:00:00

abstract：:Puberty in primates is timed by 2 hypothalamic events: during late infancy a decline in pulsatile GnRH release occurs, leading to a hypogonadotropic state that maintains quiescence of the prepubertal gonad; and in late juvenile development, pulsatile GnRH release is reactivated and puberty initiated, a phase of develo...

journal_title：Endocrinology

authors： Ramaswamy S,Dwarki K,Ali B,Gibbs RB,Plant TM

更新日期：2013-05-01 00:00:00

abstract：:Mammary gland is an organ that undergoes cycles of growth, differentiation, and function during pregnancy and lactation. Although it is known that the gland enhances its sensitivity to insulin during lactation, it remains to be investigated whether this increased sensitivity develops during pregnancy and which are the...

journal_title：Endocrinology

authors： Carrascosa JM,Ramos P,Molero JC,Herrera E

更新日期：1998-02-01 00:00:00

abstract：:Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell ...

journal_title：Endocrinology

authors： Tagliati F,Zatelli MC,Bottoni A,Piccin D,Luchin A,Culler MD,Degli Uberti EC

更新日期：2006-07-01 00:00:00

abstract：:The present studies were performed to determine whether the major biologically active metabolite of vitamin D3, 1,25-dihydroxycholecalciferol [1,25(OH)2D3], could influence the activities of rat colonic particulate guanylate cyclase and adenylate cyclase. To address these issues, colonocytes were harvested from Spragu...

journal_title：Endocrinology

authors： Khare S,Wilson DM,Tien XY,Dudeja PK,Wali RK,Sitrin MD,Brasitus TA

更新日期：1993-11-01 00:00:00

abstract：:Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...

journal_title：Endocrinology

authors： Wuttke M,Papewalis C,Meyer Y,Kessler C,Jacobs B,Willenberg HS,Schinner S,Kouatchoua C,Baehring T,Scherbaum WA,Schott M

更新日期：2008-11-01 00:00:00

abstract：:Using messenger RNA (mRNA) differential display, we isolated several putative differentially expressed complementary DNAs (cDNAs) from the periimplantation (days 11-12) endometrium of unilaterally pregnant pigs. Nucleotide sequence analysis revealed that one cDNA clone was 87% homologous to human spermidine/ spermine ...

journal_title：Endocrinology

authors： Green ML,Blaeser LL,Simmen FA,Simmen RC

更新日期：1996-12-01 00:00:00

abstract：:Progesterone modulates estrogen-stimulated responses in the uterus. Calbindin-D 9k (CaBP9k), a 17 beta-estradiol-responsive gene expressed in the uterus, was used as a marker to examine the interactions between endogenous progesterone and estradiol in the rat. The variations in uterine CaBP9k messenger RNAs (mRNAs) du...

journal_title：Endocrinology

authors： L'Horset F,Blin C,Brehier A,Thomasset M,Perret C

更新日期：1993-02-01 00:00:00

abstract：:The population of LHRH neurons was examined in young and middle-aged female rats at two different time points associated with the LH surge on proestrus. More immunopositive LHRH neurons were detected in the brains of young but not middle-aged females killed on the evening of proestrus (1830-2030 h) compared with those...

journal_title：Endocrinology

authors： Rubin BS,King JC

更新日期：1994-01-01 00:00:00

abstract：:In this study, site-directed mutagenesis and biochemical strategies have been used to establish whether disulfide bonding between extracellular Cys residues contributes to the structural integrity of the GnRH receptor (GnRH-R) and, if so, to delineate the nature of the bonding patterns involved. The majority of G prot...

journal_title：Endocrinology

authors： Cook JV,Eidne KA

更新日期：1997-07-01 00:00:00

abstract：:We have shown previously that neonatal testicular gonocytes express platelet-derived growth factor receptors (PDGFR) alpha and beta. We report the expression of a novel PDGFRbeta (V1-PDGFRbeta) transcript in gonocytes of 3-d-old rat testes. V1-PDGFRbeta nucleotide sequence spans from intron 6 to exon 23 of the PDGFRbe...

journal_title：Endocrinology

authors： Wang Y,Culty M

更新日期：2007-05-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), the predominant IGF carrier protein in circulation, is posttranslationally modified in vivo by IGFBP-3 protease(s) into a number of fragments. Based on the ascertained and predicted recognition sites for known IGFBP-3 proteases, FLAG-epitope tagged intact I...

journal_title：Endocrinology

authors： Devi GR,Yang DH,Rosenfeld RG,Oh Y

更新日期：2000-11-01 00:00:00

abstract：:Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids) and some unique brain-specific steroids. Neurosteroids are thought to mediate their action through ion gated channel receptors such as gamma-aminobutyric acid(A) and N-methyl-D-aspartate rathe...

journal_title：Endocrinology

authors： Compagnone NA,Bulfone A,Rubenstein JL,Mellon SH

更新日期：1995-11-01 00:00:00

abstract：:Effects of thyroid hormone on proteoglycan degradation in various regions of cartilage were investigated. In propylthiouracil-treated rats with hypothyroidism, proteoglycan degradation in epiphyseal cartilage during endochondral ossification was markedly suppressed. However, injections of T(4) reversed this effect of ...

journal_title：Endocrinology

authors： Makihira S,Yan W,Murakami H,Furukawa M,Kawai T,Nikawa H,Yoshida E,Hamada T,Okada Y,Kato Y

更新日期：2003-06-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...

journal_title：Endocrinology

authors： Heindel JJ,Balbus J,Birnbaum L,Brune-Drisse MN,Grandjean P,Gray K,Landrigan PJ,Sly PD,Suk W,Cory Slechta D,Thompson C,Hanson M

更新日期：2015-10-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:The present studies demonstrate that the murine adrenocortical tumor cell line Y-1 releases a digoxin-like immunoreactive material into both serum-supplemented nutrient medium and minimal Krebs-Ringer bicarbonate medium. Release of pregnenolone into minimal medium from these cells was consistently inhibited by additio...

journal_title：Endocrinology

authors： Doris PA,Kilgore MW,Durham D,Alberts D,Stocco DM

更新日期：1989-11-01 00:00:00

abstract：:Immunoreactive LHRH was detected in hypothalamic and extrahypothalamic brain extracts of the rat, bird (pigeon and chicken), reptile (tortoise and lizard), amphibian (frog and toad), teleost (cichid), and elasmobranch (dogfish) and in the whole brain of the cyclostome (bagfish). The concentration of hypothalamic immun...

journal_title：Endocrinology

authors： King JA,Millar RP

更新日期：1980-03-01 00:00:00

abstract：:Adrenal cAMP and plasma corticosterone levels were determined in pre-weanling rats subjected to treatment with either ACTH (50 mU/rat) or histamine dihydrochloride (0.2 mg/g body wt). ACTH injection elevated both serum corticosterone and adrenal cAMP levels on all days tested. However, the ACTH-induced elevation of ad...

journal_title：Endocrinology

authors： Cote TE,Yasumura S

更新日期：1975-04-01 00:00:00

abstract：:Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. We investigated the effects of activin, a factor involved in the regulation of PC growth and steroidogenic enzym...

journal_title：Endocrinology

authors： Hofland J,van Weerden WM,Steenbergen J,Dits NF,Jenster G,de Jong FH

更新日期：2012-12-01 00:00:00

abstract：:The basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (Tg) were measured in normal male rats. Serum Tg concentrations (by RIA) in Sprague-Dawley adult males ranged from 70-680 ng/ml (mean +/- SD, 218 +/- 177). In male Fisher rats, basal serum Tg concentrations were 32-263 ng/ml. ...

journal_title：Endocrinology

authors： Izumi M,Larsen PR

更新日期：1978-07-01 00:00:00

abstract：:This study examined the effect of two thirds hepatectomy on rat liver insulin-like growth factor-II (IGF-II) receptors and IGF-II receptor messenger RNA (mRNA) levels. IGF-II receptor levels were determined in liver plasma membrane and Golgi/endosome fractions from sham-operated and hepatectomized rats by ligand bindi...

journal_title：Endocrinology

authors： Scott CD,Ballesteros M,Baxter RC

更新日期：1990-11-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00